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Clinical trials · failure tracking
Oncology studies whose overall status is TERMINATED, WITHDRAWN or SUSPENDED on ClinicalTrials.gov, with the stop reason exactly as the registrant posted it. A category is attached only when an explicit keyword rule matches the text; CancerIndex never infers why a study stopped.
3,703 stopped studies mapped to Carcinoma and descendants · 91% state a reason
Over the 3,703 studies matching the cancer, status and year filters (the category filter does not change this chart). Each study is counted once, in the first matching category; greyed bars are studies whose text matched no rule or was empty.
Computedrules ci-stop-reasons-v1 · keyword matching only
A category is assigned when one of its keywords appears in the posted text (case-insensitive, whole words). Rules are tested in this order and the first match wins; every match is kept in the API (reasonMatches).
| NCT | Title | Phase | Status | First posted | Lead sponsor | Why stopped (as posted) | Category |
|---|---|---|---|---|---|---|---|
| NCT00816686 | A Phase 1 Study of the Safety and Pharmacokinetics of AGS-16M18 in Subjects With Advanced… | Phase 1 | terminated | Jan 5, 2009 | Astellas Pharma Inc | Trial was terminated due to the need to re-formulate the study drug. | Other (stated, no rule matched) |
| NCT01016054 | A Study of the Safety and Pharmacokinetics of AGS-8M4 Given in Combination With… | Phase 1 | terminated | Nov 18, 2009 | Astellas Pharma Inc | Trial was terminated to allow sponsors to evaluate the future development of the drug program | Other (stated, no rule matched) |
| NCT00977561 | A Study Of Cisplatin (Or Carboplatin) And Etoposide With Or Without Figitumumab… | Phase 2 | terminated | Sep 15, 2009 | Pfizer | See termination reason in detailed description. | Other (stated, no rule matched) |
| NCT01500824 | A Clinical Study Testing The Safety And Efficacy Of Crizotinib In East Asian Patients… | Phase 2 | withdrawn | Dec 28, 2011 | Pfizer | not stated | Not stated |
| NCT00959946 | Study Of Bosutinib With Capecitabine In Solid Tumors And Locally Advanced Or Metastatic… | Phase 1 / Phase 2 | terminated | Aug 17, 2009 | Pfizer | not stated | Not stated |
| NCT01401387 | Pancreatic Enzyme Suppletion in Pancreatic Cancer(EPC) | Phase 4 | withdrawn | Jul 25, 2011 | Foundation for Liver Research | study never started | Other (stated, no rule matched) |
| NCT00705549 | Individualized Therapy Based of Tumoral mRNA Levels of ERCC1, RRM1 and BRCA1 in Advanced… | Phase 2 | terminated | Jun 26, 2008 | Hellenic Oncology Research Group | Due to poor accrual | Enrollment / accrual |
| NCT00002796 | Phase I-II Study of Fluorouracil in Combination With Phenylbutyrate in Advanced… | Phase 1 / Phase 2 | terminated | Jan 27, 2003 | National Cancer Institute (NCI) | Administratively complete. | Other (stated, no rule matched) |
| NCT00039455 | Trastuzumab and Flavopiridol in Treating Patients With Metastatic Breast Cancer | Phase 1 | terminated | Jan 27, 2003 | National Cancer Institute (NCI) | Administratively complete. | Other (stated, no rule matched) |
| NCT00042835 | Erlotinib and Radiation Therapy Plus Combination Chemotherapy in Treating Patients With… | Phase 1 | terminated | Jan 27, 2003 | National Cancer Institute (NCI) | Administratively complete. | Other (stated, no rule matched) |
| NCT00090675 | Maintenance ZD1839 (IRESSA®) Following Completion of Front Line, Platinum-Based, Double…(IMAC/Herbst) | Phase 3 | withdrawn | Sep 3, 2004 | AstraZeneca | No patients randomised | Other (stated, no rule matched) |
| NCT00033449 | Gefitinib and Radiation Therapy With or Without Cisplatin in Treating Patients With Stage… | Phase 1 | terminated | Jan 27, 2003 | National Cancer Institute (NCI) | Administratively complete. | Other (stated, no rule matched) |
| NCT00070122 | Combination Chemotherapy and Bevacizumab in Treating Patients With Locally Advanced,… | Phase 3 | terminated | Oct 7, 2003 | National Cancer Institute (NCI) | Administratively complete. | Other (stated, no rule matched) |
| NCT00005039 | Vaccine Therapy in Treating Patients With Advanced Adenocarcinoma of the Prostate… | Phase 2 | terminated | Jan 27, 2003 | National Cancer Institute (NCI) | Administratively complete. | Other (stated, no rule matched) |
