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Clinical trials · failure tracking
Oncology studies whose overall status is TERMINATED, WITHDRAWN or SUSPENDED on ClinicalTrials.gov, with the stop reason exactly as the registrant posted it. A category is attached only when an explicit keyword rule matches the text; CancerIndex never infers why a study stopped.
3,703 stopped studies mapped to Carcinoma and descendants · 91% state a reason
Over the 3,703 studies matching the cancer, status and year filters (the category filter does not change this chart). Each study is counted once, in the first matching category; greyed bars are studies whose text matched no rule or was empty.
Computedrules ci-stop-reasons-v1 · keyword matching only
A category is assigned when one of its keywords appears in the posted text (case-insensitive, whole words). Rules are tested in this order and the first match wins; every match is kept in the API (reasonMatches).
| NCT | Title | Phase | Status | First posted | Lead sponsor | Why stopped (as posted) | Category |
|---|---|---|---|---|---|---|---|
| NCT01292083 | Azacitidine in Treating Patients With Triple Negative Stage I-IV Invasive Breast Cancer… | N/A | withdrawn | Feb 9, 2011 | University of Southern California | No accrual last 2 years | Enrollment / accrual |
| NCT00256841 | Hypo-Hyperfractionated Chest Radiation for Non Small Cell Lung Cancer With… | Phase 1 / Phase 2 | withdrawn | Nov 22, 2005 | Clinical Oncology Research Associates | Lack of funding | Funding |
| NCT00942058 | Serum CA9 Level as Biological Marker of the Treatment Response in Metastatic Renal Cell…(CA9CRM) | — | terminated | Jul 20, 2009 | Centre Hospitalier Universitaire de Saint Etienne | Difficult for recruiting | Enrollment / accrual |
| NCT00989092 | Darbepoetin Alfa and Anemia of Cancer | Phase 2 | terminated | Oct 2, 2009 | Amgen | slow enrollment and change in product development strategy | Enrollment / accrual |
| NCT01501240 | Gadoxetic Acid-enhanced MR Evaluation of Hepatocellular Carcinoma and Dysplastic Nodules…(PriMPa) | — | withdrawn | Dec 29, 2011 | Jae Ho Byun | not stated | Not stated |
| NCT01677390 | A Phase 1b Study of SGN-75 in Combination With Everolimus in Patients With Renal Cell… | Phase 1 | terminated | Sep 3, 2012 | Seagen Inc. | not stated | Not stated |
| NCT01695057 | Vorinostat Before Surgery in Treating Patients With Triple-Negative Breast Cancer | N/A | withdrawn | Sep 27, 2012 | University of Southern California | Lack of funding | Funding |
| NCT01356368 | Customizing First Line Chemotherapy in Advanced Non-Small Cell Lung Cancer(Customizing) | Phase 2 | terminated | May 19, 2011 | National Guard Health Affairs | slow accrual rate | Enrollment / accrual |
| NCT01063478 | Dose Escalation Study of RAD001 in Combination w/Chemotherapy & Radiation in Patients…(RAD001) | Phase 1 | terminated | Feb 5, 2010 | University of Chicago | Poor accrual | Enrollment / accrual |
| NCT01403103 | Cholecalciferol(25-[OH]-Vitamin D) in Treating Patients With Colorectal Cancer | Early Phase 1 | withdrawn | Jul 27, 2011 | Case Comprehensive Cancer Center | Slow Accrual | Enrollment / accrual |
| NCT00095693 | Sorafenib Tosylate in Treating Patients With Locally Advanced, Metastatic, or Locally… | Phase 2 | terminated | Nov 8, 2004 | National Cancer Institute (NCI) | not stated | Not stated |
| NCT00265603 | Safety Study: Combined Modality Treatment for Non-Small Cell Lung Cancer | Phase 1 | terminated | Dec 15, 2005 | Atlantic Health System | not stated | Not stated |
| NCT01473693 | Changes in Brain Structure Related to Systemic Chemotherapy Treatment: A Prospective… | — | terminated | Nov 17, 2011 | Memorial Sloan Kettering Cancer Center | Lack of Accrual | Enrollment / accrual |
| NCT01640730 | Safety and Exploratory Efficacy of Kanglaite Injection in Non Small Cell Lung Cancer | Phase 2 | terminated | Jul 16, 2012 | KangLaiTe USA | poor enrollment | Enrollment / accrual |
| NCT01637376 | Photodynamic Therapy (PDT) With Temoporfin for Non-Resectable Non-Small-Cell Lung Cancer | Phase 1 | withdrawn | Jul 11, 2012 | University of Arkansas | No participants were enrolled | Enrollment / accrual |
