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Clinical trials · failure tracking
Oncology studies whose overall status is TERMINATED, WITHDRAWN or SUSPENDED on ClinicalTrials.gov, with the stop reason exactly as the registrant posted it. A category is attached only when an explicit keyword rule matches the text; CancerIndex never infers why a study stopped.
2,225 stopped studies mapped to Malignant Digestive System Neoplasm and descendants · 91% state a reason
Over the 2,225 studies matching the cancer, status and year filters (the category filter does not change this chart). Each study is counted once, in the first matching category; greyed bars are studies whose text matched no rule or was empty.
Computedrules ci-stop-reasons-v1 · keyword matching only
A category is assigned when one of its keywords appears in the posted text (case-insensitive, whole words). Rules are tested in this order and the first match wins; every match is kept in the API (reasonMatches).
| NCT | Title | Phase | Status | First posted | Lead sponsor | Why stopped (as posted) | Category |
|---|---|---|---|---|---|---|---|
| NCT00494611 | A Study of the Perioperative Use of Cetuximab in Colon Cancer Patients | Phase 1 | terminated | Jul 2, 2007 | St. Luke's-Roosevelt Hospital Center | Unable to recruit subjects in timely fashion for the study | Enrollment / accrual |
| NCT00470340 | Chemotherapy or Not, Following Complete Treatment of Hepatic Cancer in Cirrhotic Patients(GEMOXIAL) | Phase 3 | terminated | May 7, 2007 | Assistance Publique - Hôpitaux de Paris | during the study | Other (stated, no rule matched) |
| NCT01330823 | L-CARnitine in the Palliative Treatment of Advanced PANcreatic Cancer (CARPAN)(CARPAN) | Phase 3 | suspended | Apr 7, 2011 | University Medicine Greifswald | after interims analysis standard errors for inflammatory and nutritional markers varied widely,… | Other (stated, no rule matched) |
| NCT01012804 | Study of Biomarkers in Tissue Samples From Patients With Metastatic Colon Cancer | — | withdrawn | Nov 13, 2009 | Georgetown University | not stated | Not stated |
| NCT00003365 | Sulindac and Plant Compounds in Preventing Colon Cancer | N/A | terminated | May 21, 2004 | University of Medicine and Dentistry of New Jersey | Study completed | Other (stated, no rule matched) |
| NCT00233623 | Irinotecan, 5-Fluorouracil and Leucovorin With or Without Iressa in the Treatment of… | Phase 2 | withdrawn | Oct 6, 2005 | AstraZeneca | not stated | Not stated |
| NCT01271166 | Glivec® Plus m-FOLFOX Avastin® in Advanced Colorectal Cancer | Phase 1 | terminated | Jan 6, 2011 | Novartis Pharmaceuticals | not stated | Not stated |
| NCT01116154 | Vorinostat and Lenalidomide in Treating Patients With Relapsed or Refractory Hodgkin… | Phase 1 | terminated | May 4, 2010 | City of Hope Medical Center | Sponsor withdrew support for the study | Other (stated, no rule matched) |
| NCT00103103 | Bortezomib, Fluorouracil, and Leucovorin in Treating Patients With Metastatic or… | Phase 2 | terminated | Feb 8, 2005 | California Cancer Consortium | not stated | Not stated |
| NCT00428597 | A Study Of Sunitinib Compared To Placebo For Patients With Advanced Pancreatic Islet Cell… | Phase 3 | terminated | Jan 30, 2007 | Pfizer | Refer to Detailed Description. | Other (stated, no rule matched) |
| NCT00102024 | Safety and Activity of 90Y-Labeled IDEC-159 in Subjects With Metastatic Colorectal… | Phase 1 / Phase 2 | terminated | Jan 20, 2005 | Biogen | not stated | Not stated |
| NCT00014651 | Vapreotide in Treating Patients Undergoing Elective Pancreatic Resection | Phase 3 | terminated | May 5, 2004 | Mayo Clinic | Teminated by the DSMB because there are no differences between the control group and the Vapreotide… | Other (stated, no rule matched) |
| NCT00791544 | Dose Finding Study of AVE1642 in Patients With Advanced or Metastatic Liver Carcinoma | Phase 1 / Phase 2 | terminated | Nov 14, 2008 | Sanofi | Company decision to discontinue the AVE1642 development program, not due to any safety or efficacy… | Safety / toxicity |
| NCT00460837 | Comparison of Bowel Preparation in Virtual Colonoscopy (VC) - Patient Experience | Phase 4 | withdrawn | Apr 17, 2007 | London North West Healthcare NHS Trust | Supply of adequate label was not provided to the MHRA | Drug supply |
