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Clinical trials · failure tracking
Oncology studies whose overall status is TERMINATED, WITHDRAWN or SUSPENDED on ClinicalTrials.gov, with the stop reason exactly as the registrant posted it. A category is attached only when an explicit keyword rule matches the text; CancerIndex never infers why a study stopped.
840 stopped studies mapped to Malignant Prostate Neoplasm and descendants · 92% state a reason
Over the 840 studies matching the cancer, status and year filters (the category filter does not change this chart). Each study is counted once, in the first matching category; greyed bars are studies whose text matched no rule or was empty.
Computedrules ci-stop-reasons-v1 · keyword matching only
A category is assigned when one of its keywords appears in the posted text (case-insensitive, whole words). Rules are tested in this order and the first match wins; every match is kept in the API (reasonMatches).
| NCT | Title | Phase | Status | First posted | Lead sponsor | Why stopped (as posted) | Category |
|---|---|---|---|---|---|---|---|
| NCT02844647 | Hyperpolarized Carbon-13 Imaging of Metastatic Prostate Cancer | Phase 1 | terminated | Jul 26, 2016 | Sunnybrook Health Sciences Centre | Lack of participants | Other (stated, no rule matched) |
| NCT03440879 | Androgen Deprivation Therapy Muscle Protein Metabolism and Blood Glucose | N/A | terminated | Feb 22, 2018 | Norwegian School of Sport Sciences | Low recruitment rate | Enrollment / accrual |
| NCT04423913 | Safety, Tolerability, Distribution & Dose Effect of Neoadjuvant Transarterial…(CAPEMCHAR) | Phase 2 | terminated | Jun 9, 2020 | Centre Hospitalier Universitaire de Nīmes | Recruitment difficulties | Enrollment / accrual |
| NCT05245435 | Diagnostic and Prognostic Accuracy of FDHT-PET and Liquid Biopsies in Prostate Cancer | N/A | withdrawn | Feb 18, 2022 | Medical University of Vienna | Recruitment was not possible with the chosen inclusion/exclusion criteria at our Institution. | Enrollment / accrual |
| NCT03122470 | Correlation of Imaging Findings With Clinical Findings and Patient Outcomes in Prostate… | N/A | withdrawn | Apr 20, 2017 | Case Comprehensive Cancer Center | PI departure - study not conducted. | Other (stated, no rule matched) |
| NCT01709734 | A 2 Part, Phase 2 Trial of Galeterone in the Treatment of Castration Resistant Prostate…(ARMOR2) | Phase 2 | terminated | Oct 18, 2012 | LTN PHARMACEUTICALS, INC. | Study was terminated prematurely in all investigational study centers upon recommendation from the… | Efficacy / futility |
| NCT02438007 | A Study of Galeterone Compared to Enzalutamide In Men Expressing Androgen Receptor Splice…(ARMOR3-SV) | Phase 3 | terminated | May 8, 2015 | LTN PHARMACEUTICALS, INC. | not stated | Not stated |
| NCT03439033 | Comparison Study of PET/CT or PET/MRI Imaging to Magnetic Resonance Imaging (MRI) Alone… | Phase 2 | terminated | Feb 20, 2018 | Weill Medical College of Cornell University | Study Drug was FDA approved Summer 2021 | Other (stated, no rule matched) |
| NCT04797078 | US/MRI Fusion Local Anestesia TransPerineal Prostate Biopsies for Detection of Prostate…(FLAPP) | N/A | withdrawn | Mar 15, 2021 | Karolinska Institutet | Planning halted due to changes in the research group constellation. | Other (stated, no rule matched) |
| NCT03921996 | Extended Pelvic Lymph Node Dissection vs. no Pelvic Lymph Node Dissection at Radical… | Phase 3 | terminated | Apr 19, 2019 | Swiss Cancer Institute | Due to lack of funding. | Funding |
| NCT01792882 | Prospective Collection of Surplus Surgical Tumor Tissues and Pre-surgical Blood Samples(GBCPRT0008) | — | withdrawn | Feb 15, 2013 | Global BioClinical | not stated | Not stated |
| NCT05705700 | Biomarker Study of in Men With PSA Progression on Abi for CR or CS PC (Bio-STAMP) | Phase 2 | withdrawn | Jan 31, 2023 | Masonic Cancer Center, University of Minnesota | Feasibility | Other (stated, no rule matched) |
| NCT05744115 | Ga-68-PSMA-11 in Men With Prostate Cancer(Ga68-PSMA-11) | Phase 3 | terminated | Feb 24, 2023 | Timothy Hoffman | The investigational product was approved by the FDA (12/20/2021) and is now commercially available | Other (stated, no rule matched) |
| NCT04873427 | In Situ Clonal Heterogeneity in Prostatic Diagnostic Biopsies | — | terminated | May 5, 2021 | Clinica Luganese Moncucco | The results of the genomic analyses were compromised due to the low DNA concentration. | Other (stated, no rule matched) |
