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Clinical trials · failure tracking
Oncology studies whose overall status is TERMINATED, WITHDRAWN or SUSPENDED on ClinicalTrials.gov, with the stop reason exactly as the registrant posted it. A category is attached only when an explicit keyword rule matches the text; CancerIndex never infers why a study stopped.
820 stopped studies mapped to Malignant Colorectal Neoplasm and descendants · 90% state a reason
Over the 820 studies matching the cancer, status and year filters (the category filter does not change this chart). Each study is counted once, in the first matching category; greyed bars are studies whose text matched no rule or was empty.
Computedrules ci-stop-reasons-v1 · keyword matching only
A category is assigned when one of its keywords appears in the posted text (case-insensitive, whole words). Rules are tested in this order and the first match wins; every match is kept in the API (reasonMatches).
| NCT | Title | Phase | Status | First posted | Lead sponsor | Why stopped (as posted) | Category |
|---|---|---|---|---|---|---|---|
| NCT00681876 | Phase II Study of Avastin + Erbitux + Irinotecan as 2nd Line Treatment of Colorectal… | Phase 2 | terminated | May 21, 2008 | Hellenic Oncology Research Group | Due to poor accrual | Enrollment / accrual |
| NCT00755534 | Irinotecan/Cetuximab Followed by XELOX/Cetuximab vs the Reverse Sequence in Metastatic CRC | Phase 2 | terminated | Sep 19, 2008 | Hellenic Oncology Research Group | Due to poor accrual | Enrollment / accrual |
| NCT00002796 | Phase I-II Study of Fluorouracil in Combination With Phenylbutyrate in Advanced… | Phase 1 / Phase 2 | terminated | Jan 27, 2003 | National Cancer Institute (NCI) | Administratively complete. | Other (stated, no rule matched) |
| NCT00087334 | Capecitabine, Oxaliplatin, and Gefitinib in Treating Patients With Metastatic Colorectal… | Phase 1 / Phase 2 | terminated | Jul 12, 2004 | Roswell Park Cancer Institute | Withdrawn due to poor/low accrual | Enrollment / accrual |
| NCT00070122 | Combination Chemotherapy and Bevacizumab in Treating Patients With Locally Advanced,… | Phase 3 | terminated | Oct 7, 2003 | National Cancer Institute (NCI) | Administratively complete. | Other (stated, no rule matched) |
| NCT00070265 | Neoadjuvant and Adjuvant Capecitabine and Oxaliplatin in Treating Patients With… | Phase 2 | terminated | Oct 7, 2003 | National Cancer Institute (NCI) | Administratively complete. | Other (stated, no rule matched) |
| NCT01619696 | Prospective Pilot Study of Multimodal Radiological Evaluation Feasibility During… | Phase 2 | terminated | Jun 14, 2012 | University Hospital, Toulouse | Insufficient recruitment | Enrollment / accrual |
| NCT00052585 | Gefitinib and Combination Chemotherapy in Treating Patients With Advanced or Recurrent… | Phase 2 | terminated | Jan 27, 2003 | National Cancer Institute (NCI) | Administratively complete. | Other (stated, no rule matched) |
| NCT00087191 | EF5 and Motexafin Lutetium in Detecting Tumor Cells in Patients With Abdominal or… | N/A | terminated | Jul 12, 2004 | National Cancer Institute (NCI) | Administratively complete. | Other (stated, no rule matched) |
| NCT00087256 | Celecoxib in Preventing Polyps in Patients Who Have Undergone Surgery for Stage I Colon… | Phase 3 | terminated | Jul 12, 2004 | NSABP Foundation Inc | For scientific, logistic, and administrative reasons. | Other (stated, no rule matched) |
| NCT00118105 | S0408: Capecitabine, Oxaliplatin, and Bevacizumab in Pts Undergoing Surgery for Liver… | Phase 2 | withdrawn | Jul 11, 2005 | SWOG Cancer Research Network | Budget Constraints | Funding |
| NCT00766220 | Yttrium Microspheres With Cetuximab Plus Irinotecan for Patients With Advanced Colorectal… | Phase 2 | withdrawn | Oct 3, 2008 | M.D. Anderson Cancer Center | Slow Accrual and withdrawn/exclusion of 2 participants. | Enrollment / accrual |
| NCT00288444 | Interaction of Docetaxel and Lonafarnib in Patients With Advanced Cancer | Phase 1 | terminated | Feb 8, 2006 | Emory University | not stated | Not stated |
| NCT00387348 | Escitalopram in Treating Depression in Patients With Advanced Lung or Gastrointestinal… | Phase 3 | terminated | Oct 13, 2006 | Massachusetts General Hospital | DSMB stopped study because placebo arm had more adverse events | Safety / toxicity |
