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Clinical trials · failure tracking
Oncology studies whose overall status is TERMINATED, WITHDRAWN or SUSPENDED on ClinicalTrials.gov, with the stop reason exactly as the registrant posted it. A category is attached only when an explicit keyword rule matches the text; CancerIndex never infers why a study stopped.
328 stopped studies mapped to Myelodysplastic Syndrome and descendants · 88% state a reason
Over the 328 studies matching the cancer, status and year filters (the category filter does not change this chart). Each study is counted once, in the first matching category; greyed bars are studies whose text matched no rule or was empty.
Computedrules ci-stop-reasons-v1 · keyword matching only
A category is assigned when one of its keywords appears in the posted text (case-insensitive, whole words). Rules are tested in this order and the first match wins; every match is kept in the API (reasonMatches).
| NCT | Title | Phase | Status | First posted | Lead sponsor | Why stopped (as posted) | Category |
|---|---|---|---|---|---|---|---|
| NCT00004239 | 506U78 in Treating Patients With Hematologic Cancer and Kidney or Liver Impairment | Phase 1 | terminated | Jan 29, 2004 | Alliance for Clinical Trials in Oncology | poor accrual | Enrollment / accrual |
| NCT00510289 | Sorafenib in Myelodysplastic Syndrome | Phase 2 | terminated | Aug 1, 2007 | Duke University | Early closure of study due to poor response | Other (stated, no rule matched) |
| NCT00664677 | Phase 1 Study of Terameprocol (EM-1421) in Patients With Leukemia | Phase 1 | terminated | Apr 23, 2008 | Erimos Pharmaceuticals | Funding constraints | Funding |
| NCT01880437 | A Study of Vismodegib in Patients With Relapsed/Refractory Acute Myelogenous Leukemia and… | Phase 2 | terminated | Jun 19, 2013 | Hoffmann-La Roche | not stated | Not stated |
| NCT01624701 | Clinical Ex Vivo Expansion of Human Umbilical Cord Blood Stem and Progenitor Cells | Phase 1 / Phase 2 | terminated | Jun 21, 2012 | Singapore General Hospital | Funding expired | Funding |
| NCT01211691 | Study of KB004 in Subjects With Hematologic Malignancies (Myelodysplastic Syndrome, MDS,… | Phase 1 / Phase 2 | suspended | Sep 29, 2010 | Humanigen, Inc. | KaloBios to Wind Down Operations | Other (stated, no rule matched) |
| NCT01615146 | Outpatient Platelet Transfusions in Myelodysplastic Syndromes and Leukemia: The OPTIMAL…(OPTIMAL) | N/A | terminated | Jun 8, 2012 | Ottawa Hospital Research Institute | Poor recruitment | Enrollment / accrual |
| NCT00569179 | A Phase I Trial of Alloreactive Cell Infusion Following Transplantation of Haplotype… | Phase 1 | terminated | Dec 7, 2007 | Indiana University | Slow accrual | Enrollment / accrual |
| NCT01908387 | Phase 1 Study of CC-486 in Japanese Subjects With Hematological Neoplasms | Phase 1 | terminated | Jul 25, 2013 | Celgene Corporation | Due to Slow Accrual study was terminated. | Enrollment / accrual |
| NCT00374296 | MGCD0103 in Elderly Patients With Previously Untreated AML/High Risk MDS or Adults With… | Phase 2 | terminated | Sep 11, 2006 | Mirati Therapeutics Inc. | The Clinical Development Program for MGCD0103 is being re-evaluated | Other (stated, no rule matched) |
| NCT00963495 | Study Evaluating the Tolerance and Biological Activity of Oral Clioquinol in Patients… | Phase 1 | terminated | Aug 21, 2009 | University Health Network, Toronto | not stated | Not stated |
| NCT00800150 | Total Marrow and Total Lymph Node Irradiation, Fludarabine, and Melphalan Followed By… | Phase 1 | terminated | Dec 1, 2008 | City of Hope Medical Center | Protocol objective could not be met. A new study with amended eligibility criteria will be… | Other (stated, no rule matched) |
| NCT00952185 | Influenza Vaccine in Preventing Flu in Patients Who Have Undergone Stem Cell Transplant… | N/A | terminated | Aug 6, 2009 | City of Hope Medical Center | Very low enrollment and follow-up, cannot meet study objectives | Enrollment / accrual |
| NCT00770419 | Perceptions of Burden in Patients With Late-Stage Cancer and Their Caregivers | — | withdrawn | Oct 10, 2008 | Rutgers, The State University of New Jersey | Slow accrual | Enrollment / accrual |
