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Clinical trials · failure tracking
Oncology studies whose overall status is TERMINATED, WITHDRAWN or SUSPENDED on ClinicalTrials.gov, with the stop reason exactly as the registrant posted it. A category is attached only when an explicit keyword rule matches the text; CancerIndex never infers why a study stopped.
848 stopped studies mapped to Malignant Large Intestinal Neoplasm and descendants · 91% state a reason
Over the 848 studies matching the cancer, status and year filters (the category filter does not change this chart). Each study is counted once, in the first matching category; greyed bars are studies whose text matched no rule or was empty.
Computedrules ci-stop-reasons-v1 · keyword matching only
A category is assigned when one of its keywords appears in the posted text (case-insensitive, whole words). Rules are tested in this order and the first match wins; every match is kept in the API (reasonMatches).
| NCT | Title | Phase | Status | First posted | Lead sponsor | Why stopped (as posted) | Category |
|---|---|---|---|---|---|---|---|
| NCT03376659 | Durvalumab Plus CV301 With Maintenance Chemotherapy in Metastatic Colorectal or… | Phase 1 / Phase 2 | terminated | Dec 18, 2017 | Georgetown University | Study closed due to lack of enrollment. | Enrollment / accrual |
| NCT01605318 | Study of Labetuzumab Govitecan in Participants With Metastatic Colorectal Cancer | Phase 1 / Phase 2 | terminated | May 24, 2012 | Gilead Sciences | not stated | Not stated |
| NCT01769222 | Ipilimumab and Local Radiation for Selected Solid Tumors | Phase 1 | terminated | Jan 16, 2013 | Stanford University | Planned Future Study | Other (stated, no rule matched) |
| NCT03500874 | Adjuvant Systemic Chemotherapy With or Without HAI-FUDR in Patients With Resected CRLM | Phase 3 | terminated | Apr 18, 2018 | Sun Yat-sen University | The study was terminated prematurely due to FUDR production halt in China | Other (stated, no rule matched) |
| NCT03422679 | Study of CB-103 in Adult Patients With Advanced or Metastatic Solid Tumours and… | Phase 1 / Phase 2 | terminated | Feb 6, 2018 | Cellestia Biotech AG | business reason | Sponsor / business decision |
| NCT03806244 | Feasibility of Stereotactic Navigation in Laparoscopic Surgery for Colorectal Cancer(PELVINAV) | N/A | terminated | Jan 16, 2019 | IHU Strasbourg | Departure of the two main investigators | Other (stated, no rule matched) |
| NCT04379830 | Preoperative Very Low Energy Diet for Obese Rectal Cancer Patients | N/A | withdrawn | May 8, 2020 | McMaster University | There were no patients recruited during the trial period. This was a result of: 1) COVID-19… | COVID-19 / pandemic |
| NCT03135652 | Consolidative Radiotherapy for Colorectal Cancer Liver Metastases Receiving Surgery or… | Phase 2 | withdrawn | May 1, 2017 | Union Hospital, Tongji Medical College, Huazhong University of Science and Technology | Inadequate patient enrollment | Enrollment / accrual |
| NCT03193814 | Safety and Efficacy Study of Chemotherapy Plus Apatinib as Second-line Therapy in…(XHZL) | Phase 2 | withdrawn | Jun 21, 2017 | Union Hospital, Tongji Medical College, Huazhong University of Science and Technology | Inadequate patient enrollment | Enrollment / accrual |
| NCT04558684 | Radiotherapy With Neoadjuvant Chemotherapy and Immunotherapy in Rectal Cancer | Phase 1 / Phase 2 | suspended | Sep 22, 2020 | Union Hospital, Tongji Medical College, Huazhong University of Science and Technology | Inadequate patient enrollment | Enrollment / accrual |
| NCT04244552 | A Phase 1b Trial of ATRC-101 in Adults With Advanced Solid Malignancies | Phase 1 | terminated | Jan 28, 2020 | Atreca, Inc. | Sponsor Decision | Sponsor / business decision |
| NCT04870034 | Binimetinib and Palbociclib Before Surgery for the Treatment of Operable KRAS-Positive… | Early Phase 1 | withdrawn | May 3, 2021 | Roswell Park Cancer Institute | Issues recruiting | Enrollment / accrual |
| NCT05363605 | A Study of [225Ac]-FPI-1966 in Participants With Advanced Solid Tumours | Phase 1 / Phase 2 | terminated | May 6, 2022 | Fusion Pharmaceuticals Inc. | Fusion announced that it is discontinuing this study as part of a portfolio prioritization and… | Sponsor / business decision |
| NCT04097795 | Incremental Cost-Utility Study on Prehabilitation Among Older Patients With Colorectal…(PreColo CU) | — | terminated | Sep 20, 2019 | Radboud University Medical Center | Inclusions lagged far behind | Other (stated, no rule matched) |
