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Clinical trials · failure tracking
Oncology studies whose overall status is TERMINATED, WITHDRAWN or SUSPENDED on ClinicalTrials.gov, with the stop reason exactly as the registrant posted it. A category is attached only when an explicit keyword rule matches the text; CancerIndex never infers why a study stopped.
847 stopped studies mapped to Malignant Bone Marrow Neoplasm and descendants · 88% state a reason
Over the 847 studies matching the cancer, status and year filters (the category filter does not change this chart). Each study is counted once, in the first matching category; greyed bars are studies whose text matched no rule or was empty.
Computedrules ci-stop-reasons-v1 · keyword matching only
A category is assigned when one of its keywords appears in the posted text (case-insensitive, whole words). Rules are tested in this order and the first match wins; every match is kept in the API (reasonMatches).
| NCT | Title | Phase | Status | First posted | Lead sponsor | Why stopped (as posted) | Category |
|---|---|---|---|---|---|---|---|
| NCT05066165 | Study Investigating NTLA-5001 in Subjects With Acute Myeloid Leukemia | Phase 1 / Phase 2 | terminated | Oct 4, 2021 | Intellia Therapeutics | Pivoting to an allogeneic version of this program currently in preclinical development. | Other (stated, no rule matched) |
| NCT06180863 | Oral Azacitidine (CC-486) Epigenetic Priming and Maintenance for Adult Acute Myeloid… | Phase 2 | withdrawn | Dec 26, 2023 | Yale University | Lack of funding. | Funding |
| NCT05201183 | A Dose Escalation Study of Intensity Modulated Total Marrow Irradiation (IMRT-TMI)… | Phase 1 / Phase 2 | withdrawn | Jan 21, 2022 | Naoyuki G. Saito, M.D., Ph.D. | insufficient staff and updates in standard practice have made it difficult to recruit participants | Enrollment / accrual |
| NCT04361058 | Nivolumab for High-Risk MDS/AML Patients After Allogeneic Stem Cell Transplant With… | Phase 1 | withdrawn | Apr 24, 2020 | SCRI Development Innovations, LLC | The single site that was deemed appropriate for this study was unable to enroll patients. Closed… | Enrollment / accrual |
| NCT05321940 | Safety Trial of STING-dependent Activators and Stimulated Dendritic Cells for Aggressive… | Phase 1 | withdrawn | Apr 11, 2022 | Juan C. Ramos, MD | Investigator decision | Investigator |
| NCT00540995 | Busulfan, Etoposide, and Intensity-Modulated Radiation Therapy Followed By Donor Stem… | Phase 1 / Phase 2 | terminated | Oct 8, 2007 | City of Hope Medical Center | Unable to safely escalate to TMLI doses that were hypothesized to be effective and less toxic than… | Enrollment / accrual |
| NCT03904251 | CPX-351 and Gemtuzumab Ozogamicin in Treating Patients With Relapsed Acute Myeloid… | Phase 1 | terminated | Apr 5, 2019 | Jonsson Comprehensive Cancer Center | slow accrual | Enrollment / accrual |
| NCT02520011 | Alvocidib Biomarker-driven Phase 2 AML Study | Phase 2 | terminated | Aug 11, 2015 | Sumitomo Pharma America, Inc. | Due to slow enrollment, the extensive time projected to conclude the study hypothesis rendered the… | Enrollment / accrual |
| NCT03593915 | A Phase 1b/2 Study of Alvocidib Plus Decitabine or Azacitidine in Patients With MDS | Phase 1 / Phase 2 | terminated | Jul 20, 2018 | Sumitomo Pharma America, Inc. | The sponsor decided not to continue the study based on the overall company strategy in AML. | Sponsor / business decision |
| NCT03969420 | Study of Alvocidib in Patients With Relapsed/Refractory AML Following Treatment With… | Phase 2 | terminated | May 31, 2019 | Sumitomo Pharma America, Inc. | Business decision to terminate the development of alvocidib program on 17 November 2020. Patients… | Sponsor / business decision |
| NCT05943314 | Clinical Study on Safety and Efficacy of Anti-CLL1 /+CD33 CAR T Cells in the Treatment of… | N/A | withdrawn | Jul 13, 2023 | Guangzhou Bio-gene Technology Co., Ltd | The clinical trial was terminated due to a change in sponsor strategy. | Sponsor / business decision |
| NCT04023071 | FT516 in Subjects With Advanced Hematologic Malignancies | Phase 1 | terminated | Jul 17, 2019 | Fate Therapeutics | The study was terminated by the Sponsor. | Other (stated, no rule matched) |
| NCT04485052 | Efficacy and Safety Evaluation of IBI188 in Combination With Demethylating Agents in… | Phase 1 / Phase 2 | suspended | Jul 24, 2020 | Innovent Biologics (Suzhou) Co. Ltd. | Pause for changes in development strategies | Sponsor / business decision |
