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Clinical trials · failure tracking
Oncology studies whose overall status is TERMINATED, WITHDRAWN or SUSPENDED on ClinicalTrials.gov, with the stop reason exactly as the registrant posted it. A category is attached only when an explicit keyword rule matches the text; CancerIndex never infers why a study stopped.
1,575 stopped studies mapped to Malignant Breast Neoplasm and descendants · 90% state a reason
Over the 1,575 studies matching the cancer, status and year filters (the category filter does not change this chart). Each study is counted once, in the first matching category; greyed bars are studies whose text matched no rule or was empty.
Computedrules ci-stop-reasons-v1 · keyword matching only
A category is assigned when one of its keywords appears in the posted text (case-insensitive, whole words). Rules are tested in this order and the first match wins; every match is kept in the API (reasonMatches).
| NCT | Title | Phase | Status | First posted | Lead sponsor | Why stopped (as posted) | Category |
|---|---|---|---|---|---|---|---|
| NCT01913067 | Evaluation of Cabazitaxel in Patients With Brain Metastasis Secondary to Breast Cancer…(CRANIAL) | Phase 2 | withdrawn | Jul 31, 2013 | Jules Bordet Institute | Scientific rationale is deemed obsolete. Funders lost interest in the trial. | Other (stated, no rule matched) |
| NCT00930527 | Omega-3-Fatty Acid on Joint Symptoms Inducted by Aromatase Inhibitors | Phase 2 | terminated | Jun 30, 2009 | Columbia University | Closed by sponsor. | Other (stated, no rule matched) |
| NCT00744653 | Electrochemotherapy for Chest Wall Recurrence af Breast Cancer: Present Challenges and… | Phase 2 | terminated | Sep 1, 2008 | Copenhagen University Hospital at Herlev | Primary endpoint measure not suitable for evaluation | Other (stated, no rule matched) |
| NCT00165880 | An Open-label, Randomized, Phase II Study of the Efficacy and Safety of Indisulam (E7070)… | Phase 2 | terminated | Sep 14, 2005 | Eisai Limited | This study was stopped prematurely due to lack of efficacy. | Efficacy / futility |
| NCT00128362 | Sentinel Node Biopsy and Axillary Sampling in Operable Breast Cancer | Phase 2 | terminated | Aug 9, 2005 | Tata Memorial Hospital | After initiation of study many studies reported an equivalence of SNB and ALND which led to… | Other (stated, no rule matched) |
| NCT00555477 | Aromatase Inhibitors in Premenopausal Breast Cancer Patients With Chemotherapy-Induced… | Phase 2 | terminated | Nov 8, 2007 | University of Michigan Rogel Cancer Center | The study was stopped after 69 subjects were enrolled because of poor accrual. | Enrollment / accrual |
| NCT00079326 | Trastuzumab and Ixabepilone in Treating Women With HER2-Positive Metastatic Breast Cancer | Phase 2 | terminated | Mar 10, 2004 | National Cancer Institute (NCI) | Slow accrual. | Enrollment / accrual |
| NCT01741597 | Dynamic Contrast Enhanced MRI in Patients With Advanced Breast or Pancreatic Cancer With… | Phase 1 | withdrawn | Dec 5, 2012 | City of Hope Medical Center | PI chose to close the study | Other (stated, no rule matched) |
| NCT00159458 | Clinical Trial of Gemcitabine and Oxaliplatin in Recurrent or Metastatic Breast Cancer | Phase 2 | terminated | Sep 12, 2005 | University of Southern California | Insufficient Accrual | Enrollment / accrual |
| NCT00183963 | A Pilot Clinical Trial to Evaluate the Biological Activity of Fulvestrant in Breast… | Phase 2 | terminated | Sep 16, 2005 | University of Southern California | Insufficient accrual | Enrollment / accrual |
| NCT01329640 | Feasibility Study of Metronomic Chemotherapy for Locally Advanced Her2- Positive Breast… | Phase 2 | terminated | Apr 6, 2011 | Instituto do Cancer do Estado de São Paulo | not stated | Not stated |
| NCT00674011 | Hypertension in Breast Cancer Patients Receiving Bevacizumab | — | terminated | May 7, 2008 | Dana-Farber Cancer Institute | Slow accrual | Enrollment / accrual |
| NCT01355523 | The Effect of Melatonin on Depression, Anxiety, Cognitive Function and Sleep Disturbances…(MELODY) | Phase 2 / Phase 3 | terminated | May 18, 2011 | Melissa Voigt Hansen | Inclusion rate not as expected. Not financially possible to involve other centres. | Funding |
