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Clinical trials · failure tracking
Oncology studies whose overall status is TERMINATED, WITHDRAWN or SUSPENDED on ClinicalTrials.gov, with the stop reason exactly as the registrant posted it. A category is attached only when an explicit keyword rule matches the text; CancerIndex never infers why a study stopped.
1,261 stopped studies mapped to Lung Carcinoma and descendants · 91% state a reason
Over the 1,261 studies matching the cancer, status and year filters (the category filter does not change this chart). Each study is counted once, in the first matching category; greyed bars are studies whose text matched no rule or was empty.
Computedrules ci-stop-reasons-v1 · keyword matching only
A category is assigned when one of its keywords appears in the posted text (case-insensitive, whole words). Rules are tested in this order and the first match wins; every match is kept in the API (reasonMatches).
| NCT | Title | Phase | Status | First posted | Lead sponsor | Why stopped (as posted) | Category |
|---|---|---|---|---|---|---|---|
| NCT00749567 | Combination of Erlotinib and Bevacizumab as Second-line Treatment in Patients With… | Phase 2 | terminated | Sep 9, 2008 | Hellenic Oncology Research Group | Poor accrual | Enrollment / accrual |
| NCT02179567 | Docetaxel Plus Bevacizumab for Elderly Patients With Stage IV NSCLC | Phase 2 | terminated | Jul 2, 2014 | Hellenic Oncology Research Group | Terminated due to poor accrual | Enrollment / accrual |
| NCT02250378 | Stereotactic Radiosurgery Followed by Wedge Resection in Treating Patients With Early… | N/A | withdrawn | Sep 26, 2014 | University of Southern California | No accrual | Enrollment / accrual |
| NCT00460317 | MONET1-MOtesanib NSCLC Efficacy and Tolerability Study | Phase 3 | terminated | Apr 13, 2007 | Amgen | Amgen discontinued the development of AMG706 because 20050201 did not meet its primary objective. | Other (stated, no rule matched) |
| NCT01057212 | Trial of Bevacizumab and Ixabepilone for Advanced or Metastatic Non-small Cell Lung… | Phase 2 | terminated | Jan 27, 2010 | Providence Health & Services | Lack of support from pharmaceutical collaborator. | Other (stated, no rule matched) |
| NCT01184287 | A Study Of Ranpirnase(Onconase®) To Pemetrexed Plus Carboplatin In Patients With… | Phase 2 | withdrawn | Aug 18, 2010 | Tamir Biotechnology, Inc. | Program discontinued | Other (stated, no rule matched) |
| NCT00050336 | Study of Lonafarnib in Combination With Paclitaxel and Carboplatin in Patients With… | Phase 3 | terminated | Dec 5, 2002 | Merck Sharp & Dohme LLC | not stated | Not stated |
| NCT00983047 | Nimotuzumab Plus Docetaxel in Chemotherapy-Refractory/Resistant Patients With Advanced… | Phase 2 | terminated | Sep 23, 2009 | Biotech Pharmaceutical Co., Ltd. | The sponsor decide to terminate | Other (stated, no rule matched) |
| NCT00704392 | Safety Study of XL647 and XL147 Administered in Combination Daily in Adults With Solid… | Phase 1 | withdrawn | Jun 24, 2008 | Exelixis | Study not initiated | Other (stated, no rule matched) |
| NCT00985998 | Nimotuzumab in Combination With Cisplatin and Docetaxel for Patients With Advanced… | Phase 1 | withdrawn | Sep 29, 2009 | Biotech Pharmaceutical Co., Ltd. | no paticipants enrolled | Enrollment / accrual |
| NCT00391586 | Erlotinib and Standard Platinum-Based Chemotherapy for Newly Diagnosed, Advanced… | Phase 2 | terminated | Oct 24, 2006 | New Mexico Cancer Research Alliance | PI left institution. | Investigator |
| NCT02405247 | TAURAS - T790 AURA ScreenFailure SOC Registry Study(TAURAS) | — | terminated | Apr 1, 2015 | AstraZeneca | Team's request. | Other (stated, no rule matched) |
| NCT01658332 | Circulating Tumor Cells in Lung Cancer(CIRCUBRONCH) | N/A | terminated | Aug 7, 2012 | Central Hospital, Nancy, France | unavailability of the investigator due to an overloaded planning | Investigator |
| NCT01064050 | Role of a Silicone Prosthesis to Prevent Airway Obstruction Recurrence in Lung Cancers(SPOC) | Phase 4 | terminated | Feb 8, 2010 | Centre Hospitalier Universitaire de Saint Etienne | Difficulty to include patient | Other (stated, no rule matched) |
| NCT00290550 | A Phase IIA Study of MK0457 in Patients With Cancer of the Lung (0457-006) | Phase 2 | terminated | Feb 13, 2006 | Merck Sharp & Dohme LLC | not stated | Not stated |
