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Clinical trials · failure tracking
Oncology studies whose overall status is TERMINATED, WITHDRAWN or SUSPENDED on ClinicalTrials.gov, with the stop reason exactly as the registrant posted it. A category is attached only when an explicit keyword rule matches the text; CancerIndex never infers why a study stopped.
5 stopped studies mapped to Meningeal Carcinomatosis and descendants · 100% state a reason
Over the 5 studies matching the cancer, status and year filters (the category filter does not change this chart). Each study is counted once, in the first matching category; greyed bars are studies whose text matched no rule or was empty.
Computedrules ci-stop-reasons-v1 · keyword matching only
A category is assigned when one of its keywords appears in the posted text (case-insensitive, whole words). Rules are tested in this order and the first match wins; every match is kept in the API (reasonMatches).
| NCT | Title | Phase | Status | First posted | Lead sponsor | Why stopped (as posted) | Category |
|---|---|---|---|---|---|---|---|
| NCT04729348 | Pembrolizumab And Lenvatinib In Leptomeningeal Metastases | Phase 2 | terminated | Jan 28, 2021 | Massachusetts General Hospital | Planned interim analysis | Efficacy / futility |
| NCT00527410 | A Safety Study of RTA 744 in Recurrent, Progressive or Refractory Neoplastic Meningitis(LMD) | Phase 1 | terminated | Sep 10, 2007 | Biogen | Business Decision | Sponsor / business decision |
| NCT04315246 | 177Lu-DTPA-Omburtamab Radioimmunotherapy for Leptomeningeal Metastasis From Solid Tumors… | Phase 1 / Phase 2 | withdrawn | Mar 19, 2020 | Y-mAbs Therapeutics | Business priorities | Sponsor / business decision |
| NCT00005812 | Temozolomide in Treating Patients With Leptomeningeal Metastases From a Solid Tumor or… | Phase 2 | terminated | Jan 27, 2003 | Dartmouth-Hitchcock Medical Center | No objective response documented, protocol terminated after 12 patients. | Other (stated, no rule matched) |
| NCT01438021 | Continuous Intraventricular Methotrexate in Treating Patients With Leptomeningeal Disease | N/A | withdrawn | Sep 21, 2011 | City of Hope Medical Center | Lack of funding | Funding |
Stop reasons are registrant-reported free text and are displayed verbatim (truncated; hover for the full text). Categories come from explicit keyword rules and are never inferred from the study design, sponsor or outcome; a study that stopped for several reasons is filed under the first rule that matched. A TERMINATED status does not imply a negative result.
Data updated 22 days agoSource updated Jul 25, 2025source: clinicaltrials