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Clinical trials · failure tracking
Oncology studies whose overall status is TERMINATED, WITHDRAWN or SUSPENDED on ClinicalTrials.gov, with the stop reason exactly as the registrant posted it. A category is attached only when an explicit keyword rule matches the text; CancerIndex never infers why a study stopped.
3,705 stopped studies mapped to Carcinoma and descendants · 91% state a reason
Over the 3,705 studies matching the cancer, status and year filters (the category filter does not change this chart). Each study is counted once, in the first matching category; greyed bars are studies whose text matched no rule or was empty.
Computedrules ci-stop-reasons-v1 · keyword matching only
A category is assigned when one of its keywords appears in the posted text (case-insensitive, whole words). Rules are tested in this order and the first match wins; every match is kept in the API (reasonMatches).
| NCT | Title | Phase | Status | First posted | Lead sponsor | Why stopped (as posted) | Category |
|---|---|---|---|---|---|---|---|
| NCT01913067 | Evaluation of Cabazitaxel in Patients With Brain Metastasis Secondary to Breast Cancer…(CRANIAL) | Phase 2 | withdrawn | Jul 31, 2013 | Jules Bordet Institute | Scientific rationale is deemed obsolete. Funders lost interest in the trial. | Other (stated, no rule matched) |
| NCT01227018 | PhII Study STA-9090 as Second or Third-Line Therapy for Metastatic Pancreas Cancer | Phase 2 | terminated | Oct 22, 2010 | Vanderbilt-Ingram Cancer Center | interim analysis found the study drug to be ineffective | Efficacy / futility |
| NCT02054793 | Phase Ib/II Study Evaluating Orteronel (Without Prednisone) Combined With Itraconazole In… | Phase 1 / Phase 2 | withdrawn | Feb 4, 2014 | Emmanuel Antonarakis, MD | This study was never able to open due to lack of funding from the pharmaceutical company. | Funding |
| NCT01722175 | Associating Liver Partition With Portal Vein Ligation For Staged Hepatectomy (ALPPS) or…(ALPPS) | Phase 2 | withdrawn | Nov 6, 2012 | Washington University School of Medicine | Safety concerns. | Safety / toxicity |
| NCT00545948 | Adjuvant Cisplatin With Either Genomic-Guided Vinorelbine or Pemetrexed for Early Stage…(TOP0703) | Phase 2 | terminated | Oct 18, 2007 | Duke University | Study terminated due to reproducibility issues with genomics prediction model. | Other (stated, no rule matched) |
| NCT01669668 | Radiofrequency Ablation in Treating Patients With Liver Cancer (Hepatocellular Carcinoma) | Phase 2 | withdrawn | Aug 21, 2012 | Washington University School of Medicine | Lack of referrals. | Other (stated, no rule matched) |
| NCT01491633 | Dasatinib in Advanced Squamous Cell Lung Cancer | Phase 2 | terminated | Dec 14, 2011 | Dana-Farber Cancer Institute | Safety issues/concerns per DF/HCC PI | Safety / toxicity |
| NCT01301612 | Study of Nimotuzumab, Radiation Therapy and Cisplatin Versus Radiation Therapy and… | Phase 2 | withdrawn | Feb 23, 2011 | Eurofarma Laboratorios S.A. | Regulatory requirement. A phase III study is being designed. | Other (stated, no rule matched) |
| NCT01418742 | SKIP - A Double-blind Placebo-controlled Randomized Multicenter Trial of Skin Toxicity… | Phase 2 | terminated | Aug 17, 2011 | Gesellschaft fur Medizinische Innovation - Hamatologie und Onkologie mbH | Recruitement did not meet expectations. Prev. differentiation of RAS-wild-type and mutated RAS are… | Enrollment / accrual |
| NCT01187615 | Determination of Safety, Efficacy, and Pharmacokinetics of "Regorafenib" Combined With… | Phase 1 | terminated | Aug 24, 2010 | Bayer | not stated | Not stated |
| NCT02157116 | Dose-Dense Induction/Neoadjuvant Chemotherapy in Locally Advanced Non-Small Cell Lung… | Phase 2 | terminated | Jun 5, 2014 | Duke University | Insufficient accrual to meet analysis goals | Enrollment / accrual |
| NCT00002947 | Indium In 111 Pentetreotide in Treating Patients With Refractory Cancer | Phase 1 | terminated | Mar 26, 2004 | Yale University | not stated | Not stated |
| NCT00145418 | Oxaliplatin and Docetaxel as First-line Therapy for Advanced Non-small Cell Lung Cancer | Phase 2 | terminated | Sep 5, 2005 | Oncology Specialists, S.C. | low enrollment | Enrollment / accrual |