| NCT00177853 | Celecoxib, Irinotecan and Concurrent Radiotherapy in Preoperative Pancreatic Cancer | Phase 1 | terminated | Sep 15, 2005 | University of Pittsburgh | terminated | Other (stated, no rule matched) |
| NCT00005997 | Rebeccamycin Analogue in Treating Patients With Advanced Liver and/or Biliary Cancer | Phase 2 | terminated | Jan 27, 2003 | Case Comprehensive Cancer Center | slow accrual for Cohort II | Enrollment / accrual |
| NCT00209729 | Phase I/II Study of Oral S-1 Plus Docetaxel in Elderly Patients With Advanced Gastric… | Phase 1 / Phase 2 | suspended | Sep 21, 2005 | Hokkaido Gastrointestinal Cancer Study Group | Registration is less | Other (stated, no rule matched) |
| NCT00568529 | Combination of Capecitabine and Oxaliplatin in Patients With Relapsed or Refractory… | Phase 2 | suspended | Dec 6, 2007 | Fudan University | There are not enough patients enrolled. | Enrollment / accrual |
| NCT00280007 | Transarterial Chemoembolisation Plus Bevacizumab for Treatment of Hepatocellular Carcinoma | Phase 2 | terminated | Jan 20, 2006 | Medical University of Vienna | Safety concerns in the treatment arm | Safety / toxicity |
| NCT00394615 | Metabolic Imaging Predict Histopathologic Response to Preop ChemoXRT for Locally Advanced… | N/A | terminated | Nov 1, 2006 | Stanford University | Protocol approval expired | Other (stated, no rule matched) |
| NCT00359476 | A Study of Vinflunine in Patients With Gastric Cancer | Phase 2 / Phase 3 | terminated | Aug 2, 2006 | Bristol-Myers Squibb | not stated | Not stated |
| NCT00909558 | Safety and Effectiveness Study of Autologous Natural Killer and Natural Killer T Cells on… | Phase 1 | suspended | May 28, 2009 | Envita Medical Center, Inc. | not stated | Not stated |
| NCT00277303 | Study of XL999 in Patients With Metastatic Colorectal Cancer | Phase 2 | terminated | Jan 16, 2006 | Symphony Evolution, Inc. | Study was terminated due to cardiac toxicities in the subjects | Safety / toxicity |
| NCT00540735 | Efficiency Evaluation of Photodynamic Therapy With Photofrin® on Unresectable Type III or…(CK/PDT) | Phase 3 | terminated | Oct 8, 2007 | University Hospital, Angers | Big difficulties to enroll patients | Enrollment / accrual |
| NCT00568971 | Study of Weekly DCF to Treat Advanced Gastric Cancer | Phase 2 | terminated | Dec 6, 2007 | Fudan University | The study has finished. | Other (stated, no rule matched) |
| NCT00251186 | First-Line Capecitabine and Cetuximab for Metastatic Colorectal Ca in Elderly Patients | Phase 2 | terminated | Nov 9, 2005 | University of Medicine and Dentistry of New Jersey | Funding unavailable | Funding |
| NCT00185874 | Phase I Intratumoral Dendritic Cell Immunotherapy in Thermally Ablated Liver Metastases | Phase 1 | terminated | Sep 16, 2005 | Stanford University | Study closed due to lack of funding | Funding |
| NCT00677287 | Histocompatibility Leukocyte Antigen (HLA)-A*2402 Restricted Peptide Vaccine Therapy in… | Phase 1 / Phase 2 | terminated | May 14, 2008 | Tokyo University | Lack of financial support | Funding |
| NCT00677612 | Histocompatibility Leukocyte Antigen (HLA)-A*0201 Restricted Peptide Vaccine Therapy in… | Phase 1 / Phase 2 | terminated | May 14, 2008 | Tokyo University | Lack of financial support | Funding |
| NCT00539318 | Infrastructure for Developing Gastrointestinal Cancer Prognostic and Predictive Markers | — | terminated | Oct 4, 2007 | Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | Low Recruitment | Enrollment / accrual |
| NCT00307723 | Study of Bevacizumab in Combination With 5-FU, Oxaliplatin and External Beam Radiation… | Phase 1 / Phase 2 | terminated | Mar 28, 2006 | Massachusetts General Hospital | poor accrual | Enrollment / accrual |
| NCT00622804 | Comparison Study for Bile Reflux and Gastric Stasis in Patients After Distal Gastrectomy | Phase 3 | withdrawn | Feb 25, 2008 | The Catholic University of Korea | It was very difficult to enroll patients in this study. | Enrollment / accrual |
| NCT00595985 | Sorafenib as a Second Line Treatment in Patients With Advanced or Metastatic Gastric… | Phase 2 | terminated | Jan 16, 2008 | Fudan University | low response rate, no evidence of PFS or OS improved. | Other (stated, no rule matched) |
| NCT00605800 | Bone Marrow Derived Adult Liver Stem Cell Recruitment After Major Liver Resections:… | — | withdrawn | Jan 31, 2008 | Memorial Sloan Kettering Cancer Center | Study was closed due to logistical issues. | Other (stated, no rule matched) |
