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Clinical trials · failure tracking
Oncology studies whose overall status is TERMINATED, WITHDRAWN or SUSPENDED on ClinicalTrials.gov, with the stop reason exactly as the registrant posted it. A category is attached only when an explicit keyword rule matches the text; CancerIndex never infers why a study stopped.
2,226 stopped studies mapped to Malignant Digestive System Neoplasm and descendants · 91% state a reason
Over the 2,226 studies matching the cancer, status and year filters (the category filter does not change this chart). Each study is counted once, in the first matching category; greyed bars are studies whose text matched no rule or was empty.
Computedrules ci-stop-reasons-v1 · keyword matching only
A category is assigned when one of its keywords appears in the posted text (case-insensitive, whole words). Rules are tested in this order and the first match wins; every match is kept in the API (reasonMatches).
| NCT | Title | Phase | Status | First posted | Lead sponsor | Why stopped (as posted) | Category |
|---|---|---|---|---|---|---|---|
| NCT00126451 | A Clinical Trial of Oral Suberoylanilide Hydroxamic Acid (SAHA) in Patients With Relapsed… | Phase 2 | terminated | Aug 4, 2005 | Merck Sharp & Dohme LLC | not stated | Not stated |
| NCT01704690 | Combination Treatment of S-1 With Paclitaxel in Advanced Esophageal Cancer | Phase 2 / Phase 3 | terminated | Oct 11, 2012 | Peking University | The enrollment of the study is much slower than expected. | Enrollment / accrual |
| NCT02618447 | 4D Phase Contrast MR: Hypertrophy in Liver Cancer | N/A | terminated | Dec 1, 2015 | Washington University School of Medicine | Insufficient funding | Funding |
| NCT00588900 | Irinotecan and Cediranib in Treating Patients With Metastatic Colorectal Cancer That Did… | Phase 2 | terminated | Jan 9, 2008 | Alliance for Clinical Trials in Oncology | not stated | Not stated |
| NCT01270438 | Combination Chemotherapy and Bevacizumab With or Without RO4929097 in Treating Patients… | Phase 2 | withdrawn | Jan 5, 2011 | National Cancer Institute (NCI) | not stated | Not stated |
| NCT02261844 | Resveratrol and Human Hepatocyte Function in Cancer | Phase 1 / Phase 2 | withdrawn | Oct 10, 2014 | University of Louisville | No funding | Funding |
| NCT01229111 | Cediranib Maleate and Combination Chemotherapy in Treating Patients With Advanced Biliary… | Phase 2 | terminated | Oct 27, 2010 | National Cancer Institute (NCI) | Lack of Drug Supply | Drug supply |
| NCT02391038 | MLN0264 in Previously Treated Asian Participants With Advanced Gastrointestinal Carcinoma… | Phase 1 | terminated | Mar 18, 2015 | Millennium Pharmaceuticals, Inc. | The study was terminated because preliminary PK and overall clinical data demonstrated compelling… | Other (stated, no rule matched) |
| NCT01405573 | Sorafenib in First-line Treatment of Advanced B Child Hepatocellular Carcinoma(BOOST) | Phase 3 | terminated | Jul 29, 2011 | National Cancer Institute, Naples | lack of enrolment | Enrollment / accrual |
| NCT02550119 | Dolasetron Mesylate and Dexamethasone With or Without Aprepitant in Preventing Nausea and… | N/A | terminated | Sep 15, 2015 | University of Southern California | Insufficient accrual | Enrollment / accrual |
| NCT02008539 | Treatment of Advanced Gastrointestinal Cancer in a Phase I/II Trial With Modified…(TREAT-ME 1) | Phase 1 / Phase 2 | terminated | Dec 11, 2013 | Apceth GmbH & Co. KG | Enrollment terminated after 13 patients (14 planned); further patients did not meet eligibility… | Enrollment / accrual |
| NCT00127036 | Trial for Microarray Analysis of Colon Cancer Outcome-A (MACCO-A) | Phase 2 | terminated | Aug 5, 2005 | H. Lee Moffitt Cancer Center and Research Institute | drug now on market | Other (stated, no rule matched) |
| NCT00609765 | Avastin, Fluorouracil, Doxorubicin and Streptozocin in Locally Advanced and Metastatic… | Phase 2 | terminated | Feb 7, 2008 | H. Lee Moffitt Cancer Center and Research Institute | Development of new chemotherapy standard of care for treatment rendered the trial obsolete. | Other (stated, no rule matched) |
| NCT00907166 | A Phase I/II Open-Label Dose-Escalation Clinical Trial of CPI-613 in Combination With… | Phase 1 / Phase 2 | terminated | May 22, 2009 | Cornerstone Pharmaceuticals | Suspended trial was not restarted. | Other (stated, no rule matched) |