| NCT01300585 | MRI Evaluation of the Breast Areolar Margin and Paryenchyma(Breast MRI) | N/A | terminated | Feb 21, 2011 | Piedmont Healthcare | Lack of patient population | Other (stated, no rule matched) |
| NCT01332916 | Impact of Cancer on Memory Functioning: Understanding Disorders Using Approaches in…(CANMEM) | Phase 2 | terminated | Apr 11, 2011 | Centre Francois Baclesse | lack of patient | Other (stated, no rule matched) |
| NCT00517361 | Phase II Study of Carboplatin and Bevacizumab (Avastin) for ER Neg, PR Neg, and HER2/Neu… | Phase 2 | terminated | Aug 16, 2007 | University of Chicago | This study has been terminated due to poor accrual | Enrollment / accrual |
| NCT01669187 | The Effects of Pre-operative Physical Therapy Education | N/A | withdrawn | Aug 20, 2012 | Oakland University | Study withdrawn. | Other (stated, no rule matched) |
| NCT01237938 | Effect of a Low Glycemic Index Diet on Breast Density | N/A | terminated | Nov 10, 2010 | Roswell Park Cancer Institute | test | Other (stated, no rule matched) |
| NCT01233505 | Veliparib, Oxaliplatin, and Capecitabine in Treating Patients With Advanced Solid Tumors | Phase 1 | terminated | Nov 3, 2010 | National Cancer Institute (NCI) | not stated | Not stated |
| NCT00010322 | Toremifene With or Without Atamestane in Treating Postmenopausal Women With Metastatic… | Phase 3 | terminated | May 5, 2004 | Intarcia Therapeutics | Withdrawn due to change in standard of care - new protocol required | Other (stated, no rule matched) |
| NCT01539876 | Tumour Necrosis Factor Release in Locally Advanced Breast Cancer Patients Receiving…(TNFactor) | Phase 1 | withdrawn | Feb 28, 2012 | London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's | Disease Site Team changed research focus unlikely to have sufficient support to complete study | Other (stated, no rule matched) |
| NCT00074139 | Docetaxel, Doxorubicin, and Cyclophosphamide in Treating Women With Advanced Breast Cancer | Phase 1 | withdrawn | Dec 11, 2003 | Case Comprehensive Cancer Center | No patients were enrolled | Enrollment / accrual |
| NCT01255553 | Partial Breast Irradiation in a Low-risk Population Screened With MRI | N/A | withdrawn | Dec 7, 2010 | University of Chicago | No patients enrolled. | Enrollment / accrual |
| NCT01131364 | Combination Therapy of F16IL2 and Doxorubicin in Solid Tumour Patients | Phase 1 / Phase 2 | terminated | May 26, 2010 | Philogen S.p.A. | not stated | Not stated |
| NCT01477060 | Modulation of Response to Hormonal Therapy With Lapatinib and/or Metformin in Patients… | Phase 2 | terminated | Nov 22, 2011 | Fondazione Michelangelo | The study was stopped due to insufficient accrual | Enrollment / accrual |
| NCT01222377 | Endoscopic Breast Surgery in Treating Patients With Breast Cancer | N/A | terminated | Oct 18, 2010 | University of Southern California | P.I. left | Other (stated, no rule matched) |
| NCT01292083 | Azacitidine in Treating Patients With Triple Negative Stage I-IV Invasive Breast Cancer… | N/A | withdrawn | Feb 9, 2011 | University of Southern California | No accrual last 2 years | Enrollment / accrual |
| NCT00481585 | The Biology of Claudin 3 in Primary Human Mammary Epithelial Cell Culture | — | terminated | Jun 1, 2007 | Hackensack Meridian Health | study team failed to complete timely reviews, study suspended | Other (stated, no rule matched) |
| NCT01392586 | Systemic Therapy With or Without Upfront Surgery in Metastatic Breast Cancer(SUBMIT) | Phase 3 | terminated | Jul 12, 2011 | Jeroen Bosch Ziekenhuis | due to low accrual rate | Enrollment / accrual |
| NCT01695057 | Vorinostat Before Surgery in Treating Patients With Triple-Negative Breast Cancer | N/A | withdrawn | Sep 27, 2012 | University of Southern California | Lack of funding | Funding |
| NCT00827567 | Trial of RAD001 in Triple Negative Metastatic Breast Cancer | Phase 2 | terminated | Jan 22, 2009 | Milton S. Hershey Medical Center | Slow accrual | Enrollment / accrual |
| NCT00903656 | Lapatinib Plus Caelyx in Patients With Advanced Metastatic Breast Cancer Following… | Phase 2 | terminated | May 18, 2009 | Arbeitsgemeinschaft medikamentoese Tumortherapie | Caelyx was not available anymore | Other (stated, no rule matched) |