| NCT03690154 | A Phase 1 Study to Evaluate FN-1501 Monotherapy in Patients With Advanced Solid Tumors… | Phase 1 | terminated | Oct 1, 2018 | Shanghai Fosun Pharmaceutical Industrial Development Co. Ltd. | Despite demonstrated safety and tolerability the trial was terminated early due to program… | Safety / toxicity |
| NCT04629651 | Captopril Use on the Degree of Marrow Fibrosis in Bone Marrow Fibrosis/Myeloproliferative… | Phase 1 / Phase 2 | withdrawn | Nov 16, 2020 | Case Comprehensive Cancer Center | PI discretion | Other (stated, no rule matched) |
| NCT02957032 | A Study of the Tumor-targeting Human F16IL2 Monoclonal Antibody-cytokine Fusion Protein… | Phase 1 | terminated | Nov 7, 2016 | Philogen S.p.A. | New agents for the same indication impacted on patients' recruitment | Enrollment / accrual |
| NCT02743611 | Safety & Activity of Controllable PRAME-TCR Therapy in Previously Treated AML/MDS or… | Phase 1 / Phase 2 | terminated | Apr 19, 2016 | Bellicum Pharmaceuticals | company decision | Sponsor / business decision |
| NCT04166929 | Haploidentical Stem Cell Transplant With or Without NK Cell Infusion in AML and MDS(Bigeminy) | Phase 2 | terminated | Nov 18, 2019 | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | low recruitment | Enrollment / accrual |
| NCT05456269 | A Study of Bisantrene Combined With Cytarabine or With Decitabine for Adult Subjects With…(BISECT) | Phase 1 | withdrawn | Jul 13, 2022 | Racura Oncology Ltd | commercial reason | Other (stated, no rule matched) |
| NCT02065869 | Safety Study of Gene Modified Donor T-cells Following TCRαβ+ Depleted Stem Cell Transplant | Phase 1 / Phase 2 | terminated | Feb 19, 2014 | Bellicum Pharmaceuticals | Sponsor decision | Sponsor / business decision |
| NCT03699475 | Study of Haplo-HSCT + Rivogenlecleucel vs Haplo-HSCT + Post Transplant Cyclophosphamide…(THRIVE) | Phase 2 / Phase 3 | terminated | Oct 9, 2018 | Bellicum Pharmaceuticals | Funding, portfolio re-prioritization | Funding |
| NCT03733249 | Long Term Follow-up Study for Patients Enrolled on the BP-004 Clinical Study | Phase 1 / Phase 2 | terminated | Nov 7, 2018 | Bellicum Pharmaceuticals | not stated | Not stated |
| NCT03067571 | Daratumumab in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia or… | Phase 2 | terminated | Mar 1, 2017 | M.D. Anderson Cancer Center | Study terminated early because of lack of efficacy | Efficacy / futility |
| NCT04614636 | FT538 in Subjects With Advanced Hematologic Malignancies | Phase 1 | terminated | Nov 4, 2020 | Fate Therapeutics | This study was terminated by the Sponsor. | Other (stated, no rule matched) |
| NCT05144334 | A Study of BTX-1188 in Subjects With Advanced Malignancies | Phase 1 | terminated | Dec 3, 2021 | Biotheryx, Inc. | Business decision | Sponsor / business decision |
| NCT04002115 | Clofarabine Pre-conditioning Followed by Stem Cell Transplant for Non-remission AML | Phase 2 | terminated | Jun 28, 2019 | Milton S. Hershey Medical Center | terminated due to low accrual | Enrollment / accrual |
| NCT04079738 | Study Augmenting TAK-659 Action in Relapsed/Refractory AML by Addition Ofthe Proteasome… | Phase 1 / Phase 2 | terminated | Sep 6, 2019 | H Scott Boswell | Funder requested termination due to halting internal development of TAK-659 | Other (stated, no rule matched) |
| NCT01044745 | Rituximab in Preventing Acute Graft-Versus-Host Disease in a Donor Stem Cell Transplant… | Phase 2 | terminated | Jan 8, 2010 | University of Nebraska | Study was closed to accrual for safety related to the frequency of BK infections. | Safety / toxicity |
| NCT03224819 | Study of Emerfetamab (AMG 673) in Adults With Relapsed/Refractory Acute Myeloid Leukemia… | Early Phase 1 | terminated | Jul 21, 2017 | Amgen | Priortization of other Programs | Other (stated, no rule matched) |
| NCT05320380 | A Study of the Drug IMGN632 in Children With Leukemia That Has Come Back After Treatment… | Phase 1 / Phase 2 | withdrawn | Apr 11, 2022 | Children's Oncology Group | Withdrawn per CS0150757 | Other (stated, no rule matched) |
| NCT05519527 | STI-6129 CD38 ADC for the Treatment of Patients With Relapsed or Refractory Systemic ALL… | Phase 1 | withdrawn | Aug 29, 2022 | M.D. Anderson Cancer Center | 0 patient accrual | Enrollment / accrual |
| NCT04480086 | Safety and Tolerability Study of Mivebresib Tablet Alone or in Combination With… | Phase 1 | terminated | Jul 21, 2020 | AbbVie | Strategic considerations | Sponsor / business decision |