| NCT00912366 | Assessment of Video Assisted Thoracoscopic Surgery (VATS) Versus Open Surgery for… | — | terminated | Jun 3, 2009 | Medtronic - MITG | Slow Enrollment | Enrollment / accrual |
| NCT00907179 | Pemetrexed and LBH589 in Patients With Advanced Non-Small Cell Lung Cancer | Phase 1 | terminated | May 22, 2009 | University of Pittsburgh | Widespread use firstline Pemetrexed; slow recruitment; funding withdrawn.. | Enrollment / accrual |
| NCT01444118 | A Randomized Trial to Study the Safety and Efficacy of EGF Cancer Vaccination in…(NSCLC) | Phase 3 | terminated | Sep 30, 2011 | Bioven Europe | The early termination is not related to safety/toxicity but to initiate new Phase III with… | Safety / toxicity |
| NCT01282151 | TaxoteRe Plus Cisplatin Versus AlImta Plus Cisplatin in 1st Line Non-squamous Cell Type…(TRAIL) | Phase 3 | terminated | Jan 24, 2011 | Chonnam National University Hospital | Difficulty in recruitment due to approval of maintenance pemetrexed treatment | Enrollment / accrual |
| NCT01928160 | Pemetrexed Disodium and Carboplatin or Cisplatin With or Without Erlotinib Hydrochloride… | Phase 2 | withdrawn | Aug 23, 2013 | Vanderbilt-Ingram Cancer Center | study not accruing | Enrollment / accrual |
| NCT01685346 | Biofeedback Training in Patients With Advanced Lung Cancer - A Pilot Study | N/A | terminated | Sep 14, 2012 | Case Comprehensive Cancer Center | Research Cancelled | Other (stated, no rule matched) |
| NCT02368990 | T790M Mutation Positive 2nd Line STandard of cAre Registry(T-STAR) | — | withdrawn | Feb 23, 2015 | AstraZeneca | Since the conception of the study, the competitive environment has developed and as a result this… | Other (stated, no rule matched) |
| NCT00697060 | A Safety and Efficacy Trial of Amplimexon Plus Taxotere in Metastatic Non-Small Cell Lung… | Phase 2 | withdrawn | Jun 13, 2008 | AmpliMed Corporation | Study cancelled prior to start due to change in company priorities. | Sponsor / business decision |
| NCT01487499 | Bronchoscopic Intratumoral Chemotherapy for Small Cell Lung Cancer (SCLC)(SCLC) | Phase 3 | terminated | Dec 7, 2011 | University of Florida | Unable to enroll adequate number of participants | Enrollment / accrual |
| NCT00378404 | Phase I Trial of Docetaxel and Low-Dose Fractionated Radiation in the Treatment of… | Phase 1 | terminated | Sep 20, 2006 | Susanne Arnold | Slow accrual | Enrollment / accrual |
| NCT01222572 | Stereotactic Boost for Locally Advanced Non-Small Cell Lung Cancer | Phase 1 / Phase 2 | terminated | Oct 18, 2010 | Dana-Farber Cancer Institute | Slow accrual due to restrictive eligibility criteria | Enrollment / accrual |
| NCT01421316 | Hair-sparing Whole Brain Radiotherapy | Phase 2 | terminated | Aug 22, 2011 | University Hospital, Ghent | No reduction in hair loss 1 month after treatment | Other (stated, no rule matched) |
| NCT00431613 | Study of Docetaxel/Gemcitabine Followed by Chemo-radiotherapy (Chemo-RT), With or Without… | Phase 2 | terminated | Feb 6, 2007 | Hellenic Oncology Research Group | Due to Poor Accrual | Enrollment / accrual |
| NCT01720901 | Increased Dose of Icotinib in Advanced None Small Cell Lung Cancer Patients After Routine… | Phase 4 | suspended | Nov 2, 2012 | Betta Pharmaceuticals Co., Ltd. | Accrual limitations | Enrollment / accrual |
| NCT01038752 | Evaluation of Non-cytotoxic Suramin as a Chemosensitizer in Non-small Cell Lung Cancer | Phase 2 | terminated | Dec 24, 2009 | Optimum Therapeutics, LLC | not stated | Not stated |
| NCT00238615 | Phase II Docetaxel / Carboplatin / XRT + Surgical Resection in Stage III NSCLC | Phase 2 | terminated | Oct 13, 2005 | Stanford University | low accrual | Enrollment / accrual |
| NCT00934076 | Tarceva and AT-101 for Patients With Advanced Non-Small Cell Lung Cancer | Phase 1 | withdrawn | Jul 8, 2009 | University of Alabama at Birmingham | Study was never activated | Other (stated, no rule matched) |
| NCT01893580 | Perioperative Rehabilitation in Operation for Lung Cancer(PROLUCA) | N/A | terminated | Jul 9, 2013 | Rigshospitalet, Denmark | Due to low recruiment rate, the study design is chanced to a feasibility study | Other (stated, no rule matched) |
| NCT01507740 | Profile of Soluble and Cellular Biomarkers and of Functional Imaging During… | — | terminated | Jan 11, 2012 | Medical University Innsbruck | Study was stopped 04.10.2014 prematurly after recruitment of HCC and RCC patients. NSCLC (2 of 10… | Enrollment / accrual |
