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Clinical trials · failure tracking
Oncology studies whose overall status is TERMINATED, WITHDRAWN or SUSPENDED on ClinicalTrials.gov, with the stop reason exactly as the registrant posted it. A category is attached only when an explicit keyword rule matches the text; CancerIndex never infers why a study stopped.
86 stopped studies mapped to Myelodysplastic/Myeloproliferative Neoplasm and descendants · 91% state a reason
Over the 86 studies matching the cancer, status and year filters (the category filter does not change this chart). Each study is counted once, in the first matching category; greyed bars are studies whose text matched no rule or was empty.
Computed
A category is assigned when one of its keywords appears in the posted text (case-insensitive, whole words). Rules are tested in this order and the first match wins; every match is kept in the API (reasonMatches).
| NCT | Title | Phase | Status | First posted | Lead sponsor | Why stopped (as posted) | Category |
|---|---|---|---|---|---|---|---|
| NCT00708721 | Low-dose Oral Clofarabine for the Treatment of IPSS INT-1, INT-2 or HIGH Myelodysplastic… | Phase 1 / Phase 2 | terminated | Jul 2, 2008 | University of Utah | Data analysis revealed sufficient data for safety and efficacy | Safety / toxicity |
| NCT02259348 | Repeat Transplantation for Relapsed or Refractory Hematologic Malignancies Following… | Phase 2 | terminated | Oct 8, 2014 | St. Jude Children's Research Hospital | Investigator's decision. | Investigator |
| NCT00555048 | Alemtuzumab, Busulfan, and Cyclophosphamide Followed By a Donor Stem Cell Transplant in… | Phase 1 / Phase 2 | terminated | Nov 7, 2007 | Fred Hutchinson Cancer Center | Low accrual | Enrollment / accrual |
| NCT00324324 | Moxifloxacin in Preventing Bacterial Infections in Patients Who Have Undergone Donor Stem… | Phase 3 | terminated | May 11, 2006 | OHSU Knight Cancer Institute | not stated | Not stated |
| NCT00900068 | Blood Samples From Patients on a Clinical Trial to CINV During HSCT | — | terminated | May 12, 2009 | OHSU Knight Cancer Institute | not stated | Not stated |
| NCT02564536 | Pacritinib in Combination With Low Dose Decitabine in Intermediate-High Risk… | Phase 1 | withdrawn | Sep 30, 2015 | Washington University School of Medicine | Lack of funding following full FDA clinical hold | Funding |
| NCT01118013 | Donor Stem Cell Transplant in Treating Patients With Relapsed Hematologic Malignancies or… | Phase 2 | terminated | May 6, 2010 | Alliance for Clinical Trials in Oncology | not stated | Not stated |
| NCT01749111 | Comparison Between Cyclophosphamide and Combination of Methotrexate + Calcineurin…(CICLODECH) | Phase 3 | terminated | Dec 13, 2012 | Hospital Israelita Albert Einstein | Lack of accrual | Enrollment / accrual |
| NCT01621477 | T-Cell Replete Haploidentical Donor Hematopoietic Stem Cell Plus Natural Killer (NK) Cell… | Phase 2 | terminated | Jun 18, 2012 | St. Jude Children's Research Hospital | Study was terminated in August 2016 due to replacement by a new study. | Other (stated, no rule matched) |
| NCT00946283 | Lactobacillus in Preventing Infection in Patients Undergoing a Donor Stem Cell Transplant… | N/A | terminated | Jul 24, 2009 | Rutgers, The State University of New Jersey | slow accrual | Enrollment / accrual |
| NCT00255684 | Fludarabine, Cyclophosphamide, and Total-Body Irradiation Followed by Cyclosporine and… | N/A | terminated | Nov 21, 2005 | University of Rochester | low accrual | Enrollment / accrual |
| NCT02147873 | Study of Azacitidine With or Without Birinapant in Subjects With MDS or CMMoL | Phase 2 | terminated | May 28, 2014 | TetraLogic Pharmaceuticals | Study terminated due to lack of efficacy | Efficacy / futility |
| NCT01652014 | Single or Double Donor Umbilical Cord Blood Transplant in Treating Patients With… | Phase 2 | withdrawn | Jul 27, 2012 | University of Medicine and Dentistry of New Jersey | Funding unavailable | Funding |
| NCT00664677 | Phase 1 Study of Terameprocol (EM-1421) in Patients With Leukemia | Phase 1 | terminated | Apr 23, 2008 | Erimos Pharmaceuticals | Funding constraints | Funding |
| NCT01908387 | Phase 1 Study of CC-486 in Japanese Subjects With Hematological Neoplasms | Phase 1 | terminated | Jul 25, 2013 | Celgene Corporation | Due to Slow Accrual study was terminated. | Enrollment / accrual |
| NCT00800150 | Total Marrow and Total Lymph Node Irradiation, Fludarabine, and Melphalan Followed By… | Phase 1 | terminated | Dec 1, 2008 | City of Hope Medical Center | Protocol objective could not be met. A new study with amended eligibility criteria will be… | Other (stated, no rule matched) |
| NCT00952185 | Influenza Vaccine in Preventing Flu in Patients Who Have Undergone Stem Cell Transplant… | N/A | terminated | Aug 6, 2009 | City of Hope Medical Center | Very low enrollment and follow-up, cannot meet study objectives | Enrollment / accrual |
