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Clinical trials · failure tracking
Oncology studies whose overall status is TERMINATED, WITHDRAWN or SUSPENDED on ClinicalTrials.gov, with the stop reason exactly as the registrant posted it. A category is attached only when an explicit keyword rule matches the text; CancerIndex never infers why a study stopped.
2,226 stopped studies mapped to Malignant Digestive System Neoplasm and descendants · 91% state a reason
Over the 2,226 studies matching the cancer, status and year filters (the category filter does not change this chart). Each study is counted once, in the first matching category; greyed bars are studies whose text matched no rule or was empty.
Computedrules ci-stop-reasons-v1 · keyword matching only
A category is assigned when one of its keywords appears in the posted text (case-insensitive, whole words). Rules are tested in this order and the first match wins; every match is kept in the API (reasonMatches).
| NCT | Title | Phase | Status | First posted | Lead sponsor | Why stopped (as posted) | Category |
|---|---|---|---|---|---|---|---|
| NCT01171755 | Phase II Study of Gemcitabine and TS-1 in Biliary Trat Cancer(GetBil) | Phase 2 | terminated | Jul 28, 2010 | Samsung Medical Center | The objective response rate by more than two people are confirmed. | Other (stated, no rule matched) |
| NCT01167816 | Phase I Trial of 5-Azacitidine Plus Gemcitabine in Patients With Advanced Pancreatic… | Phase 1 | terminated | Jul 22, 2010 | University of Oklahoma | The study was terminated as the Prinicipal Investigator left the site- all previous subjects… | Investigator |
| NCT01963949 | Prospective, Observational Study of Biomarkers in Liver Cancer - Identification of… | — | withdrawn | Oct 17, 2013 | University of Texas Southwestern Medical Center | not stated | Not stated |
| NCT00493428 | Treatment of Non-Metastatic Hepatocellular Carcinoma in Humans by Increasing Gabaergic… | Phase 2 | withdrawn | Jun 28, 2007 | University of Manitoba | The study have been stoped because the protocol is going to be modify. | Other (stated, no rule matched) |
| NCT00023946 | BMS-247550 in Treating Patients With Liver or Gallbladder Cancer | Phase 2 | terminated | Jan 27, 2003 | National Cancer Institute (NCI) | not stated | Not stated |
| NCT00290719 | Gefitinib, Cisplatin, Irinotecan, and Radiation Therapy Before Surgery in Treating… | Phase 1 | terminated | Feb 13, 2006 | University of California, San Francisco | low enrollment | Enrollment / accrual |
| NCT01025570 | A Study Evaluating Gemcitabine Plus Bosutinib for Patients With Resected Pancreatic Cancer | Phase 1 | terminated | Dec 3, 2009 | University of California, San Francisco | Terminated due to slow accrual | Enrollment / accrual |
| NCT00878657 | Intensity-Modulated Radiation Therapy and Gemcitabine in Treating Patients With Locally… | Phase 1 | terminated | Apr 9, 2009 | Rutgers, The State University of New Jersey | Slow accrual | Enrollment / accrual |
| NCT00933985 | Obatoclax Mesylate, Vincristine Sulfate, Doxorubicin Hydrochloride, and Dexrazoxane… | Phase 1 | terminated | Jul 8, 2009 | National Cancer Institute (NCI) | not stated | Not stated |
| NCT01587872 | Double-balloon Colonoscopy to Increase Colonoscopy Completion Rate | N/A | terminated | Apr 30, 2012 | Sorlandet Hospital HF | Slow patient recruitment, not enough patients willing to participate within the prespecified time… | Enrollment / accrual |
| NCT01233505 | Veliparib, Oxaliplatin, and Capecitabine in Treating Patients With Advanced Solid Tumors | Phase 1 | terminated | Nov 3, 2010 | National Cancer Institute (NCI) | not stated | Not stated |
| NCT00088933 | Vaccine Therapy and Sargramostim With or Without Docetaxel in Treating Patients With… | Phase 1 | terminated | Aug 5, 2004 | National Cancer Institute (NCI) | not stated | Not stated |
| NCT00101907 | Safety of AMG 706 Plus Panitumumab Plus Gemcitabine-Cisplatin in the Treatment of… | Phase 1 | terminated | Jan 19, 2005 | Amgen | Study terminated per recommendation of Data Review Team | Other (stated, no rule matched) |
| NCT01320267 | Single Port Laparoscopic Colectomy(SILS) | Phase 1 / Phase 2 | withdrawn | Mar 22, 2011 | University of British Columbia | Industry Funding Withdrawn | Funding |