| NCT00974662 | Study Using WST11 in Patients With Obstructing Endobronchial Non-Small Cell Lung Cancer | Phase 2 | terminated | Sep 10, 2009 | Steba Biotech S.A. | Early end of enrolment with regards to difficulty met to enrol patients. | Enrollment / accrual |
| NCT00903942 | Abraxane and RT for Non-Small Cell Lung Cancer (NSCLC) | Phase 2 | withdrawn | May 19, 2009 | University of Rochester | funding was withdrawn from Drug company | Funding |
| NCT01379976 | Acetyl-L-carnitine in Combination With a Cisplatin-containing Chemotherapy as First Line… | Phase 3 | terminated | Jun 23, 2011 | Mario Negri Institute for Pharmacological Research | Recruitment was prematurely stopped due to difficulty of recruitment encountered by the… | Enrollment / accrual |
| NCT00707252 | Study of Polyphenon E in Addition to Erlotinib in Advanced Non Small Cell Lung Cancer | Phase 1 | terminated | Jun 30, 2008 | Louisiana State University Health Sciences Center Shreveport | Phase II not initiated due to cancellation of supply of Poly E by collaborator. | Drug supply |
| NCT01714037 | A Clinical Study on the Safety and Efficacy of Debio 0932 in Combination With Standard of…(HALO) | Phase 1 | terminated | Oct 25, 2012 | Debiopharm International SA | not stated | Not stated |
| NCT00940875 | A Study of Tarceva (Erlotinib) in Sequential Combination With Gemcitabine as First Line… | Phase 2 | terminated | Jul 16, 2009 | Hoffmann-La Roche | Study was stopped due to slower than expected recruitment. | Enrollment / accrual |
| NCT00254891 | Trial of Paclitaxel/Carboplatin + PF-3512676 vs Paclitaxel/Carboplatin Alone in Patients… | Phase 3 | terminated | Nov 17, 2005 | Pfizer | See Termination Reason in Detailed Description | Other (stated, no rule matched) |
| NCT00254904 | Randomized Trial of Gemcitabine/Cisplatin + PF-3512676 vs Gemcitabine/Cisplatin Alone in… | Phase 3 | terminated | Nov 17, 2005 | Pfizer | See Termination Reason in Detailed Description | Other (stated, no rule matched) |
| NCT02059967 | Phase I IGART Study Using Active Breathing Control and Simultaneous Boost for Patients… | Phase 1 | withdrawn | Feb 11, 2014 | Virginia Commonwealth University | Due to no accrual. | Enrollment / accrual |
| NCT01486459 | A Feasibility Trial Using Lithium As A Neuroprotective Agent In Patients Undergoing…(TULIP) | N/A | terminated | Dec 6, 2011 | Barwon Health | Insufficient recruits | Enrollment / accrual |
| NCT00251589 | A Phase I/II Clinical Trial of Vorinostat in Combination With Erlotinib for Patients With… | Phase 1 / Phase 2 | terminated | Nov 10, 2005 | Merck Sharp & Dohme LLC | This trial is being closed based on lack of substantive efficacy, slow accrual and overall… | Efficacy / futility |
| NCT01591512 | A Prospective Longitudinal Collection of Subjects Diagnosed With Small Cell Lung Cancer | — | terminated | May 4, 2012 | Fujirebio Diagnostics, Inc. | Decision was made by Sponsor to stop the trial. | Other (stated, no rule matched) |
| NCT01048983 | Reducing Symptom Burden - Non Small Cell Lung Cancer (NSCLC) | Phase 1 / Phase 2 | withdrawn | Jan 14, 2010 | M.D. Anderson Cancer Center | No accrual. | Enrollment / accrual |
| NCT00803842 | Erlotinib Pharmacokinetics During Doxycycline Treatment for Erlotinib-induced Rash | N/A | withdrawn | Dec 8, 2008 | Northwestern University | Investigator left the institution and decided not to continue with the study. | Investigator |
| NCT00564876 | Phase II Study Evaluating The Safety And Response To Neoadjuvant Dasatinib In Early Stage…(TOP0706) | Phase 2 | terminated | Nov 28, 2007 | Duke University | Lack of accrual, study closed. | Enrollment / accrual |
| NCT01647334 | Shrinking Target Adaptive Radiotherapy for Locally Advanced Non-Small Cell Lung Cancer | N/A | terminated | Jul 23, 2012 | London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's | Poor accrual | Enrollment / accrual |
Stop reasons are registrant-reported free text and are displayed verbatim (truncated; hover for the full text). Categories come from explicit keyword rules and are never inferred from the study design, sponsor or outcome; a study that stopped for several reasons is filed under the first rule that matched. A TERMINATED status does not imply a negative result.
Data updated 23 days agoSource updated Sep 28, 2015source: clinicaltrials