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Clinical trials · failure tracking
Oncology studies whose overall status is TERMINATED, WITHDRAWN or SUSPENDED on ClinicalTrials.gov, with the stop reason exactly as the registrant posted it. A category is attached only when an explicit keyword rule matches the text; CancerIndex never infers why a study stopped.
975 stopped studies mapped to Digestive System Carcinoma and descendants · 93% state a reason
Over the 975 studies matching the cancer, status and year filters (the category filter does not change this chart). Each study is counted once, in the first matching category; greyed bars are studies whose text matched no rule or was empty.
Computedrules ci-stop-reasons-v1 · keyword matching only
A category is assigned when one of its keywords appears in the posted text (case-insensitive, whole words). Rules are tested in this order and the first match wins; every match is kept in the API (reasonMatches).
| NCT | Title | Phase | Status | First posted | Lead sponsor | Why stopped (as posted) | Category |
|---|---|---|---|---|---|---|---|
| NCT01128803 | Immunotherapy of Hepatocellular Carcinoma by Induction of Anti-alpha Fetoprotein Response | Phase 1 / Phase 2 | terminated | May 24, 2010 | Nantes University Hospital | not stated | Not stated |
| NCT01215838 | MRI of the Liver With Eovist | — | terminated | Oct 7, 2010 | University of Washington | Unable to meet enrollment expectations. | Enrollment / accrual |
| NCT01192763 | RO4929097 Before Surgery in Treating Patients With Pancreatic Cancer | Phase 1 | terminated | Sep 1, 2010 | National Cancer Institute (NCI) | not stated | Not stated |
| NCT01705340 | Akt Inhibitor MK2206, Lapatinib Ditosylate, and Trastuzumab in Treating Patients With… | Phase 1 | terminated | Oct 12, 2012 | National Cancer Institute (NCI) | not stated | Not stated |
| NCT01618253 | Radiation Therapy With Sorafenib for TACE-Resistant Hepatocellular Carcinoma | Phase 1 | withdrawn | Jun 13, 2012 | Medical College of Wisconsin | Closed due to poor accrual. | Enrollment / accrual |
| NCT00862082 | Randomized Phase 1/2 Open-Label Trial of PR104 and Sorafenib in Patients With Advanced… | Phase 1 / Phase 2 | terminated | Mar 16, 2009 | Proacta, Incorporated | PR104 plus sorafenib was poorly tolerated in patients with advanced HCC | Other (stated, no rule matched) |
| NCT01830322 | Safety and Effectiveness Study of CPI-613 and/or Gemcitabine to Treat Metastatic… | Phase 2 | withdrawn | Apr 12, 2013 | Cornerstone Pharmaceuticals | not stated | Not stated |
| NCT00708877 | Liver Transplantation for Cholangiocarcinoma | N/A | terminated | Jul 2, 2008 | University of Utah | study procedures have become standard of care as patients seeking Model for End-Stage Liver Disease… | Other (stated, no rule matched) |
| NCT00026468 | Exisulind in Preventing Polyps in Patients With Familial Adenomatous Polyposis | Phase 2 / Phase 3 | withdrawn | Jan 27, 2003 | University of Utah | Principle Investigator has left the University. | Investigator |
| NCT00003486 | Antineoplaston Therapy in Treating Patients With Colon Cancer | Phase 2 | withdrawn | Jan 27, 2003 | Burzynski Research Institute | not stated | Not stated |
| NCT00003514 | Antineoplaston Therapy in Treating Patients With Neuroendocrine Tumor That Is Metastatic… | Phase 2 | withdrawn | Jan 27, 2003 | Burzynski Research Institute | not stated | Not stated |
| NCT00896467 | Psychological and Emotional Impact in Patients Undergoing Treatment For Metastatic Cancer… | — | terminated | May 11, 2009 | Centre Oscar Lambret | not stated | Not stated |
| NCT00098527 | FR901228 in Treating Patients With Refractory Stomach Cancer or Gastroesophageal Junction… | Phase 2 | terminated | Dec 8, 2004 | National Cancer Institute (NCI) | not stated | Not stated |
| NCT01257035 | Predictive Value of 18F-FAZA in Rectum Cancer(FAZA) | — | terminated | Dec 9, 2010 | Vejle Hospital | The logistics of this trial (incl. supply of tracer) in connection with the patients' treatment… | Drug supply |