| NCT00100152 | A Notch Signalling Pathway Inhibitor for Patients With T-cell Acute Lymphoblastic… | Phase 1 | terminated | Dec 24, 2004 | Merck Sharp & Dohme LLC | not stated | Not stated |
| NCT00666497 | Phase 2 Study of Azacitidine (Vidaza) vs MGCD0103 vs Combination in Elderly Subjects With… | Phase 2 | terminated | Apr 25, 2008 | Mirati Therapeutics Inc. | Celgene terminated its collaboration agreement with MethylGene for the development of MGCD0103. All… | Other (stated, no rule matched) |
| NCT00109538 | Study of Lonafarnib Versus Placebo in Subjects With Either Myelodysplastic Syndrome (MDS)… | Phase 3 | terminated | Apr 29, 2005 | Merck Sharp & Dohme LLC | not stated | Not stated |
| NCT00669890 | Allogenic Stem Cell Transplantation in Patients With High Risk CD33+ AML/MDS/JMML(High Risk) | Phase 1 | terminated | May 1, 2008 | New York Medical College | PI left institution | Investigator |
| NCT01203228 | Dose-reduced Versus Standard Conditioning in MDS/sAML(RICMAC) | Phase 3 | terminated | Sep 16, 2010 | European Society for Blood and Marrow Transplantation | not stated | Not stated |
| NCT01488253 | Sirolimus/Tacrolimus Combination After HLA Matched Related Peripheral Blood Stem Cell… | Phase 2 | terminated | Dec 8, 2011 | The Korean Society of Blood and Marrow Transplantation | We could not receive the support from the national medical insurance owing to the changed policy of… | Other (stated, no rule matched) |
| NCT00002790 | Prevention of Graft-Versus-Host Disease in Patients With Hematologic Malignancies Who Are… | Phase 1 / Phase 2 | withdrawn | Sep 2, 2004 | Fred Hutchinson Cancer Center | not stated | Not stated |
| NCT00916045 | Pilot Study of Unrelated Cord Blood Transplantation | Phase 2 | terminated | Jun 8, 2009 | King's College Hospital NHS Trust | Recruitment issues | Enrollment / accrual |
| NCT01010373 | Safety and Efficacy Study of AS101 to Treat Elderly Acute Myeloid Leukemia (AML) and… | Phase 2 | suspended | Nov 10, 2009 | BioMAS Ltd | The sponsor is currently focusing on different indications | Other (stated, no rule matched) |
| NCT00509249 | Aflibercept in Treating Patients With Myelodysplastic Syndromes | Phase 2 | terminated | Jul 31, 2007 | National Cancer Institute (NCI) | Early termination for discouraging results | Other (stated, no rule matched) |
| NCT01077440 | Presence of Donor-Derived DNA in Semen Samples From Cancer Survivors Who Underwent Donor… | — | terminated | Mar 1, 2010 | Vanderbilt University | PI leaving institution | Other (stated, no rule matched) |
| NCT00081055 | OTI-010 for Graft-Versus-Host Disease Prophylaxis in Treating Patients Who Are Undergoing… | Phase 2 | withdrawn | Apr 8, 2004 | Mesoblast International Sàrl | not stated | Not stated |
| NCT00594308 | In-Vivo Activated T-Cell Depletion to Prevent GVHD | N/A | terminated | Jan 15, 2008 | Indiana University | Treatment ineffective | Other (stated, no rule matched) |
| NCT00593645 | Clofarabine, Cytarabine, and Thymoglobulin for Allogeneic Transplantation | Phase 2 | terminated | Jan 15, 2008 | Washington University School of Medicine | toxicities were worse than expected | Safety / toxicity |
| NCT00008216 | Blood Stem Cell Transplant in Treating Patients With Hematologic Cancer | — | terminated | Jan 27, 2003 | Columbia University | Poor enrollment | Enrollment / accrual |
| NCT00608517 | Treatment of Single or Double Umbilical Cord Trans + Graft-versus-host Disease (GVHD)… | N/A | terminated | Feb 6, 2008 | Vanderbilt-Ingram Cancer Center | slow accrual | Enrollment / accrual |
| NCT00949117 | Cyproheptadine Hydrochloride and Nutritional Supplementation in Treating Young Patients… | Phase 2 | terminated | Jul 30, 2009 | University of South Florida | study not feasible with low accrual. DSMB recommended closure | Enrollment / accrual |
| NCT00943293 | Minor Histocompatibility Vaccination After Allogeneic Stem Cell Transplantation for… | Phase 1 | terminated | Jul 22, 2009 | University of Chicago | Poor accrual; did not enter phase 2 | Enrollment / accrual |
| NCT00396968 | AMD3100 With Busulfan, Fludarabine and Thymoglobulin for Allogeneic Stem Cell Transplant… | Phase 1 / Phase 2 | withdrawn | Nov 8, 2006 | Genzyme, a Sanofi Company | not stated | Not stated |