| NCT00081211 | Intratumoral PV701 in Treating Patients With Advanced or Recurrent Unresectable Squamous… | Phase 1 | terminated | Apr 8, 2004 | National Cancer Institute (NCI) | Administratively complete. | Other (stated, no rule matched) |
| NCT00776295 | Autologous SCT Followed by Dendritic Cell p53 Vaccination in Patients With Limited Stage… | Phase 2 | terminated | Oct 21, 2008 | H. Lee Moffitt Cancer Center and Research Institute | Low accrual | Enrollment / accrual |
| NCT00009919 | SU5416 in Treating Patients With Metastatic Kidney Cancer That Has Not Responded to… | Phase 2 | terminated | Jan 1, 2004 | National Cancer Institute (NCI) | Administratively complete. | Other (stated, no rule matched) |
| NCT00047333 | Erlotinib in Treating Patients With Liver Cancer That Cannot be Surgically Removed | Phase 2 | terminated | Jan 27, 2003 | National Cancer Institute (NCI) | Administratively complete. | Other (stated, no rule matched) |
| NCT00061958 | Arsenic Trioxide in Treating Patients With Advanced Cancer of the Esophagus or… | Phase 2 | terminated | Jun 6, 2003 | National Cancer Institute (NCI) | Administratively complete. | Other (stated, no rule matched) |
| NCT01619696 | Prospective Pilot Study of Multimodal Radiological Evaluation Feasibility During… | Phase 2 | terminated | Jun 14, 2012 | University Hospital, Toulouse | Insufficient recruitment | Enrollment / accrual |
| NCT00005067 | Photodynamic Therapy With Lutetium Texaphyrin in Treating Patients With Locally Recurrent… | Phase 1 | terminated | Jan 27, 2003 | National Cancer Institute (NCI) | Administratively complete. | Other (stated, no rule matched) |
| NCT00016276 | Combination Chemotherapy, Surgery, and Radiation Therapy With or Without Dexrazoxane and… | Phase 3 | terminated | Sep 4, 2003 | National Cancer Institute (NCI) | Administratively complete. | Other (stated, no rule matched) |
| NCT00040768 | Bortezomib in Treating Patients With Advanced Non-small Cell Lung Cancer | Phase 2 | terminated | Jan 27, 2003 | National Cancer Institute (NCI) | Administratively complete. | Other (stated, no rule matched) |
| NCT00052585 | Gefitinib and Combination Chemotherapy in Treating Patients With Advanced or Recurrent… | Phase 2 | terminated | Jan 27, 2003 | National Cancer Institute (NCI) | Administratively complete. | Other (stated, no rule matched) |
| NCT00087191 | EF5 and Motexafin Lutetium in Detecting Tumor Cells in Patients With Abdominal or… | N/A | terminated | Jul 12, 2004 | National Cancer Institute (NCI) | Administratively complete. | Other (stated, no rule matched) |
| NCT00095888 | 3-AP and Gemcitabine in Treating Patients With Refractory Metastatic Breast Cancer | Phase 2 | terminated | Nov 9, 2004 | National Cancer Institute (NCI) | Administratively complete. | Other (stated, no rule matched) |
| NCT00699374 | Study Of Sunitinib Malate Versus Sorafenib In Patients With Inoperable Liver Cancer | Phase 3 | terminated | Jun 18, 2008 | Pfizer | See termination reason in detailed description. | Other (stated, no rule matched) |
| NCT01245660 | A Phase 0 of Neoadjuvant Lapatinib in Infiltrative Bladder Carcinoma Before Cystectomy(LAPAINBLAD) | Early Phase 1 | terminated | Nov 22, 2010 | University Hospital, Bordeaux | The rythm of enrollment was not compatible with the objective of recruitement in the research. | Enrollment / accrual |
| NCT00862134 | Randomized, Multi-center, Open-label, Study of PR104 Versus PR104/Docetaxel in Non-Small… | Phase 2 | terminated | Mar 16, 2009 | Proacta, Incorporated | Interim analysis indicated low probability of clinically significant result | Efficacy / futility |
| NCT00512668 | Hormone Therapy and Temsirolimus in Treating Patients With Relapsed Prostate Cancer | Phase 1 | terminated | Aug 8, 2007 | National Cancer Institute (NCI) | not stated | Not stated |
| NCT00288444 | Interaction of Docetaxel and Lonafarnib in Patients With Advanced Cancer | Phase 1 | terminated | Feb 8, 2006 | Emory University | not stated | Not stated |
| NCT01015664 | Combination of Cisplatin, Cetuximab and Temsirolimus in Recurrent or Metastatic Squamous… | Phase 1 / Phase 2 | terminated | Nov 18, 2009 | University of Tennessee Cancer Institute | not stated | Not stated |
| NCT00817362 | Efficacy and Safety of IPI-504 With Trastuzumab Pretreated, Locally Advanced or… | Phase 2 | terminated | Jan 6, 2009 | Infinity Pharmaceuticals, Inc. | Limited efficacy response observed during interim analysis. | Efficacy / futility |
