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Clinical trials · failure tracking
Oncology studies whose overall status is TERMINATED, WITHDRAWN or SUSPENDED on ClinicalTrials.gov, with the stop reason exactly as the registrant posted it. A category is attached only when an explicit keyword rule matches the text; CancerIndex never infers why a study stopped.
430 stopped studies mapped to Liver Carcinoma and descendants · 93% state a reason
Over the 430 studies matching the cancer, status and year filters (the category filter does not change this chart). Each study is counted once, in the first matching category; greyed bars are studies whose text matched no rule or was empty.
Computedrules ci-stop-reasons-v1 · keyword matching only
A category is assigned when one of its keywords appears in the posted text (case-insensitive, whole words). Rules are tested in this order and the first match wins; every match is kept in the API (reasonMatches).
| NCT | Title | Phase | Status | First posted | Lead sponsor | Why stopped (as posted) | Category |
|---|---|---|---|---|---|---|---|
| NCT01829971 | A Multicenter Phase I Study of MRX34, MicroRNA miR-RX34 Liposomal Injection | Phase 1 | terminated | Apr 11, 2013 | Mirna Therapeutics, Inc. | Five immune related serious adverse events | Safety / toxicity |
| NCT01964235 | Study of Efficacy and Safety INC280 in Patients With Advanced Hepatocellular Carcinoma | Phase 2 | withdrawn | Oct 17, 2013 | Novartis Pharmaceuticals | Study was cancelled by Sponsor. | Other (stated, no rule matched) |
| NCT01020812 | Combination SBRT With TACE for Unresectable Hepatocellular Carcinoma | Phase 1 / Phase 2 | terminated | Nov 26, 2009 | Stanford University | enrollment was too low | Enrollment / accrual |
| NCT00767234 | Permission to Collect Blood Over Time for Research | — | terminated | Oct 7, 2008 | Stanford University | Accrual issues - Low Accrual | Enrollment / accrual |
| NCT01744639 | Analysis of Body Composition in Patients With Hepatocellular Carcinoma in Radioablation | N/A | withdrawn | Dec 7, 2012 | Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran | Unable to find patients | Other (stated, no rule matched) |
| NCT00971126 | Study of Sorafenib With Combination of Thalidomide in Hepatocellular Carcinoma (HCC) | Phase 1 / Phase 2 | terminated | Sep 3, 2009 | National Health Research Institutes, Taiwan | Two patients in the first dose level be counted as reaching DLT. DSMB recommend terminated early… | Other (stated, no rule matched) |
| NCT01480817 | Sorafenib VS TACE in HCC Patients With Portal Vein Invasion | Phase 2 | terminated | Nov 29, 2011 | Seoul National University Hospital | Difficulty of participant enrollment. | Enrollment / accrual |
| NCT01857726 | Comparison of TACE Versus TACE/TACI Combination in Advanced Hepatocellular Carcinoma With… | N/A | withdrawn | May 20, 2013 | Seoul National University Hospital | No participants were enrolled | Enrollment / accrual |
| NCT01953406 | The Efficacy of 5-fluorouracil/Mitomycin for the Patients With Pulmonary Metastasis of… | Phase 2 | withdrawn | Oct 1, 2013 | Seoul National University Hospital | No participants were enrolled. Therefore, we stop this study, prematurely. | Enrollment / accrual |
| NCT02004210 | A Phase 3 Trial Comparing TACE and TARE in Unilobar Advanced Hepatocellular Carcinoma | Phase 3 | withdrawn | Dec 9, 2013 | Seoul National University Hospital | No participants were enrolled. | Enrollment / accrual |
| NCT01875549 | Comparison Between Unilateral Versus Bilateral Stenting for Malignant Hilar Biliary… | N/A | withdrawn | Jun 12, 2013 | Kwang Hyuck Lee | no enrollment | Enrollment / accrual |
| NCT01807156 | Phase II Trial of Tivozanib in Advanced Hepatocellular Cancer | Phase 2 | terminated | Mar 8, 2013 | Emory University | Primary endpoint not met | Other (stated, no rule matched) |
| NCT00582400 | A Phase II Protocol of Arsenic Trioxide (Trisenox) in Subjects With Advanced Primary… | Phase 2 | terminated | Dec 28, 2007 | The University of Texas Medical Branch, Galveston | recruiting or enrolling participants has halted prematurely and will not resume; participants are… | Enrollment / accrual |
| NCT00532441 | Erlotinib in Combination With Docetaxel in Advanced Hepatocellular and Biliary Tract… | Phase 2 | terminated | Sep 20, 2007 | Gabi Chiorean, MD | Terminated due to funding issues. | Funding |