| NCT02721979 | Apalutamide in Treating Patients With Prostate Cancer Who Are in Active Surveillance | Phase 2 | terminated | Mar 29, 2016 | University of Washington | Terminated due to slow accrual | Enrollment / accrual |
| NCT02420652 | Metformin Hydrochloride and Aspirin in Treating Patients With Hormone-Dependent Prostate…(PRIMA) | Phase 2 | terminated | Apr 20, 2015 | Rutgers, The State University of New Jersey | Slow accrual | Enrollment / accrual |
| NCT01045226 | Proton Radiation Therapy in Treating Patients With Prostate Cancer | N/A | terminated | Jan 8, 2010 | Abramson Cancer Center at Penn Medicine | participants are no longer being followed up. | Other (stated, no rule matched) |
| NCT02146833 | SHIP (Selinexor in Hormone Insensitive Prostate Cancer)(SHIP) | Phase 2 | terminated | May 26, 2014 | Karyopharm Therapeutics Inc | Due to enrollment challenges. The termination is not a consequence of any safety concern. | Safety / toxicity |
| NCT03982173 | Basket Trial for Combination Therapy With Durvalumab (Anti-PDL1) (MEDI4736) and…(MATILDA) | Phase 2 | withdrawn | Jun 11, 2019 | Gustave Roussy, Cancer Campus, Grand Paris | Similar clinical trials showed not very encouraging results, which made us decide, after several… | Other (stated, no rule matched) |
| NCT03796195 | (SGB) in Men Treated for Prostate Cancer Improve Hot Flashes | Phase 4 | terminated | Jan 8, 2019 | Northwestern University | Enrollment issues | Enrollment / accrual |
| NCT03111914 | Applications of Dual Energy CT in Patients With Osseous Metastases From… | N/A | terminated | Apr 13, 2017 | Duke University | Budgetary Issues | Funding |
| NCT04457245 | Randomized Trial of PSMA PET Scan Before Definitive Radiation Therapy for Prostate Cancer(PSMA-dRT) | Phase 3 | terminated | Jul 7, 2020 | Jonsson Comprehensive Cancer Center | accrual | Enrollment / accrual |
| NCT03365076 | Exercise for Improving Prostate Oxygenation in Prostate Tumors (Exipox)(EXIPOX) | N/A | terminated | Dec 7, 2017 | University Hospital of North Norway | Slow inclusion rate due to patients operated before intervention is implementable | Other (stated, no rule matched) |
| NCT02454517 | Diet and Exercise Program to Promote Weight Loss and Improve Health in Men With Low- or…(PALS) | N/A | terminated | May 27, 2015 | Fred Hutchinson Cancer Center | Terminated due to insufficient funding | Funding |
| NCT02745587 | Evaluating the Impact of Prostate Only Versus Pelvic Radiation for N+ Prostate Cancer.(PROPER) | Phase 3 | terminated | Apr 20, 2016 | University Hospital, Ghent | Stopped because of poor accrual in June 2021 after the inclusion of 69 patients | Enrollment / accrual |
| NCT03987568 | Characterize Tumor Hypoxia by Magnetic Resonance Imaging | N/A | withdrawn | Jun 17, 2019 | Wake Forest University Health Sciences | Issues in reserving MRI scanner | Other (stated, no rule matched) |
| NCT03971110 | A Study of Neoadjuvant Hormone Therapy in Patient With Advanced Prostate Cancer… | Phase 4 | terminated | Jun 3, 2019 | AstraZeneca | Due to the limited potential patients pool, the enrollment goal could not be achieved. After review… | Enrollment / accrual |
| NCT04742972 | Prostate PMSABR Study | N/A | withdrawn | Feb 8, 2021 | Darren Poon | The lack of well-defined oligometastasis, high disease burden in mCRPC and high sensitivity of… | Enrollment / accrual |
| NCT04928820 | 68Ga-PSMA-11 PET/CT for the Diagnosis of Bone Metastases in Patients With Prostate Cancer… | Phase 2 | terminated | Jun 16, 2021 | Jonsson Comprehensive Cancer Center | slow recruitment | Enrollment / accrual |
| NCT00581503 | Early Detection and Staging of Endobronchial Lung and Pleural Cancer, Airway Injury, and… | — | withdrawn | Dec 27, 2007 | University of California, Irvine | Not NIH defined clinical trial | Other (stated, no rule matched) |
| NCT04727710 | Testing the Effect of Mindfulness for Prostatectomy Outcomes(TEMPO) | N/A | terminated | Jan 27, 2021 | University of Michigan Rogel Cancer Center | Study was held due to COVID19 and unable to enroll in virtual platform | COVID-19 / pandemic |
| NCT04237584 | A Study Comparing ARB With Radium-223 vs ARB Therapy With Placebo and the Effect Upon…(ESCALATE) | Phase 3 | terminated | Jan 23, 2020 | MANA RBM | The study was stopped due to insurmountable enrollment challenges affecting trial accrual,… | Enrollment / accrual |
| NCT03709550 | Enzalutamide and Decitabine in Treating Patients With Metastatic Castration Resistant… | Phase 1 / Phase 2 | withdrawn | Oct 17, 2018 | Roswell Park Cancer Institute | lack of funding | Funding |
