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Clinical trials · failure tracking
Oncology studies whose overall status is TERMINATED, WITHDRAWN or SUSPENDED on ClinicalTrials.gov, with the stop reason exactly as the registrant posted it. A category is attached only when an explicit keyword rule matches the text; CancerIndex never infers why a study stopped.
845 stopped studies mapped to Malignant Bone Marrow Neoplasm and descendants · 88% state a reason
Over the 845 studies matching the cancer, status and year filters (the category filter does not change this chart). Each study is counted once, in the first matching category; greyed bars are studies whose text matched no rule or was empty.
Computedrules ci-stop-reasons-v1 · keyword matching only
A category is assigned when one of its keywords appears in the posted text (case-insensitive, whole words). Rules are tested in this order and the first match wins; every match is kept in the API (reasonMatches).
| NCT | Title | Phase | Status | First posted | Lead sponsor | Why stopped (as posted) | Category |
|---|---|---|---|---|---|---|---|
| NCT01655875 | AMD3100 for Sensitizing in Allogeneic Blood or Marrow Transplant for Chemotherapy…(BMTAMD3100) | Phase 1 | terminated | Aug 2, 2012 | Emory University | lack of patient enrollment | Enrollment / accrual |
| NCT00949117 | Cyproheptadine Hydrochloride and Nutritional Supplementation in Treating Young Patients… | Phase 2 | terminated | Jul 30, 2009 | University of South Florida | study not feasible with low accrual. DSMB recommended closure | Enrollment / accrual |
| NCT01426334 | Dasatinib and Cyclosporine in Treating Patients With Chronic Myelogenous Leukemia… | Phase 1 | terminated | Aug 31, 2011 | National Cancer Institute (NCI) | not stated | Not stated |
| NCT00943293 | Minor Histocompatibility Vaccination After Allogeneic Stem Cell Transplantation for… | Phase 1 | terminated | Jul 22, 2009 | University of Chicago | Poor accrual; did not enter phase 2 | Enrollment / accrual |
| NCT00866346 | PR1-Specific Cytotoxic T-Lymphocyte Infusion With Recurrent Chronic Myelogenous Leukemia… | Phase 1 | withdrawn | Mar 20, 2009 | M.D. Anderson Cancer Center | Study failed to accrue any patients due to regulatory issues with PR1 vaccine and T cell production. | Enrollment / accrual |
| NCT00396968 | AMD3100 With Busulfan, Fludarabine and Thymoglobulin for Allogeneic Stem Cell Transplant… | Phase 1 / Phase 2 | withdrawn | Nov 8, 2006 | Genzyme, a Sanofi Company | not stated | Not stated |
| NCT01478074 | ALT-801-activated Natural Killer Cells After FLAG Induction for Acute Myeloid Leukemia | Phase 1 | withdrawn | Nov 23, 2011 | Altor BioScience | The treatment planned was determined to be of low feasibility as no subject was found eligible and… | Enrollment / accrual |
| NCT00818961 | Donor Stem Cell Transplant in Treating Patients With High-Risk Hematologic Cancer | Phase 2 | terminated | Jan 8, 2009 | Northside Hospital, Inc. | terminated early due to meeting end point with fewer patients than anticipated | Other (stated, no rule matched) |
| NCT00923234 | Combination of 5-azacitidine and Lenalidomide in Myelodysplastic Syndromes (MDS) or Acute…(AZALE) | Phase 1 | terminated | Jun 18, 2009 | Technische Universität Dresden | The primary objective has already been answered with the number of recruited patients. | Enrollment / accrual |
| NCT00672152 | A Phase I Study of WT1 Peptides to Induce Anti-Leukemia Immune Responses Following…(WT-1) | Phase 1 | terminated | May 6, 2008 | Michael Morse, MD | low accrual | Enrollment / accrual |
| NCT00967525 | Intraosseous Infusion of Unrelated Cord Blood Grafts | N/A | terminated | Aug 28, 2009 | Emory University | poor enrollment | Enrollment / accrual |
| NCT00814983 | Myeloablative Allogeneic Stem Cell Transplantation Using a Naive T-Cell Depleted… | Phase 1 / Phase 2 | terminated | Dec 29, 2008 | Duke University | IND approval for naive T-cell depletion not obtained | Other (stated, no rule matched) |
| NCT01500161 | Pooled Unrelated Donor Umbilical Cord Blood Transplant For Hematologic Malignancy Needing… | Phase 2 | terminated | Dec 28, 2011 | Texas Oncology Cancer Center | Insufficient accruals | Enrollment / accrual |
| NCT00297921 | A Phase 2 Study of Tandutinib in Patients With Newly Diagnosed Acute Myelogenous Leukemia… | Phase 1 / Phase 2 | withdrawn | Mar 1, 2006 | Millennium Pharmaceuticals, Inc. | not stated | Not stated |