| NCT00746655 | SBRT + TACE for Primary Hepatocellular Carcinoma | N/A | withdrawn | Sep 4, 2008 | University of Pittsburgh | Unable to recruit | Enrollment / accrual |
| NCT00669136 | Immunization With AFP + GM CSF Plasmid Prime and AFP Adenoviral Vector Boost in Patients… | Phase 1 | terminated | Apr 29, 2008 | Lisa H. Butterfield, Ph.D. | Poor accrual and limited target patient population for future accrual. Did not complete the Phase 1… | Enrollment / accrual |
| NCT02304445 | Chemoembolization With or Without Stereotactic Body Radiosurgery for Liver Cancer(TACE-SBRT) | N/A | withdrawn | Dec 2, 2014 | Juan Sanabria, MD | Necessary equipment could not be obtained. | Other (stated, no rule matched) |
| NCT01521780 | Characterization of Baseline Biomarker Variability in Participants With Hepatocellular… | Phase 1 | terminated | Jan 31, 2012 | Merck Sharp & Dohme LLC | not stated | Not stated |
| NCT01911273 | A Study To Evaluate The Efficacy And Safety of The Investigational Drug PF-03446962 (A… | Phase 2 | terminated | Jul 30, 2013 | Pfizer | See termination reason in detailed description. | Other (stated, no rule matched) |
| NCT01108705 | Comparison of Brivanib and Best Supportive Care (BSC) With Placebo and BSC for Treatment…(BRISK-APS) | Phase 3 | terminated | Apr 22, 2010 | Bristol-Myers Squibb | not stated | Not stated |
| NCT01239355 | MK2206 in Treating Patients With Advanced Liver Cancer That Did Not Respond to Previous… | Phase 2 | terminated | Nov 11, 2010 | National Cancer Institute (NCI) | Early termination for discouraging results | Other (stated, no rule matched) |
| NCT01968629 | 24hr Imaging Of HCC After EOVIST | Early Phase 1 | withdrawn | Oct 24, 2013 | Massachusetts General Hospital | No eligible subject enrolled | Enrollment / accrual |
| NCT01348503 | Lenalidomide in Combination With a Fixed Dose of Sorafenib for the Treatment of… | Phase 1 | terminated | May 5, 2011 | Indiana University | Treatment was ineffective | Other (stated, no rule matched) |
| NCT01539018 | Sorafenib Plus Tegafur-uracil (UFT) Versus Sorafenib as First Line Systemic Treatment for… | Phase 2 | terminated | Feb 27, 2012 | Egyptian Society of Liver Cancer | After interim results data showed no evidence of a difference between both groups | Other (stated, no rule matched) |
| NCT01686880 | Y90 Radioembolization Prior to Surgical Resection or Radiofrequency for Hepatocellular…(TRYPHON) | Phase 2 | terminated | Sep 18, 2012 | Jules Bordet Institute | poor recruitment and an unexpected low treatment rate | Enrollment / accrual |
| NCT02482909 | A Study Comparing Radiofrequency Ablation and Hepatic Resection for Hepatocellular… | N/A | terminated | Jun 26, 2015 | Seoul National University Hospital | The post-treatment recurrence rate was expected to be different between two treatment groups. | Other (stated, no rule matched) |
| NCT01775280 | Response of Hepatic Tumors to Radioembolization(RESRAD) | Phase 2 | withdrawn | Jan 24, 2013 | University of Zurich | Lack of enrollment | Enrollment / accrual |
| NCT01507740 | Profile of Soluble and Cellular Biomarkers and of Functional Imaging During… | — | terminated | Jan 11, 2012 | Medical University Innsbruck | Study was stopped 04.10.2014 prematurly after recruitment of HCC and RCC patients. NSCLC (2 of 10… | Enrollment / accrual |
| NCT01029418 | AZD6244 and Sorafenib in Advanced Hepatocellular Carcinoma | Phase 1 / Phase 2 | terminated | Dec 10, 2009 | National Cancer Centre, Singapore | The phase II portion was not conducted due to funding issue. | Funding |
| NCT01801163 | A Phase Ib Study of Stereotactic Body Radiotherapy (SBRT) Plus Sorafenib in Patients With… | Phase 1 | withdrawn | Feb 28, 2013 | Indiana University | Trial had no patients accrued while open | Enrollment / accrual |
| NCT00081900 | A Safety and Efficacy Study of DENSPM in Patients With Liver Cancer Who Are Not Eligible… | Phase 1 / Phase 2 | terminated | Apr 28, 2004 | Genzyme, a Sanofi Company | This study was terminated early by Genzyme because there were insufficient data to support clinical… | Other (stated, no rule matched) |
| NCT02070419 | TACE With or Without Radiation Therapy in Treating Patients With Stage A-C Liver Cancer | Phase 2 | withdrawn | Feb 25, 2014 | Case Comprehensive Cancer Center | Principal Investigator left institution | Investigator |
| NCT00808145 | Study of Sorafenib, Gemcitabine, and Cisplatin in Advanced Hepatocellular Carcinoma (HCC) | Phase 2 | withdrawn | Dec 15, 2008 | Lahey Clinic | Lack of enrollment, many screen failures and non eligible study participants | Enrollment / accrual |
