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Clinical trials · failure tracking
Oncology studies whose overall status is TERMINATED, WITHDRAWN or SUSPENDED on ClinicalTrials.gov, with the stop reason exactly as the registrant posted it. A category is attached only when an explicit keyword rule matches the text; CancerIndex never infers why a study stopped.
196 stopped studies mapped to Malignant Esophageal Neoplasm and descendants · 93% state a reason
Over the 196 studies matching the cancer, status and year filters (the category filter does not change this chart). Each study is counted once, in the first matching category; greyed bars are studies whose text matched no rule or was empty.
Computedrules ci-stop-reasons-v1 · keyword matching only
A category is assigned when one of its keywords appears in the posted text (case-insensitive, whole words). Rules are tested in this order and the first match wins; every match is kept in the API (reasonMatches).
| NCT | Title | Phase | Status | First posted | Lead sponsor | Why stopped (as posted) | Category |
|---|---|---|---|---|---|---|---|
| NCT01704690 | Combination Treatment of S-1 With Paclitaxel in Advanced Esophageal Cancer | Phase 2 / Phase 3 | terminated | Oct 11, 2012 | Peking University | The enrollment of the study is much slower than expected. | Enrollment / accrual |
| NCT02274012 | Trial of Afatinib in Combination With Weekly Paclitaxel in the Second Line Treatment | Phase 2 | withdrawn | Oct 24, 2014 | Columbia University | Former PI left institution and had plans to continue at another institution. | Investigator |
| NCT02843750 | Study of Inspiratory Muscle Training for Patients Undergoing Esophageal Surgery | N/A | withdrawn | Jul 26, 2016 | Mayo Clinic | Difficulty recruiting patients | Enrollment / accrual |
| NCT00767234 | Permission to Collect Blood Over Time for Research | — | terminated | Oct 7, 2008 | Stanford University | Accrual issues - Low Accrual | Enrollment / accrual |
| NCT00003381 | Quality of Life Assessment of Patients Receiving Treatment for Esophageal Cancer… | — | terminated | Jun 16, 2004 | Alliance for Clinical Trials in Oncology | companion study to CALGB-9781 which closed administratively due to poor accrual | Enrollment / accrual |
| NCT00268437 | Radiation Therapy, Pemetrexed Disodium, and Carboplatin in Treating Patients With Locally… | Phase 2 | terminated | Dec 22, 2005 | Alliance for Clinical Trials in Oncology | Trial closed early because, during an interim analysis, the primary endpoint fell short. | Efficacy / futility |
| NCT00524186 | Sunitinib, Irinotecan, Fluorouracil, and Leucovorin In Treating Patients With Advanced… | Phase 1 | terminated | Sep 3, 2007 | Roswell Park Cancer Institute | PI left institute | Investigator |
| NCT02689401 | MRI Iron Oxide Imaging for Lymph Node Staging in Esophageal Cancer | Phase 1 | withdrawn | Feb 24, 2016 | Dana-Farber Cancer Institute | Awaiting additional safety data | Safety / toxicity |
| NCT02598687 | Testing TH-302, in Combination With Preoperative Chemoradiotherapy, in Esophageal Cancer. | Phase 1 | withdrawn | Nov 6, 2015 | Maastricht Radiation Oncology | 2 Phase 3 trials didn't meet their primary endpoint, so further development and testing of TH-302… | Other (stated, no rule matched) |
| NCT02491372 | A Pilot Study of the Effectiveness of Acceptance and Commitment Therapy With a Post-Upper… | N/A | withdrawn | Jul 8, 2015 | Martin Dempster | Unable to recruit sufficient number of participants in the time available. | Enrollment / accrual |
| NCT02323776 | Defining the Radiotherapy Dose and Volume Parameters Affecting Postoperative… | — | terminated | Dec 23, 2014 | Maastricht Radiation Oncology | not stated | Not stated |
| NCT00130936 | Study of Epirubicin (Pharmorubicin®), Carboplatin (Paraplatin®) and Capecitabine… | Phase 1 / Phase 2 | terminated | Aug 17, 2005 | AHS Cancer Control Alberta | not stated | Not stated |