| NCT00770419 | Perceptions of Burden in Patients With Late-Stage Cancer and Their Caregivers | — | withdrawn | Oct 10, 2008 | Rutgers, The State University of New Jersey | Slow accrual | Enrollment / accrual |
| NCT00669890 | Allogenic Stem Cell Transplantation in Patients With High Risk CD33+ AML/MDS/JMML(High Risk) | Phase 1 | terminated | May 1, 2008 | New York Medical College | PI left institution | Investigator |
| NCT00509249 | Aflibercept in Treating Patients With Myelodysplastic Syndromes | Phase 2 | terminated | Jul 31, 2007 | National Cancer Institute (NCI) | Early termination for discouraging results | Other (stated, no rule matched) |
| NCT01077440 | Presence of Donor-Derived DNA in Semen Samples From Cancer Survivors Who Underwent Donor… | — | terminated | Mar 1, 2010 | Vanderbilt University | PI leaving institution | Other (stated, no rule matched) |
| NCT00008216 | Blood Stem Cell Transplant in Treating Patients With Hematologic Cancer | — | terminated | Jan 27, 2003 | Columbia University | Poor enrollment | Enrollment / accrual |
| NCT00387426 | Sunitinib in Treating Patients With Idiopathic Myelofibrosis | Phase 2 | terminated | Oct 13, 2006 | National Cancer Institute (NCI) | not stated | Not stated |
| NCT00818961 | Donor Stem Cell Transplant in Treating Patients With High-Risk Hematologic Cancer | Phase 2 | terminated | Jan 8, 2009 | Northside Hospital, Inc. | terminated early due to meeting end point with fewer patients than anticipated | Other (stated, no rule matched) |
| NCT00049582 | Decitabine in Treating Patients With Myelodysplastic Syndromes or Acute Myeloid Leukemia | Phase 1 | terminated | Jan 27, 2003 | National Cancer Institute (NCI) | not stated | Not stated |
| NCT00066417 | Peripheral Stem Cell Transplant in Treating Patients With High-Risk Leukemia | Phase 2 | terminated | Aug 7, 2003 | National Heart, Lung, and Blood Institute (NHLBI) | Trial was withdrawn for drug availability issues. | Drug supply |
| NCT00899951 | Studying Fentanyl in Patients With Cancer | — | terminated | May 12, 2009 | Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | poor accrual | Enrollment / accrual |
| NCT01101412 | Antimicrobial Solution or Saline Solution in Maintaining Catheter Patency and Preventing… | Phase 1 / Phase 2 | withdrawn | Apr 12, 2010 | M.D. Anderson Cancer Center | Study was not opened. | Other (stated, no rule matched) |
| NCT00301912 | Busulfan and Fludarabine Before Donor Stem Cell Transplant in Treating Patients With… | Phase 2 | withdrawn | Mar 13, 2006 | University of California, San Francisco | Withdrawn because study never opened to accrual | Enrollment / accrual |
| NCT00062231 | Moxifloxacin Compared With Ciprofloxacin/Amoxicillin in Treating Fever and Neutropenia in… | N/A | terminated | Jun 6, 2003 | European Organisation for Research and Treatment of Cancer - EORTC | low accrual | Enrollment / accrual |
| NCT00113321 | Low-Dose Decitabine in Myelodysplastic Syndrome Post Azacytidine Failure | Phase 2 | terminated | Jun 8, 2005 | M.D. Anderson Cancer Center | Low Accrual | Enrollment / accrual |
| NCT01558778 | Mechanical Stimulation in Preventing Bone Density Loss in Patients Undergoing Donor Stem… | N/A | withdrawn | Mar 20, 2012 | Roswell Park Cancer Institute | device not available | Other (stated, no rule matched) |
| NCT00253552 | G-CSF-Treated Donor Bone Marrow Transplant in Treating Patients With Hematologic Disorders | N/A | terminated | Nov 15, 2005 | OHSU Knight Cancer Institute | Terminated at request of PI as study was outdated. | Other (stated, no rule matched) |
| NCT00074750 | Study of DT388GMCSF Fusion Protein in Acute Myelogenous Leukemia (AML) and Chronic… | Phase 1 | terminated | Dec 23, 2003 | M.D. Anderson Cancer Center | Slow accrual. | Enrollment / accrual |
| NCT00813501 | Immunologic Diagnostic Blood Test in Predicting Side-Effects in Patients Undergoing a… | — | terminated | Dec 23, 2008 | City of Hope Medical Center | Terminated at the request of the study sponsor | Other (stated, no rule matched) |
| NCT00004058 | 12-O-Tetradecanoylphorbol-13-acetate in Treating Patients With Hematologic Cancer or Bone… | Phase 1 | terminated | Jan 27, 2003 | University of Medicine and Dentistry of New Jersey | At this time it is felt that we will not gain further information from an additional patients. | Other (stated, no rule matched) |
Stop reasons are registrant-reported free text and are displayed verbatim (truncated; hover for the full text). Categories come from explicit keyword rules and are never inferred from the study design, sponsor or outcome; a study that stopped for several reasons is filed under the first rule that matched. A TERMINATED status does not imply a negative result.
Data updated 22 days agoSource updated Jun 1, 2017source: clinicaltrials