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Clinical trials · failure tracking
Oncology studies whose overall status is TERMINATED, WITHDRAWN or SUSPENDED on ClinicalTrials.gov, with the stop reason exactly as the registrant posted it. A category is attached only when an explicit keyword rule matches the text; CancerIndex never infers why a study stopped.
848 stopped studies mapped to Malignant Large Intestinal Neoplasm and descendants · 91% state a reason
Over the 848 studies matching the cancer, status and year filters (the category filter does not change this chart). Each study is counted once, in the first matching category; greyed bars are studies whose text matched no rule or was empty.
Computedrules ci-stop-reasons-v1 · keyword matching only
A category is assigned when one of its keywords appears in the posted text (case-insensitive, whole words). Rules are tested in this order and the first match wins; every match is kept in the API (reasonMatches).
| NCT | Title | Phase | Status | First posted | Lead sponsor | Why stopped (as posted) | Category |
|---|---|---|---|---|---|---|---|
| NCT01238965 | Panobinostat and Fluorouracil Followed By Leucovorin Calcium in Treating Patients With… | Phase 1 | terminated | Nov 11, 2010 | University of Southern California | Adverse Events | Safety / toxicity |
| NCT00735241 | FOLFOX6 Plus Sir-Spheres Microspheres Plus Avastin in Patients With Nonresectable Liver…(FAST) | Phase 2 / Phase 3 | withdrawn | Aug 14, 2008 | Sirtex Medical | Withdrawn by the study sponsor. | Other (stated, no rule matched) |
| NCT01198535 | Phase I Study of Cetuximab With RO4929097 in Metastatic Colorectal Cancer | Phase 1 | terminated | Sep 10, 2010 | National Cancer Institute (NCI) | not stated | Not stated |
| NCT02235324 | Ziv-Aflibercept Followed by Ziv-Aflibercept, Fluorouracil, and Leucovorin Calcium in… | Phase 2 | withdrawn | Sep 9, 2014 | University of Southern California | Lack of funding | Funding |
| NCT00459901 | Study of the Antitumor Activity of Capecitabine in Combination With Erlotinib in Patients… | Phase 2 | terminated | Apr 13, 2007 | Peter Kozuch | Study halted by drug manufacturer | Drug supply |
| NCT01507740 | Profile of Soluble and Cellular Biomarkers and of Functional Imaging During… | — | terminated | Jan 11, 2012 | Medical University Innsbruck | Study was stopped 04.10.2014 prematurly after recruitment of HCC and RCC patients. NSCLC (2 of 10… | Enrollment / accrual |
| NCT00826800 | Neoadjuvant FOLFOX Plus Bevacizumab Chemotherapy in Patients With Locally Advanced Colon… | N/A | terminated | Jan 22, 2009 | Memorial Sloan Kettering Cancer Center | Lack of accrual | Enrollment / accrual |
| NCT01882972 | Strength for Health | N/A | withdrawn | Jun 21, 2013 | Loyola University | investigator left Loyola | Investigator |
| NCT01440127 | Impact of Pretreatment With Metformin on Colorectal Cancer Stem Cells (CCSC) and Related… | Phase 1 | terminated | Sep 26, 2011 | Tufts Medical Center | Unable to accrue all planned subjects in a timely fashion, but data collected will still be… | Enrollment / accrual |
| NCT00873600 | Outpatient Health Care Program for Older Patients Receiving Chemotherapy for Newly… | — | withdrawn | Apr 1, 2009 | Case Comprehensive Cancer Center | No accrual | Enrollment / accrual |
| NCT01706822 | Radial Reload Laparoscopic LAR Case Series | Phase 4 | terminated | Oct 15, 2012 | Medtronic - MITG | Slow recruitment | Enrollment / accrual |
| NCT00720512 | Second-Line Combination Chemotherapy With or Without Bevacizumab in Treating Patients…(BEBYP) | Phase 3 | terminated | Jul 22, 2008 | Gruppo Oncologico del Nord-Ovest | not stated | Not stated |
| NCT00575640 | Hydralazine as a Demethylating Agent in Rectal Cancer | Phase 1 / Phase 2 | withdrawn | Dec 18, 2007 | University of Arkansas | No enrollment | Enrollment / accrual |
| NCT01717014 | Radial Reload Open LAR Case Series | N/A | terminated | Oct 30, 2012 | Medtronic - MITG | not stated | Not stated |
| NCT00003843 | Irinotecan in Treating Patients With Colorectal Cancer | — | terminated | Jan 27, 2003 | California Cancer Consortium | Study terminated due to poor accrual | Enrollment / accrual |