| NCT01432314 | Efficacy of Radiation Therapy and Transarterial Chemoembolization (TACE) to Treat…(RTANDTACE) | Phase 2 | withdrawn | Sep 12, 2011 | Asan Medical Center | Another phase 2 randomized study has been started by other investigators. | Other (stated, no rule matched) |
| NCT01793636 | A Study Comparing AZD2014 vs Everolimus in Patients With Metastatic Renal Cancer(ZEBRA) | Phase 2 | terminated | Feb 15, 2013 | Queen Mary University of London | Inferior efficacy of study drug in renal indication. | Efficacy / futility |
| NCT00907504 | Study Of The Effect Of CP-751,871 In Combination With Gemcitabine And Cisplatin In…(ADVIGO1017) | Phase 3 | withdrawn | May 22, 2009 | Pfizer | not stated | Not stated |
| NCT01360827 | EMD 1201081 + 5-FU + Cisplatin + Cetuximab in Subjects With Recurrent / Metastatic… | Phase 1 | terminated | May 26, 2011 | Merck KGaA, Darmstadt, Germany | Study terminated due to potential safety concerns in combination with platinum-based therapies | Safety / toxicity |
| NCT00507429 | Study of Combretastatin and Paclitaxel/Carboplatin in the Treatment of Anaplastic Thyroid…(FACT) | Phase 2 / Phase 3 | terminated | Jul 26, 2007 | Mateon Therapeutics | Low rate of subject accrual | Enrollment / accrual |
| NCT00079326 | Trastuzumab and Ixabepilone in Treating Women With HER2-Positive Metastatic Breast Cancer | Phase 2 | terminated | Mar 10, 2004 | National Cancer Institute (NCI) | Slow accrual. | Enrollment / accrual |
| NCT01365143 | Prospective Randomized Trial Comparing Robotic Versus Open Radical Prostatectomy | Phase 4 | terminated | Jun 3, 2011 | Mayo Clinic | Closing due to slow enrollment | Enrollment / accrual |
| NCT00112905 | Sorafenib in Treating Patients With Regional or Metastatic Cancer of the Urothelium | Phase 2 | terminated | Jun 3, 2005 | National Cancer Institute (NCI) | not stated | Not stated |
| NCT00976677 | Carboplatin, Paclitaxel, and Bevacizumab With or Without Erlotinib Hydrochloride in… | Phase 2 | terminated | Sep 14, 2009 | National Cancer Institute (NCI) | not stated | Not stated |
| NCT01741597 | Dynamic Contrast Enhanced MRI in Patients With Advanced Breast or Pancreatic Cancer With… | Phase 1 | withdrawn | Dec 5, 2012 | City of Hope Medical Center | PI chose to close the study | Other (stated, no rule matched) |
| NCT00084487 | Rebeccamycin Analog as Second-Line Therapy in Treating Patients With Limited-Stage or… | Phase 2 | terminated | Jun 11, 2004 | National Cancer Institute (NCI) | not stated | Not stated |
| NCT00835679 | Cetuximab and/or Dasatinib in Patients With Colorectal Cancer and Liver Metastases That… | Early Phase 1 | terminated | Feb 4, 2009 | National Cancer Institute (NCI) | not stated | Not stated |
| NCT00183963 | A Pilot Clinical Trial to Evaluate the Biological Activity of Fulvestrant in Breast… | Phase 2 | terminated | Sep 16, 2005 | University of Southern California | Insufficient accrual | Enrollment / accrual |
| NCT00184028 | Combination of Taxotere and Oxaliplatin in Squamous Cell Carcinoma of the Head and Neck | Phase 2 | terminated | Sep 16, 2005 | University of Southern California | Insufficient Accrual | Enrollment / accrual |
| NCT00614484 | Chemotherapy and Proton Radiation for the Treatment of Locally Advanced Lung Cancer | Phase 1 / Phase 2 | terminated | Feb 13, 2008 | Loma Linda University | Low participant enrollment rates. Significant comparative data not obtained. | Enrollment / accrual |
| NCT00303862 | AZD2171 in Treating Patients With Refractory Metastatic Kidney Cancer | Phase 2 | terminated | Mar 17, 2006 | National Cancer Institute (NCI) | not stated | Not stated |
| NCT01329640 | Feasibility Study of Metronomic Chemotherapy for Locally Advanced Her2- Positive Breast… | Phase 2 | terminated | Apr 6, 2011 | Instituto do Cancer do Estado de São Paulo | not stated | Not stated |
| NCT01963949 | Prospective, Observational Study of Biomarkers in Liver Cancer - Identification of… | — | withdrawn | Oct 17, 2013 | University of Texas Southwestern Medical Center | not stated | Not stated |
| NCT00493428 | Treatment of Non-Metastatic Hepatocellular Carcinoma in Humans by Increasing Gabaergic… | Phase 2 | withdrawn | Jun 28, 2007 | University of Manitoba | The study have been stoped because the protocol is going to be modify. | Other (stated, no rule matched) |
| NCT00684996 | Bevacizumab With or Without MEDI-522 in Treating Patients With Unresectable or Metastatic… | Phase 1 / Phase 2 | terminated | May 28, 2008 | National Cancer Institute (NCI) | not stated | Not stated |