| NCT02323906 | Safety and Efficacy Study of CC-122 Combined With Sorafenib for Primary Liver Cancer | Phase 1 | terminated | Dec 24, 2014 | Celgene | Slow enrollment and business decision. No safety concerns were identified for the study drugs. | Safety / toxicity |
| NCT02857608 | A Prospective, Open-Label, Multi-center Comparison of Lymphoseek Identified Lymph Nodes… | Phase 2 | withdrawn | Aug 5, 2016 | Cardinal Health 414, LLC | not stated | Not stated |
| NCT02274012 | Trial of Afatinib in Combination With Weekly Paclitaxel in the Second Line Treatment | Phase 2 | withdrawn | Oct 24, 2014 | Columbia University | Former PI left institution and had plans to continue at another institution. | Investigator |
| NCT02301338 | Improving Health of Patients With Colon Cancer Following Surgery: A Trial of SA-ICAN Via… | — | terminated | Nov 25, 2014 | Memorial Sloan Kettering Cancer Center | Lack of accrual | Enrollment / accrual |
| NCT01457846 | Efficacy and Safety of AZD4547 Versus Paclitaxel in Patients With Advanced Gastric or…(SHINE) | Phase 2 | terminated | Oct 24, 2011 | AstraZeneca | not stated | Not stated |
| NCT01032590 | Internet-Based Weight-Loss Program for Colorectal Cancer Survivors | N/A | withdrawn | Dec 15, 2009 | Rutgers, The State University of New Jersey | Trial was only opened at RCINJ for analysis of data, no patient enrollment took place here. | Enrollment / accrual |
| NCT01895790 | Endoscopic Pancreatic Duct Stenting for Relief of Obstructive Pain in Patients With… | Phase 1 / Phase 2 | withdrawn | Jul 11, 2013 | Johns Hopkins University | We could not find any candidate eligible for recruitment | Enrollment / accrual |
| NCT00510627 | Study Comparing Radio Frequency Ablation Plus Chemotherapy and Chemotherapy Alone in…(Prometheus) | Phase 4 | withdrawn | Aug 2, 2007 | Boston Scientific Corporation | Boston Scientific has decided to close the Study. | Other (stated, no rule matched) |
| NCT01108458 | A Phase 2 Study of Pertuzumab and Erlotinib for Refractory Pancreatic Adenocarcinoma | Phase 2 | terminated | Apr 22, 2010 | George Albert Fisher | Extreme toxicity of Pertuzumab and Erlotinib combination | Safety / toxicity |
| NCT00470535 | Erlotinib in Treating Patients With Stage III or Stage IV Pancreatic Cancer | Phase 2 | terminated | May 7, 2007 | Roswell Park Cancer Institute | This study was terminated earlier due to a phase III study that showed this drug inferior to… | Other (stated, no rule matched) |
| NCT00361244 | SU011248 in Combination With Irinotecan and Cetuximab as a Second Line Regimen for Stage… | Phase 1 / Phase 2 | terminated | Aug 8, 2006 | Massachusetts General Hospital | Slow Accrual | Enrollment / accrual |
| NCT00576056 | Effectiveness and Safety Study of TACE Plus Oral Sorafenib for Unresectable HCC | Phase 2 | terminated | Dec 18, 2007 | University of Pittsburgh | Bayer Healthcare is no supplying the study drug | Other (stated, no rule matched) |
| NCT02242409 | Study of Gemcitabine and Abraxane for Pancreas Cancer | Phase 2 | terminated | Sep 17, 2014 | Georgetown University | Testing of combination no longer relevant | Other (stated, no rule matched) |
| NCT02366858 | Comparison Between the 19 and 22 Gauge Needles for Core Tissue Procurement During… | N/A | withdrawn | Feb 19, 2015 | AdventHealth | PI decision was made to discontinue the study | Other (stated, no rule matched) |
| NCT02423174 | Eval. of Safety and Effectiveness of the FMwand Ferromagnetic Surgical System During… | — | withdrawn | Apr 22, 2015 | Domain Surgical, Inc. | Funding | Funding |
| NCT00276861 | Gemcitabine and Oxaliplatin as Second-Line Therapy in Treating Patients With Metastatic… | Phase 2 | terminated | Jan 13, 2006 | University of Miami | Low Accrual | Enrollment / accrual |
| NCT00448682 | Combination Chemotherapy as First-Line Therapy in Treating Patients With Stage IV Gastric… | Phase 2 | terminated | Mar 19, 2007 | University of Miami | not stated | Not stated |
| NCT00019604 | Radiofrequency Ablation in Treating Patients With Unresectable Primary or Metastatic… | Phase 2 | terminated | Jan 27, 2003 | National Institutes of Health Clinical Center (CC) | Principal investigator left the institution. | Investigator |
