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Clinical trials · failure tracking
Oncology studies whose overall status is TERMINATED, WITHDRAWN or SUSPENDED on ClinicalTrials.gov, with the stop reason exactly as the registrant posted it. A category is attached only when an explicit keyword rule matches the text; CancerIndex never infers why a study stopped.
2,225 stopped studies mapped to Malignant Genitourinary System Neoplasm and descendants · 88% state a reason
Over the 2,225 studies matching the cancer, status and year filters (the category filter does not change this chart). Each study is counted once, in the first matching category; greyed bars are studies whose text matched no rule or was empty.
Computedrules ci-stop-reasons-v1 · keyword matching only
A category is assigned when one of its keywords appears in the posted text (case-insensitive, whole words). Rules are tested in this order and the first match wins; every match is kept in the API (reasonMatches).
| NCT | Title | Phase | Status | First posted | Lead sponsor | Why stopped (as posted) | Category |
|---|---|---|---|---|---|---|---|
| NCT00958893 | An Extension Study Evaluating Safety and Efficacy of Proellex® In Women Who Have… | Phase 2 | terminated | Aug 13, 2009 | Repros Therapeutics Inc. | Repros stopped the study for safety and FDA put the study on hold for safety. | Safety / toxicity |
| NCT00470067 | Doxorubicin Hydrochloride Liposome and Carboplatin in Treating Patients With Recurrent,… | Phase 2 | terminated | May 7, 2007 | Roswell Park Cancer Institute | Due to low accrual | Enrollment / accrual |
| NCT00536523 | Effect of Serotonin Level on Constipation Caused by Chemotherapy in Patients With… | — | terminated | Sep 28, 2007 | University of Minnesota | Funding unavailable | Funding |
| NCT01284075 | The Effect of Guided Imagery and Music Therapy on Post-Operative Recovery After… | N/A | terminated | Jan 26, 2011 | University of Minnesota | Low accrual | Enrollment / accrual |
| NCT00683917 | Pharmacokinetics, Safety and Efficacy Study of Proellex in Pre-menopausal Women With… | Phase 2 | terminated | May 26, 2008 | Repros Therapeutics Inc. | Repros stopped the study for safety and FDA put the study on hold for safety. | Safety / toxicity |
| NCT00702702 | Safety and Efficacy of Proellex in Pre-menopausal Anemic Women With Symptomatic Uterine… | Phase 3 | terminated | Jun 20, 2008 | Repros Therapeutics Inc. | Repros stopped study for safety and FDA put study on hold because of safety. | Safety / toxicity |
| NCT00735553 | Evaluating the Safety and Efficacy of Proellex® (CDB-4124) in Premenopausal Women With… | Phase 3 | terminated | Aug 15, 2008 | Repros Therapeutics Inc. | Repros stopped the study for safety and FDA put the study on hold for safety. | Safety / toxicity |
| NCT00737282 | Multicenter Study Evaluating the Safety of Proellex® in Premenopausal Women With Uterine… | Phase 3 | terminated | Aug 18, 2008 | Repros Therapeutics Inc. | Repros stopped study for safety and FDA put study on hold. | Safety / toxicity |
| NCT00785356 | Safety and Efficacy of Proellex in Pre-Menopausal Anemic Women With Symptomatic Uterine… | Phase 3 | terminated | Nov 5, 2008 | Repros Therapeutics Inc. | Repros stopped the study for safety and FDA put the study on hold for safety. | Safety / toxicity |
| NCT00853567 | Evaluating the Safety and Efficacy of Proellex® in Premenopausal Women With Symptomatic… | Phase 3 | terminated | Mar 2, 2009 | Repros Therapeutics Inc. | Repros stopped the study for safety and FDA put the study on hold for safety. | Safety / toxicity |
| NCT01069120 | Safety of 25 and 50 mg Proellex® in the Treatment of Women With Symptomatic Uterine… | Phase 3 | terminated | Feb 17, 2010 | Repros Therapeutics Inc. | Repros stopped study due to safety and FDA placed study on hold | Safety / toxicity |
| NCT00385827 | A Safety and Efficacy Study of Siltuximab (CNTO 328) in Male Subjects With Metastatic… | Phase 2 | terminated | Oct 11, 2006 | Centocor, Inc. | Prematurely stopped after Independent Data Monitoring Committee (IDMC) evaluation for lack of… | Efficacy / futility |
| NCT01606358 | Influence of Chemotherapy on Gamma-delta T Cells in Patients With Epithelial Ovarian…(IClyCO) | — | withdrawn | May 25, 2012 | Rennes University Hospital | not stated | Not stated |
