Loading clinical trials…
Loading clinical trials…
Clinical trials · failure tracking
Oncology studies whose overall status is TERMINATED, WITHDRAWN or SUSPENDED on ClinicalTrials.gov, with the stop reason exactly as the registrant posted it. A category is attached only when an explicit keyword rule matches the text; CancerIndex never infers why a study stopped.
33 stopped studies mapped to Malignant Giant Cell Neoplasm and descendants · 82% state a reason
Over the 33 studies matching the cancer, status and year filters (the category filter does not change this chart). Each study is counted once, in the first matching category; greyed bars are studies whose text matched no rule or was empty.
Computedrules ci-stop-reasons-v1 · keyword matching only
A category is assigned when one of its keywords appears in the posted text (case-insensitive, whole words). Rules are tested in this order and the first match wins; every match is kept in the API (reasonMatches).
| NCT | Title | Phase | Status | First posted | Lead sponsor | Why stopped (as posted) | Category |
|---|---|---|---|---|---|---|---|
| NCT05218408 | CYNK-001 IV and IC in Combination With IL2 in Surgical Eligible Recurrent GBM With IDH-1…(CYNK001GBM02) | Phase 1 / Phase 2 | withdrawn | Feb 1, 2022 | Celularity Incorporated | No participants were enrolled. Study was withdrawn prior to treatment initiation. | Enrollment / accrual |
| NCT06806228 | Phase I Pilot Study to Evaluate the Anti-glioblastoma Effect of S-Gboxin in Standard… | Phase 1 | suspended | Feb 4, 2025 | Petrov, Andrey | The study protocol will be changed | Other (stated, no rule matched) |
| NCT04482933 | HSV G207 With a Single Radiation Dose in Children With Recurrent High-Grade Glioma | Phase 2 | withdrawn | Jul 23, 2020 | Pediatric Brain Tumor Consortium | The PBTC lost federal funding and will cease operations in March 2026.PBTC-061 was permanently… | Enrollment / accrual |
| NCT03912818 | Durvalumab and Standard Chemotherapy Before Surgery in Treating Patients With Variant… | Phase 2 | terminated | Apr 11, 2019 | Stanford University | Difficulty with enrollment | Enrollment / accrual |
| NCT04489420 | Natural Killer Cell (CYNK-001) IV Infusion or IT Administration in Adults With Recurrent…(CYNK001GBM01) | Phase 1 | terminated | Jul 28, 2020 | Celularity Incorporated | Business decision. | Sponsor / business decision |
| NCT02255461 | Palbociclib Isethionate in Treating Younger Patients With Recurrent, Progressive, or… | Phase 1 | terminated | Oct 2, 2014 | Pediatric Brain Tumor Consortium | Data for the primary objectives is complete and the MTD identified in Stratum II. | Other (stated, no rule matched) |
| NCT03014804 | Autologous Dendritic Cells Pulsed With Tumor Lysate Antigen Vaccine and Nivolumab in… | Phase 2 | withdrawn | Jan 9, 2017 | Jonsson Comprehensive Cancer Center | Final contract negotiations | Other (stated, no rule matched) |
| NCT00943462 | Study of 18F-FEC for Positron Emission Tomography-Computed Tomography (PET-CT) Imaging of… | — | withdrawn | Jul 22, 2009 | Centre hospitalier de l'Université de Montréal (CHUM) | No eligible patients could be recruited. | Enrollment / accrual |
| NCT01478321 | Efficacy of Hypofractionated XRT w/Bev. + Temozolomide for Recurrent Gliomas | Phase 2 | terminated | Nov 23, 2011 | Northwestern University | Slow accrual to some cohorts | Enrollment / accrual |
| NCT00568906 | Microarray Analysis of Gene Expression and Identification of Progenitor Cells in Lung… | — | terminated | Dec 6, 2007 | Stanford University | not stated | Not stated |
| NCT01103375 | Erlotinib Hydrochloride and Isotretinoin in Treating Patients With Recurrent Malignant… | Phase 1 | terminated | Apr 14, 2010 | Wake Forest University Health Sciences | Slow accrual | Enrollment / accrual |
| NCT01575275 | Aminolevulinic Acid in Visualizing a Tumor During Surgery in Patients With Glioblastoma… | Phase 2 | terminated | Apr 11, 2012 | Michael Vogelbaum, MD, PhD | Drugs unavailable | Other (stated, no rule matched) |
| NCT01836549 | Imetelstat Sodium in Treating Younger Patients With Recurrent or Refractory Brain Tumors | Phase 2 | terminated | Apr 22, 2013 | Pediatric Brain Tumor Consortium | Due to several intracranial hemorrhages and recommendation by the PBTC DSMB. | Other (stated, no rule matched) |
| NCT01234805 | Yoga Therapy in Treating Patients With Malignant Brain Tumors | N/A | terminated | Nov 4, 2010 | Wake Forest University Health Sciences | Slow Accruals | Enrollment / accrual |