| NCT01174199 | Temsirolimus and Vorinostat in Treating Patients With Metastatic Prostate Cancer | Phase 1 | terminated | Aug 3, 2010 | Roswell Park Cancer Institute | no value in finding efficacy | Efficacy / futility |
| NCT04535908 | Hypofractionated Radiotherapy in Prostate Cancer Patients Aged 75 Years or Older. | N/A | terminated | Sep 2, 2020 | Medical University of Graz | Treatment standard has changed. | Other (stated, no rule matched) |
| NCT02766478 | Genistein Supplementation to Mitigate Cardiometabolic Dysfunction in Patients Undergoing…(GeniPro) | Phase 2 | terminated | May 9, 2016 | Emory University | Enrollment and study activities were suspended due to COVID-19. | COVID-19 / pandemic |
| NCT04279561 | Effect of Androgen Receptor Signaling Inhibitors on 68Ga-PSMA-11 PET/CT Imaging in… | Phase 1 | terminated | Feb 21, 2020 | Jonsson Comprehensive Cancer Center | slow accrual | Enrollment / accrual |
| NCT02203513 | A Phase II Single Arm Pilot Study of the Chk1/2 Inhibitor (LY2606368) in BRCA1/2 Mutation… | Phase 2 | terminated | Jul 30, 2014 | National Cancer Institute (NCI) | Eli Lilly prematurely terminated the study. | Other (stated, no rule matched) |
| NCT02290366 | Prospective Evaluation of Focal Brachytherapy Using Cesium-131 For Patients With Low Risk… | N/A | withdrawn | Nov 14, 2014 | Ronald M. Benoit, MD | Principal Investigator decision | Investigator |
| NCT04060342 | GB1275 Monotherapy and in Combination With an Anti-PD1 Antibody in Patients With… | Phase 1 | terminated | Aug 19, 2019 | GB006, Inc., a wholly owned subsidiary of Gossamer Bio, Inc. | No clear benefit of GB1275 was observed either as monotherapy or in combination with pembrolizumab. | Other (stated, no rule matched) |
| NCT05191017 | Study of NUV-422 in Combination With Enzalutamide in Patients With mCRPC | Phase 1 / Phase 2 | withdrawn | Jan 13, 2022 | Nuvation Bio Inc. | Sponsor decision | Sponsor / business decision |
| NCT02419846 | Informed Decision Making Intervention in Screening for Prostate Cancer of Predominantly… | N/A | terminated | Apr 17, 2015 | Case Comprehensive Cancer Center | Unable to recruit due to COVID limitations / Funding Unavailable | COVID-19 / pandemic |
| NCT03531827 | Combining CRLX101, a Nanoparticle Camptothecin, With Enzalutamide in People With… | Phase 2 | terminated | May 22, 2018 | National Cancer Institute (NCI) | Study was closed for toxicity. | Safety / toxicity |
| NCT01681433 | OGX-427 in Metastatic Castrate-Resistant Prostate Cancer With Prostate-Specific Antigen… | Phase 2 | terminated | Sep 10, 2012 | Costantine Albany | lack of accrual | Enrollment / accrual |
| NCT02582749 | Androgen Deprivation Therapy +/- Radium-223 Dichloride in Metastatic Prostate Cancer With… | Phase 2 | terminated | Oct 21, 2015 | Ajjai Alva, MD | Funding withdrawn | Funding |
| NCT04288336 | Daily, Long-Term Intermittent Fasting for the Prevention of PSA-Recurrence in Patients… | Early Phase 1 | withdrawn | Feb 28, 2020 | Mayo Clinic | No patient accrual | Enrollment / accrual |
| NCT04634344 | Assess the Safety, Tolerability, PK and Anti-tumor Efficacy of DZD2269 in Patients With… | Phase 1 | terminated | Nov 18, 2020 | Dizal Pharmaceuticals | Due to reasons of internal business strategy, not related to study or site conduct. | Sponsor / business decision |
| NCT02663908 | A Trial Comparing Cardiovascular Safety of Degarelix Versus Leuprolide in Patients With…(PRONOUNCE) | Phase 3 | terminated | Jan 26, 2016 | Ferring Pharmaceuticals | Recruitment rate; a lower than anticipated observed cardiovascular event rate. The Sponsor decision… | COVID-19 / pandemic |
| NCT03964337 | Immediate Prostatectomy vs. Cabozantinib Followed by Prostatectomy in Men With High-Risk…(SPARC) | Phase 2 | terminated | May 28, 2019 | Duke University | Poor accrual. | Enrollment / accrual |
| NCT03290508 | Long-term Study to Evaluate and Clinical Outcomes in Patients With Favorable Intermediate… | — | terminated | Sep 25, 2017 | Myriad Genetic Laboratories, Inc. | There is sufficient follow-up data to meet the endpoints of the study. | Other (stated, no rule matched) |
Stop reasons are registrant-reported free text and are displayed verbatim (truncated; hover for the full text). Categories come from explicit keyword rules and are never inferred from the study design, sponsor or outcome; a study that stopped for several reasons is filed under the first rule that matched. A TERMINATED status does not imply a negative result.
Data updated 23 days agoSource updated Mar 28, 2023source: clinicaltrials