| NCT02283359 | Selinexor in Combination With Irinotecan in Adenocarcinoma of Stomach and Distal Esophagus | Phase 1 | terminated | Nov 5, 2014 | H. Lee Moffitt Cancer Center and Research Institute | Principal Investigator left the institution | Investigator |
| NCT01998347 | Paclitaxel Liposome and Cisplatin as First-line Chemotherapy in Patients With Metastatic… | Phase 3 | withdrawn | Nov 28, 2013 | Shantou University Medical College | slow enrollment | Enrollment / accrual |
| NCT00109850 | S0414 Cetuximab, Combo Chemo, and RT in Locally Advanced Esophageal Cancer | Phase 2 | terminated | May 4, 2005 | SWOG Cancer Research Network | Closed due to poor accrual | Enrollment / accrual |
| NCT00093652 | Oxaliplatin, Gefitinib, and Radiation Therapy in Treating Patients With Locally Advanced… | Phase 1 / Phase 2 | terminated | Oct 8, 2004 | Roswell Park Cancer Institute | not stated | Not stated |
| NCT01301495 | Prospective Evaluation of a New Covered Metal Stent for Malignant Lesions of the Esophagus | Phase 2 | withdrawn | Feb 23, 2011 | Weill Medical College of Cornell University | No participants enrolled for more than 1 year. | Enrollment / accrual |
| NCT02023541 | Proton Beam Therapy to Treat Esophageal Cancer | Phase 1 | terminated | Dec 30, 2013 | Washington University School of Medicine | Lack of insurance coverage for proton beam treatment | Other (stated, no rule matched) |
| NCT00735345 | Chemotherapy Induction and Chemoradiotherapy in Patients With Esophageal Carcinoma | Phase 2 | terminated | Aug 14, 2008 | Arbeitsgemeinschaft medikamentoese Tumortherapie | because of safety concerns the study was terminated prematurely | Safety / toxicity |
| NCT02033538 | Neoadjuvant Chemotherapy of Nanoparticle Albumin-bound Paclitaxel in Squamous Cell… | Phase 2 | withdrawn | Jan 10, 2014 | Zhejiang University | This clinical trial was closed due to slow recruitment of patients. | Enrollment / accrual |
| NCT02034968 | Nimotuzumab Plus Nab-paclitaxel and Cisplatin in Treating Patients With Advanced… | Phase 2 | withdrawn | Jan 14, 2014 | Zhejiang University | No recruitment | Enrollment / accrual |
| NCT02041819 | Neoadjuvant Chemotherapy of Nimotuzumab Plus Nab-Paclitaxel in Squamous Cell Carcinoma of… | Phase 2 | withdrawn | Jan 22, 2014 | Zhejiang University | No recruitment | Enrollment / accrual |
| NCT02011594 | Phase II Study of Maintenance Treatment of Nimotuzumab for Advanced Esophageal Carcinoma | Phase 2 | withdrawn | Dec 13, 2013 | Zhejiang University | There was no participants enrolled in this clinical trial. | Enrollment / accrual |
| NCT02205463 | KD019 and Trastuzumab in Patients With Esophagus, Gastroesophageal Junction and Stomach… | Phase 1 | withdrawn | Jul 31, 2014 | NYU Langone Health | IND application withdrawn | Other (stated, no rule matched) |
| NCT01627080 | Cardiac Biomarker Study in Esophageal Cancer Patients Treated With Chemotherapy and… | — | withdrawn | Jun 25, 2012 | M.D. Anderson Cancer Center | not stated | Not stated |
| NCT00183807 | A Study of Irinotecan, Cisplatin and Celebrex in Patients With Metastatic or Unresectable… | Phase 2 | terminated | Sep 16, 2005 | University of Southern California | Insufficient Accrual | Enrollment / accrual |
| NCT00290719 | Gefitinib, Cisplatin, Irinotecan, and Radiation Therapy Before Surgery in Treating… | Phase 1 | terminated | Feb 13, 2006 | University of California, San Francisco | low enrollment | Enrollment / accrual |
| NCT00101907 | Safety of AMG 706 Plus Panitumumab Plus Gemcitabine-Cisplatin in the Treatment of… | Phase 1 | terminated | Jan 19, 2005 | Amgen | Study terminated per recommendation of Data Review Team | Other (stated, no rule matched) |
| NCT00619242 | The Effects of Sorafenib on Molecular Barrett's Esophagus Cancer(Barrett's) | N/A | terminated | Feb 20, 2008 | University of Chicago | Low accrual | Enrollment / accrual |
| NCT01256203 | Efficacy and Safety of a Sunscreen Against Porfimer Sodium-induced Phototoxicity to… | Phase 2 | withdrawn | Dec 8, 2010 | Pinnacle Biologics Inc. | Sponsor cancelled the study | Other (stated, no rule matched) |
