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Clinical trials · failure tracking
Oncology studies whose overall status is TERMINATED, WITHDRAWN or SUSPENDED on ClinicalTrials.gov, with the stop reason exactly as the registrant posted it. A category is attached only when an explicit keyword rule matches the text; CancerIndex never infers why a study stopped.
691 stopped studies mapped to Malignant Head and Neck Neoplasm and descendants · 92% state a reason
Over the 691 studies matching the cancer, status and year filters (the category filter does not change this chart). Each study is counted once, in the first matching category; greyed bars are studies whose text matched no rule or was empty.
Computedrules ci-stop-reasons-v1 · keyword matching only
A category is assigned when one of its keywords appears in the posted text (case-insensitive, whole words). Rules are tested in this order and the first match wins; every match is kept in the API (reasonMatches).
| NCT | Title | Phase | Status | First posted | Lead sponsor | Why stopped (as posted) | Category |
|---|---|---|---|---|---|---|---|
| NCT03261180 | Nestle Impact Advanced Recovery in Improving Surgery Recovery in Patients With Head and… | N/A | withdrawn | Aug 24, 2017 | OHSU Knight Cancer Institute | Insufficient funding | Funding |
| NCT01557881 | Positron Emission Tomography/Magnetic Resonance Imaging in Patients | N/A | terminated | Mar 20, 2012 | Case Comprehensive Cancer Center | Funding unavailable | Funding |
| NCT01057277 | RAD001, Cisplatin and Concurrent Radiation for Locally Advanced, Inoperable Head and Neck… | Phase 1 | terminated | Jan 27, 2010 | howard safran | Pharmaceutical co- re aligned their specialties- no longer will fund H\&N ca | Funding |
| NCT02569788 | Trail Evaluating Carbon Ion Radiotherapy for Locally Recurrent Nasopharyngeal Carcinoma | Phase 1 / Phase 2 | terminated | Oct 7, 2015 | Shanghai Proton and Heavy Ion Center | Slow accrual of patients. | Enrollment / accrual |
| NCT02801487 | Trial Evaluating Carbon Ion Radiotherapy With Concurrent Chemotherapy for Locally… | Phase 1 / Phase 2 | terminated | Jun 15, 2016 | Shanghai Proton and Heavy Ion Center | Slow accrual of patients. | Enrollment / accrual |
| NCT02576665 | A Study of Toca 511, a Retroviral Replicating Vector, Combined With Toca FC in Patients… | Phase 1 | terminated | Oct 15, 2015 | Tocagen Inc. | Sponsor decision | Sponsor / business decision |
| NCT03323424 | Phase II Trial Assessing the Efficacy of Immuno-Radiation Abscopal Effect in Patients…(IRAM) | Phase 2 | withdrawn | Oct 27, 2017 | Institut de Cancérologie de la Loire | No patient enrolled during the authorized period | Enrollment / accrual |
| NCT03463161 | Epacadostat and Pembrolizumab in Patients With Head and Neck Cancer That Have Failed…(ORKA) | Phase 2 | terminated | Mar 13, 2018 | University of Chicago | Study stopped early due to investigator conflict of interest. | Investigator |
| NCT03106090 | Studying Survivorship Care Plans in Head and Neck Cancer | N/A | terminated | Apr 10, 2017 | Duke University | Unable to meet accrual goals. | Enrollment / accrual |
| NCT03297957 | Fluorescence Imaging in Head and Neck Cancer | N/A | terminated | Sep 29, 2017 | Washington University School of Medicine | Low accrual | Enrollment / accrual |
| NCT02686008 | Pharmacodynamic Study to Assess the Anti-proliferative Activity of the PARP Inhibitor… | Phase 1 | withdrawn | Feb 19, 2016 | Yale University | The study was stopped due to lack of funding. | Funding |
| NCT02429089 | Study of LEE011plus Cetuximab in Patients With a Cancer of the Head and Neck(CETLEE011) | Phase 1 | terminated | Apr 29, 2015 | Cliniques universitaires Saint-Luc- Université Catholique de Louvain | Decided by the investigator due to the difficulties to recruit | Investigator |
| NCT03342352 | Nivolumab Plus Epacadostat in Combination With Chemotherapy Versus the EXTREME Regimen in… | Phase 3 | withdrawn | Nov 14, 2017 | Incyte Corporation | Study was cancelled prior to enrolling any patients. | Enrollment / accrual |
| NCT02390739 | Administering Peripheral Blood Lymphocytes Transduced With a Murine T-Cell Receptor… | Phase 1 / Phase 2 | withdrawn | Mar 18, 2015 | National Cancer Institute (NCI) | not stated | Not stated |
