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Clinical trials · failure tracking
Oncology studies whose overall status is TERMINATED, WITHDRAWN or SUSPENDED on ClinicalTrials.gov, with the stop reason exactly as the registrant posted it. A category is attached only when an explicit keyword rule matches the text; CancerIndex never infers why a study stopped.
1,441 stopped studies mapped to Leukemia and descendants · 87% state a reason
Over the 1,441 studies matching the cancer, status and year filters (the category filter does not change this chart). Each study is counted once, in the first matching category; greyed bars are studies whose text matched no rule or was empty.
Computedrules ci-stop-reasons-v1 · keyword matching only
A category is assigned when one of its keywords appears in the posted text (case-insensitive, whole words). Rules are tested in this order and the first match wins; every match is kept in the API (reasonMatches).
| NCT | Title | Phase | Status | First posted | Lead sponsor | Why stopped (as posted) | Category |
|---|---|---|---|---|---|---|---|
| NCT01794169 | Azacitidine Compared to Conventional Chemotherapy as Consolidation of Elderly Patients… | Phase 2 | terminated | Feb 18, 2013 | Karolinska University Hospital | Poor recruitment | Enrollment / accrual |
| NCT02338050 | Moxetumomab Pasudotox (CAT-8015, HA22) in Children With B-lineage Acute Lymphoblastic… | Phase 2 | terminated | Jan 14, 2015 | Center for International Blood and Marrow Transplant Research | not stated | Not stated |
| NCT01615146 | Outpatient Platelet Transfusions in Myelodysplastic Syndromes and Leukemia: The OPTIMAL…(OPTIMAL) | N/A | terminated | Jun 8, 2012 | Ottawa Hospital Research Institute | Poor recruitment | Enrollment / accrual |
| NCT00569179 | A Phase I Trial of Alloreactive Cell Infusion Following Transplantation of Haplotype… | Phase 1 | terminated | Dec 7, 2007 | Indiana University | Slow accrual | Enrollment / accrual |
| NCT00446173 | Autologous Stem Cell Transplants for Chronic Myelogenous Leukemia | Phase 2 | withdrawn | Mar 12, 2007 | M.D. Anderson Cancer Center | Terminated due to low accrual. | Enrollment / accrual |
| NCT00464113 | Study of XL228 in Subjects With Chronic Myeloid Leukemia or… | Phase 1 | terminated | Apr 20, 2007 | Exelixis | Sponsor decision | Sponsor / business decision |
| NCT01260714 | Azacitidine, Mitoxantrone Hydrochloride, and Etoposide in Treating Older Patients With… | Phase 1 | terminated | Dec 15, 2010 | National Cancer Institute (NCI) | Inadequate accrual rate | Enrollment / accrual |
| NCT02109224 | Ibrutinib in Treating Relapsed or Refractory B-Cell Non-Hodgkin Lymphoma in Patients With… | Phase 1 | terminated | Apr 9, 2014 | National Cancer Institute (NCI) | Inadequate accrual rate | Enrollment / accrual |
| NCT00004040 | Monoclonal Antibody Therapy or Biological Therapy in Treating Patients With Chronic… | Phase 2 | withdrawn | Aug 5, 2004 | Hoag Memorial Hospital Presbyterian | no patient accruals | Enrollment / accrual |
| NCT01489722 | Safety, Tolerability, Pharmacokinetics and Efficacy of AZD1208 in Acute Myelogenous… | Phase 1 | terminated | Dec 12, 2011 | AstraZeneca | not stated | Not stated |
| NCT00871546 | SCH 727965 in Patients With Mantle Cell Lymphoma or B-Cell Chronic Lymphocytic Leukemia… | Phase 2 | terminated | Mar 30, 2009 | Merck Sharp & Dohme LLC | not stated | Not stated |
| NCT01642563 | Italian Platelet Technology Assessment Study(IPTAS) | Phase 3 | terminated | Jul 17, 2012 | Centro Nazionale Sangue | Patient enrolment below planned schedule | Enrollment / accrual |
| NCT01908387 | Phase 1 Study of CC-486 in Japanese Subjects With Hematological Neoplasms | Phase 1 | terminated | Jul 25, 2013 | Celgene Corporation | Due to Slow Accrual study was terminated. | Enrollment / accrual |
| NCT00363779 | Effect of Cyclosporine Therapy on Gene Expression in Patients With Large Granular… | Phase 2 | terminated | Aug 15, 2006 | National Cancer Institute (NCI) | Study terminated due to low accrual and the investigator left the NIH. | Investigator |