| NCT00043004 | Chemotherapy and Bevacizumab With or Without Radiofrequency Ablation in Treating… | Phase 2 | terminated | Jan 27, 2003 | European Organisation for Research and Treatment of Cancer - EORTC | low accrual | Enrollment / accrual |
| NCT00025532 | Radiolabeled Monoclonal Antibody Therapy in Treating Patients With Gastrointestinal Cancer | Phase 1 | withdrawn | Nov 21, 2003 | University of California, San Francisco | not stated | Not stated |
| NCT00828620 | Positron Emission Tomography - Computed Tomography (PET-CT) Cetuximab Project | — | terminated | Jan 26, 2009 | Universitaire Ziekenhuizen KU Leuven | Lack of recruitment | Enrollment / accrual |
| NCT00062023 | Comparison of Sulindac, Aspirin, and Ursodiol in Preventing Colorectal Cancer | Phase 2 | terminated | Jun 6, 2003 | M.D. Anderson Cancer Center | Study closed by the NCI. | Other (stated, no rule matched) |
| NCT00070434 | S0304 Induct Chemo Then Chemo-RT in Pts w/Locally Advanced Adenocarcinoma of the Rectum | Phase 2 | withdrawn | Oct 7, 2003 | SWOG Cancer Research Network | poor accrual | Enrollment / accrual |
| NCT01056809 | Treatment Strategies for Primarily Generalized Colorectal Cancer(PGC) | N/A | terminated | Jan 26, 2010 | Vrinnevi Hospital | Too slow recruitment | Enrollment / accrual |
| NCT00006269 | Octreotide in the Prevention of Diarrhea in Patients Receiving Irinotecan for Metastatic… | Phase 3 | terminated | May 24, 2004 | Novartis | not stated | Not stated |
| NCT00824161 | Phase II Study of TAS-109 to Treat Advanced Colorectal Cancer | Phase 2 | terminated | Jan 16, 2009 | Taiho Pharmaceutical Co., Ltd. | not stated | Not stated |
| NCT01109615 | Pemetrexed and Gemcitabine for Treatment Resistant Patients With Metastatic Colorectal…(PG) | Phase 2 | terminated | Apr 23, 2010 | Vejle Hospital | Lacking effect of treatment | Other (stated, no rule matched) |
| NCT01196000 | Laparoscopic Surgery or Robotic-Assisted Laparoscopic Surgery in Treating Patients With… | N/A | withdrawn | Sep 8, 2010 | City of Hope Medical Center | The study has never been opened to accrual at COH. Study to be closed at COH due to the lack of… | Enrollment / accrual |
| NCT00503932 | Proton Therapy With Capecitabine for Rectal Cancer | Phase 1 / Phase 2 | withdrawn | Jul 19, 2007 | M.D. Anderson Cancer Center | No participant enrollment. | Enrollment / accrual |
| NCT01126450 | Lenalidomide and Cetuximab in Treating Patients With Metastatic Colorectal Cancer | Phase 1 | terminated | May 19, 2010 | Case Comprehensive Cancer Center | low accrual,loss of funding and results from EU study showing drug ineffective. | Enrollment / accrual |
| NCT00137683 | Colorectal Cancer Control in Appalachian Churches | Phase 2 / Phase 3 | withdrawn | Aug 30, 2005 | Centers for Disease Control and Prevention | not stated | Not stated |
| NCT00110721 | GM-CT-01 Plus 5-Fluorouracil as Third- or Fourth-Line Therapy for Metastatic Colorectal… | Phase 2 | terminated | May 13, 2005 | Galectin Therapeutics Inc. | Study protocol amended to a new treatment regimen: study DAVFU-006. | Other (stated, no rule matched) |
| NCT00532987 | Assessment of Health Related Quality of Life in Patients Treated for Rectal Cancer | — | terminated | Sep 21, 2007 | Stanford University | not stated | Not stated |
| NCT01212887 | Treated Blood Cells, Cyclophosphamide, Fludarabine Phosphate, and Aldesleukin in Treating… | Phase 1 | terminated | Oct 1, 2010 | Cancer Research UK | due to safety concerns and lack of efficacy | Safety / toxicity |
| NCT01096381 | Potential Biomarkers for Bevacizumab-Induced High Blood Pressure in Patients With Solid… | — | terminated | Mar 31, 2010 | Vanderbilt-Ingram Cancer Center | funding withdrawn due to fellow's departure from VICC | Funding |
| NCT00609310 | Dietary Bioflavonoid Supplementation for the Prevention of Neoplasia Recurrence | Phase 2 | suspended | Feb 7, 2008 | Technische Universität Dresden | not stated | Not stated |
| NCT00969033 | CS-1008 Used With Irinotecan Versus Irinotecan Alone in Subjects With Metastatic… | Phase 2 | terminated | Aug 31, 2009 | Daiichi Sankyo | not stated | Not stated |