| NCT00023946 | BMS-247550 in Treating Patients With Liver or Gallbladder Cancer | Phase 2 | terminated | Jan 27, 2003 | National Cancer Institute (NCI) | not stated | Not stated |
| NCT01471197 | Safety and Efficacy Trial of Ipilimumab Versus Pemetrexed in Non-Squamous Non-Small Cell… | Phase 2 | terminated | Nov 15, 2011 | Bristol-Myers Squibb | Administrative reasons | Other (stated, no rule matched) |
| NCT01701349 | Fosbretabulin or Placebo in Combination With Carboplatin/Paclitaxel in Anaplastic Thyroid…(FACT2) | Phase 3 | withdrawn | Oct 5, 2012 | Mateon Therapeutics | Expected inability to recruit study participants in a reasonable amount of time. | Enrollment / accrual |
| NCT00778817 | IMC-A12 With Mitotane vs Mitotane Alone in Recurrent, Metastatic, or Primary ACC That… | Phase 2 | terminated | Oct 23, 2008 | National Cancer Institute (NCI) | The trial was permanently halted due to futility concerns. | Efficacy / futility |
| NCT01907308 | Trebananib (AMG 386) in Combination With Docetaxel for Advanced Urothelial Carcinoma | Phase 2 | withdrawn | Jul 24, 2013 | University of Colorado, Denver | Sponsor's decision to terminate the study | Sponsor / business decision |
| NCT01233505 | Veliparib, Oxaliplatin, and Capecitabine in Treating Patients With Advanced Solid Tumors | Phase 1 | terminated | Nov 3, 2010 | National Cancer Institute (NCI) | not stated | Not stated |
| NCT00088933 | Vaccine Therapy and Sargramostim With or Without Docetaxel in Treating Patients With… | Phase 1 | terminated | Aug 5, 2004 | National Cancer Institute (NCI) | not stated | Not stated |
| NCT00112060 | A Study to Assess the Safety and Preliminary Efficacy of PT-523 in Patients With Advanced… | Phase 1 / Phase 2 | withdrawn | May 30, 2005 | Spectrum Pharmaceuticals, Inc | not stated | Not stated |
| NCT00203931 | Trial Comparing Cetuximab With Pemetrexed/Cetuximab Therapy for Non-Small Cell Lung Cancer | Phase 2 | terminated | Sep 20, 2005 | University of Chicago | Slow accrual and evidence from other studies showing benefit of early initiation of pemetrexed… | Enrollment / accrual |
| NCT01409681 | A Multi-Centered Trial Evaluating the Role of Vitamin D Metabolism in Non-Small Cell Lung…(EBUS) | — | terminated | Aug 4, 2011 | University of Michigan Rogel Cancer Center | PI decided to terminate the study | Other (stated, no rule matched) |
| NCT01617980 | Multimodal Hypoxia Imaging and Intensity Modulated Radiotherapy for Inoperable…(HIL) | N/A | terminated | Jun 13, 2012 | German Cancer Research Center | Slow accrual | Enrollment / accrual |
| NCT01215565 | Study of Sunitinib in Patients With Advanced/Inoperable Fibrolamellar Carcinoma(Fibrolam) | Phase 2 | terminated | Oct 6, 2010 | Assistance Publique - Hôpitaux de Paris | lack of inclusion | Other (stated, no rule matched) |
| NCT01641575 | A Dose Ascending Study of Gemcitabine Elaidate (CO-101) in Combination With Cisplatin | Phase 1 | terminated | Jul 17, 2012 | Clovis Oncology, Inc. | Registrational study did not meet endpoint so entire program (including CO-101-011) was terminated. | Other (stated, no rule matched) |
| NCT02080962 | Hypofractionated Radiotherapy for Nonmelanoma Skin Cancer | Phase 2 | terminated | Mar 7, 2014 | Barretos Cancer Hospital | Low rate of recruitment. | Enrollment / accrual |
| NCT00369551 | Bevacizumab, Paclitaxel, Carboplatin, and Radiation Therapy to the Chest in Treating… | Phase 1 | terminated | Aug 29, 2006 | National Cancer Institute (NCI) | not stated | Not stated |
| NCT01256203 | Efficacy and Safety of a Sunscreen Against Porfimer Sodium-induced Phototoxicity to… | Phase 2 | withdrawn | Dec 8, 2010 | Pinnacle Biologics Inc. | Sponsor cancelled the study | Other (stated, no rule matched) |
| NCT00763776 | Parenchyma Resection of Cirrhotic Liver by the Clamp Crushing Technique and the…(SECCI) | N/A | terminated | Oct 1, 2008 | Assistance Publique - Hôpitaux de Paris | difficulty for the patient recruiting | Enrollment / accrual |
Stop reasons are registrant-reported free text and are displayed verbatim (truncated; hover for the full text). Categories come from explicit keyword rules and are never inferred from the study design, sponsor or outcome; a study that stopped for several reasons is filed under the first rule that matched. A TERMINATED status does not imply a negative result.
Data updated 24 days agoSource updated Jul 24, 2014source: clinicaltrials