| NCT02114827 | Efficacy of a Patient Education Video | N/A | terminated | Apr 15, 2014 | Virginia Commonwealth University | study closed due to slow accrual | Enrollment / accrual |
| NCT00905398 | Nilotinib With Chemotherapy for the Treatment of Philadelphia Chromosome Positive Acute…(ALLPhi) | Phase 1 / Phase 2 | terminated | May 20, 2009 | Rony Schaffel | The study was terminated due to excessive toxicity and low compliance to the protocol scheme. | Safety / toxicity |
| NCT00374296 | MGCD0103 in Elderly Patients With Previously Untreated AML/High Risk MDS or Adults With… | Phase 2 | terminated | Sep 11, 2006 | Mirati Therapeutics Inc. | The Clinical Development Program for MGCD0103 is being re-evaluated | Other (stated, no rule matched) |
| NCT00413478 | 5-Azacytidine (Azacytidine; Vidaza) in Chronic Lymphocytic Leukemia | Phase 2 | terminated | Dec 19, 2006 | M.D. Anderson Cancer Center | Slow accrual. | Enrollment / accrual |
| NCT00771602 | Alemtuzumab + Rituximab Consolidation in CLL | Phase 2 | terminated | Oct 13, 2008 | M.D. Anderson Cancer Center | Lack of accrual. | Enrollment / accrual |
| NCT00963495 | Study Evaluating the Tolerance and Biological Activity of Oral Clioquinol in Patients… | Phase 1 | terminated | Aug 21, 2009 | University Health Network, Toronto | not stated | Not stated |
| NCT01222143 | Safety and Efficacy Study of Nilotinib Combined With Mitoxantrone, Etoposide, and… | Phase 1 / Phase 2 | terminated | Oct 18, 2010 | University Health Network, Toronto | not stated | Not stated |
| NCT01521936 | Cholecalciferol in Treating Patients With Acute Myeloid Leukemia Undergoing Intensive… | Phase 2 | terminated | Jan 31, 2012 | Roswell Park Cancer Institute | Lack of funding | Funding |
| NCT01204788 | Prophylactic White Cell Transfusions Versus Therapeutic White Cell Transfusions in… | Phase 2 | terminated | Sep 17, 2010 | M.D. Anderson Cancer Center | Low Recruitment | Enrollment / accrual |
| NCT00800150 | Total Marrow and Total Lymph Node Irradiation, Fludarabine, and Melphalan Followed By… | Phase 1 | terminated | Dec 1, 2008 | City of Hope Medical Center | Protocol objective could not be met. A new study with amended eligibility criteria will be… | Other (stated, no rule matched) |
| NCT00952185 | Influenza Vaccine in Preventing Flu in Patients Who Have Undergone Stem Cell Transplant… | N/A | terminated | Aug 6, 2009 | City of Hope Medical Center | Very low enrollment and follow-up, cannot meet study objectives | Enrollment / accrual |
| NCT01271283 | Lenalidomide in Treating Patients With High-Risk Chronic Lymphocytic Leukemia | Phase 2 | withdrawn | Jan 6, 2011 | National Cancer Institute (NCI) | not stated | Not stated |
| NCT00500240 | Effect of Tight Control of Blood Glucose During Hyper-CVAD Chemotherapy For Acute… | Phase 3 | terminated | Jul 12, 2007 | M.D. Anderson Cancer Center | Terminated early due to futility. | Efficacy / futility |
| NCT00770419 | Perceptions of Burden in Patients With Late-Stage Cancer and Their Caregivers | — | withdrawn | Oct 10, 2008 | Rutgers, The State University of New Jersey | Slow accrual | Enrollment / accrual |
| NCT01397149 | Eltrombopag in Thrombocytopenic Chronic Lymphocytic Leukemia (CLL) Patients (CLL2S Study… | Phase 1 / Phase 2 | terminated | Jul 19, 2011 | University of Ulm | Insufficient recruitment | Enrollment / accrual |
| NCT00100152 | A Notch Signalling Pathway Inhibitor for Patients With T-cell Acute Lymphoblastic… | Phase 1 | terminated | Dec 24, 2004 | Merck Sharp & Dohme LLC | not stated | Not stated |
| NCT01130688 | Safety of Zileuton (Zyflo) in Combination With Imatinib Mesylate (Gleevec) in CML. | Phase 1 | terminated | May 26, 2010 | University of Massachusetts, Worcester | Lack of enrollment | Enrollment / accrual |
| NCT02310997 | Myloablative Cord Blood Transplant in Haematological Malignancies (MAC UCBT)(MAC UCBT) | Phase 2 | terminated | Dec 8, 2014 | University College, London | Trial closed early due to poor recruitment | Enrollment / accrual |
| NCT01188889 | RAD001 in Patients With Chronic Phase Chronic Myeloid Leukemia w/ Molecular Disease. | Phase 1 / Phase 2 | withdrawn | Aug 26, 2010 | University of Michigan Rogel Cancer Center | Unable to obtain sufficient funding. | Funding |