| NCT00585117 | Pilot Study of (61)CuATSM-PET Imaging in Cancer Patients | N/A | terminated | Jan 3, 2008 | University of Wisconsin, Madison | change in imaging priorities | Other (stated, no rule matched) |
| NCT00582712 | An Initial Study of Lithium in Patients With Medullary Thyroid Cancer | Phase 2 | terminated | Dec 28, 2007 | University of Wisconsin, Madison | Budget/Funding | Funding |
| NCT03578432 | Everolimus in Restoring Salivary Gland Function in Participants With Locally Advanced… | Early Phase 1 | terminated | Jul 6, 2018 | University of Arizona | UACC-PHX is no longer able to support the study and Novartis is unable to provide drug beyond… | Other (stated, no rule matched) |
| NCT01974284 | Percutaneous Ethanol Injection for Primary Papillary Thyroid Microcarcinoma | N/A | terminated | Nov 1, 2013 | Yale University | Lack of patient enrollment | Enrollment / accrual |
| NCT02110992 | Safety Study of SBRT and Docetaxel for Locally Recurrent or Second Primary Squamous Cell… | Phase 1 | terminated | Apr 10, 2014 | University of Cincinnati | slow accrual | Enrollment / accrual |
| NCT01883908 | Acupuncture in Reducing the Severity of Chemoradiation-induced Mucositis in Patients With…(GCC1229) | N/A | terminated | Jun 21, 2013 | University of Maryland, Baltimore | The project is terminated due to that fact that the PI has moved to another institution and there… | Other (stated, no rule matched) |
| NCT00416793 | Bortezomib and Carboplatin in Treating Patients With Metastatic Pancreatic Cancer | Phase 2 | terminated | Dec 28, 2006 | National Cancer Institute (NCI) | Study was terminated due to poor accrual | Enrollment / accrual |
| NCT02124850 | A Phase Ib Study of Neoadjuvant of Cetuximab Plus Motolimod and Cetuximab Plus Motolimod… | Phase 1 | terminated | Apr 28, 2014 | Celgene | not stated | Not stated |
| NCT02657369 | A Phase 2 Trial of Lenvatinib for the Treatment of Anaplastic Thyroid Cancer (ATC) | Phase 2 | terminated | Jan 15, 2016 | Eisai Inc. | Overall response rate was 3% (only 1 out of 33 participants had confirmed PR). | Other (stated, no rule matched) |
| NCT01230476 | Induction and Concurrent Chemoradiotherapy With Cetuximab for Patients With Locally… | Phase 2 | terminated | Oct 29, 2010 | University of Malaya | not stated | Not stated |
| NCT02062632 | Doxepin Hydrochloride in Treating Esophageal Pain in Patients With Thoracic Cancer… | Phase 2 | terminated | Feb 14, 2014 | Mayo Clinic | Poor accrual | Enrollment / accrual |
| NCT00408252 | Efficacy of SU 011248 in Head And Neck Carcinoma | Phase 2 | terminated | Dec 6, 2006 | Cliniques universitaires Saint-Luc- Université Catholique de Louvain | Too frequent grade 3-4 toxicities | Safety / toxicity |
| NCT02789189 | Nedaplatin Combined With Gemcitabine in the Treatment of Recurrent and/or Metastatic… | Phase 2 | terminated | Jun 2, 2016 | Sun Yat-sen University | not stated | Not stated |
| NCT03575234 | Nivolumab & IRX-2 With Surgery for Resectable Stage III-IVA Oral Cavity Cancer or… | Phase 1 | withdrawn | Jul 2, 2018 | Emory University | funding and drug were withdrawn | Funding |
| NCT03611205 | Interim Digital PET/CT in Predicting Outcomes for Participants With Locally Advanced… | N/A | withdrawn | Aug 2, 2018 | Ohio State University Comprehensive Cancer Center | PI decision | Other (stated, no rule matched) |
| NCT00387530 | Phenylbutyrate and Valganciclovir in Treating Patients With Relapsed or Refractory… | Phase 2 | withdrawn | Oct 13, 2006 | University of California, San Diego | not stated | Not stated |
| NCT01709006 | Phase I-II Study on Treatment of Advanced Oropharynx Cancer in Elderly Population by… | N/A | terminated | Oct 17, 2012 | Centre hospitalier de l'Université de Montréal (CHUM) | Not enough patients to conclude | Other (stated, no rule matched) |
| NCT02289144 | Ceritinib in Mutation and Oncogene Directed Therapy in Thyroid Cancer | Phase 2 | withdrawn | Nov 13, 2014 | University of Texas Southwestern Medical Center | study was on hold for protocol redesign; decided to not move forward with study. | Other (stated, no rule matched) |
| NCT01739439 | Chemoradiation and Radiosurgery Boost in Treating Patients With Locally Advance… | Phase 1 | terminated | Dec 3, 2012 | Fox Chase Cancer Center | Slow accrual | Enrollment / accrual |