| NCT01215565 | Study of Sunitinib in Patients With Advanced/Inoperable Fibrolamellar Carcinoma(Fibrolam) | Phase 2 | terminated | Oct 6, 2010 | Assistance Publique - Hôpitaux de Paris | lack of inclusion | Other (stated, no rule matched) |
| NCT00619242 | The Effects of Sorafenib on Molecular Barrett's Esophagus Cancer(Barrett's) | N/A | terminated | Feb 20, 2008 | University of Chicago | Low accrual | Enrollment / accrual |
| NCT00003786 | Irofulven in Treating Patients With Metastatic or Recurrent Colorectal Cancer | Phase 2 | withdrawn | Aug 4, 2004 | University of Chicago | NO participants | Other (stated, no rule matched) |
| NCT01079767 | Temsirolimus in Treating Patients With Advanced Liver Cancer and Cirrhosis | Phase 2 | terminated | Mar 3, 2010 | Federation Francophone de Cancerologie Digestive | The study treminated early according to DSMB recommendantions | Other (stated, no rule matched) |
| NCT01256203 | Efficacy and Safety of a Sunscreen Against Porfimer Sodium-induced Phototoxicity to… | Phase 2 | withdrawn | Dec 8, 2010 | Pinnacle Biologics Inc. | Sponsor cancelled the study | Other (stated, no rule matched) |
| NCT00763776 | Parenchyma Resection of Cirrhotic Liver by the Clamp Crushing Technique and the…(SECCI) | N/A | terminated | Oct 1, 2008 | Assistance Publique - Hôpitaux de Paris | difficulty for the patient recruiting | Enrollment / accrual |
| NCT00101205 | Oxaliplatin, Ifosfamide and Etoposide in Treating Young Patients With Recurrent or… | Phase 1 | terminated | Jan 10, 2005 | National Cancer Institute (NCI) | not stated | Not stated |
| NCT00003434 | Biological Therapy in Stage I, Stage II, or Stage III Surgically Resected Pancreatic… | Phase 1 | terminated | Apr 27, 2004 | Duke University | not stated | Not stated |
| NCT00394992 | Adjuvant Xeloda Plus Eloxatin +/- Avastin After Radical Resection of Liver Metastasis of… | Phase 3 | terminated | Nov 2, 2006 | Dutch Colorectal Cancer Group | Data from the C08 study and Avant study | Other (stated, no rule matched) |
| NCT01501240 | Gadoxetic Acid-enhanced MR Evaluation of Hepatocellular Carcinoma and Dysplastic Nodules…(PriMPa) | — | withdrawn | Dec 29, 2011 | Jae Ho Byun | not stated | Not stated |
| NCT00165594 | A Study of E7070 in Patients With Gastric Cancer | Phase 1 / Phase 2 | terminated | Sep 14, 2005 | Eisai Co., Ltd. | Study was completed. | Other (stated, no rule matched) |
| NCT00553813 | A Phase II Trial of TPI 287 in Patients Advanced, Unresectable Pancreatic Cancer | Phase 2 | terminated | Nov 6, 2007 | Cortice Biosciences, Inc. | Insufficient funding | Funding |
| NCT00636883 | Oxaliplatin, Gemcitabine, and Erlotinib Study in Patients With Advanced Chemo-naïve…(GEMOX-T) | Phase 2 | terminated | Mar 17, 2008 | National Guard Health Affairs | slow accrual rate | Enrollment / accrual |
| NCT01403103 | Cholecalciferol(25-[OH]-Vitamin D) in Treating Patients With Colorectal Cancer | Early Phase 1 | withdrawn | Jul 27, 2011 | Case Comprehensive Cancer Center | Slow Accrual | Enrollment / accrual |
| NCT00819754 | A Phase I/II Study of IXO With Bevacizumab in Patients With Metastatic Colorectal Cancer(IXO+A) | Phase 1 / Phase 2 | terminated | Jan 9, 2009 | Ottawa Hospital Research Institute | not stated | Not stated |
| NCT01096732 | Hedgehog Inhibition for Pancreatic Ductal Adenocarcinoma (PDAC) in the Preoperative…(HIPPoS) | Phase 2 | terminated | Mar 31, 2010 | Lisa Bax | Slow recruitment | Enrollment / accrual |
| NCT01070290 | A Study of ARQ 197 Versus Investigator's Choice of Second-Line Chemotherapy in Patients… | Phase 2 | withdrawn | Feb 18, 2010 | ArQule, Inc., a subsidiary of Merck Sharp & Dohme LLC, a subsidiary of Merck & Co., Inc. (Rahway, NJ USA) | not stated | Not stated |
| NCT00613730 | Adenocarcinoma of the Pancreas Treated With Panitumumab and Gemcitabine Regimen to…(APPRISE 1) | Phase 2 | terminated | Feb 13, 2008 | Amgen | APPRISE closure prompted by SWOG S0205 not meeting primary endpoint-improving OS. APPRISE… | Safety / toxicity |
| NCT00005591 | Cetuximab Plus Gemcitabine in Treating Patients With Locally Advanced, Metastatic, or… | Phase 2 | withdrawn | Aug 9, 2004 | University of Alabama at Birmingham | not stated | Not stated |