| NCT00816413 | Donor Stem Cell Transplant, Pentostatin, and Total-Body Irradiation in Treating Patients… | Phase 1 / Phase 2 | withdrawn | Jan 1, 2009 | University of Nebraska | Screenings yielded inadequate eligible subjects to enroll. | Enrollment / accrual |
| NCT05501171 | Psychological Mobile App for Patients With AML | N/A | terminated | Aug 15, 2022 | Massachusetts General Hospital | the funding agency (blue note therapeutics) pulled out and did not provide funding | Funding |
| NCT02134782 | Yoga Fatigue Study | N/A | terminated | May 9, 2014 | The Hospital for Sick Children | The study was closed early for poor accrual when 125/210 planned participants had been enrolled and… | Enrollment / accrual |
| NCT03932318 | Venetoclax, Azacitidine, and Lintuzumab-Ac225 in AML Patients | Phase 1 / Phase 2 | withdrawn | Apr 30, 2019 | Actinium Pharmaceuticals | study postponed | Other (stated, no rule matched) |
| NCT03745352 | Pevonedistat With Azacitidine Versus Azacitidine Alone in Treating Patients With Relapsed… | Phase 2 | withdrawn | Nov 19, 2018 | National Cancer Institute (NCI) | Inadequate accrual rate | Enrollment / accrual |
| NCT03272633 | Irradiated Donor Cells Following Stem Cell Transplant in Controlling Cancer in Patients… | Early Phase 1 | terminated | Sep 5, 2017 | Rutgers, The State University of New Jersey | Lack of enrollment | Enrollment / accrual |
| NCT04679194 | Study of Mana 312 (Multi Tumor-Associated Antigen T Cells) in Adults With AML/MDS After… | Phase 1 | terminated | Dec 22, 2020 | Mana Therapeutics | Product manufacturing | Drug supply |
| NCT04896112 | A Study of LNK01002 in Patients With Primary or Secondary Myelofibrosis,Polycythemia Vera… | Phase 1 | withdrawn | May 21, 2021 | Lynk Pharmaceuticals Co., Ltd | sponsor decision | Sponsor / business decision |
| NCT02882321 | Oxidative Phosphorylation Inhibitor IACS-010759 in Treating Patients With Relapsed or… | Phase 1 | terminated | Aug 29, 2016 | M.D. Anderson Cancer Center | The study was terminated by the Sponsor for apparent lack of effectiveness. | Other (stated, no rule matched) |
| NCT03634228 | Milademetan Tosylate and Low-Dose Cytarabine With or Without Venetoclax in Treating… | Phase 1 / Phase 2 | terminated | Aug 16, 2018 | M.D. Anderson Cancer Center | This study was terminated early due to lack of adequate response, and did not move to the Phase II… | Other (stated, no rule matched) |
| NCT02440685 | A Phase 1/2 Study To Evaluate ASN002 In Relapsed/Refractory Lymphoma And Advanced Solid… | Phase 1 / Phase 2 | terminated | May 12, 2015 | Asana BioSciences | Business decision | Sponsor / business decision |
| NCT05077423 | A Phase 1 Trial of CD33xCD3 BsAb in Pediatric Patients With Relapsed or Refractory Acute… | Phase 1 | terminated | Oct 14, 2021 | Y-mAbs Therapeutics | Study terminated due to business priorities | Sponsor / business decision |
| NCT04631211 | Thrombosomes® in Bleeding Thrombocytopenic Patients Study | Phase 2 | terminated | Nov 17, 2020 | Cellphire Therapeutics, Inc. | This study was terminated due to loss of funding for this indication from the Biomedical Advanced… | Funding |
| NCT02203773 | Study of ABT-199 (GDC-0199) in Combination With Azacitidine or Decitabine (Chemo Combo)… | Phase 1 | terminated | Jul 30, 2014 | AbbVie | Strategic considerations | Sponsor / business decision |
| NCT05256277 | NK Cell Therapy for AML | Phase 1 | terminated | Feb 25, 2022 | Zhejiang University | A new study is planed to replace the current study due to IP upgrade | Other (stated, no rule matched) |
| NCT03233074 | Constitution of a Biological Cohort Following Bone Marrow Sampling From MDS or AML…(COSMOS) | — | terminated | Jul 28, 2017 | Centre Hospitalier Universitaire de Saint Etienne | Achievement of scientific objectives | Other (stated, no rule matched) |
| NCT05330377 | GM-CLAG in Relapsed/Refractory FLT3-mutated AML | Phase 1 | withdrawn | Apr 15, 2022 | Ayman H Qasrawi | Sponsor withdrew funding | Funding |
| NCT03465540 | Safety, Tolerability, Pharmacokinetics and Efficacy of AMG 397 in Subjects With Selected… | Phase 1 | terminated | Mar 14, 2018 | Amgen | Strategic decisions | Sponsor / business decision |
Stop reasons are registrant-reported free text and are displayed verbatim (truncated; hover for the full text). Categories come from explicit keyword rules and are never inferred from the study design, sponsor or outcome; a study that stopped for several reasons is filed under the first rule that matched. A TERMINATED status does not imply a negative result.
Data updated 23 days agoSource updated Dec 28, 2023source: clinicaltrials