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Clinical trials · failure tracking
Oncology studies whose overall status is TERMINATED, WITHDRAWN or SUSPENDED on ClinicalTrials.gov, with the stop reason exactly as the registrant posted it. A category is attached only when an explicit keyword rule matches the text; CancerIndex never infers why a study stopped.
12 stopped studies mapped to Brain Glioblastoma and descendants · 92% state a reason
Over the 12 studies matching the cancer, status and year filters (the category filter does not change this chart). Each study is counted once, in the first matching category; greyed bars are studies whose text matched no rule or was empty.
Computedrules ci-stop-reasons-v1 · keyword matching only
A category is assigned when one of its keywords appears in the posted text (case-insensitive, whole words). Rules are tested in this order and the first match wins; every match is kept in the API (reasonMatches).
| NCT | Title | Phase | Status | First posted | Lead sponsor | Why stopped (as posted) | Category |
|---|---|---|---|---|---|---|---|
| NCT03170141 | Immunogene-modified T (IgT) Cells Against Glioblastoma Multiforme | Phase 1 | terminated | May 30, 2017 | Shenzhen Geno-Immune Medical Institute | not stated | Not stated |
| NCT05627323 | CAR T Cells in Patients With MMP2+ Recurrent or Progressive Glioblastoma | Phase 1 | terminated | Nov 25, 2022 | Chimeric Therapeutics | IND application withdrawn | Other (stated, no rule matched) |
| NCT04222309 | Laparoscopically Harvested Omental Free Tissue Autograft to Bypass the Blood Brain… | Phase 1 | suspended | Jan 9, 2020 | Northwell Health | Per IRB closed and opened a new study. | Other (stated, no rule matched) |
| NCT04105374 | Testing the Addition of an Anti-cancer Viral Gene Therapy, Toca 511/Toca FC, to the Usual… | Phase 2 / Phase 3 | withdrawn | Sep 26, 2019 | NRG Oncology | NCI approval withdrawn | Other (stated, no rule matched) |
| NCT04825275 | Neuro-pharmacological Properties of Repurposed Posaconazole in Glioblastoma: A Phase 0… | Early Phase 1 | terminated | Apr 1, 2021 | Milton S. Hershey Medical Center | The study was stopped due to slow accrual. | Enrollment / accrual |
| NCT06193174 | Re-Administration of C134 in Patients With Recurrent GBM (C134-HSV-1) | Phase 1 | terminated | Jan 5, 2024 | University of Alabama at Birmingham | Not enough eligible participants to enroll. | Enrollment / accrual |
| NCT04869449 | Neuro-pharmacological Properties of Repurposed Ketoconazole in Glioblastomas | Early Phase 1 | terminated | May 3, 2021 | Milton S. Hershey Medical Center | Enrollment was stopped due to direction from the scientific review committee of the Penn State… | Enrollment / accrual |
| NCT01430351 | Temozolomide, Memantine Hydrochloride, Mefloquine, and Metformin Hydrochloride in… | Phase 1 | terminated | Sep 8, 2011 | M.D. Anderson Cancer Center | \<75 % participant accrual | Enrollment / accrual |
| NCT04854044 | ONC201 and Radiation Therapy Before Surgery for the Treatment of Recurrent Glioblastoma | Phase 1 | withdrawn | Apr 22, 2021 | Jonsson Comprehensive Cancer Center | The P.I. is not prepared to move forward at this thime | Other (stated, no rule matched) |
| NCT02395692 | Methoxyamine and Temozolomide in Treating Patients With Recurrent Glioblastoma | Phase 2 | terminated | Mar 24, 2015 | National Cancer Institute (NCI) | Pre-specified response criteria not met to proceed to next stage of study. | Other (stated, no rule matched) |
| NCT02348255 | NovoTTF-100A With Bevacizumab and Carmustine in Treating Patients With Glioblastoma… | Phase 2 | withdrawn | Jan 28, 2015 | University of California, Davis | Poor Accrual | Enrollment / accrual |
| NCT02521090 | EGFRBi-Armed Autologous T Cells in Treating Patients With Recurrent or Refractory… | Phase 1 / Phase 2 | withdrawn | Aug 13, 2015 | Barbara Ann Karmanos Cancer Institute | Due to lack of funding and a primary co-investigator of the trial leaving the institution. | Investigator |
Stop reasons are registrant-reported free text and are displayed verbatim (truncated; hover for the full text). Categories come from explicit keyword rules and are never inferred from the study design, sponsor or outcome; a study that stopped for several reasons is filed under the first rule that matched. A TERMINATED status does not imply a negative result.
Data updated 22 days agoSource updated Aug 24, 2026source: clinicaltrials