| NCT01872988 | Tenofovir Antiviral Therapy Following Transarterial Chemoembolization for HBV Related… | Phase 3 | terminated | Jun 7, 2013 | Taichung Veterans General Hospital | Difficult in patient enrollment | Enrollment / accrual |
| NCT01722175 | Associating Liver Partition With Portal Vein Ligation For Staged Hepatectomy (ALPPS) or…(ALPPS) | Phase 2 | withdrawn | Nov 6, 2012 | Washington University School of Medicine | Safety concerns. | Safety / toxicity |
| NCT01669668 | Radiofrequency Ablation in Treating Patients With Liver Cancer (Hepatocellular Carcinoma) | Phase 2 | withdrawn | Aug 21, 2012 | Washington University School of Medicine | Lack of referrals. | Other (stated, no rule matched) |
| NCT01432314 | Efficacy of Radiation Therapy and Transarterial Chemoembolization (TACE) to Treat…(RTANDTACE) | Phase 2 | withdrawn | Sep 12, 2011 | Asan Medical Center | Another phase 2 randomized study has been started by other investigators. | Other (stated, no rule matched) |
| NCT01963949 | Prospective, Observational Study of Biomarkers in Liver Cancer - Identification of… | — | withdrawn | Oct 17, 2013 | University of Texas Southwestern Medical Center | not stated | Not stated |
| NCT00493428 | Treatment of Non-Metastatic Hepatocellular Carcinoma in Humans by Increasing Gabaergic… | Phase 2 | withdrawn | Jun 28, 2007 | University of Manitoba | The study have been stoped because the protocol is going to be modify. | Other (stated, no rule matched) |
| NCT00023946 | BMS-247550 in Treating Patients With Liver or Gallbladder Cancer | Phase 2 | terminated | Jan 27, 2003 | National Cancer Institute (NCI) | not stated | Not stated |
| NCT01215565 | Study of Sunitinib in Patients With Advanced/Inoperable Fibrolamellar Carcinoma(Fibrolam) | Phase 2 | terminated | Oct 6, 2010 | Assistance Publique - Hôpitaux de Paris | lack of inclusion | Other (stated, no rule matched) |
| NCT00763776 | Parenchyma Resection of Cirrhotic Liver by the Clamp Crushing Technique and the…(SECCI) | N/A | terminated | Oct 1, 2008 | Assistance Publique - Hôpitaux de Paris | difficulty for the patient recruiting | Enrollment / accrual |
| NCT01501240 | Gadoxetic Acid-enhanced MR Evaluation of Hepatocellular Carcinoma and Dysplastic Nodules…(PriMPa) | — | withdrawn | Dec 29, 2011 | Jae Ho Byun | not stated | Not stated |
| NCT01128803 | Immunotherapy of Hepatocellular Carcinoma by Induction of Anti-alpha Fetoprotein Response | Phase 1 / Phase 2 | terminated | May 24, 2010 | Nantes University Hospital | not stated | Not stated |
| NCT01215838 | MRI of the Liver With Eovist | — | terminated | Oct 7, 2010 | University of Washington | Unable to meet enrollment expectations. | Enrollment / accrual |
| NCT01618253 | Radiation Therapy With Sorafenib for TACE-Resistant Hepatocellular Carcinoma | Phase 1 | withdrawn | Jun 13, 2012 | Medical College of Wisconsin | Closed due to poor accrual. | Enrollment / accrual |
| NCT00862082 | Randomized Phase 1/2 Open-Label Trial of PR104 and Sorafenib in Patients With Advanced… | Phase 1 / Phase 2 | terminated | Mar 16, 2009 | Proacta, Incorporated | PR104 plus sorafenib was poorly tolerated in patients with advanced HCC | Other (stated, no rule matched) |
| NCT01466504 | Effect of Sorafenib or Regorafenib on P63 Expression and Keratinocyte Differentiation in… | — | terminated | Nov 8, 2011 | Dartmouth-Hitchcock Medical Center | Accrual did not meet expectations. Over nearly 2 years just 4 subjects were treated on study. The… | Enrollment / accrual |
| NCT00828594 | Global Study Looking at the Combination of RAD001 and Sorafenib to Treat Patients With… | Phase 1 | terminated | Jan 26, 2009 | Novartis Pharmaceuticals | not stated | Not stated |
| NCT00405873 | Study to Evaluate Tumour Response in Cancer Patients With Advanced Hepatocellular… | Phase 2 | terminated | Nov 30, 2006 | Auron Healthcare GmbH | Lack of efficacy | Efficacy / futility |
Stop reasons are registrant-reported free text and are displayed verbatim (truncated; hover for the full text). Categories come from explicit keyword rules and are never inferred from the study design, sponsor or outcome; a study that stopped for several reasons is filed under the first rule that matched. A TERMINATED status does not imply a negative result.
Data updated 23 days agoSource updated Sep 27, 2016source: clinicaltrials