| NCT00818961 | Donor Stem Cell Transplant in Treating Patients With High-Risk Hematologic Cancer | Phase 2 | terminated | Jan 8, 2009 | Northside Hospital, Inc. | terminated early due to meeting end point with fewer patients than anticipated | Other (stated, no rule matched) |
| NCT00923234 | Combination of 5-azacitidine and Lenalidomide in Myelodysplastic Syndromes (MDS) or Acute…(AZALE) | Phase 1 | terminated | Jun 18, 2009 | Technische Universität Dresden | The primary objective has already been answered with the number of recruited patients. | Enrollment / accrual |
| NCT00672152 | A Phase I Study of WT1 Peptides to Induce Anti-Leukemia Immune Responses Following…(WT-1) | Phase 1 | terminated | May 6, 2008 | Michael Morse, MD | low accrual | Enrollment / accrual |
| NCT00967525 | Intraosseous Infusion of Unrelated Cord Blood Grafts | N/A | terminated | Aug 28, 2009 | Emory University | poor enrollment | Enrollment / accrual |
| NCT00814983 | Myeloablative Allogeneic Stem Cell Transplantation Using a Naive T-Cell Depleted… | Phase 1 / Phase 2 | terminated | Dec 29, 2008 | Duke University | IND approval for naive T-cell depletion not obtained | Other (stated, no rule matched) |
| NCT01500161 | Pooled Unrelated Donor Umbilical Cord Blood Transplant For Hematologic Malignancy Needing… | Phase 2 | terminated | Dec 28, 2011 | Texas Oncology Cancer Center | Insufficient accruals | Enrollment / accrual |
| NCT00049582 | Decitabine in Treating Patients With Myelodysplastic Syndromes or Acute Myeloid Leukemia | Phase 1 | terminated | Jan 27, 2003 | National Cancer Institute (NCI) | not stated | Not stated |
| NCT00301769 | SJG-136 in Treating Patients With Relapsed or Refractory Acute Leukemia, Myelodysplastic… | Phase 1 | terminated | Mar 13, 2006 | National Cancer Institute (NCI) | not stated | Not stated |
| NCT00720850 | Lenalidomide Maintenance Therapy in Patients With Myelodysplastic Syndromes (MDS) or…(LENAMAINT) | Phase 2 | terminated | Jul 23, 2008 | Technische Universität Dresden | Low recruitment, scientific rationale not applicable anymore to all patients and possible induction… | Enrollment / accrual |
| NCT00996359 | Partially HLA-Matched Irradiated Allogeneic Cellular Therapy After Reduced Intensity… | Phase 1 | terminated | Oct 16, 2009 | University of Medicine and Dentistry of New Jersey | Slow accrual | Enrollment / accrual |
| NCT00965861 | SCRI Tissue Testing Registry | — | terminated | Aug 26, 2009 | SCRI Development Innovations, LLC | Replaced by a study with a similar design. | Other (stated, no rule matched) |
| NCT00514722 | Pilot Study of Umbilical Cord Blood Transplantation in Adult Patient With Advanced… | N/A | terminated | Aug 10, 2007 | University of California, San Francisco | low accrual | Enrollment / accrual |
| NCT00513318 | Pilot Study of Reduced-Intensity Umbilical Cord Blood Transplantation in Adult Patients… | — | terminated | Aug 8, 2007 | University of California, San Francisco | Insufficient enrollment to justify keeping open. | Enrollment / accrual |
| NCT01463410 | Accuracy Testing of the Chromosomal Aberration and Gene Mutation Markers of the… | — | terminated | Nov 1, 2011 | Skyline Diagnostics BV | The required number of banked samples could not be met due to limited availability. There is no… | Other (stated, no rule matched) |
| NCT00899951 | Studying Fentanyl in Patients With Cancer | — | terminated | May 12, 2009 | Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | poor accrual | Enrollment / accrual |
| NCT00658411 | Deferoxamine for Iron Overload Before Allogeneic Stem Cell Transplantation | N/A | terminated | Apr 15, 2008 | Dana-Farber Cancer Institute | Closed due to slow patient accrual | Enrollment / accrual |
| NCT00499668 | Aprepitant or Ondansetron in Treating Nausea and Vomiting Caused By Opioids in Patients… | N/A | withdrawn | Jul 11, 2007 | Vanderbilt-Ingram Cancer Center | slow accrual | Enrollment / accrual |
Stop reasons are registrant-reported free text and are displayed verbatim (truncated; hover for the full text). Categories come from explicit keyword rules and are never inferred from the study design, sponsor or outcome; a study that stopped for several reasons is filed under the first rule that matched. A TERMINATED status does not imply a negative result.
Data updated 23 days agoSource updated Jul 4, 2016source: clinicaltrials