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Clinical trials · failure tracking
Oncology studies whose overall status is TERMINATED, WITHDRAWN or SUSPENDED on ClinicalTrials.gov, with the stop reason exactly as the registrant posted it. A category is attached only when an explicit keyword rule matches the text; CancerIndex never infers why a study stopped.
820 stopped studies mapped to Malignant Colorectal Neoplasm and descendants · 90% state a reason
Over the 820 studies matching the cancer, status and year filters (the category filter does not change this chart). Each study is counted once, in the first matching category; greyed bars are studies whose text matched no rule or was empty.
Computedrules ci-stop-reasons-v1 · keyword matching only
A category is assigned when one of its keywords appears in the posted text (case-insensitive, whole words). Rules are tested in this order and the first match wins; every match is kept in the API (reasonMatches).
| NCT | Title | Phase | Status | First posted | Lead sponsor | Why stopped (as posted) | Category |
|---|---|---|---|---|---|---|---|
| NCT01557881 | Positron Emission Tomography/Magnetic Resonance Imaging in Patients | N/A | terminated | Mar 20, 2012 | Case Comprehensive Cancer Center | Funding unavailable | Funding |
| NCT00544700 | Bevacizumab in Treating Patients Who Have Undergone First-Line Therapy for Metastatic… | Phase 3 | terminated | Oct 16, 2007 | Swiss Cancer Institute | Data collection is completed. As no changes in the endpoints were expected in the future, no… | Other (stated, no rule matched) |
| NCT03035279 | A Study of SC-006 and in Combination With ABBV-181 in Subjects With Advanced Colorectal… | Phase 1 | terminated | Jan 30, 2017 | AbbVie | Strategic considerations | Sponsor / business decision |
| NCT02687009 | A Study of Niclosamide in Patients With Resectable Colon Cancer | Phase 1 | terminated | Feb 22, 2016 | Michael Morse, MD | low accrual | Enrollment / accrual |
| NCT01057017 | First-Line FOLFOX-Bevacizumab for Advanced Colorectal Cancer With Wild-Type Ras | Phase 2 | terminated | Jan 27, 2010 | Brown University | possible lack of efficacy | Efficacy / futility |
| NCT01669720 | Adjuvant Aflibercept for Metastatic Colorectal Cancer(C261) | Phase 2 | terminated | Aug 21, 2012 | Brown University | Lack of efficacy and enrollment | Efficacy / futility |
| NCT03413930 | Transanal Versus Laparoscopic Total Mesorectal Excision for Rectal Cancer | N/A | withdrawn | Jan 29, 2018 | Ruijin Hospital | No funding was raised | Funding |
| NCT02523911 | Efficacy and Tolerability of Suprep With and Without Simethicone for Routine Colonoscopy… | N/A | withdrawn | Aug 14, 2015 | MercyOne Des Moines Medical Center | investigator graduated and is not longer at this institution | Investigator |
| NCT00541112 | Radiation Therapy, Chemotherapy, and Cetuximab Followed by Surgery, Chemotherapy, and… | Phase 2 | terminated | Oct 8, 2007 | UNICANCER | Toxicity and lack of efficacy | Safety / toxicity |
| NCT02425683 | Study of Colorectal Cancer Patients (Stage IIIC) With Either Regorafenib or Standard of… | Phase 2 | terminated | Apr 24, 2015 | US Oncology Research | insufficient accrual | Enrollment / accrual |
| NCT02576665 | A Study of Toca 511, a Retroviral Replicating Vector, Combined With Toca FC in Patients… | Phase 1 | terminated | Oct 15, 2015 | Tocagen Inc. | Sponsor decision | Sponsor / business decision |
| NCT03323424 | Phase II Trial Assessing the Efficacy of Immuno-Radiation Abscopal Effect in Patients…(IRAM) | Phase 2 | withdrawn | Oct 27, 2017 | Institut de Cancérologie de la Loire | No patient enrolled during the authorized period | Enrollment / accrual |
| NCT01741038 | AlloStim® In-Situ Vaccine in Pre-Treated Metastatic Colorectal Cancer | Phase 2 / Phase 3 | withdrawn | Dec 4, 2012 | Mirror Biologics, Inc. | moved study to USA | Other (stated, no rule matched) |
| NCT02809846 | Quell Opioid Reduction and Pain Relief in Patients With Cancer | N/A | terminated | Jun 22, 2016 | Scripps Translational Science Institute | Unable to recruit enough participants. | Enrollment / accrual |
| NCT01532804 | 2nd-line Treatment of Metastatic Colorectal Cancer(BEVATOMOX) | Phase 2 | terminated | Feb 15, 2012 | Institut du Cancer de Montpellier - Val d'Aurelle | too slow recruiting | Enrollment / accrual |