| NCT01097083 | Coriolus Versicolor as Palliative Therapy Compared to Placebo in Patients With Child-Pugh… | Phase 2 | terminated | Apr 1, 2010 | National University Hospital, Singapore | not stated | Not stated |
| NCT00596830 | Carboplatin And Paclitaxel With Or Without CP-751, 871 (An IGF-1R Inhibitor) For Advanced… | Phase 3 | terminated | Jan 17, 2008 | Pfizer | See termination reason in detailed description. | Other (stated, no rule matched) |
| NCT01096732 | Hedgehog Inhibition for Pancreatic Ductal Adenocarcinoma (PDAC) in the Preoperative…(HIPPoS) | Phase 2 | terminated | Mar 31, 2010 | Lisa Bax | Slow recruitment | Enrollment / accrual |
| NCT01202890 | Study of Revlimid With Doxil and Avastin for Patients With Platinum Resistant Ovarian… | Phase 1 | terminated | Sep 16, 2010 | New Mexico Cancer Research Alliance | Terminated due to inadequate rate of accrual. | Enrollment / accrual |
| NCT00613730 | Adenocarcinoma of the Pancreas Treated With Panitumumab and Gemcitabine Regimen to…(APPRISE 1) | Phase 2 | terminated | Feb 13, 2008 | Amgen | APPRISE closure prompted by SWOG S0205 not meeting primary endpoint-improving OS. APPRISE… | Safety / toxicity |
| NCT01871480 | CIK Cell Transfusion Plus Gefitinib As Second Or Third-Line Treatment for Advanced… | Phase 2 | terminated | Jun 6, 2013 | Kunming Medical University | not stated | Not stated |
| NCT00558636 | A Trial Comparing Safety and Efficacy of Carboplatin and Paclitaxel Plus or Minus… | Phase 3 | terminated | Nov 15, 2007 | Bayer | Terminated early when the results from Study NCT00300885 showed an overall lack of efficacy in… | Efficacy / futility |
| NCT01479023 | Evaluation of 64Cu-DOTA-U3-1287 in Subjects With Advanced Solid Tumors | Phase 1 | terminated | Nov 24, 2011 | Washington University School of Medicine | treatment was not working | Other (stated, no rule matched) |
| NCT01836341 | Afatinib In Combination With Cisplatin Or Carboplatin + Pemetrexed In Patients With… | Phase 1 | withdrawn | Apr 19, 2013 | Memorial Sloan Kettering Cancer Center | not stated | Not stated |
| NCT01982487 | Vaccine Therapy and IDO1 Inhibitor INCB024360 in Treating Patients With Epithelial… | Phase 1 / Phase 2 | withdrawn | Nov 13, 2013 | Roswell Park Cancer Institute | not stated | Not stated |
| NCT00071942 | Vaccine Therapy in Treating Patients With Metastatic Breast Cancer | Phase 1 | terminated | Nov 6, 2003 | National Cancer Institute (NCI) | not stated | Not stated |
| NCT01728480 | Entolimod in Treating Patients With Stage III-IV Squamous Cell Head and Neck Cancer… | Phase 1 | withdrawn | Nov 19, 2012 | Roswell Park Cancer Institute | Financial Sponsor requested termination | Funding |
| NCT01533727 | CIK Cell Transfusion Plus Chemotherapy as Adjuvant Therapy for Stage IB-IIIA Non-Small… | Phase 2 | withdrawn | Feb 15, 2012 | Sun Yat-sen University | Few patients would like to participate ,since CIK cell transfusion was a new treatment and its… | Efficacy / futility |
| NCT00887315 | The Synergistic Metastases Annihilation With Radiotherapy and Docetaxel (Taxotere)…(SMART) | Phase 2 | terminated | Apr 23, 2009 | University of Chicago | Slow accrual and loss of sponsor | Enrollment / accrual |
| NCT00701870 | Study of Telintra for Treatment of Chemotherapy Induced Neutropenia in Patients With… | Phase 2 | terminated | Jun 19, 2008 | Telik | Study TLK199.2102 was terminated for lack of enrollment. | Enrollment / accrual |
| NCT01504542 | Immune Response and Safety of HS110 Vaccine in Combination With Erlotinib in Patients… | Phase 2 | withdrawn | Jan 5, 2012 | Heat Biologics | Lack of enrollment | Enrollment / accrual |
| NCT00636298 | Study of Cetuximab and Bevacizumab in Cancer of the Esophagus After Failure of Patient's… | Phase 2 | withdrawn | Mar 14, 2008 | Emory University | lack of funding | Funding |
| NCT00095641 | S0225 Capecitabine in Treating Patients Who Have Undergone Surgery for Locally Recurrent… | Phase 2 | withdrawn | Nov 8, 2004 | SWOG Cancer Research Network | no longer studying this disease site | Other (stated, no rule matched) |
