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Clinical trials · failure tracking
Oncology studies whose overall status is TERMINATED, WITHDRAWN or SUSPENDED on ClinicalTrials.gov, with the stop reason exactly as the registrant posted it. A category is attached only when an explicit keyword rule matches the text; CancerIndex never infers why a study stopped.
848 stopped studies mapped to Malignant Large Intestinal Neoplasm and descendants · 91% state a reason
Over the 848 studies matching the cancer, status and year filters (the category filter does not change this chart). Each study is counted once, in the first matching category; greyed bars are studies whose text matched no rule or was empty.
Computedrules ci-stop-reasons-v1 · keyword matching only
A category is assigned when one of its keywords appears in the posted text (case-insensitive, whole words). Rules are tested in this order and the first match wins; every match is kept in the API (reasonMatches).
| NCT | Title | Phase | Status | First posted | Lead sponsor | Why stopped (as posted) | Category |
|---|---|---|---|---|---|---|---|
| NCT03264274 | Trial of Aflibercept Monotherapy With DCE-US in Chemorefractory Metastatic Colorectal…(AUSCOR) | Phase 2 | withdrawn | Aug 29, 2017 | Barts & The London NHS Trust | Funding restrictions - study never opened to recruitment | Enrollment / accrual |
| NCT02345746 | Hepatic Arterial Infusion With FOLFOX Alone or in Combination With IV Chemotherapy in… | Phase 2 | withdrawn | Jan 26, 2015 | Western Regional Medical Center | patient population | Other (stated, no rule matched) |
| NCT01114256 | FNA Tumor Sampling for CD137 Modulation: A Pilot Study | — | terminated | May 3, 2010 | Stanford University | not stated | Not stated |
| NCT02079220 | A Phase II Study of Ziv-aflibercept in Combination With Capecitabine/Oxaliplatin (XELOX)… | Phase 2 | withdrawn | Mar 5, 2014 | James J Lee | Funding for the study was withdrawn, no participants were ever recruited. | Enrollment / accrual |
| NCT01847599 | Educational Intervention to Adherence of Patients Treated by Capecitabine +/- Lapatinib(ProMETheX) | N/A | terminated | May 7, 2013 | Centre Jean Perrin | interim analysis : discontinuation for efficacy of the intervention | Efficacy / futility |
| NCT00002664 | Monoclonal Antibody Therapy and Colony- Stimulating Factor in Treating Patients With… | Phase 2 | withdrawn | May 24, 2004 | James Ahlgren | No recruitment | Enrollment / accrual |
| NCT01309126 | Study of Imprime PGG® in Combination With Cetuximab in Subjects With Recurrent or…(PRIMUS) | Phase 3 | terminated | Mar 4, 2011 | HiberCell, Inc. | Due to enrollment challenges resulting from changing treatment patterns in the use of cetuximab,… | Enrollment / accrual |
| NCT01095523 | Prospective Randomized Trial Evaluating Mandatory Second Look Surgery With HIPEC and CRS… | Phase 2 | withdrawn | Mar 30, 2010 | National Cancer Institute (NCI) | not stated | Not stated |
| NCT01176500 | A Pilot, Open-label Study of 18F-Fluciclatide PET/CT Imaging in the Evaluation of… | Phase 1 / Phase 2 | withdrawn | Aug 6, 2010 | National Cancer Institute (NCI) | not stated | Not stated |
| NCT01386502 | CT-011 and p53 Genetic Vaccine for Advanced Solid Tumors | Phase 1 | withdrawn | Jul 1, 2011 | National Cancer Institute (NCI) | not stated | Not stated |
| NCT01936961 | Study of Immunochemotherapy +/- Hypofractionated Radiation for Complete Response in Solid…(I-CREST) | N/A | withdrawn | Sep 6, 2013 | Western Regional Medical Center | No patients enrolled | Enrollment / accrual |
| NCT00408772 | Oxaliplatin, Capecitabine, and Bevacizumab Followed By Surgery and/or Radiofrequency… | Phase 2 | withdrawn | Dec 7, 2006 | University of California, Davis | Lack of accrual | Enrollment / accrual |
| NCT01940237 | A Pilot Trial of Interpersonal Psychotherapy for the Treatment of Depression in Patients… | N/A | terminated | Sep 12, 2013 | New York State Psychiatric Institute | Low recruitment | Enrollment / accrual |
| NCT00449163 | Combination Chemotherapy and Bevacizumab in Treating Patients With Stage IV Colorectal… | Phase 2 | terminated | Mar 19, 2007 | University of Miami | Study terminated by University of Miami Institutional Review Board | Other (stated, no rule matched) |