| NCT02273752 | Pharmacokinetically Guided Everolimus in Patients With Breast Cancer, Pancreatic… | Phase 2 | terminated | Oct 24, 2014 | Emory University | Slow accrual | Enrollment / accrual |
| NCT01801085 | Nursing and Pharmacy Time for Delivering Xeloda® Versus 5-Fluoruracil Regimens | — | terminated | Feb 28, 2013 | Vivian Wing Yan Lee | Slow recruitment pace | Enrollment / accrual |
| NCT02063412 | Nursing and Pharmacy Care Between Capecitabine and 5-Fluoruracil Regimens | — | withdrawn | Feb 14, 2014 | Vivian Wing Yan Lee | Slow recruitment pace | Enrollment / accrual |
| NCT02965417 | Sym004 in Metastatic Colorectal Cancer and ECD-EGFR Patients | Phase 2 | withdrawn | Nov 16, 2016 | Symphogen A/S | Symphogen made a business decision to no longer perform the clinical study. | Sponsor / business decision |
| NCT02772575 | A Study to See if we Can Predict How Your Liver Tumor or Liver Metastases Will Respond to… | — | withdrawn | May 13, 2016 | Memorial Sloan Kettering Cancer Center | not stated | Not stated |
| NCT01163526 | Perfusion CT as a Predictor of Treatment Response in Patients With Hepatic Malignancies | — | terminated | Jul 15, 2010 | Stanford University | accrual | Enrollment / accrual |
| NCT02446379 | Use of the EnLightTM and LightPathTM Imaging Systems in Gastrointestinal Tumour Surgery(CLIO) | — | withdrawn | May 18, 2015 | Lightpoint Medical Limited | Technology licensed to third party. Sponsor did not proceed with study. | Other (stated, no rule matched) |
| NCT02046538 | Phase II Study of Zaltrap and Chemotherapy for Advanced Resectable Colorectal Cancer | Phase 2 | withdrawn | Jan 27, 2014 | Weill Medical College of Cornell University | Investigator terminated due to funding issues | Investigator |
| NCT01718808 | Cetuximab for Elderly Patients With mCRC | Phase 2 | terminated | Oct 31, 2012 | Swiss Cancer Institute | FU for 3 years from randomization as initially planned is stopped as we do not expect any changes… | Other (stated, no rule matched) |
| NCT02586610 | Trial of Chemoradiation and Pembrolizumab in Patients With Rectal Cancer | Phase 2 | withdrawn | Oct 26, 2015 | Osama Rahma, MD | Dr. Rahma decided to run the study through a different group | Other (stated, no rule matched) |
| NCT01946646 | Phase I Study of TS-1 With Concurrent Radiotherapy to Treat Pancreatic Cancer(SR-GS) | Phase 1 | terminated | Sep 19, 2013 | National Taiwan University Hospital | slow recruitment | Enrollment / accrual |
| NCT00072098 | Interleukin-12 Gene in Treating Patients With Liver Metastases Secondary to Colorectal… | Phase 1 | terminated | Nov 6, 2003 | Max Sung | limited funding | Funding |
| NCT02319200 | Primary Prevention Hepatocellular Carcinoma by Metformin(METFOVIR) | Phase 3 | terminated | Dec 18, 2014 | Assistance Publique - Hôpitaux de Paris | Decision of investigator | Investigator |
| NCT02785068 | Evaluation of MM-151 + Nal-IRI + 5-FU + Leucovorin in RAS/RAF Wild-type Metastatic… | Phase 1 / Phase 2 | withdrawn | May 27, 2016 | Merrimack Pharmaceuticals | not stated | Not stated |
| NCT01433861 | Laparoscopy-assisted Proximal Gastrectomy Versus and Laparoscopy-assisted Total…(PRAPT) | Phase 3 | terminated | Sep 14, 2011 | Seoul National University Bundang Hospital | We planed to study later | Other (stated, no rule matched) |
| NCT00537823 | Pre- and Post-operative FOLFOX Based Therapy for Patients With Colorectal Cancer With… | Phase 2 | terminated | Oct 1, 2007 | Washington University School of Medicine | Poor accrual. | Enrollment / accrual |
| NCT02511756 | Visualization of Anti-angiogenic Effects With Perfusion Computed Tomography (CTP)(AVA-CTP) | N/A | terminated | Jul 30, 2015 | Patrick Veit-Haibach | Slow accrual | Enrollment / accrual |
| NCT00081224 | Neoadjuvant Celecoxib and Capecitabine Combined With Pelvic Irradiation in Treating… | Phase 2 | terminated | Apr 8, 2004 | Alliance for Clinical Trials in Oncology | not stated | Not stated |
Stop reasons are registrant-reported free text and are displayed verbatim (truncated; hover for the full text). Categories come from explicit keyword rules and are never inferred from the study design, sponsor or outcome; a study that stopped for several reasons is filed under the first rule that matched. A TERMINATED status does not imply a negative result.
Data updated 24 days agoSource updated Apr 10, 2017source: clinicaltrials