| NCT00585845 | Study of Safety and Tolerability of Intravenous CRS-207 in Adults With Selected Advanced… | Phase 1 | terminated | Jan 3, 2008 | Anza Therapeutics, Inc. | not stated | Not stated |
| NCT00209612 | Phase I/II Study of Paclitaxel Plus CPT-11 in Pts. With 2nd Line Chemotherapy of… | Phase 1 / Phase 2 | withdrawn | Sep 21, 2005 | Hokkaido Gastrointestinal Cancer Study Group | due to strong side effect | Other (stated, no rule matched) |
| NCT00129870 | CONCEPT: Comparison of Oxaliplatin vs Conventional Methods With Calcium/Magnesium in… | Phase 4 | terminated | Aug 12, 2005 | Sanofi | Unplanned interim analysis by DSMB indicated possible reduced response rate with the addition of… | Efficacy / futility |
| NCT00327093 | Elaboration of a Model for Predicting Efficacy of Monoclonal Antibodies (Cetuximab and… | Phase 4 | terminated | May 18, 2006 | Hospices Civils de Lyon | The scientific commitee decided to stop the inclusions and exploit the results. | Other (stated, no rule matched) |
| NCT00503321 | Phase II Study of TS-1 Therapy and TS-1+PSK Therapy Against Advanced Gastric Carcinoma(eNCIT-Japan) | Phase 2 / Phase 3 | terminated | Jul 18, 2007 | Eastern Network of Cancer Immunological Therapy, Japan | Patients' enrollment was not sufficient. | Enrollment / accrual |
| NCT00090025 | XL119 Versus 5-Fluorouracil (5-FU) Plus Leucovorin (LV) in Subjects With Advanced Biliary… | Phase 3 | terminated | Aug 23, 2004 | Helsinn Healthcare SA | Futility reasons after Independent Data Monitoring Committee interim analysis | Efficacy / futility |
| NCT00637364 | High Intensity Focused Ultrasound Tumor Treatment for Pancreatic Cancer Pain(HIFU Pancreas) | Phase 1 / Phase 2 | suspended | Mar 18, 2008 | CMED HIFU Development Corporation | Sponsor is not proceeding with USA human trial at this time | Other (stated, no rule matched) |
| NCT00319683 | A Study of ADH300004 and 5-Fluorouracil in Locally Advanced, Recurrent, or Metastatic… | Phase 1 / Phase 2 | terminated | Apr 27, 2006 | Adherex Technologies, Inc. | Lack of funds | Funding |
| NCT00165633 | A Phase II/III Clinical Study on Inhibitory Effects of E0167 on Recurrence of… | Phase 2 / Phase 3 | terminated | Sep 14, 2005 | Eisai Limited | not stated | Not stated |
| NCT00493857 | Study of Nimotuzumab and Irinotecan in Metastatic Colorectal Cancer | Phase 2 | terminated | Jun 28, 2007 | YM BioSciences | Cohort 2 not going forward. Manadate changes in Company | Sponsor / business decision |
| NCT00415155 | A Study of LY2181308 in Patients With Advanced Hepatocellular Carcinoma | Phase 1 / Phase 2 | withdrawn | Dec 22, 2006 | Eli Lilly and Company | Trial cancelled | Other (stated, no rule matched) |
| NCT00351195 | Etoposide, Oxaliplatin and Capecitabine in Advanced Hepatocellular Carcinoma (HCC) | Phase 2 | terminated | Jul 12, 2006 | Rigshospitalet, Denmark | Did not meet the criteria for continuation to second stage | Other (stated, no rule matched) |
| NCT00155883 | Bi-Weekly Docetaxel Plus 24-Hour Infusion of High-Dose 5-Fluorouracil / Leucovorin (HDFL)… | Phase 2 | terminated | Sep 12, 2005 | National Taiwan University Hospital | slow a accrul due to many competitive trials. | Enrollment / accrual |
| NCT00239200 | Lapatinib (GW572016) for Metastatic or Recurrent Squamous Cell Carcinoma Esophagus | Phase 2 | terminated | Oct 14, 2005 | University of Michigan Rogel Cancer Center | notification from sponsor | Other (stated, no rule matched) |
| NCT00419978 | The Significance of Sentinel Node Analysis in Colon Cancer | N/A | terminated | Jan 9, 2007 | Legacy Health System | Slow accrural to study. | Enrollment / accrual |
| NCT00399009 | Comparative Study of Circular Stapling Instruments | N/A | terminated | Nov 14, 2006 | Uppsala University Hospital | One of the instruments in the study was withdrawn from the market before the calculated number of… | Other (stated, no rule matched) |
Stop reasons are registrant-reported free text and are displayed verbatim (truncated; hover for the full text). Categories come from explicit keyword rules and are never inferred from the study design, sponsor or outcome; a study that stopped for several reasons is filed under the first rule that matched. A TERMINATED status does not imply a negative result.
Data updated 23 days agoSource updated May 19, 2011source: clinicaltrials