| NCT01326065 | Implementation of Laparoscopy-assisted Surgery for Colon Cancer | — | terminated | Mar 30, 2011 | Helse Stavanger HF | Study had to be terminated due to lack of funding | Funding |
| NCT01646554 | Efficacy of FOLFOX Versus FOLFOX Plus Aflibercept in K-ras Mutant Patients With…(BOS3) | Phase 2 / Phase 3 | withdrawn | Jul 20, 2012 | European Organisation for Research and Treatment of Cancer - EORTC | not stated | Not stated |
| NCT02277093 | Pacritinib to Inhibit JAK/STAT Signaling in Refractory Colorectal Cancer | Phase 2 | terminated | Oct 28, 2014 | Washington University School of Medicine | FDA issued a clinical hold as pacritinib had increased side effects | Other (stated, no rule matched) |
| NCT02060669 | Xeloda Maintenance Versus BSC in Metastatic Colorectal Cancer | Phase 3 | terminated | Feb 12, 2014 | Samsung Medical Center | others | Other (stated, no rule matched) |
| NCT02413853 | Combination Chemotherapy and Bevacizumab With or Without PRI-724 in Treating Patients…(PRIMIER) | Phase 2 | withdrawn | Apr 10, 2015 | University of Southern California | Study drug supply issues | Drug supply |
| NCT00126451 | A Clinical Trial of Oral Suberoylanilide Hydroxamic Acid (SAHA) in Patients With Relapsed… | Phase 2 | terminated | Aug 4, 2005 | Merck Sharp & Dohme LLC | not stated | Not stated |
| NCT00588900 | Irinotecan and Cediranib in Treating Patients With Metastatic Colorectal Cancer That Did… | Phase 2 | terminated | Jan 9, 2008 | Alliance for Clinical Trials in Oncology | not stated | Not stated |
| NCT01270438 | Combination Chemotherapy and Bevacizumab With or Without RO4929097 in Treating Patients… | Phase 2 | withdrawn | Jan 5, 2011 | National Cancer Institute (NCI) | not stated | Not stated |
| NCT00127036 | Trial for Microarray Analysis of Colon Cancer Outcome-A (MACCO-A) | Phase 2 | terminated | Aug 5, 2005 | H. Lee Moffitt Cancer Center and Research Institute | drug now on market | Other (stated, no rule matched) |
| NCT02857608 | A Prospective, Open-Label, Multi-center Comparison of Lymphoseek Identified Lymph Nodes… | Phase 2 | withdrawn | Aug 5, 2016 | Cardinal Health 414, LLC | not stated | Not stated |
| NCT02301338 | Improving Health of Patients With Colon Cancer Following Surgery: A Trial of SA-ICAN Via… | — | terminated | Nov 25, 2014 | Memorial Sloan Kettering Cancer Center | Lack of accrual | Enrollment / accrual |
| NCT01032590 | Internet-Based Weight-Loss Program for Colorectal Cancer Survivors | N/A | withdrawn | Dec 15, 2009 | Rutgers, The State University of New Jersey | Trial was only opened at RCINJ for analysis of data, no patient enrollment took place here. | Enrollment / accrual |
| NCT00361244 | SU011248 in Combination With Irinotecan and Cetuximab as a Second Line Regimen for Stage… | Phase 1 / Phase 2 | terminated | Aug 8, 2006 | Massachusetts General Hospital | Slow Accrual | Enrollment / accrual |
| NCT02423174 | Eval. of Safety and Effectiveness of the FMwand Ferromagnetic Surgical System During… | — | withdrawn | Apr 22, 2015 | Domain Surgical, Inc. | Funding | Funding |
| NCT00276861 | Gemcitabine and Oxaliplatin as Second-Line Therapy in Treating Patients With Metastatic… | Phase 2 | terminated | Jan 13, 2006 | University of Miami | Low Accrual | Enrollment / accrual |
| NCT01801085 | Nursing and Pharmacy Time for Delivering Xeloda® Versus 5-Fluoruracil Regimens | — | terminated | Feb 28, 2013 | Vivian Wing Yan Lee | Slow recruitment pace | Enrollment / accrual |
| NCT02965417 | Sym004 in Metastatic Colorectal Cancer and ECD-EGFR Patients | Phase 2 | withdrawn | Nov 16, 2016 | Symphogen A/S | Symphogen made a business decision to no longer perform the clinical study. | Sponsor / business decision |
| NCT01163526 | Perfusion CT as a Predictor of Treatment Response in Patients With Hepatic Malignancies | — | terminated | Jul 15, 2010 | Stanford University | accrual | Enrollment / accrual |
| NCT02046538 | Phase II Study of Zaltrap and Chemotherapy for Advanced Resectable Colorectal Cancer | Phase 2 | withdrawn | Jan 27, 2014 | Weill Medical College of Cornell University | Investigator terminated due to funding issues | Investigator |
