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Clinical trials · failure tracking
Oncology studies whose overall status is TERMINATED, WITHDRAWN or SUSPENDED on ClinicalTrials.gov, with the stop reason exactly as the registrant posted it. A category is attached only when an explicit keyword rule matches the text; CancerIndex never infers why a study stopped.
2,061 stopped studies mapped to Malignant Neoplasm of Unknown Primary and descendants · 91% state a reason
Over the 2,061 studies matching the cancer, status and year filters (the category filter does not change this chart). Each study is counted once, in the first matching category; greyed bars are studies whose text matched no rule or was empty.
Computedrules ci-stop-reasons-v1 · keyword matching only
A category is assigned when one of its keywords appears in the posted text (case-insensitive, whole words). Rules are tested in this order and the first match wins; every match is kept in the API (reasonMatches).
| NCT | Title | Phase | Status | First posted | Lead sponsor | Why stopped (as posted) | Category |
|---|---|---|---|---|---|---|---|
| NCT02110953 | Irinotecan-Eluting Beads in Treating Patients With Refractory Metastatic Colon or Rectal… | Phase 1 | terminated | Apr 10, 2014 | Fox Chase Cancer Center | IRB study closure by investigator due to low enrollment | Investigator |
| NCT02345772 | Neoadjuvant Hormonal Therapy Combined With Chemoimmunotherapy(Neohttp) | Phase 1 / Phase 2 | terminated | Jan 26, 2015 | Western Regional Medical Center | PI no longer at site. Data was not collected | Other (stated, no rule matched) |
| NCT02496832 | A Study of Hypoxia Imaging in Advanced Pancreatic Cancer Patients Being Treated With… | N/A | withdrawn | Jul 14, 2015 | University Health Network, Toronto | Study was never initiated | Other (stated, no rule matched) |
| NCT00878215 | Clinical Application of Image-Guided Liver Surgery | Phase 2 | terminated | Apr 8, 2009 | Washington University School of Medicine | The image-guidance system became commercially available | Other (stated, no rule matched) |
| NCT02392377 | Molecular Phenotyping in Predicting Response in Patients With Stage IB-III Esophageal… | Phase 2 | terminated | Mar 19, 2015 | Case Comprehensive Cancer Center | Slow accrual | Enrollment / accrual |
| NCT01934179 | Telomere Length in Predicting Toxicity in Older Patients With Stage III-IV Colorectal… | — | terminated | Sep 4, 2013 | Fox Chase Cancer Center | Low Accrual Rate | Enrollment / accrual |
| NCT02338570 | Outcome-related Factors in Patients With Metastatic Renal Cell Carcinoma Treated With…(ORCHIDEE) | Phase 4 | terminated | Jan 14, 2015 | Mario Negri Institute for Pharmacological Research | Stopped on November 16th 2016, because of recruitment failure. | Enrollment / accrual |
| NCT01456143 | Optical Imaging of Head and Neck Cancer | N/A | terminated | Oct 20, 2011 | Sharmila Anandasabapathy, MD | PI left, study to be re-open with new PI, no planned data analysis | Investigator |
| NCT01956864 | Study of High-Dose Oral Vitamin D for the Prevention of Liver Cancer | Phase 1 | withdrawn | Oct 8, 2013 | Johns Hopkins University | PI transferred from Georgetown to Johns Hopkins University. No participants enrolled at either… | Enrollment / accrual |
| NCT02407561 | Prospective Validation Study for the Proprietary Rectal and Anal Cancer Protein… | — | terminated | Apr 3, 2015 | Castle Biosciences Incorporated | Futility - unable to secure sites and samples for participation | Efficacy / futility |
| NCT01984892 | Treatment of Solid Tumors With Intratumoral Hiltonol® (Poly-ICLC)(Hiltonol) | Phase 2 | terminated | Nov 15, 2013 | Nina Bhardwaj | PI discretion, low enrollment | Enrollment / accrual |
| NCT01237678 | A Study of IMGN901 for Patients With Advanced Solid Tumors and Extensive Stage Small Cell… | Phase 1 / Phase 2 | terminated | Nov 9, 2010 | ImmunoGen, Inc. | Study was stopped early due to lack of efficacy signal and safety concerns | Safety / toxicity |
| NCT02494388 | Needle-based Confocal Laser Endomicroscopy on Pancreatic Cystic Lesions(CINE-Cyst) | — | terminated | Jul 10, 2015 | University of Medicine and Pharmacy Craiova | not stated | Not stated |