| NCT02328664 | SCar-biopsies After Malignant Colorectal Polypectomy of Uncertain RAdicality(SCAPURA) | N/A | terminated | Dec 31, 2014 | Dr. Frank ter Borg MD PhD | Interim analysis showed no added value of second look endoscopy | Efficacy / futility |
| NCT00923052 | The Natural History of Solid Organ Cancer Stem Cells (SOCSC) | — | terminated | Jun 18, 2009 | National Cancer Institute (NCI) | not stated | Not stated |
| NCT00580073 | Phase II Trial of Neoadjuvant FOLFOX4 and Cetuximab for Localized Adenocarcinoma of Rectum | Phase 2 | terminated | Dec 24, 2007 | University of Wisconsin, Madison | Loss of funding | Funding |
| NCT01902823 | Effect of Cancer Nurse Navigators on Patient Outcomes | Phase 2 / Phase 3 | terminated | Jul 18, 2013 | University of Wisconsin, Madison | Clinicians were not offering the study to eligible potential subjects. | Other (stated, no rule matched) |
| NCT01881932 | Acupuncture to Prevent Chemotherapy Dose Reduction Due to Chemotherapy-induced Peripheral… | N/A | terminated | Jun 20, 2013 | University of Maryland, Baltimore | The PI has moved to another institution, which resulted in significant changes in the study design… | Other (stated, no rule matched) |
| NCT02290574 | Efficacy of NeoThermo-Radio-chemotherapy for LA Rectal Cancer Before Laparoscopic TME:…(NEOTREAT) | N/A | terminated | Nov 14, 2014 | Samsung Medical Center | slow accrual | Enrollment / accrual |
| NCT02318901 | Pembrolizumab and Monoclonal Antibody Therapy in Advanced Cancer(PembroMab) | Phase 1 / Phase 2 | terminated | Dec 17, 2014 | Western Regional Medical Center | PI no longer at sight. Results not collected | Other (stated, no rule matched) |
| NCT00078897 | Selenium for Prevention of Adenomatous Colorectal Polyps | Phase 3 | terminated | Mar 9, 2004 | University of Arizona | Concluded - Terminated by PI | Other (stated, no rule matched) |
| NCT03272659 | The Correlation of Surgical Colorectal Cancer Specimen Pathology With the Fluorescence of…(PDD) | Phase 2 | withdrawn | Sep 5, 2017 | Dr. Te Vuong | Long process and due to strict deadline, project was stopped. | Other (stated, no rule matched) |
| NCT03408561 | Social Media Listening in Improving Clinical Trial Recruitment in Patients With Cancer | N/A | withdrawn | Jan 24, 2018 | University of Southern California | No accrual | Enrollment / accrual |
| NCT03682133 | PreColo Practice Variation | — | terminated | Sep 24, 2018 | Radboud University Medical Center | Retrospective part completed, prospective part response too low | Other (stated, no rule matched) |
| NCT00397878 | AZD0530 (NSC 735464) in Treating Patients With Previously Treated Metastatic Colon Cancer… | Phase 2 | terminated | Nov 10, 2006 | National Cancer Institute (NCI) | The study was terminated after all enrolled participants progressed. | Enrollment / accrual |
| NCT02233595 | Evaluation of Rectal Cancer Treatment Response Using PET/MRI(Rectal PET/MRI) | — | terminated | Sep 8, 2014 | University of California, San Francisco | Low Accrual | Enrollment / accrual |
| NCT03204201 | Validation of ICG to Identify the Urethra During Rectal Surgery | Phase 1 / Phase 2 | terminated | Jun 29, 2017 | Oxford University Hospitals NHS Trust | Technique failed | Other (stated, no rule matched) |
| NCT03204994 | Fluorescence Targeted Pelvic Lymph Node Mapping | Phase 1 / Phase 2 | terminated | Jul 2, 2017 | Oxford University Hospitals NHS Trust | Not able to recruit | Enrollment / accrual |
| NCT03161574 | FOLFOXIRI Chemotherapy Alone as Neoadjuvant Treatment for Circumferential Radial Margin… | Phase 2 | withdrawn | May 22, 2017 | Guangxi Medical University | No participants were recruited | Enrollment / accrual |
| NCT00126867 | Thymidylate Synthase Polymorphisms as a Predictor of Toxicity to Capecitabine… | — | terminated | Aug 5, 2005 | AHS Cancer Control Alberta | Insufficient accrual and no funding | Enrollment / accrual |
| NCT02422680 | Patient Satisfaction With Colonoscopy in a Danish Setting - What Are the Most Important… | — | withdrawn | Apr 21, 2015 | Aalborg University Hospital | Cancelled according to PhD-protocol with insufficient time to complete the study | Other (stated, no rule matched) |