| NCT01063998 | A Urinary Tumor Marker (Kidney Injury Molecule-1) for the Detection of Renal Cell… | — | terminated | Feb 5, 2010 | Jason Hafron | Preliminary data did not show expected outcomes. | Other (stated, no rule matched) |
| NCT01128803 | Immunotherapy of Hepatocellular Carcinoma by Induction of Anti-alpha Fetoprotein Response | Phase 1 / Phase 2 | terminated | May 24, 2010 | Nantes University Hospital | not stated | Not stated |
| NCT00365183 | Trial of Motexafin Gadolinium and Pemetrexed (Alimta®) for Second Line Treatment in… | Phase 2 | terminated | Aug 17, 2006 | Pharmacyclics LLC. | not stated | Not stated |
| NCT01060514 | Pazopanib + Vinorelbine in Non Small Cell Lung Cancer (NSCLC) and Breast Cancer | Phase 1 | terminated | Feb 2, 2010 | Northwestern University | Lack of timely accrual. | Enrollment / accrual |
| NCT01215838 | MRI of the Liver With Eovist | — | terminated | Oct 7, 2010 | University of Washington | Unable to meet enrollment expectations. | Enrollment / accrual |
| NCT00110344 | Research Study for Patients With Metastatic Renal Cell Carcinoma | Phase 2 | terminated | May 9, 2005 | Bayer | not stated | Not stated |
| NCT01674738 | TS Stratified Chemotherapy and VEGF Inhibition in Non-Squamous Non-Small Cell Lung Cancer…(SELECT-A) | Phase 2 | withdrawn | Aug 29, 2012 | Aktion Bronchialkarzinom e.V. | Decision of the Sponsor, as the funding of the study was no longer guaranteed. | Funding |
| NCT00536107 | Study to Assess Safety/Tolerability/Efficacy of Gefitinib Versus Docetaxel in Locally… | Phase 4 | terminated | Sep 27, 2007 | AstraZeneca | not stated | Not stated |
| NCT01192763 | RO4929097 Before Surgery in Treating Patients With Pancreatic Cancer | Phase 1 | terminated | Sep 1, 2010 | National Cancer Institute (NCI) | not stated | Not stated |
| NCT01705340 | Akt Inhibitor MK2206, Lapatinib Ditosylate, and Trastuzumab in Treating Patients With… | Phase 1 | terminated | Oct 12, 2012 | National Cancer Institute (NCI) | not stated | Not stated |
| NCT00203866 | Trial of G250 Peptide and IL-2 Following Surgical Resection of Locally… | Phase 2 | terminated | Sep 20, 2005 | University of Chicago | Study completed | Other (stated, no rule matched) |
| NCT01618253 | Radiation Therapy With Sorafenib for TACE-Resistant Hepatocellular Carcinoma | Phase 1 | withdrawn | Jun 13, 2012 | Medical College of Wisconsin | Closed due to poor accrual. | Enrollment / accrual |
| NCT01210131 | Hypoxia-guided Radiotherapy With Cisplatin-etoposide in Stage I-III : Small Cell Lung…(HX4 in SCLC) | N/A | withdrawn | Sep 28, 2010 | Maastricht Radiation Oncology | not stated | Not stated |
| NCT00862082 | Randomized Phase 1/2 Open-Label Trial of PR104 and Sorafenib in Patients With Advanced… | Phase 1 / Phase 2 | terminated | Mar 16, 2009 | Proacta, Incorporated | PR104 plus sorafenib was poorly tolerated in patients with advanced HCC | Other (stated, no rule matched) |
| NCT01830322 | Safety and Effectiveness Study of CPI-613 and/or Gemcitabine to Treat Metastatic… | Phase 2 | withdrawn | Apr 12, 2013 | Cornerstone Pharmaceuticals | not stated | Not stated |
| NCT00708877 | Liver Transplantation for Cholangiocarcinoma | N/A | terminated | Jul 2, 2008 | University of Utah | study procedures have become standard of care as patients seeking Model for End-Stage Liver Disease… | Other (stated, no rule matched) |
| NCT01728181 | A Phase I/II Study of Tivozanib and Erlotinib as Initial Treatment for Metastatic… | Phase 1 / Phase 2 | withdrawn | Nov 16, 2012 | University of Utah | Stopped before approval due to ineffective drug | Other (stated, no rule matched) |
Stop reasons are registrant-reported free text and are displayed verbatim (truncated; hover for the full text). Categories come from explicit keyword rules and are never inferred from the study design, sponsor or outcome; a study that stopped for several reasons is filed under the first rule that matched. A TERMINATED status does not imply a negative result.
Data updated 24 days agoSource updated Feb 6, 2014source: clinicaltrials