| NCT02908165 | Randomized Phase II Trial of Chemoembolization and Sorafenib | Phase 2 | withdrawn | Sep 20, 2016 | Yale University | A future study will be taking place using the same patient population. | Other (stated, no rule matched) |
| NCT00848783 | Irinotecan/Cisplatin, Potentially Curative Surgery With or Without Floxuridine, Followed… | Phase 2 | terminated | Feb 20, 2009 | NYU Langone Health | Due to slow accrual | Enrollment / accrual |
| NCT01488318 | Cetuximab and Dasatinib in Recurrent Squamous Cell Carcinoma | Phase 2 | terminated | Dec 8, 2011 | Julie E. Bauman, MD, MPH | PI leaving the institution | Other (stated, no rule matched) |
| NCT02993991 | Pre-operative Mocetinostat (MGCD0103) and Durvalumab (MEDI4736) (PRIMED) for Squamous…(PRIMED-001) | Phase 1 | withdrawn | Dec 15, 2016 | University Health Network, Toronto | The study has been terminated due to a change in internal prioritization and not due to any safety… | Safety / toxicity |
| NCT01012362 | Study of Pazopanib and Ixabepilone in Patients With Solid Tumors | Phase 1 | terminated | Nov 13, 2009 | Masonic Cancer Center, University of Minnesota | PI left institution. | Investigator |
| NCT01372618 | Breast Cancer Chemoprevention by SOM230, an IGF-I Action Inhibitor | Phase 1 / Phase 2 | terminated | Jun 14, 2011 | NYU Langone Health | PI has passed away. Requested by department to terminate study. | Other (stated, no rule matched) |
| NCT01762592 | REDECT 2: REnal Masses: Pivotal Trial to DEteCT Clear Cell Renal Cell Carcinoma With… | Phase 3 | withdrawn | Jan 7, 2013 | Heidelberg Pharma AG | new sponsor | Other (stated, no rule matched) |
| NCT01051791 | Phase II Study of RAD001 Head and Neck Cancer | Phase 2 | terminated | Jan 20, 2010 | Julie E. Bauman, MD, MPH | not stated | Not stated |
| NCT03307941 | Assessment of Metabolic & Path Response w/ RCT & ImT Before Surgery in Locally Advanced…(ARTEMIS-Eso) | Phase 1 / Phase 2 | withdrawn | Oct 12, 2017 | Jules Bordet Institute | Suspended collaboration with the company providing the study drug | Sponsor / business decision |
| NCT02406508 | Sequential Melphalan for Use With Hepatic Delivery System Treatment Followed by Sorafenib… | Phase 2 | withdrawn | Apr 2, 2015 | Delcath Systems Inc. | No enrollment in the study | Enrollment / accrual |
| NCT01221753 | Docetaxel/Cisplatin/5-Fluorouracil (TPF) Human Papillomavirus (HPV) Squamous Cell… | Phase 2 | terminated | Oct 15, 2010 | Dana-Farber Cancer Institute | Due to slow accrual | Enrollment / accrual |
| NCT01200810 | Bicalutamide and RO4929097 in Treating Patients With Previously Treated Prostate Cancer | Phase 2 | terminated | Sep 14, 2010 | National Cancer Institute (NCI) | Drug was no longer available | Other (stated, no rule matched) |
| NCT02473094 | Neoadjuvant Metformin in Association to Chemoradiotherapy for Locally Advanced Rectal…(NEOMETRE) | Phase 2 | terminated | Jun 16, 2015 | University of Campinas, Brazil | Slow Accrual | Enrollment / accrual |
| NCT00903396 | Palonosetron Hydrochloride in Preventing Nausea and Vomiting Caused by Radiation Therapy… | Phase 2 | terminated | May 18, 2009 | Alliance for Clinical Trials in Oncology | Slow accrual | Enrollment / accrual |
| NCT02122003 | Second Line Sorafenib After Pazopanib in Patients With RCC(SOAP) | Phase 2 | terminated | Apr 24, 2014 | Fondazione IRCCS Istituto Nazionale dei Tumori, Milano | availability of new and more promising therapeutic agents than expected in the experimentation in… | Other (stated, no rule matched) |
| NCT02549755 | 11C-acetate for Treatment Response After Radiotherapy for HCC | Phase 2 | terminated | Sep 15, 2015 | Justin Sims | Poor enrollment | Enrollment / accrual |
| NCT00003530 | Antineoplaston Therapy in Treating Patients With Primary Liver Cancer | Phase 2 | terminated | Jan 27, 2003 | Burzynski Research Institute | Slow accrual | Enrollment / accrual |
| NCT00158886 | Oral Topotecan As A Radiosensitizing Agent In Rectal Cancer | Phase 1 | terminated | Sep 12, 2005 | GlaxoSmithKline | not stated | Not stated |
| NCT00570674 | Abraxane in Combination With Carboplatin, Erbitux and IMRT for Locally Advanced Squamous… | Phase 1 / Phase 2 | terminated | Dec 11, 2007 | Dana-Farber Cancer Institute | The study did not continue to phase II due to the importance of HPV status as a prognostic factor… | Other (stated, no rule matched) |