| NCT01718808 | Cetuximab for Elderly Patients With mCRC | Phase 2 | terminated | Oct 31, 2012 | Swiss Cancer Institute | FU for 3 years from randomization as initially planned is stopped as we do not expect any changes… | Other (stated, no rule matched) |
| NCT02586610 | Trial of Chemoradiation and Pembrolizumab in Patients With Rectal Cancer | Phase 2 | withdrawn | Oct 26, 2015 | Osama Rahma, MD | Dr. Rahma decided to run the study through a different group | Other (stated, no rule matched) |
| NCT00072098 | Interleukin-12 Gene in Treating Patients With Liver Metastases Secondary to Colorectal… | Phase 1 | terminated | Nov 6, 2003 | Max Sung | limited funding | Funding |
| NCT02785068 | Evaluation of MM-151 + Nal-IRI + 5-FU + Leucovorin in RAS/RAF Wild-type Metastatic… | Phase 1 / Phase 2 | withdrawn | May 27, 2016 | Merrimack Pharmaceuticals | not stated | Not stated |
| NCT00537823 | Pre- and Post-operative FOLFOX Based Therapy for Patients With Colorectal Cancer With… | Phase 2 | terminated | Oct 1, 2007 | Washington University School of Medicine | Poor accrual. | Enrollment / accrual |
| NCT02511756 | Visualization of Anti-angiogenic Effects With Perfusion Computed Tomography (CTP)(AVA-CTP) | N/A | terminated | Jul 30, 2015 | Patrick Veit-Haibach | Slow accrual | Enrollment / accrual |
| NCT00081224 | Neoadjuvant Celecoxib and Capecitabine Combined With Pelvic Irradiation in Treating… | Phase 2 | terminated | Apr 8, 2004 | Alliance for Clinical Trials in Oncology | not stated | Not stated |
| NCT02560740 | A Study of the Efficacy and Safety of PerOx Quench on the Prevention of Oxaliplatin… | N/A | terminated | Sep 25, 2015 | SMR Biotech Co., Ltd. | Subjects' not-well compliance due to diarrhea and softening stool after taking PerOx Quench 4… | Other (stated, no rule matched) |
| NCT02573220 | Irinotecan Hydrochloride With FOLFIRI and Cetuximab as First-Line Therapy in Treating… | Phase 1 | withdrawn | Oct 9, 2015 | University of Chicago | Study terminated by PI due to inability to accrue. | Enrollment / accrual |
| NCT01522677 | A Study of Neoadjuvant Photodynamic Immunomodulation for Colon Cancer | Phase 1 / Phase 2 | withdrawn | Jan 31, 2012 | Edward Nelson | Slow accrual | Enrollment / accrual |
| NCT02045030 | Study to Identify Biomarkers of Clinical Response to Aflibercept in Patients With… | Phase 2 | terminated | Jan 24, 2014 | CR-CSSS Champlain-Charles-Le Moyne | Drug (Aflibercept) no longuer available for the study | Other (stated, no rule matched) |
| NCT01276405 | An Observational Study of Xeloda (Capecitabine) Monotherapy in Patients With Colorectal… | — | terminated | Jan 13, 2011 | Hoffmann-La Roche | not stated | Not stated |
| NCT01338558 | A Study of Avastin (Bevacizumab) in Combination With mFOLFOX6 in Treatment-Naïve Patients… | Phase 3 | withdrawn | Apr 19, 2011 | Hoffmann-La Roche | not stated | Not stated |
| NCT01060423 | TACE With Irinotecan Drug-eluting Beads and Intravenous (IV) Cetuximab in Refractory…(DEBIRITUX) | Phase 2 | terminated | Feb 2, 2010 | Hans-Joachim Schmoll, MD | Terminated due to poor subject enrolment | Enrollment / accrual |
| NCT01085331 | MEK Inhibitor MSC1936369B Plus FOLFIRI in Second Line K-Ras Mutated Metastatic Colorectal… | Phase 1 / Phase 2 | terminated | Mar 11, 2010 | EMD Serono | Conduct the randomized Phase 2 part not recommended due to the achieved MTD for pimasertib… | Other (stated, no rule matched) |
| NCT00952016 | Methotrexate in Metastatic Colorectal Cancer With MSH2 Deficiency(MESH) | Phase 2 | terminated | Aug 4, 2009 | Royal Marsden NHS Foundation Trust | Lack of recruitment - only 2 patients recruited. | Enrollment / accrual |
| NCT02287727 | Regorafenib in Reducing Recurrence in Patients With Non-metastatic Rectal Cancer Who Have… | Phase 2 | withdrawn | Nov 11, 2014 | Roswell Park Cancer Institute | not stated | Not stated |
Stop reasons are registrant-reported free text and are displayed verbatim (truncated; hover for the full text). Categories come from explicit keyword rules and are never inferred from the study design, sponsor or outcome; a study that stopped for several reasons is filed under the first rule that matched. A TERMINATED status does not imply a negative result.
Data updated 23 days agoSource updated Aug 31, 2017source: clinicaltrials