| NCT00832559 | A Study of the Intratumoural Administration of CAVATAK to Head and Neck Cancer Patients…(VLA-X06) | Phase 1 | terminated | Jan 30, 2009 | Viralytics | Poor recruitment rate. | Enrollment / accrual |
| NCT01987375 | Cetuximab IRDye800 Study as an Optical Imaging Agent to Detect Cancer During Surgical… | Phase 1 | terminated | Nov 19, 2013 | Eben Rosenthal | logistics | Other (stated, no rule matched) |
| NCT02137096 | Autologous Stem Cell Transplantation for Patients With Recurrent Nasopharyngeal Carcinoma | Phase 3 | terminated | May 13, 2014 | University of Florida | This is a rare disease, and enrollment was poor. | Enrollment / accrual |
| NCT02980601 | The Use of Integra in Coverage of Radial Forearm Free Flap Donor Site Defect | N/A | terminated | Dec 2, 2016 | Wake Forest University Health Sciences | not stated | Not stated |
| NCT02410382 | Dexamethasone for Treatment of Radiation-related Fatigue in Patients Receiving RT for… | Phase 2 | terminated | Apr 7, 2015 | University of Arizona | IRB suspension, did not resume | Other (stated, no rule matched) |
| NCT02789267 | Nutrition and Quality of Life of Patients With Head and Neck Carcinoma After Radiotherapy(NUQUE3) | N/A | terminated | Jun 2, 2016 | University Hospital, Caen | Insufficient funding | Funding |
| NCT03325465 | Neoadjuvant Pembrolizumab + Epacadostat Prior to Curative Surgical Care for Squamous Cell… | Phase 2 | withdrawn | Oct 30, 2017 | University of Chicago | Site decided not to move forward with trial. Study never opened to enrollment. | Enrollment / accrual |
| NCT03386838 | An Immuno-therapy Study of Nivolumab in Combination With Experimental Medication… | Phase 3 | withdrawn | Dec 29, 2017 | Bristol-Myers Squibb | Business objectives have changed. | Sponsor / business decision |
| NCT02706691 | BGJ398 in Treating Patients With FGFR Positive Recurrent Head and Neck Cancer | Phase 2 | terminated | Mar 11, 2016 | University of Chicago | Study stopped due to poor enrollment. | Enrollment / accrual |
| NCT01011842 | Real-Time kV Imaging vs. Real-Time 3D Patient Surface Tracking for Head & Neck Cancer | N/A | terminated | Nov 11, 2009 | Stanford University | not stated | Not stated |
| NCT03114280 | Pembrolizumab and Induction Chemotherapy in Head and Neck Squamous Cell Carcinoma (PICH…(PICH) | Phase 1 / Phase 2 | withdrawn | Apr 14, 2017 | Centre Antoine Lacassagne | MSD would not able to support the study's continuation after protocol modifications required by… | Other (stated, no rule matched) |
| NCT02472080 | Gemcitabine - Oxaliplatin for Advanced Refractory Thyroid Cancer Patients: a Phase II…(THYGEMOX) | Phase 2 | terminated | Jun 15, 2015 | Assistance Publique - Hôpitaux de Paris | inefficiency | Other (stated, no rule matched) |
| NCT02657850 | Head and Neck Cancer Treatment Related Dysphagia | — | withdrawn | Jan 18, 2016 | Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | study approval lapsed | Other (stated, no rule matched) |
| NCT00750555 | Maintenance of Tarceva (Erlotinib) in Patients With Locally Advanced Head and Neck Cancer | Phase 2 | terminated | Sep 10, 2008 | Geisinger Clinic | PI Law left Geisinger-study terminated prematurely - 4 patients enrolled | Enrollment / accrual |
| NCT03179956 | Impact of Ribociclib on Head and Neck Squamous Cell Cancer | Early Phase 1 | terminated | Jun 7, 2017 | Fox Chase Cancer Center | Slow accrual | Enrollment / accrual |
| NCT00896350 | MRI in Finding Hypoxia in Patients Undergoing Chemo and Radiation for Head and Neck Cancer | Phase 1 | terminated | May 11, 2009 | University of Texas Southwestern Medical Center | not stated | Not stated |
| NCT00484601 | Ifosfamide and Doxorubicin in Patients With Refractory Nasopharyngeal Carcinoma | Phase 2 | terminated | Jun 11, 2007 | Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | Low accrual. | Enrollment / accrual |
Stop reasons are registrant-reported free text and are displayed verbatim (truncated; hover for the full text). Categories come from explicit keyword rules and are never inferred from the study design, sponsor or outcome; a study that stopped for several reasons is filed under the first rule that matched. A TERMINATED status does not imply a negative result.
Data updated 23 days agoSource updated Feb 25, 2020source: clinicaltrials