| NCT00296062 | Dose Dense Therapy and Bevacizumab in Solid Tumors and Colorectal Cancer | Phase 1 | terminated | Feb 24, 2006 | Case Comprehensive Cancer Center | Trial did not move to Phase II portion due to poor tolerance of treatment | Other (stated, no rule matched) |
| NCT00860249 | Outreach for Patients That Are Newly Eligible for Colorectal Cancer Screening(UPQUAL) | N/A | terminated | Mar 12, 2009 | Northwestern University | Lack of sufficient participants meeting the eligibility criteria to complete study in proposed and… | Other (stated, no rule matched) |
| NCT01175291 | FOLFOX/Bevacizumab +/- MK-0646 in Metastatic Colorectal Cancer | Phase 2 | withdrawn | Aug 4, 2010 | H. Lee Moffitt Cancer Center and Research Institute | treatment deemed ineffective so accrual was closed | Enrollment / accrual |
| NCT00779311 | A Phase I Trial Evaluating mFOLFOX6 and Avastin With Nexavar as First-Line Treatment for… | Phase 1 | terminated | Oct 24, 2008 | Accelerated Community Oncology Research Network | Dose limiting toxicity at the lowest planned dose level. | Safety / toxicity |
| NCT00725400 | Comparative Study of Cetuximab and Radiation Vs Surgery Before or After Radiation in… | Phase 2 | withdrawn | Jul 30, 2008 | American Scitech International | Study is withdrawn due to unavailability of eligible subject population. We will request the… | Enrollment / accrual |
| NCT00898781 | Study of Circulating Cancer Cells in Patients With Metastatic Breast, Ovarian, Colon, or… | — | terminated | May 12, 2009 | Mayo Clinic | Due to poor accrual | Enrollment / accrual |
| NCT01126866 | Curative Resectability of Not Optimally Resectable Liver and/or Lung Metastases From…(APRIORI) | Phase 2 | terminated | May 20, 2010 | National Center for Tumor Diseases, Heidelberg | recruiting inadequate | Enrollment / accrual |
| NCT00494611 | A Study of the Perioperative Use of Cetuximab in Colon Cancer Patients | Phase 1 | terminated | Jul 2, 2007 | St. Luke's-Roosevelt Hospital Center | Unable to recruit subjects in timely fashion for the study | Enrollment / accrual |
| NCT01012804 | Study of Biomarkers in Tissue Samples From Patients With Metastatic Colon Cancer | — | withdrawn | Nov 13, 2009 | Georgetown University | not stated | Not stated |
| NCT00003365 | Sulindac and Plant Compounds in Preventing Colon Cancer | N/A | terminated | May 21, 2004 | University of Medicine and Dentistry of New Jersey | Study completed | Other (stated, no rule matched) |
| NCT00233623 | Irinotecan, 5-Fluorouracil and Leucovorin With or Without Iressa in the Treatment of… | Phase 2 | withdrawn | Oct 6, 2005 | AstraZeneca | not stated | Not stated |
| NCT01271166 | Glivec® Plus m-FOLFOX Avastin® in Advanced Colorectal Cancer | Phase 1 | terminated | Jan 6, 2011 | Novartis Pharmaceuticals | not stated | Not stated |
| NCT00102024 | Safety and Activity of 90Y-Labeled IDEC-159 in Subjects With Metastatic Colorectal… | Phase 1 / Phase 2 | terminated | Jan 20, 2005 | Biogen | not stated | Not stated |
| NCT00460837 | Comparison of Bowel Preparation in Virtual Colonoscopy (VC) - Patient Experience | Phase 4 | withdrawn | Apr 17, 2007 | London North West Healthcare NHS Trust | Supply of adequate label was not provided to the MHRA | Drug supply |
| NCT00394615 | Metabolic Imaging Predict Histopathologic Response to Preop ChemoXRT for Locally Advanced… | N/A | terminated | Nov 1, 2006 | Stanford University | Protocol approval expired | Other (stated, no rule matched) |
| NCT00909558 | Safety and Effectiveness Study of Autologous Natural Killer and Natural Killer T Cells on… | Phase 1 | suspended | May 28, 2009 | Envita Medical Center, Inc. | not stated | Not stated |
| NCT00277303 | Study of XL999 in Patients With Metastatic Colorectal Cancer | Phase 2 | terminated | Jan 16, 2006 | Symphony Evolution, Inc. | Study was terminated due to cardiac toxicities in the subjects | Safety / toxicity |
Stop reasons are registrant-reported free text and are displayed verbatim (truncated; hover for the full text). Categories come from explicit keyword rules and are never inferred from the study design, sponsor or outcome; a study that stopped for several reasons is filed under the first rule that matched. A TERMINATED status does not imply a negative result.
Data updated 23 days agoSource updated Feb 13, 2013source: clinicaltrials