| NCT01659424 | Phase II Trial of Preoperative High-dose-rate Endorectal Brachytherapy and FOLFOX…(HDRBT) | Phase 2 | withdrawn | Aug 7, 2012 | Beth Israel Medical Center | No participants were enrolled | Enrollment / accrual |
| NCT01631539 | Chemoembolisation With CPT11 Loaded DC Bead With Cetuximab and 5FU/LV in First Line in… | N/A | withdrawn | Jun 29, 2012 | Universitaire Ziekenhuizen KU Leuven | No patients enrolled | Enrollment / accrual |
| NCT01544452 | Total Preoperative MR Diagnostic Evaluation Versus Standard Diagnostic Evaluation in… | N/A | terminated | Mar 6, 2012 | Herlev Hospital | Lack of MR scanning capacity | Other (stated, no rule matched) |
| NCT01889680 | Safety and Effectiveness Study of Chemotherapy and Ziv-aflibercept to Treat Metastatic… | Phase 2 | withdrawn | Jun 28, 2013 | NSABP Foundation Inc | not stated | Not stated |
| NCT00823810 | Treatment Monitoring of Advanced Colorectal Cancer With 18F-FDG PET/CT(RESCORE) | N/A | terminated | Jan 16, 2009 | Turku University Hospital | Recruitment promlems | Enrollment / accrual |
| NCT00390364 | Everolimus in Treating Patients With Advanced or Metastatic Colorectal Cancer That Did… | Phase 2 | terminated | Oct 19, 2006 | Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | Withdrawn due to low accrual | Enrollment / accrual |
| NCT01149434 | Study of JI-101 in Patients With Advanced Low Grade Endocrine Tumors, Ovarian Cancers or… | Phase 1 / Phase 2 | terminated | Jun 23, 2010 | University of Utah | Lack of drug efficacy | Efficacy / futility |
| NCT00642746 | Erlotinib and Chemotherapy for 2nd Line Treatment (Tx) of Metastatic Colorectal Cancer… | Phase 2 | terminated | Mar 25, 2008 | OHSU Knight Cancer Institute | Terminated due to poor enrollment and grade 3 toxicities noted during an interim analysis. | Safety / toxicity |
| NCT02228785 | A Study of the Safety and Tolerance of Three Doses of G17DT in Metastatic Colorectal…(CC1C) | Phase 2 | terminated | Aug 29, 2014 | Cancer Advances Inc. | Poor local tolerance to injection. | Other (stated, no rule matched) |
| NCT00538291 | Cetuximab and Capecitabine in Treating Patients With Metastatic Colorectal Cancer That… | Phase 2 | terminated | Oct 2, 2007 | City of Hope Medical Center | Study was terminated early due to lack of efficacy. | Efficacy / futility |
| NCT01365910 | Linifanib in Treating Patients With Advanced, Refractory Colorectal Cancer | Phase 2 | terminated | Jun 3, 2011 | Vanderbilt-Ingram Cancer Center | Interim analysis determined the study did not meet criteria to proceed | Efficacy / futility |
| NCT01574677 | Assessment of Septin9 Biomarker for Detection of Colorectal Cancer in Patients With… | — | withdrawn | Apr 10, 2012 | Epigenomics, Inc | not stated | Not stated |
| NCT00499369 | Irinotecan and Cetuximab With or Without Bevacizumab in Treating Patients With Metastatic… | Phase 3 | terminated | Jul 11, 2007 | National Cancer Institute (NCI) | Due to inadequate accrual, study was terminated and limited outcome data was reported. | Enrollment / accrual |
| NCT02204332 | Phase II-b Randomized Clinical Trial of Cabazitaxel in Metastatic Colorectal Cancer…(COMETA) | Phase 2 | terminated | Jul 30, 2014 | Hospital Clinico Universitario de Santiago | Interim analysis performed on the first 10 patients showed no efficacy of cabazitaxel | Efficacy / futility |
| NCT01198548 | High-Dose Cholecalciferol in Treating Patients Receiving Combination Chemotherapy and… | Phase 2 | terminated | Sep 10, 2010 | Roswell Park Cancer Institute | Lack of funding | Funding |
| NCT01941173 | Short-Infusion Ziv-aflibercept in Treating Patients With Metastatic Colorectal Cancer… | N/A | withdrawn | Sep 13, 2013 | City of Hope Medical Center | Lack of accrual | Enrollment / accrual |
| NCT01418742 | SKIP - A Double-blind Placebo-controlled Randomized Multicenter Trial of Skin Toxicity… | Phase 2 | terminated | Aug 17, 2011 | Gesellschaft fur Medizinische Innovation - Hamatologie und Onkologie mbH | Recruitement did not meet expectations. Prev. differentiation of RAS-wild-type and mutated RAS are… | Enrollment / accrual |
| NCT00107315 | Bevacizumab and Capecitabine as First-Line Therapy in Treating Older Patients With… | Phase 2 | terminated | Apr 6, 2005 | Roswell Park Cancer Institute | Terminated due to low accrual | Enrollment / accrual |