| NCT02298595 | Cetuximab, Cisplatin and BYL719 for HPV-Associated Oropharyngeal Squamous Cell Carcinoma | Phase 1 / Phase 2 | withdrawn | Nov 24, 2014 | Julie E. Bauman, MD, MPH | not stated | Not stated |
| NCT02297087 | Next-generation Sequencing of Small Cell Lung Cancer to Identify Actionable Targets for… | N/A | terminated | Nov 21, 2014 | Western Regional Medical Center | PI no longer at site and he does | Other (stated, no rule matched) |
| NCT02138578 | Trial Comparing Stereotactic Body Radiation Therapy to Radiofrequency Ablation for Renal… | N/A | terminated | May 14, 2014 | University of Michigan Rogel Cancer Center | Due to changes in scanning procedure, and infeasible biopsy and baseline imaging, the trial closed… | Enrollment / accrual |
| NCT02958163 | Clinical Trial Comparing TACE With TACE + SABR in Stage BCLC B HCC (HepSTAR)(HepSTAR) | Phase 2 | terminated | Nov 8, 2016 | Cliniques universitaires Saint-Luc- Université Catholique de Louvain | lack of recruitment | Enrollment / accrual |
| NCT00070317 | Lymph Node Mapping and Sentinel Lymph Node Identification in Patients With Stage IB1… | N/A | terminated | Oct 7, 2003 | Gynecologic Oncology Group | not stated | Not stated |
| NCT00400205 | Study of Induction Docetaxel, Cisplatin and 5-Fluorouracil | Phase 2 | terminated | Nov 16, 2006 | Emory University | Safety reasons | Safety / toxicity |
| NCT01492192 | RGD-PET-CT in Cancer Angiogenesis | Phase 2 | terminated | Dec 14, 2011 | Oxford University Hospitals NHS Trust | not stated | Not stated |
| NCT01606124 | Polyphenon E in Treating Patients With High-Risk of Colorectal Cancer | Phase 2 | terminated | May 25, 2012 | Mayo Clinic | pending expiration of the supply of study agent. | Drug supply |
| NCT02076243 | Treatment With Nab-paclitaxel in Cutaneous SCC | Phase 2 | terminated | Mar 3, 2014 | Icahn School of Medicine at Mount Sinai | Closed by sponsor | Other (stated, no rule matched) |
| NCT02564549 | MRI-Based Active Surveillance to Avoid the Risks of Serial Biopsies in Men With Low-Risk… | N/A | terminated | Sep 30, 2015 | Virginia Commonwealth University | Study halted prematurely and will not resume | Other (stated, no rule matched) |
| NCT02026362 | Multiple Antigen Specific Cell Therapy (MASCT) for Hepatocellular Carcinoma(HCC) Patients…(HCC DC CTL) | Phase 1 / Phase 2 | suspended | Jan 3, 2014 | HRYZ Biotech Co. | Interim analysis | Efficacy / futility |
| NCT02068157 | Interstitial Photodynamic Therapy in Treating Patients With Recurrent Head and Neck Cancer | Phase 2 | terminated | Feb 21, 2014 | Roswell Park Cancer Institute | Study no longer has an active IDE | Other (stated, no rule matched) |
| NCT01784978 | Efficacy Study of Sunitinib and Everolimus (Rotational vs Sequential Arm) in Pats. With m…(SUNRISES) | Phase 2 | terminated | Feb 6, 2013 | Associació per a la Recerca Oncologica, Spain | Lack of recruitment | Enrollment / accrual |
| NCT00003496 | Antineoplaston Therapy in Treating Patients With Recurrent or Extensive-Stage Small Cell… | Phase 2 | terminated | Jan 27, 2003 | Burzynski Research Institute | slow accrual | Enrollment / accrual |
| NCT02831179 | Veliparib, Capecitabine, and Temozolomide in Patients With Advanced, Metastatic, and… | Phase 1 | withdrawn | Jul 13, 2016 | Vanderbilt-Ingram Cancer Center | Loss of funding support | Funding |
| NCT01145508 | Docetaxel and Prednisone With or Without Vaccine Therapy in Treating Patients With… | Phase 2 | terminated | Jun 16, 2010 | National Cancer Institute (NCI) | Poor accrual | Enrollment / accrual |
| NCT02876081 | Phase II Study of Afatinib as Third- or Further-line Treatment for Patients With Stage IV…(THEN) | Phase 2 | withdrawn | Aug 23, 2016 | Fondation Hôpital Saint-Joseph | medical decision | Other (stated, no rule matched) |
| NCT02211027 | Biological Vaccine: Semi-allogeneic Human Fibroblasts (MRC-5) Transfected With DNA | Phase 1 | withdrawn | Aug 7, 2014 | Robert Ferris | not stated | Not stated |
Stop reasons are registrant-reported free text and are displayed verbatim (truncated; hover for the full text). Categories come from explicit keyword rules and are never inferred from the study design, sponsor or outcome; a study that stopped for several reasons is filed under the first rule that matched. A TERMINATED status does not imply a negative result.
Data updated 23 days agoSource updated Feb 26, 2018source: clinicaltrials