| NCT01463852 | A Study of the Effect of Vinca Alkaloids on c-Jun N-terminal Kinase (JNK) Phosphorylation… | Early Phase 1 | terminated | Nov 2, 2011 | Dartmouth-Hitchcock Medical Center | Enrollment underperformance. | Enrollment / accrual |
| NCT00666497 | Phase 2 Study of Azacitidine (Vidaza) vs MGCD0103 vs Combination in Elderly Subjects With… | Phase 2 | terminated | Apr 25, 2008 | Mirati Therapeutics Inc. | Celgene terminated its collaboration agreement with MethylGene for the development of MGCD0103. All… | Other (stated, no rule matched) |
| NCT00944008 | PROCEDYTE: Depocyte® Administration (Liposomal Cytarabine) as Prophylaxis of…(2009-009422-92) | Phase 3 | terminated | Jul 22, 2009 | PETHEMA Foundation | not stated | Not stated |
| NCT01769911 | Genetically Modified Peripheral Blood Stem Cell Transplant in Treating Patients With… | N/A | withdrawn | Jan 17, 2013 | Fred Hutchinson Cancer Center | not stated | Not stated |
| NCT00262925 | Combination Chemotherapy and Alemtuzumab in Treating Patients With Relapsed or Refractory… | Phase 2 | terminated | Dec 7, 2005 | National Cancer Institute (NCI) | slow accrual | Enrollment / accrual |
| NCT01392170 | Pegasys in Patients With Chronic Myeloid Leukemia (CML) | Phase 2 | terminated | Jul 12, 2011 | M.D. Anderson Cancer Center | Slow Accrual | Enrollment / accrual |
| NCT00109538 | Study of Lonafarnib Versus Placebo in Subjects With Either Myelodysplastic Syndrome (MDS)… | Phase 3 | terminated | Apr 29, 2005 | Merck Sharp & Dohme LLC | not stated | Not stated |
| NCT00024115 | BL22 Immunotoxin in Treating Patients With Non-Hodgkin's Lymphoma or Chronic Lymphocytic… | Phase 1 | withdrawn | Jan 27, 2003 | National Cancer Institute (NCI) | not stated | Not stated |
| NCT00669890 | Allogenic Stem Cell Transplantation in Patients With High Risk CD33+ AML/MDS/JMML(High Risk) | Phase 1 | terminated | May 1, 2008 | New York Medical College | PI left institution | Investigator |
| NCT00093314 | HuMax-CD20 in Chronic Lymphocytic Leukemia | Phase 1 / Phase 2 | withdrawn | Oct 8, 2004 | GlaxoSmithKline | Acquired asset | Other (stated, no rule matched) |
| NCT01050439 | Unrelated Donor Transplant for Malignant and Non-Malignant Disorders | Phase 2 | terminated | Jan 15, 2010 | Columbia University | PI left the institution | Investigator |
| NCT00943553 | A Randomized Study of Epigenetic Priming Using Decitabine With Front Line Induction… | Phase 2 | withdrawn | Jul 22, 2009 | Eisai Inc. | Terminated by Sponsor | Other (stated, no rule matched) |
| NCT01065545 | The Role of Maintenance Oral Clofarabine in Older Adults With Acute Myeloid Leukemia | Phase 1 | withdrawn | Feb 9, 2010 | Northwestern University | Due to funding issues. | Funding |
| NCT00549835 | Acupuncture for Mucositis Pain in Cancer Care | N/A | withdrawn | Oct 26, 2007 | Johns Hopkins University | Inadequate funding | Funding |
| NCT01203228 | Dose-reduced Versus Standard Conditioning in MDS/sAML(RICMAC) | Phase 3 | terminated | Sep 16, 2010 | European Society for Blood and Marrow Transplantation | not stated | Not stated |
| NCT01488253 | Sirolimus/Tacrolimus Combination After HLA Matched Related Peripheral Blood Stem Cell… | Phase 2 | terminated | Dec 8, 2011 | The Korean Society of Blood and Marrow Transplantation | We could not receive the support from the national medical insurance owing to the changed policy of… | Other (stated, no rule matched) |
| NCT01100658 | Effects of Methylphenidate on Attention Deficits in Childhood Cancer Survivors | N/A | terminated | Apr 9, 2010 | University of Minnesota | Due to slow accrual | Enrollment / accrual |
Stop reasons are registrant-reported free text and are displayed verbatim (truncated; hover for the full text). Categories come from explicit keyword rules and are never inferred from the study design, sponsor or outcome; a study that stopped for several reasons is filed under the first rule that matched. A TERMINATED status does not imply a negative result.
Data updated 23 days agoSource updated Sep 22, 2015source: clinicaltrials