| NCT00835679 | Cetuximab and/or Dasatinib in Patients With Colorectal Cancer and Liver Metastases That… | Early Phase 1 | terminated | Feb 4, 2009 | National Cancer Institute (NCI) | not stated | Not stated |
| NCT00006037 | Chemotherapy Plus IM-862 in Treating Patients With Metastatic Colorectal Cancer | Phase 2 | terminated | Feb 26, 2004 | University of Southern California | Drug not available | Other (stated, no rule matched) |
| NCT00323011 | FOLFIRI + Bevacizumab With or Without Dalteparin in First Line Treatment of Advanced… | Phase 2 | terminated | May 9, 2006 | University of Southern California | drug not available | Other (stated, no rule matched) |
| NCT01587872 | Double-balloon Colonoscopy to Increase Colonoscopy Completion Rate | N/A | terminated | Apr 30, 2012 | Sorlandet Hospital HF | Slow patient recruitment, not enough patients willing to participate within the prespecified time… | Enrollment / accrual |
| NCT01233505 | Veliparib, Oxaliplatin, and Capecitabine in Treating Patients With Advanced Solid Tumors | Phase 1 | terminated | Nov 3, 2010 | National Cancer Institute (NCI) | not stated | Not stated |
| NCT00088933 | Vaccine Therapy and Sargramostim With or Without Docetaxel in Treating Patients With… | Phase 1 | terminated | Aug 5, 2004 | National Cancer Institute (NCI) | not stated | Not stated |
| NCT01320267 | Single Port Laparoscopic Colectomy(SILS) | Phase 1 / Phase 2 | withdrawn | Mar 22, 2011 | University of British Columbia | Industry Funding Withdrawn | Funding |
| NCT00003786 | Irofulven in Treating Patients With Metastatic or Recurrent Colorectal Cancer | Phase 2 | withdrawn | Aug 4, 2004 | University of Chicago | NO participants | Other (stated, no rule matched) |
| NCT00394992 | Adjuvant Xeloda Plus Eloxatin +/- Avastin After Radical Resection of Liver Metastasis of… | Phase 3 | terminated | Nov 2, 2006 | Dutch Colorectal Cancer Group | Data from the C08 study and Avant study | Other (stated, no rule matched) |
| NCT01403103 | Cholecalciferol(25-[OH]-Vitamin D) in Treating Patients With Colorectal Cancer | Early Phase 1 | withdrawn | Jul 27, 2011 | Case Comprehensive Cancer Center | Slow Accrual | Enrollment / accrual |
| NCT00819754 | A Phase I/II Study of IXO With Bevacizumab in Patients With Metastatic Colorectal Cancer(IXO+A) | Phase 1 / Phase 2 | terminated | Jan 9, 2009 | Ottawa Hospital Research Institute | not stated | Not stated |
| NCT01344902 | An Open Dose-finding Study of Oral Applied Hexaminolevulinate (HAL) Imaging in Patients… | Phase 1 / Phase 2 | terminated | Apr 29, 2011 | Photocure | The study was stopped due to inadequate efficacy after 13 patients were evaluated. | Efficacy / futility |
| NCT00719199 | Study of FOLFIRI Plus Cetuximab Plus IMO-2055 in Patients With Colorectal Cancer | Phase 1 | terminated | Jul 21, 2008 | EMD Serono | Sponsor will discontinue further development of EMD 1201081 | Other (stated, no rule matched) |
| NCT01016860 | OSI-906 and Irinotecan in Patients With Advanced Cancer | Phase 1 | terminated | Nov 20, 2009 | University of Colorado, Denver | This study was discontinued due to a shown lack of efficacy in the investigational agent | Efficacy / futility |
| NCT00870961 | Vitamin D Supplement in Preventing Colon Cancer in African Americans With Colon Polyps | N/A | terminated | Mar 27, 2009 | Northwestern University | PI changed institutions and accrual was not completed. | Enrollment / accrual |
| NCT00145860 | Do Patients With Colorectal Cancer Understand That Their Family is at Risk? | — | terminated | Sep 5, 2005 | University of Chicago | not stated | Not stated |
| NCT00033306 | BMS-247550 in Treating Patients With Metastatic Colorectal Cancer | Phase 2 | terminated | Aug 6, 2003 | University of Alabama at Birmingham | not stated | Not stated |
Stop reasons are registrant-reported free text and are displayed verbatim (truncated; hover for the full text). Categories come from explicit keyword rules and are never inferred from the study design, sponsor or outcome; a study that stopped for several reasons is filed under the first rule that matched. A TERMINATED status does not imply a negative result.
Data updated 22 days agoSource updated May 27, 2015source: clinicaltrials