| NCT02585271 | Transanal Decompression Tube Versus Stent for Acute Malignant Left-sided Colonic and… | N/A | terminated | Oct 23, 2015 | Xuzhou Central Hospital | We can not get enough sample size. | Other (stated, no rule matched) |
| NCT02005614 | A Pilot/Phase II Study of Gamma Knife Radiosurgery for Brain Metastases Using 3Tesla MRI… | N/A | terminated | Dec 9, 2013 | Yale University | Unable to recruit patients. | Enrollment / accrual |
| NCT03431311 | T Cell Receptor Based Therapy of Metastatic Colorectal Cancer(TCR-CRC-001) | Phase 1 / Phase 2 | terminated | Feb 13, 2018 | Oslo University Hospital | Sponsor decision | Sponsor / business decision |
| NCT00777192 | Longitudinal Study of Symptoms in Colorectal Cancer | — | terminated | Oct 22, 2008 | M.D. Anderson Cancer Center | Terminated at continuing review | Other (stated, no rule matched) |
| NCT03532204 | Oligometastases of the LIVer Treated With Chemotherapy With ou Without Extracranial…(OLIVER) | N/A | withdrawn | May 22, 2018 | UNICANCER | no participants enrolled | Enrollment / accrual |
| NCT03634202 | Study of Radiation Therapy in Combination With Xeloda, for Initially Metastatic, Low and…(DESIR) | N/A | terminated | Aug 16, 2018 | Institut Cancerologie de l'Ouest | the study was stopped for lack of inclusion | Other (stated, no rule matched) |
| NCT03645876 | SHR-1210 in Combination With BP102 and XELOX in Patient With Metastatic Colorectal Cancer | Phase 2 | terminated | Aug 24, 2018 | Jiangsu HengRui Medicine Co., Ltd. | The study was terminated early due to company decision | Sponsor / business decision |
| NCT03070574 | Mesalamine for Colorectal Cancer Prevention Program in Lynch Syndrome(MesaCAPP) | Phase 2 | terminated | Mar 3, 2017 | Christoph Gasche | Due to poor patient recruitment and insufficient financing. | Enrollment / accrual |
| NCT01479465 | Efficacy and Safety of Simtuzumab (SIM) With FOLFIRI as Second Line Treatment in… | Phase 2 | terminated | Nov 24, 2011 | Gilead Sciences | not stated | Not stated |
| NCT01879943 | Capsule Versus Conventional Colonoscopy in Patient Following Colorectal Surgery | N/A | terminated | Jun 18, 2013 | IHU Strasbourg | Operational difficulties related to medical staff turnover (investigators departure and sickness… | Other (stated, no rule matched) |
| NCT00423345 | Colon Investigation - Factors Determining Choice of Procedure | — | terminated | Jan 18, 2007 | Sykehuset Telemark | One of the examinations (double contrast baium enema) became outdated in Norway | Other (stated, no rule matched) |
| NCT00835055 | Expression of Molecular Markers Before and After Neo-adjuvant Chemoradiotherapy in Rectal… | — | withdrawn | Feb 3, 2009 | St. Claraspital AG | never started several reasons | Other (stated, no rule matched) |
| NCT02139475 | Factors Influencing Quality of Bowel Cleansing for Colonoscopy in Patients With… | — | terminated | May 15, 2014 | Yonsei University | All the patients who had been targeted were registered. | Other (stated, no rule matched) |
| NCT02568046 | Sym004 in Combination With FOLFIRI in Metastatic Colorectal Cancer Patients | Phase 1 / Phase 2 | terminated | Oct 5, 2015 | Symphogen A/S | Discontinued development of Sym004 in combination with FOLFIRI | Other (stated, no rule matched) |
| NCT03455751 | Precision Pain Management for Major Abdominal Surgery in Colorectal Surgery(PPaM) | N/A | terminated | Mar 7, 2018 | The Cleveland Clinic | Failed to meet enrollment goals | Enrollment / accrual |
| NCT00264979 | Evaluation of 2 Resection Strategies of Synchronous Colorectal Cancer Metastases(METASYNC) | N/A | terminated | Dec 13, 2005 | Rennes University Hospital | Stop recommended following the last sequential analysis | Other (stated, no rule matched) |
| NCT01445054 | 111 Indium CHX-A DTPA Trastuzumab (Indium-Herceptin) for Imaging Breast Cancer | Early Phase 1 | terminated | Oct 3, 2011 | National Cancer Institute (NCI) | not stated | Not stated |
Stop reasons are registrant-reported free text and are displayed verbatim (truncated; hover for the full text). Categories come from explicit keyword rules and are never inferred from the study design, sponsor or outcome; a study that stopped for several reasons is filed under the first rule that matched. A TERMINATED status does not imply a negative result.
Data updated 23 days agoSource updated Feb 24, 2020source: clinicaltrials