| NCT00084461 | Romidepsin in Treating Patients With Locally Advanced or Metastatic Neuroendocrine Tumors | Phase 2 | terminated | Jun 11, 2004 | National Cancer Institute (NCI) | not stated | Not stated |
| NCT01859169 | Safety and Efficiency of Photodynamic Therapy for Blie Duct Carcinoma | — | suspended | May 21, 2013 | li xiong | Modifying the clinnicaltrials | Other (stated, no rule matched) |
| NCT00012246 | Vaccine Therapy in Treating Patients With Cancer of the Gastrointestinal Tract | Phase 2 | terminated | Jan 27, 2003 | The University of Texas Medical Branch, Galveston | Administratively Terminated | Other (stated, no rule matched) |
| NCT01466504 | Effect of Sorafenib or Regorafenib on P63 Expression and Keratinocyte Differentiation in… | — | terminated | Nov 8, 2011 | Dartmouth-Hitchcock Medical Center | Accrual did not meet expectations. Over nearly 2 years just 4 subjects were treated on study. The… | Enrollment / accrual |
| NCT00828594 | Global Study Looking at the Combination of RAD001 and Sorafenib to Treat Patients With… | Phase 1 | terminated | Jan 26, 2009 | Novartis Pharmaceuticals | not stated | Not stated |
| NCT01329809 | Neoadjuvant Study of Recombinant Vaccinia Virus to Treat Metastatic Colorectal Carcinoma… | Phase 2 | terminated | Apr 6, 2011 | Jennerex Biotherapeutics | not stated | Not stated |
| NCT00405561 | Study to Evaluate Progression Free Survival in Cancer Patients With Advanced Colorectal… | Phase 2 / Phase 3 | terminated | Nov 30, 2006 | Auron Healthcare GmbH | Lack of efficacy | Efficacy / futility |
| NCT00405873 | Study to Evaluate Tumour Response in Cancer Patients With Advanced Hepatocellular… | Phase 2 | terminated | Nov 30, 2006 | Auron Healthcare GmbH | Lack of efficacy | Efficacy / futility |
| NCT00959946 | Study Of Bosutinib With Capecitabine In Solid Tumors And Locally Advanced Or Metastatic… | Phase 1 / Phase 2 | terminated | Aug 17, 2009 | Pfizer | not stated | Not stated |
| NCT01401387 | Pancreatic Enzyme Suppletion in Pancreatic Cancer(EPC) | Phase 4 | withdrawn | Jul 25, 2011 | Foundation for Liver Research | study never started | Other (stated, no rule matched) |
| NCT00002796 | Phase I-II Study of Fluorouracil in Combination With Phenylbutyrate in Advanced… | Phase 1 / Phase 2 | terminated | Jan 27, 2003 | National Cancer Institute (NCI) | Administratively complete. | Other (stated, no rule matched) |
| NCT00070122 | Combination Chemotherapy and Bevacizumab in Treating Patients With Locally Advanced,… | Phase 3 | terminated | Oct 7, 2003 | National Cancer Institute (NCI) | Administratively complete. | Other (stated, no rule matched) |
| NCT00047333 | Erlotinib in Treating Patients With Liver Cancer That Cannot be Surgically Removed | Phase 2 | terminated | Jan 27, 2003 | National Cancer Institute (NCI) | Administratively complete. | Other (stated, no rule matched) |
| NCT00061958 | Arsenic Trioxide in Treating Patients With Advanced Cancer of the Esophagus or… | Phase 2 | terminated | Jun 6, 2003 | National Cancer Institute (NCI) | Administratively complete. | Other (stated, no rule matched) |
| NCT01619696 | Prospective Pilot Study of Multimodal Radiological Evaluation Feasibility During… | Phase 2 | terminated | Jun 14, 2012 | University Hospital, Toulouse | Insufficient recruitment | Enrollment / accrual |
| NCT00052585 | Gefitinib and Combination Chemotherapy in Treating Patients With Advanced or Recurrent… | Phase 2 | terminated | Jan 27, 2003 | National Cancer Institute (NCI) | Administratively complete. | Other (stated, no rule matched) |
| NCT00087191 | EF5 and Motexafin Lutetium in Detecting Tumor Cells in Patients With Abdominal or… | N/A | terminated | Jul 12, 2004 | National Cancer Institute (NCI) | Administratively complete. | Other (stated, no rule matched) |
| NCT00699374 | Study Of Sunitinib Malate Versus Sorafenib In Patients With Inoperable Liver Cancer | Phase 3 | terminated | Jun 18, 2008 | Pfizer | See termination reason in detailed description. | Other (stated, no rule matched) |
| NCT00288444 | Interaction of Docetaxel and Lonafarnib in Patients With Advanced Cancer | Phase 1 | terminated | Feb 8, 2006 | Emory University | not stated | Not stated |