| NCT03525392 | Study to Evaluate the Safety and Activity (Including Distribution) of 177Lu-3BP-227 in… | Phase 1 | terminated | May 15, 2018 | Ipsen | Due to agreement to transfer rights for IPN01087 to an external partner, not due to safety concerns | Safety / toxicity |
| NCT02519140 | Assessing How the Viscosity of Submucosal Gel Injections Helps With Endoscopic Mucosal… | Phase 3 | withdrawn | Aug 10, 2015 | Antonios Likourezos | not stated | Not stated |
| NCT01133990 | FOLFIRI Alone Versus FOLFIRI Plus Bevacizumab Versus FOLFIRI Plus E7820 as Second-Line… | Phase 1 / Phase 2 | terminated | May 31, 2010 | Eisai Inc. | The study was terminated early as the combination of E7820 and FOLFIRI was deemed to be not… | Efficacy / futility |
| NCT03555149 | A Study Evaluating the Efficacy and Safety of Multiple Immunotherapy-Based Treatment… | Phase 1 / Phase 2 | terminated | Jun 13, 2018 | Hoffmann-La Roche | The Sponsor made the decision to terminate the study due to start up and recruitment issues caused… | Enrollment / accrual |
| NCT04623515 | Radiation Therapy on Pelvic Floor Disorders in Women(RadPFD) | — | terminated | Nov 10, 2020 | Wake Forest University Health Sciences | IRB closure, slow accrual | Enrollment / accrual |
| NCT04854434 | A Study to Evaluate the Safety and Efficacy of Selinexor With or Without Pembrolizumab… | Phase 2 | terminated | Apr 22, 2021 | Karyopharm Therapeutics Inc | Sponsor decision | Sponsor / business decision |
| NCT04054752 | Vaccine Response With NT-I7 | Phase 1 | withdrawn | Aug 13, 2019 | National Cancer Institute (NCI) | No subjects enrolled. | Enrollment / accrual |
| NCT01545141 | Chemokine-Modulatory Regimen for Recurrent Resectable Colorectal Cancer | Phase 1 / Phase 2 | terminated | Mar 6, 2012 | Roswell Park Cancer Institute | not stated | Not stated |
| NCT02626377 | Multicenter Prospective Cohort of Informal Caregivers in Burgundy and Franche-Comté(ICE) | N/A | terminated | Dec 10, 2015 | Centre Hospitalier Universitaire de Besancon | inclusions problems | Other (stated, no rule matched) |
| NCT03592641 | Savolitinib in Treating Patients With MET Amplified Metastatic or Unresectable Colorectal… | Phase 2 | terminated | Jul 19, 2018 | National Cancer Institute (NCI) | Inadequate accrual rate | Enrollment / accrual |
| NCT05821582 | Study SBX-01-101: A Stool Collection Study in Colorectal Cancer (CRC) Patients Treated… | — | withdrawn | Apr 20, 2023 | Sanguine Biosciences | Insufficient recruitment population. | Enrollment / accrual |
| NCT00006046 | Monoclonal Antibody Therapy in Treating Patients With Advanced Colorectal Cancer | Phase 1 | terminated | May 21, 2003 | Ludwig Institute for Cancer Research | poor recruitment | Enrollment / accrual |
| NCT00745134 | Radiation Therapy and Capecitabine With or Without Curcumin Before Surgery in Treating… | Phase 2 | terminated | Sep 3, 2008 | M.D. Anderson Cancer Center | The trial was stopped early because there was only one patient with pCR among the first 15 patients… | Other (stated, no rule matched) |
| NCT05092750 | Magnetic Particle-ICG Lymph Node Mapping in Colorectal Cancer | Phase 1 / Phase 2 | withdrawn | Oct 26, 2021 | M.D. Anderson Cancer Center | 0 accrual | Enrollment / accrual |
| NCT02535988 | Abscopal Effect for Metastatic Colorectal Cancer | Phase 2 | withdrawn | Aug 31, 2015 | Zhejiang Provincial People's Hospital | No recruitment. | Enrollment / accrual |
| NCT04106167 | Long-term, Non-interventional, Observational Study Following Treatment With Fate… | — | terminated | Sep 26, 2019 | Fate Therapeutics | This study was terminated by the Sponsor. | Other (stated, no rule matched) |
| NCT05395052 | FT536 Monotherapy and in Combination With Monoclonal Antibodies in Advanced Solid Tumors | Phase 1 | terminated | May 27, 2022 | Fate Therapeutics | This study was terminated by the Sponsor. | Other (stated, no rule matched) |
| NCT05412706 | Niraparib Maintenance Treatment in mCRC With a Partial o Complete Response After…(Bohème) | Phase 2 | withdrawn | Jun 9, 2022 | Ospedale Policlinico San Martino | The Principal Investigator has retired and has not been replaced has retired and a new one has not… | Investigator |
| NCT01011478 | Rosuvastatin in Treating Patients With Stage I or Stage II Colon Cancer That Was Removed… | Phase 3 | terminated | Nov 11, 2009 | NSABP Foundation Inc | not stated | Not stated |