| NCT01071434 | Feasibility of Using Real-time Cine-MRI for Treating Moving & Deforming Tumors | — | terminated | Feb 19, 2010 | Stanford University | PI left | Investigator |
| NCT01004510 | Zometa Adjuvant Treatment of Malignant Pleural Effusion Due To Non-Small Cell Lung Cancer(ZAP) | Phase 2 | terminated | Oct 30, 2009 | Peter Bushunow MD | failure to accrue projected number of patients | Enrollment / accrual |
| NCT01415986 | Interstitial Photodynamic Therapy (PDT) With Temoporfin for Advanced Head and Neck Cancers | Phase 2 | terminated | Aug 12, 2011 | University of Arkansas | The patient was "lost to follow-up" and the PI left the institution. | Investigator |
| NCT00427102 | MRX, Radiation, and Chemotherapy for Patients With Resected Squamous Cell Carcinoma of… | Phase 1 | terminated | Jan 26, 2007 | Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | No subjects enrolled and PI went to another facility | Enrollment / accrual |
| NCT01438021 | Continuous Intraventricular Methotrexate in Treating Patients With Leptomeningeal Disease | N/A | withdrawn | Sep 21, 2011 | City of Hope Medical Center | Lack of funding | Funding |
| NCT01124812 | 131I-L19SIP Radioimmunotherapy Combined With Radiochemotherapy in Patients With… | Phase 1 | terminated | May 17, 2010 | Philogen S.p.A. | not stated | Not stated |
| NCT00966251 | Safety and Tolerability Study of the Monoclonal Antibody CT-011 in Patients With… | Phase 1 / Phase 2 | terminated | Aug 26, 2009 | CureTech Ltd | The study was stopped because of slow accrual | Enrollment / accrual |
| NCT00002921 | S9427, Suramin in Treating Patients With Stage III or Stage IV Adrenocortical Cancer… | Phase 2 | terminated | Jul 30, 2004 | SWOG Cancer Research Network | Permanently Closed Due to Lack of Accrual | Enrollment / accrual |
| NCT01663415 | A Study to Evaluate the Safety and Efficacy of Enzalutamide in Chemotherapy-Naïve,… | Phase 2 | withdrawn | Aug 13, 2012 | Astellas Pharma Global Development, Inc. | A business decision was made to not initiate this study. | Sponsor / business decision |
| NCT01009593 | Efficacy and Tolerability of ABT-869 Versus Sorafenib in Advanced Hepatocellular… | Phase 3 | terminated | Nov 6, 2009 | Abbott | See termination reason in detailed description | Other (stated, no rule matched) |
| NCT00082459 | Trial to Compare the Routes of Administration of an Investigational, Personalized,… | Phase 2 | terminated | May 12, 2004 | Agenus Inc. | Lack of enrollment | Enrollment / accrual |
| NCT00126178 | Clinical Trial Studying a Personalized Cancer Vaccine in Patients With Non-metastatic… | Phase 3 | terminated | Aug 3, 2005 | Agenus Inc. | not stated | Not stated |
| NCT00694603 | Cetuximab as Therapy for Recurrent Non-Small Cell Lung Cancer Patients Who Have Received… | Phase 2 | terminated | Jun 10, 2008 | Lecia V. Sequist | Slow accrual | Enrollment / accrual |
| NCT00838968 | The Efficiency of Postoperative Interferon-alpha Treatment in p48 Positive Patients With… | N/A | withdrawn | Feb 9, 2009 | Fudan University | we have found another marker (microRNA26) which is more sensitive to evaluate the effect of… | Other (stated, no rule matched) |
| NCT00093132 | Satraplatin for Locally Advanced Non-Small Cell Lung Cancer With Simultaneous Radiotherapy | Phase 1 / Phase 2 | terminated | Oct 4, 2004 | Agennix | Sponsor decided to discontinue study drug development. | Sponsor / business decision |
| NCT01563601 | Efficacy and Safety of Obatoclax Mesylate in Combination With Carboplatin and Etoposide… | Phase 3 | withdrawn | Mar 27, 2012 | Cephalon | Business Decision | Sponsor / business decision |
| NCT00713687 | Gemcitabine/Oxaliplatin and Photodynamic Therapy in Cholangiocarcinoma(GemOx-PDT) | Phase 2 | withdrawn | Jul 11, 2008 | Technical University of Munich | recruiting failed | Enrollment / accrual |
Stop reasons are registrant-reported free text and are displayed verbatim (truncated; hover for the full text). Categories come from explicit keyword rules and are never inferred from the study design, sponsor or outcome; a study that stopped for several reasons is filed under the first rule that matched. A TERMINATED status does not imply a negative result.
Data updated 24 days agoSource updated Feb 27, 2013source: clinicaltrials