| NCT00636298 | Study of Cetuximab and Bevacizumab in Cancer of the Esophagus After Failure of Patient's… | Phase 2 | withdrawn | Mar 14, 2008 | Emory University | lack of funding | Funding |
| NCT00258297 | Gefitinib in Treating Patients With Stage I, Stage II, or Stage III Esophageal Cancer… | Phase 2 | terminated | Nov 24, 2005 | University of Rochester | Withdrawn for lack of funding and accrual | Enrollment / accrual |
| NCT01705340 | Akt Inhibitor MK2206, Lapatinib Ditosylate, and Trastuzumab in Treating Patients With… | Phase 1 | terminated | Oct 12, 2012 | National Cancer Institute (NCI) | not stated | Not stated |
| NCT01010334 | Comparison of Standard of Care or Treatment on Protocol | N/A | terminated | Nov 10, 2009 | New Mexico Cancer Research Alliance | PI deparature and very low (\<2%) accrual rate.(No results required) | Enrollment / accrual |
| NCT00896467 | Psychological and Emotional Impact in Patients Undergoing Treatment For Metastatic Cancer… | — | terminated | May 11, 2009 | Centre Oscar Lambret | not stated | Not stated |
| NCT00098527 | FR901228 in Treating Patients With Refractory Stomach Cancer or Gastroesophageal Junction… | Phase 2 | terminated | Dec 8, 2004 | National Cancer Institute (NCI) | not stated | Not stated |
| NCT00012246 | Vaccine Therapy in Treating Patients With Cancer of the Gastrointestinal Tract | Phase 2 | terminated | Jan 27, 2003 | The University of Texas Medical Branch, Galveston | Administratively Terminated | Other (stated, no rule matched) |
| NCT00061958 | Arsenic Trioxide in Treating Patients With Advanced Cancer of the Esophagus or… | Phase 2 | terminated | Jun 6, 2003 | National Cancer Institute (NCI) | Administratively complete. | Other (stated, no rule matched) |
| NCT00387348 | Escitalopram in Treating Depression in Patients With Advanced Lung or Gastrointestinal… | Phase 3 | terminated | Oct 13, 2006 | Massachusetts General Hospital | DSMB stopped study because placebo arm had more adverse events | Safety / toxicity |
| NCT00025532 | Radiolabeled Monoclonal Antibody Therapy in Treating Patients With Gastrointestinal Cancer | Phase 1 | withdrawn | Nov 21, 2003 | University of California, San Francisco | not stated | Not stated |
| NCT00368329 | Phase I Dose Escalation of Stereotactic Radiosurgical Boost for Locally Advanced… | Phase 1 | terminated | Aug 24, 2006 | Stanford University | low accrual | Enrollment / accrual |
| NCT00004897 | Combination Chemotherapy and Interferon Alfa Followed by Surgery and/or Radiation Therapy… | Phase 2 | terminated | Jul 26, 2004 | Northwestern University | Institutional Review Board requested termination - all patients deceased and no new accrual. | Enrollment / accrual |
| NCT01203163 | Case Analysis on Real Life Incidence of Photodynamic Therapy (PDT) Safety Outcomes(CALIPSO) | — | withdrawn | Sep 16, 2010 | Pinnacle Biologics Inc. | Sponsor cancelled the study | Other (stated, no rule matched) |
| NCT00585741 | Pilot Study of 18F-FLT PET | N/A | terminated | Jan 3, 2008 | University of Wisconsin, Madison | not stated | Not stated |
| NCT00732745 | Vandetanib, Oxaliplatin, and Docetaxel in Advanced Cancer of the Esophagus or… | Phase 1 | terminated | Aug 12, 2008 | Case Comprehensive Cancer Center | Lost funding for Phase II portion of study | Funding |
| NCT00239200 | Lapatinib (GW572016) for Metastatic or Recurrent Squamous Cell Carcinoma Esophagus | Phase 2 | terminated | Oct 14, 2005 | University of Michigan Rogel Cancer Center | notification from sponsor | Other (stated, no rule matched) |
Stop reasons are registrant-reported free text and are displayed verbatim (truncated; hover for the full text). Categories come from explicit keyword rules and are never inferred from the study design, sponsor or outcome; a study that stopped for several reasons is filed under the first rule that matched. A TERMINATED status does not imply a negative result.
Data updated 22 days agoSource updated Apr 7, 2017source: clinicaltrials