| NCT01071434 | Feasibility of Using Real-time Cine-MRI for Treating Moving & Deforming Tumors | — | terminated | Feb 19, 2010 | Stanford University | PI left | Investigator |
| NCT00966251 | Safety and Tolerability Study of the Monoclonal Antibody CT-011 in Patients With… | Phase 1 / Phase 2 | terminated | Aug 26, 2009 | CureTech Ltd | The study was stopped because of slow accrual | Enrollment / accrual |
| NCT01009593 | Efficacy and Tolerability of ABT-869 Versus Sorafenib in Advanced Hepatocellular… | Phase 3 | terminated | Nov 6, 2009 | Abbott | See termination reason in detailed description | Other (stated, no rule matched) |
| NCT00838968 | The Efficiency of Postoperative Interferon-alpha Treatment in p48 Positive Patients With… | N/A | withdrawn | Feb 9, 2009 | Fudan University | we have found another marker (microRNA26) which is more sensitive to evaluate the effect of… | Other (stated, no rule matched) |
| NCT00713687 | Gemcitabine/Oxaliplatin and Photodynamic Therapy in Cholangiocarcinoma(GemOx-PDT) | Phase 2 | withdrawn | Jul 11, 2008 | Technical University of Munich | recruiting failed | Enrollment / accrual |
| NCT00426829 | Proton Therapy and Bevacizumab for Primary Liver Tumors | Phase 1 | terminated | Jan 25, 2007 | M.D. Anderson Cancer Center | Low Accural | Other (stated, no rule matched) |
| NCT00562666 | Immunotherapy of Hepatocellular Carcinoma With Gamma Delta T Cells(ICAR) | Phase 1 | terminated | Nov 22, 2007 | Rennes University Hospital | not stated | Not stated |
| NCT01327521 | Transarterial Chemoembolization vs CyberKnife for Recurrent Hepatocellular Carcinoma | Phase 3 | withdrawn | Apr 1, 2011 | Albert Koong | Accrual below target levels | Enrollment / accrual |
| NCT00618384 | TACE and Sorafenib for Advanced Hepatocellular Carcinoma (HCC)(SOCRATES) | Phase 2 | terminated | Feb 20, 2008 | Heinrich-Heine University, Duesseldorf | not stated | Not stated |
| NCT01031056 | Collection of Biospecimen & Clinical Information in Patients w/ Gastrointestinal Cancers | — | withdrawn | Dec 14, 2009 | Stanford University | Change in research focus | Other (stated, no rule matched) |
| NCT01194206 | Stereotactic Body Radiation Therapy in Liver Cancer That Cannot be Removed by Surgery or… | Phase 2 | withdrawn | Sep 2, 2010 | Case Comprehensive Cancer Center | Study being rewritten | Other (stated, no rule matched) |
| NCT01337492 | Pilot Study Sorafenib as Bridge to Orthotopic Liver Transplantation (OLT) | Early Phase 1 | terminated | Apr 19, 2011 | Case Comprehensive Cancer Center | slow accrual | Enrollment / accrual |
| NCT00151671 | Effect of a Perioperative Oral Nutritional Supplementation on Patients Undergoing Hepatic…(IMPACT) | Phase 2 / Phase 3 | terminated | Sep 9, 2005 | Rennes University Hospital | insufficient enrollment rate | Enrollment / accrual |
| NCT01318200 | Transarterial Chemoembolization (TACE) vs. CyberKnife for Recurrent Hepatocellular… | Phase 3 | withdrawn | Mar 18, 2011 | Accuray Incorporated | not stated | Not stated |
| NCT01441388 | A Study Of Crizotinib Plus VEGF Inhibitor Combinations In Patients With Advanced Solid… | Phase 1 | withdrawn | Sep 27, 2011 | Pfizer | Business/Operational issues | Sponsor / business decision |
| NCT00593008 | Temsirolimus in Combination With Gemcitabine in Previously Untreated Metastatic… | Phase 1 | terminated | Jan 14, 2008 | Massachusetts General Hospital | not stated | Not stated |
| NCT01245582 | Oxaliplatin and Capecitabine on Top of Sorafenib Versus Sorafenib Alone in Advanced…(SECOX) | Phase 3 | withdrawn | Nov 22, 2010 | Sanofi | not stated | Not stated |
Stop reasons are registrant-reported free text and are displayed verbatim (truncated; hover for the full text). Categories come from explicit keyword rules and are never inferred from the study design, sponsor or outcome; a study that stopped for several reasons is filed under the first rule that matched. A TERMINATED status does not imply a negative result.
Data updated 23 days agoSource updated Nov 7, 2013source: clinicaltrials