| NCT00004050 | Leuvectin Followed By Surgery in Treating Patients With Stage II or Stage III Prostate… | Phase 2 | terminated | Oct 29, 2003 | Vical | Development in prostate cancer indication halted | Other (stated, no rule matched) |
| NCT00005072 | Leuvectin in Treating Patients With Locally Recurrent Prostate Cancer | Phase 1 / Phase 2 | terminated | Nov 4, 2003 | Vical | Development in prostate cancer indication halted | Other (stated, no rule matched) |
| NCT01550380 | BKM120 in Advanced, Metastatic, or Recurrent Endometrial Cancers(BKM120) | Phase 2 | withdrawn | Mar 12, 2012 | University of Utah | not stated | Not stated |
| NCT01688414 | Imaging During Surgery in Diagnosing Patients With Prostate, Bladder, or Kidney Cancer | N/A | withdrawn | Sep 19, 2012 | Stanford University | PI left Stanford | Investigator |
| NCT00001703 | Vaccine Therapy With Tumor Specific Mutated VHL Peptides in Adult Cancer Patients With… | Phase 2 | terminated | Nov 4, 1999 | National Cancer Institute (NCI) | Due to poor accrual and lack of peptide vaccine | Enrollment / accrual |
| NCT02054793 | Phase Ib/II Study Evaluating Orteronel (Without Prednisone) Combined With Itraconazole In… | Phase 1 / Phase 2 | withdrawn | Feb 4, 2014 | Emmanuel Antonarakis, MD | This study was never able to open due to lack of funding from the pharmaceutical company. | Funding |
| NCT00610662 | Digital Colposcopy in Finding Cervical Intraepithelial Neoplasia in Patients With An… | — | withdrawn | Feb 8, 2008 | British Columbia Cancer Agency | Study modified and has been running as CDR0000581286 instead. | Other (stated, no rule matched) |
| NCT00626561 | Bevacizumab and Paclitaxel for Neuroendocrine Tumors of the Cervix | Phase 2 | terminated | Feb 29, 2008 | M.D. Anderson Cancer Center | Due to slow accrual. | Enrollment / accrual |
| NCT00949962 | Post-operative or Early Salvage XRT and ADT for High Risk PCa | Phase 3 | terminated | Jul 31, 2009 | European Organisation for Research and Treatment of Cancer - EORTC | Poorly recruiting | Enrollment / accrual |
| NCT00002947 | Indium In 111 Pentetreotide in Treating Patients With Refractory Cancer | Phase 1 | terminated | Mar 26, 2004 | Yale University | not stated | Not stated |
| NCT00874302 | Safety and Efficacy of 25 and 50 mg Doses of Proellex® in Treating the Recurrence of… | Phase 3 | withdrawn | Apr 2, 2009 | Repros Therapeutics Inc. | Study terminated for safety and the FDA put the study on hold for safety. | Safety / toxicity |
| NCT01793636 | A Study Comparing AZD2014 vs Everolimus in Patients With Metastatic Renal Cancer(ZEBRA) | Phase 2 | terminated | Feb 15, 2013 | Queen Mary University of London | Inferior efficacy of study drug in renal indication. | Efficacy / futility |
| NCT00418093 | Oxaliplatin, Gemcitabine and Bevacizumab in Women With Recurrent Mullerian Carcinoma | Phase 2 | terminated | Jan 4, 2007 | Dana-Farber Cancer Institute | THe study was terminated early due to a lack of accural | Other (stated, no rule matched) |
| NCT00515112 | Testosterone Replacement in Men With Non-Metastatic Castrate Resistant Prostate Cancer | Phase 2 | terminated | Aug 13, 2007 | University of Chicago | This study has been terminated due to poor accrual | Enrollment / accrual |
| NCT00089076 | MDX-010 in Treating Patients With Recurrent or Refractory Lymphoma | Phase 1 / Phase 2 | terminated | Aug 5, 2004 | National Cancer Institute (NCI) | not stated | Not stated |
| NCT00112905 | Sorafenib in Treating Patients With Regional or Metastatic Cancer of the Urothelium | Phase 2 | terminated | Jun 3, 2005 | National Cancer Institute (NCI) | not stated | Not stated |
| NCT01068470 | Determining the Lymphokine Activated Killer (LAK) Cytotoxicity Present in Patients…(LAK) | — | terminated | Feb 15, 2010 | Loma Linda University | PI left the institution | Investigator |
| NCT00835679 | Cetuximab and/or Dasatinib in Patients With Colorectal Cancer and Liver Metastases That… | Early Phase 1 | terminated | Feb 4, 2009 | National Cancer Institute (NCI) | not stated | Not stated |
| NCT00303862 | AZD2171 in Treating Patients With Refractory Metastatic Kidney Cancer | Phase 2 | terminated | Mar 17, 2006 | National Cancer Institute (NCI) | not stated | Not stated |