| NCT00112866 | Cilengitide in Treating Patients Who Are Undergoing Surgery for Recurrent or Progressive… | Phase 2 | terminated | Jun 3, 2005 | National Cancer Institute (NCI) | due to poor accrual | Enrollment / accrual |
| NCT01122901 | Gamma-Secretase/Notch Signalling Pathway Inhibitor RO4929097 in Treating Patients With… | Phase 2 | terminated | May 13, 2010 | National Cancer Institute (NCI) | Stopped prematurely by Company due to decision to terminate all CTEP supplied drug for further… | Sponsor / business decision |
| NCT02194452 | Efficacy of 68Ga-DOTATOC Positron Emission Tomography (PET) CT in Children and Young… | N/A | withdrawn | Jul 18, 2014 | Sue O'Dorisio | not stated | Not stated |
| NCT01996527 | 3T MRI Biomarkers of Glioma Treatment Response | Early Phase 1 | terminated | Nov 27, 2013 | Vanderbilt-Ingram Cancer Center | PI left institution | Investigator |
| NCT02967380 | Gadobutrol Versus Gadopentetate Dimeglumine or Gadobenate Dimeglumine Before DCE-MRI in… | N/A | terminated | Nov 18, 2016 | University of Southern California | Insufficient Accrual | Enrollment / accrual |
| NCT02175745 | 18F-FDOPA PET/CT or PET/MRI in Measuring Tumors in Patients With Newly-Diagnosed or… | N/A | terminated | Jun 26, 2014 | Erik Mittra | Re-evaluate indication with the referring physicians | Other (stated, no rule matched) |
| NCT01148966 | Aminolevulinic Acid During Surgery in Treating Patients With Malignant Brain Tumors | Phase 1 | terminated | Jun 23, 2010 | University of Washington | not stated | Not stated |
| NCT02031965 | Oncolytic HSV-1716 in Treating Younger Patients With Refractory or Recurrent High Grade… | Phase 1 | terminated | Jan 9, 2014 | Pediatric Brain Tumor Consortium | not stated | Not stated |
| NCT01189240 | RO4929097and Bevacizumab in Treating Patients With Progressive or Recurrent Malignant… | Phase 1 / Phase 2 | terminated | Aug 26, 2010 | National Cancer Institute (NCI) | Company decided to stop development of drug - 7/31/12 | Sponsor / business decision |
| NCT01122888 | Cilengitide and Sunitinib Malate in Treating Patients With Advanced Solid Tumors or… | Phase 1 | terminated | May 13, 2010 | National Cancer Institute (NCI) | not stated | Not stated |
| NCT01378481 | High-Dose Vorinostat and Fractionated Stereotactic Body Radiation Therapy in Treating… | Phase 1 | terminated | Jun 22, 2011 | National Cancer Institute (NCI) | not stated | Not stated |
| NCT02055196 | Genetically Modified Stem Cells and Irinotecan Hydrochloride in Treating Patients With… | Phase 1 | withdrawn | Feb 5, 2014 | City of Hope Medical Center | New study written | Other (stated, no rule matched) |
| NCT01095094 | Ritonavir and Lopinavir in Treating Patients With Progressive or Recurrent High-Grade… | Phase 2 | terminated | Mar 29, 2010 | Case Comprehensive Cancer Center | Study did not meet its primary objective | Other (stated, no rule matched) |
| NCT01269411 | RO4929097 in Treating Patients With Recurrent Invasive Gliomas | Phase 1 | terminated | Jan 4, 2011 | National Cancer Institute (NCI) | Administratively complete. | Other (stated, no rule matched) |
| NCT00005856 | Oxaliplatin in Treating Patients With Newly Diagnosed Glioblastoma Multiforme | Phase 1 / Phase 2 | terminated | Jan 27, 2003 | National Cancer Institute (NCI) | Administratively complete. | Other (stated, no rule matched) |
| NCT00006773 | Bortezomib in Treating Patients With Recurrent Glioma | Phase 1 | terminated | Jan 27, 2003 | National Cancer Institute (NCI) | Administratively complete. | Other (stated, no rule matched) |
| NCT00075491 | Neoadjuvant and Adjuvant Fenretinide Compared With Adjuvant Fenretinide Alone in Treating… | Phase 2 | terminated | Jan 12, 2004 | National Cancer Institute (NCI) | Administratively complete. | Other (stated, no rule matched) |
| NCT00110032 | Positron Emission Tomography Using Fluorine F 18 EF5 to Find Oxygen in Tumor Cells of… | Phase 1 | terminated | May 4, 2005 | National Cancer Institute (NCI) | Administratively complete. | Other (stated, no rule matched) |
| NCT00430079 | Use of EF5 to Measure the Oxygen Level in Tumor Cells of Patients Undergoing Surgery or… | N/A | terminated | Feb 1, 2007 | National Cancer Institute (NCI) | Administratively complete. | Other (stated, no rule matched) |
Stop reasons are registrant-reported free text and are displayed verbatim (truncated; hover for the full text). Categories come from explicit keyword rules and are never inferred from the study design, sponsor or outcome; a study that stopped for several reasons is filed under the first rule that matched. A TERMINATED status does not imply a negative result.
Data updated 22 days agoSource updated Jun 8, 2026source: clinicaltrials