| NCT00985530 | Tamibarotene and Arsenic Trioxide for Relapsed Acute Promyelocytic Leukemia | Phase 1 | terminated | Sep 28, 2009 | Northwestern University | Supporting agency withdrew funding for study. | Funding |
| NCT00049582 | Decitabine in Treating Patients With Myelodysplastic Syndromes or Acute Myeloid Leukemia | Phase 1 | terminated | Jan 27, 2003 | National Cancer Institute (NCI) | not stated | Not stated |
| NCT00301769 | SJG-136 in Treating Patients With Relapsed or Refractory Acute Leukemia, Myelodysplastic… | Phase 1 | terminated | Mar 13, 2006 | National Cancer Institute (NCI) | not stated | Not stated |
| NCT00720850 | Lenalidomide Maintenance Therapy in Patients With Myelodysplastic Syndromes (MDS) or…(LENAMAINT) | Phase 2 | terminated | Jul 23, 2008 | Technische Universität Dresden | Low recruitment, scientific rationale not applicable anymore to all patients and possible induction… | Enrollment / accrual |
| NCT01159301 | Entinostat and Sorafenib Tosylate in Treating Patients With Advanced or Metastatic Solid… | Phase 1 | terminated | Jul 9, 2010 | National Cancer Institute (NCI) | not stated | Not stated |
| NCT00996359 | Partially HLA-Matched Irradiated Allogeneic Cellular Therapy After Reduced Intensity… | Phase 1 | terminated | Oct 16, 2009 | University of Medicine and Dentistry of New Jersey | Slow accrual | Enrollment / accrual |
| NCT00965861 | SCRI Tissue Testing Registry | — | terminated | Aug 26, 2009 | SCRI Development Innovations, LLC | Replaced by a study with a similar design. | Other (stated, no rule matched) |
| NCT00514722 | Pilot Study of Umbilical Cord Blood Transplantation in Adult Patient With Advanced… | N/A | terminated | Aug 10, 2007 | University of California, San Francisco | low accrual | Enrollment / accrual |
| NCT00513318 | Pilot Study of Reduced-Intensity Umbilical Cord Blood Transplantation in Adult Patients… | — | terminated | Aug 8, 2007 | University of California, San Francisco | Insufficient enrollment to justify keeping open. | Enrollment / accrual |
| NCT00150878 | Standard vs. Reduced-Intensity Conditioning in Patients With Acute Myeloid Leukemia in… | Phase 3 | terminated | Sep 8, 2005 | University Hospital Carl Gustav Carus | Insurance coverage reached | Other (stated, no rule matched) |
| NCT00101231 | Flavopiridol in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia,… | Phase 1 | terminated | Jan 10, 2005 | National Cancer Institute (NCI) | not stated | Not stated |
| NCT00103272 | 17-N-Allylamino-17-Demethoxygeldanamycin and Bortezomib in Treating Patients With… | Phase 1 | terminated | Feb 8, 2005 | National Cancer Institute (NCI) | not stated | Not stated |
| NCT01463410 | Accuracy Testing of the Chromosomal Aberration and Gene Mutation Markers of the… | — | terminated | Nov 1, 2011 | Skyline Diagnostics BV | The required number of banked samples could not be met due to limited availability. There is no… | Other (stated, no rule matched) |
| NCT00066417 | Peripheral Stem Cell Transplant in Treating Patients With High-Risk Leukemia | Phase 2 | terminated | Aug 7, 2003 | National Heart, Lung, and Blood Institute (NHLBI) | Trial was withdrawn for drug availability issues. | Drug supply |
| NCT00393380 | Study of Parathyroid Hormone Following Sequential Cord Blood Transplantation From an… | Phase 2 | terminated | Oct 27, 2006 | The Emmes Company, LLC | Study stopped because of toxicity concerns. | Safety / toxicity |
| NCT00899951 | Studying Fentanyl in Patients With Cancer | — | terminated | May 12, 2009 | Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | poor accrual | Enrollment / accrual |
| NCT00658411 | Deferoxamine for Iron Overload Before Allogeneic Stem Cell Transplantation | N/A | terminated | Apr 15, 2008 | Dana-Farber Cancer Institute | Closed due to slow patient accrual | Enrollment / accrual |
| NCT00499668 | Aprepitant or Ondansetron in Treating Nausea and Vomiting Caused By Opioids in Patients… | N/A | withdrawn | Jul 11, 2007 | Vanderbilt-Ingram Cancer Center | slow accrual | Enrollment / accrual |
| NCT01101412 | Antimicrobial Solution or Saline Solution in Maintaining Catheter Patency and Preventing… | Phase 1 / Phase 2 | withdrawn | Apr 12, 2010 | M.D. Anderson Cancer Center | Study was not opened. | Other (stated, no rule matched) |