| NCT00228683 | Hepatoblastoma Biology Study and Tissue Bank | N/A | withdrawn | Sep 29, 2005 | Emory University | national study, local site not responsible for any analysis/results/etc | Other (stated, no rule matched) |
| NCT00636298 | Study of Cetuximab and Bevacizumab in Cancer of the Esophagus After Failure of Patient's… | Phase 2 | withdrawn | Mar 14, 2008 | Emory University | lack of funding | Funding |
| NCT01128803 | Immunotherapy of Hepatocellular Carcinoma by Induction of Anti-alpha Fetoprotein Response | Phase 1 / Phase 2 | terminated | May 24, 2010 | Nantes University Hospital | not stated | Not stated |
| NCT01344902 | An Open Dose-finding Study of Oral Applied Hexaminolevulinate (HAL) Imaging in Patients… | Phase 1 / Phase 2 | terminated | Apr 29, 2011 | Photocure | The study was stopped due to inadequate efficacy after 13 patients were evaluated. | Efficacy / futility |
| NCT00719199 | Study of FOLFIRI Plus Cetuximab Plus IMO-2055 in Patients With Colorectal Cancer | Phase 1 | terminated | Jul 21, 2008 | EMD Serono | Sponsor will discontinue further development of EMD 1201081 | Other (stated, no rule matched) |
| NCT01016860 | OSI-906 and Irinotecan in Patients With Advanced Cancer | Phase 1 | terminated | Nov 20, 2009 | University of Colorado, Denver | This study was discontinued due to a shown lack of efficacy in the investigational agent | Efficacy / futility |
| NCT00258297 | Gefitinib in Treating Patients With Stage I, Stage II, or Stage III Esophageal Cancer… | Phase 2 | terminated | Nov 24, 2005 | University of Rochester | Withdrawn for lack of funding and accrual | Enrollment / accrual |
| NCT01215838 | MRI of the Liver With Eovist | — | terminated | Oct 7, 2010 | University of Washington | Unable to meet enrollment expectations. | Enrollment / accrual |
| NCT01192763 | RO4929097 Before Surgery in Treating Patients With Pancreatic Cancer | Phase 1 | terminated | Sep 1, 2010 | National Cancer Institute (NCI) | not stated | Not stated |
| NCT01705340 | Akt Inhibitor MK2206, Lapatinib Ditosylate, and Trastuzumab in Treating Patients With… | Phase 1 | terminated | Oct 12, 2012 | National Cancer Institute (NCI) | not stated | Not stated |
| NCT00870961 | Vitamin D Supplement in Preventing Colon Cancer in African Americans With Colon Polyps | N/A | terminated | Mar 27, 2009 | Northwestern University | PI changed institutions and accrual was not completed. | Enrollment / accrual |
| NCT00145860 | Do Patients With Colorectal Cancer Understand That Their Family is at Risk? | — | terminated | Sep 5, 2005 | University of Chicago | not stated | Not stated |
| NCT01618253 | Radiation Therapy With Sorafenib for TACE-Resistant Hepatocellular Carcinoma | Phase 1 | withdrawn | Jun 13, 2012 | Medical College of Wisconsin | Closed due to poor accrual. | Enrollment / accrual |
| NCT00862082 | Randomized Phase 1/2 Open-Label Trial of PR104 and Sorafenib in Patients With Advanced… | Phase 1 / Phase 2 | terminated | Mar 16, 2009 | Proacta, Incorporated | PR104 plus sorafenib was poorly tolerated in patients with advanced HCC | Other (stated, no rule matched) |
| NCT01010334 | Comparison of Standard of Care or Treatment on Protocol | N/A | terminated | Nov 10, 2009 | New Mexico Cancer Research Alliance | PI deparature and very low (\<2%) accrual rate.(No results required) | Enrollment / accrual |
| NCT01830322 | Safety and Effectiveness Study of CPI-613 and/or Gemcitabine to Treat Metastatic… | Phase 2 | withdrawn | Apr 12, 2013 | Cornerstone Pharmaceuticals | not stated | Not stated |
| NCT00017537 | Vaccine Therapy in Treating Patients With Metastatic or Recurrent Cancer | Phase 1 | withdrawn | Jan 8, 2004 | University of Alabama at Birmingham | not stated | Not stated |
Stop reasons are registrant-reported free text and are displayed verbatim (truncated; hover for the full text). Categories come from explicit keyword rules and are never inferred from the study design, sponsor or outcome; a study that stopped for several reasons is filed under the first rule that matched. A TERMINATED status does not imply a negative result.
Data updated 23 days agoSource updated May 21, 2014source: clinicaltrials