| NCT00003094 | Carotenoid Rich Diet in Treating Cervical Dysplasia | Phase 2 | withdrawn | Apr 27, 2004 | University of California, San Diego | Study was halted prematurely, prior to enrollment of first participant | Enrollment / accrual |
| NCT00684996 | Bevacizumab With or Without MEDI-522 in Treating Patients With Unresectable or Metastatic… | Phase 1 / Phase 2 | terminated | May 28, 2008 | National Cancer Institute (NCI) | not stated | Not stated |
| NCT01907308 | Trebananib (AMG 386) in Combination With Docetaxel for Advanced Urothelial Carcinoma | Phase 2 | withdrawn | Jul 24, 2013 | University of Colorado, Denver | Sponsor's decision to terminate the study | Sponsor / business decision |
| NCT01483586 | Safety and Efficacy of Kanglaite Gelcaps in Prostate Cancer | Phase 2 | terminated | Dec 1, 2011 | KangLaiTe USA | Sponsor decision | Sponsor / business decision |
| NCT00678015 | Pharmacokinetic and Efficacy Study of Nordihydroguaiaretic Acid (NDGA) in Non Metastatic… | Phase 2 | terminated | May 15, 2008 | University of California, San Francisco | Per protocol - interim analysis showed no significant PSA declines among the first 12 patients… | Efficacy / futility |
| NCT01233505 | Veliparib, Oxaliplatin, and Capecitabine in Treating Patients With Advanced Solid Tumors | Phase 1 | terminated | Nov 3, 2010 | National Cancer Institute (NCI) | not stated | Not stated |
| NCT01602783 | 11C Acetate Imaging Post Prostatectomy | N/A | terminated | May 21, 2012 | Massachusetts General Hospital | Slow accrual; no further funding | Enrollment / accrual |
| NCT01613521 | Tumor Perfusion and Hypoxia Assessed by DCE-MRI and 18F-FMISO PET as Biomarkers of… | N/A | terminated | Jun 7, 2012 | Memorial Sloan Kettering Cancer Center | Lack of accrual | Enrollment / accrual |
| NCT01100866 | Study of POMELLA™ Extract to Treat Prostate Cancer | N/A | terminated | Apr 9, 2010 | Vancouver Coastal Health | due to slow enrollment | Enrollment / accrual |
| NCT01007214 | Guided Biopsy for Mapping Prostate Cancer(HIT) | N/A | terminated | Nov 3, 2009 | Roswell Park Cancer Institute | Not able to meet accrual | Enrollment / accrual |
| NCT00887640 | Impact of Temsirolimus Therapy on Circulating Tumor Cell Biology In Men With Castration… | Phase 2 | terminated | Apr 24, 2009 | Duke University | not stated | Not stated |
| NCT01734681 | Phase 2 Study of G-202 in Patients With Chemotherapy-Naïve Metastatic Castrate-Resistant… | Phase 2 | withdrawn | Nov 28, 2012 | GenSpera, Inc. | not stated | Not stated |
| NCT00967928 | Everolimus Dose Finding Study for Stage IV or Recurrent Cervical Cancer | Phase 1 | withdrawn | Aug 28, 2009 | Accelerated Community Oncology Research Network | Lack of enrollment | Enrollment / accrual |
| NCT01176513 | GE-148-002: A Phase 2, Open-label, Single-Center Study to Assess GE-148 (18F) Injection… | Phase 2 | terminated | Aug 6, 2010 | GE Healthcare | Lack of Subject enrollment | Enrollment / accrual |
| NCT01409473 | Stereotactic Body Radiotherapy (SBRT) With Concurrent Boost for Low- and…(Prostate SBRT) | Phase 2 | withdrawn | Aug 4, 2011 | Rocky Mountain Cancer Centers | not stated | Not stated |
| NCT00523640 | A Phase II Trial of Gemcitabine, Capecitabine, and Bevacizumab in Metastatic Renal Cell… | Phase 2 | terminated | Aug 31, 2007 | University of Chicago | Too slow accrual | Enrollment / accrual |
| NCT00802633 | Radical Cystectomy: Can We Improve Our Surgical Technique With the Ligasure Impact… | N/A | terminated | Dec 5, 2008 | Vanderbilt University | Enrollment was stopped after eighty patients were enrolled. | Enrollment / accrual |
| NCT00942058 | Serum CA9 Level as Biological Marker of the Treatment Response in Metastatic Renal Cell…(CA9CRM) | — | terminated | Jul 20, 2009 | Centre Hospitalier Universitaire de Saint Etienne | Difficult for recruiting | Enrollment / accrual |
Stop reasons are registrant-reported free text and are displayed verbatim (truncated; hover for the full text). Categories come from explicit keyword rules and are never inferred from the study design, sponsor or outcome; a study that stopped for several reasons is filed under the first rule that matched. A TERMINATED status does not imply a negative result.
Data updated 24 days agoSource updated Aug 25, 2014source: clinicaltrials