| NCT01265225 | Prognostic Value of Stem Cell Related Markers | — | withdrawn | Dec 23, 2010 | The Baruch Padeh Medical Center, Poriya | no finance | Funding |
| NCT00674206 | A Phase II Trial of Gemcitabine and Oxaliplatin for Triple Negative Metastatic Breast… | Phase 2 | terminated | May 7, 2008 | Emory University | Sponsor funding stopped | Funding |
| NCT00071942 | Vaccine Therapy in Treating Patients With Metastatic Breast Cancer | Phase 1 | terminated | Nov 6, 2003 | National Cancer Institute (NCI) | not stated | Not stated |
| NCT01141530 | Deep Sequencing of the Breast Cancer Transcriptome | — | withdrawn | Jun 10, 2010 | University of Arkansas | Study withdrawn due to inability to enroll subjects. | Enrollment / accrual |
| NCT00301080 | D-cycloserine in the Management of Chemotherapy-Induced Peripheral Neuropathic Pain | Phase 3 | terminated | Mar 10, 2006 | Northwestern University | Funding for the study fell through. | Funding |
| NCT01392248 | Prediction of Pain After Breast Cancer Surgery With EEG | — | terminated | Jul 12, 2011 | Maastricht University Medical Center | funding and recruiting problems | Enrollment / accrual |
| NCT00118053 | Trastuzumab, Docetaxel, and Carboplatin in Treating Women With Stage II, Stage III, or… | Phase 2 | terminated | Jul 11, 2005 | University of Medicine and Dentistry of New Jersey | slow accrual | Enrollment / accrual |
| NCT00529334 | A Pilot Study of CyberKnife Radiosurgery Delivered to the Partial Breast(CK-PBI) | N/A | withdrawn | Sep 14, 2007 | Georgetown University | PI left institution | Investigator |
| NCT00301886 | S0308 Zoledronate or Ibandronate in Preventing Bone Problems in Women With Stage IV… | Phase 3 | withdrawn | Mar 13, 2006 | SWOG Cancer Research Network | withdrawn support for study | Other (stated, no rule matched) |
| NCT00003432 | Immunotherapy in Treating Patients With Metastatic Breast Cancer | Phase 1 / Phase 2 | terminated | Apr 25, 2003 | Duke University | low accrual | Enrollment / accrual |
| NCT01060514 | Pazopanib + Vinorelbine in Non Small Cell Lung Cancer (NSCLC) and Breast Cancer | Phase 1 | terminated | Feb 2, 2010 | Northwestern University | Lack of timely accrual. | Enrollment / accrual |
| NCT00726180 | Use of Trastuzumab to Induce Increased ER Expression in ER-negative/Low, Her-2/Neu… | Phase 1 / Phase 2 | terminated | Jul 31, 2008 | University of Michigan Rogel Cancer Center | Due to low enrollment | Enrollment / accrual |
| NCT01208441 | RO4929097 and Letrozole in Treating Post-Menopausal Women With Hormone Receptor-Positive… | Phase 1 | terminated | Sep 24, 2010 | National Cancer Institute (NCI) | not stated | Not stated |
| NCT01705340 | Akt Inhibitor MK2206, Lapatinib Ditosylate, and Trastuzumab in Treating Patients With… | Phase 1 | terminated | Oct 12, 2012 | National Cancer Institute (NCI) | not stated | Not stated |
| NCT00104624 | Docetaxel in Treating Older Women With Metastatic Breast Cancer | Phase 2 | terminated | Mar 4, 2005 | UNICANCER | Toxicity issues | Safety / toxicity |
| NCT01301040 | Early Cardiac Toxicity of Adjuvant CT in Elderly BC. | Phase 2 | terminated | Feb 23, 2011 | Jules Bordet Institute | Slow recruitment | Enrollment / accrual |
| NCT01240928 | MK-2206+Endocrine Therapy in Patients With Hormone Receptor-Positive Breast Cancer | Phase 1 | withdrawn | Nov 15, 2010 | Vanderbilt-Ingram Cancer Center | Funding not available, study did not open to accrual and will not open in future | Enrollment / accrual |
| NCT01240941 | Trial of MK-2206 + Endocrine Treatment in Patients With Hormone Receptor Positive Breast… | Phase 2 | withdrawn | Nov 15, 2010 | Vanderbilt-Ingram Cancer Center | Funding was not available | Funding |
Stop reasons are registrant-reported free text and are displayed verbatim (truncated; hover for the full text). Categories come from explicit keyword rules and are never inferred from the study design, sponsor or outcome; a study that stopped for several reasons is filed under the first rule that matched. A TERMINATED status does not imply a negative result.
Data updated 23 days agoSource updated Jul 24, 2014source: clinicaltrials