| NCT04066894 | Sacral Nerve Stimulation in Treating Low Anterior Resection Syndrome or Fecal… | Phase 2 | terminated | Aug 26, 2019 | M.D. Anderson Cancer Center | Due to Issues Enrolling Patients | Enrollment / accrual |
| NCT05107661 | Colorectal Screening Strategies in Underserved Populations | — | terminated | Nov 4, 2021 | Virtua Health, Inc. | Preliminary findings revealed to many barriers to successfully complete this trial. | Other (stated, no rule matched) |
| NCT00470353 | Cholecalciferol and Calcium Carbonate in Treating Patients With Colon Cancer That Has… | N/A | terminated | May 7, 2007 | Roswell Park Cancer Institute | Withdrawn due to poor accrual/lack of funding | Enrollment / accrual |
| NCT00601198 | A Study of Amifostine (Ethyol) in Patients With Colorectal Cancer | Phase 2 | terminated | Jan 25, 2008 | University of Cincinnati | Funding support withdrawn | Funding |
| NCT03576131 | GEN1029 (HexaBody®-DR5/DR5) Safety Trial in Patients With Malignant Solid Tumors | Phase 1 / Phase 2 | terminated | Jul 3, 2018 | Genmab | Sponsor decision | Sponsor / business decision |
| NCT01468623 | Study Comparing Optimized 5-FU Dosing and Standard Dosing in Metastatic Colorectal Cancer…(PROFUSE) | Phase 4 | terminated | Nov 9, 2011 | Myriad Genetic Laboratories, Inc. | Study terminated due to slow enrollment. | Enrollment / accrual |
| NCT05951842 | Anesthesia, TIVA, Balanced Anesthesia, NK Cell | N/A | withdrawn | Jul 19, 2023 | Gangnam Severance Hospital | participants are no longer being examined or receiving intervention | Other (stated, no rule matched) |
| NCT00677924 | Zalutumumab With or Without Irinotecan Chemotherapy in Cetuximab-Refractory Colorectal…(GEN206) | Phase 1 / Phase 2 | terminated | May 15, 2008 | Genmab | Due to changes in portfolio review | Sponsor / business decision |
| NCT04139967 | Study of Short Course Radiation Therapy for Elderly Patients With Rectal Cancer | N/A | terminated | Oct 25, 2019 | University of Rochester | recruitment rates were too low | Enrollment / accrual |
| NCT00303628 | Postoperative Chemotherapy With or Without Bevacizumab for Patients With Stage II or III… | Phase 3 | terminated | Mar 17, 2006 | ECOG-ACRIN Cancer Research Group | The study was terminated before reaching its accrual goal due to slow accrual. | Enrollment / accrual |
| NCT00002525 | Perioperative Chemotherapy in Treating Patients With Colon Cancer That Can Be Surgically… | Phase 3 | terminated | Apr 6, 2004 | ECOG-ACRIN Cancer Research Group | The study was stopped before reaching its accrual goal due to slow accrual | Enrollment / accrual |
| NCT01347645 | Irinotecan Plus E7820 Versus FOLFIRI in Second-Line Therapy in Patients With Locally… | Phase 1 / Phase 2 | terminated | May 4, 2011 | Eisai Inc. | The study was terminated by the Sponsor due to E7820 plus irinotecan being potentially inferior to… | Other (stated, no rule matched) |
| NCT04348916 | Study of ONCR-177 Alone and in Combination With PD-1 Blockade in Adult Subjects With… | Phase 1 | terminated | Apr 16, 2020 | Oncorus, Inc. | Terminated due to Oncorus portfolio reprioritization | Sponsor / business decision |
| NCT05582031 | Regorafenib With Tislelizumab in Patients With Selected Mismatch…(REFIT-MSS) | Phase 2 | withdrawn | Oct 17, 2022 | Translational Research in Oncology | Study never started/ will not proceed. | Other (stated, no rule matched) |
| NCT04535492 | Technology-Based Cancer Screening Intervention | N/A | withdrawn | Sep 2, 2020 | Medical University of South Carolina | No further funding | Funding |
| NCT02682485 | Serial Endoscopic Surveillance & Direct Topical Antibiotics to Define the Role of…(SES-DTA) | Phase 2 | withdrawn | Feb 15, 2016 | University of Chicago | Lack of funding | Funding |
| NCT05246943 | The Correlation of a D-dimer Testing Protocol With Venous Thromboembolism in Surgical… | — | withdrawn | Feb 18, 2022 | The University of Texas Medical Branch, Galveston | No participants enrolled. | Enrollment / accrual |
Stop reasons are registrant-reported free text and are displayed verbatim (truncated; hover for the full text). Categories come from explicit keyword rules and are never inferred from the study design, sponsor or outcome; a study that stopped for several reasons is filed under the first rule that matched. A TERMINATED status does not imply a negative result.
Data updated 23 days agoSource updated Feb 5, 2024source: clinicaltrials