| NCT00006220 | Arsenic Trioxide With or Without Tretinoin in Treating Patients With Hematologic Cancer… | Phase 1 / Phase 2 | terminated | May 20, 2004 | Washington University School of Medicine | Study drug became commercially available. | Other (stated, no rule matched) |
| NCT00089388 | Cilengitide in Treating Patients With Acute Myeloid Leukemia | Phase 2 | terminated | Aug 5, 2004 | National Cancer Institute (NCI) | Administratively complete. | Other (stated, no rule matched) |
| NCT00096148 | Idarubicin and Cytarabine With or Without Bevacizumab in Treating Patients With Newly… | Phase 2 | terminated | Nov 9, 2004 | National Cancer Institute (NCI) | Administratively complete. | Other (stated, no rule matched) |
| NCT00023920 | Bevacizumab, Idarubicin, and Cytarabine in Treating Patients With Blast Phase Chronic… | Phase 2 | terminated | Jan 27, 2003 | National Cancer Institute (NCI) | Administratively complete. | Other (stated, no rule matched) |
| NCT00042796 | Decitabine in Treating Children With Relapsed or Refractory Acute Myeloid Leukemia or… | Phase 1 | terminated | Jan 27, 2003 | National Cancer Institute (NCI) | Administratively complete. | Other (stated, no rule matched) |
| NCT01265199 | Study of the Safety, Tolerability, Pharmacokinetics and Pharmacodynamic Properties of… | Phase 1 | terminated | Dec 23, 2010 | Ascenta Therapeutics | Study was terminated before a MTD was determined for administrative reasons | Other (stated, no rule matched) |
| NCT00101088 | Temsirolimus and Imatinib Mesylate in Treating Patients With Chronic Myelogenous Leukemia | Phase 1 | terminated | Jan 10, 2005 | National Cancer Institute (NCI) | not stated | Not stated |
| NCT00125606 | Phase 3 Trial for AML Patients in CR2 Comparing 8Gy TBI /Fludarabine to Conditioning With… | Phase 3 | terminated | Aug 1, 2005 | University Hospital Muenster | insufficient patient recruitement | Enrollment / accrual |
| NCT00005641 | Removal of T Cells to Prevent Graft-Versus-Host Disease in Patients Undergoing Bone… | Phase 2 | terminated | Jun 8, 2004 | H. Lee Moffitt Cancer Center and Research Institute | low study accrual | Enrollment / accrual |
| NCT00005852 | Bone Marrow Transplantation in Treating Patients With Severe Aplastic Anemia or Rejection… | Phase 2 | terminated | Jul 26, 2004 | H. Lee Moffitt Cancer Center and Research Institute | low accrual | Enrollment / accrual |
| NCT00790855 | Bendamustine in Acute Leukemia and MDS | Phase 1 / Phase 2 | terminated | Nov 14, 2008 | M.D. Anderson Cancer Center | Lack of Response | Other (stated, no rule matched) |
| NCT00069992 | Total-Body Irradiation, Fludarabine, and Alemtuzumab Followed By Stem Cell Transplant in…(MPDMDSBMT) | Phase 2 | terminated | Oct 7, 2003 | Baylor College of Medicine | Closed due to competing protocols | Other (stated, no rule matched) |
| NCT00301912 | Busulfan and Fludarabine Before Donor Stem Cell Transplant in Treating Patients With… | Phase 2 | withdrawn | Mar 13, 2006 | University of California, San Francisco | Withdrawn because study never opened to accrual | Enrollment / accrual |
| NCT00062231 | Moxifloxacin Compared With Ciprofloxacin/Amoxicillin in Treating Fever and Neutropenia in… | N/A | terminated | Jun 6, 2003 | European Organisation for Research and Treatment of Cancer - EORTC | low accrual | Enrollment / accrual |
| NCT00676728 | A Study of the Histone-deacetylase Inhibitor JNJ-26481585 in Patients With Advanced or… | Phase 1 | terminated | May 13, 2008 | Johnson & Johnson Pharmaceutical Research & Development, L.L.C. | Sponsor Decision | Sponsor / business decision |
| NCT00038818 | CD8 DLI for Patients With Relapse or Residual Disease Following Allogeneic Stem Cell… | N/A | terminated | Jun 7, 2002 | M.D. Anderson Cancer Center | Low accrual. | Enrollment / accrual |
| NCT00113321 | Low-Dose Decitabine in Myelodysplastic Syndrome Post Azacytidine Failure | Phase 2 | terminated | Jun 8, 2005 | M.D. Anderson Cancer Center | Low Accrual | Enrollment / accrual |
Stop reasons are registrant-reported free text and are displayed verbatim (truncated; hover for the full text). Categories come from explicit keyword rules and are never inferred from the study design, sponsor or outcome; a study that stopped for several reasons is filed under the first rule that matched. A TERMINATED status does not imply a negative result.
Data updated 23 days agoSource updated Apr 7, 2014source: clinicaltrials