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Clinical trials · failure tracking
Oncology studies whose overall status is TERMINATED, WITHDRAWN or SUSPENDED on ClinicalTrials.gov, with the stop reason exactly as the registrant posted it. A category is attached only when an explicit keyword rule matches the text; CancerIndex never infers why a study stopped.
1,232 stopped studies mapped to B-Cell Malignant Neoplasm and descendants · 88% state a reason
Over the 1,232 studies matching the cancer, status and year filters (the category filter does not change this chart). Each study is counted once, in the first matching category; greyed bars are studies whose text matched no rule or was empty.
Computedrules ci-stop-reasons-v1 · keyword matching only
A category is assigned when one of its keywords appears in the posted text (case-insensitive, whole words). Rules are tested in this order and the first match wins; every match is kept in the API (reasonMatches).
| NCT | Title | Phase | Status | First posted | Lead sponsor | Why stopped (as posted) | Category |
|---|---|---|---|---|---|---|---|
| NCT04149821 | Umbralisib Plus Ublituximab (U2) in Progressive CLL After Novel Therapy | Phase 2 | terminated | Nov 4, 2019 | Weill Medical College of Cornell University | Terminated due to low accrual | Enrollment / accrual |
| NCT04649060 | Study of Melflufen (Melphalan Flufenamide) in Combination With Daratumumab in…(LIGHTHOUSE) | Phase 3 | terminated | Dec 2, 2020 | Oncopeptides AB | The sponsor decided to terminate the study due to financial issues following an FDA request for a… | Funding |
| NCT02440685 | A Phase 1/2 Study To Evaluate ASN002 In Relapsed/Refractory Lymphoma And Advanced Solid… | Phase 1 / Phase 2 | terminated | May 12, 2015 | Asana BioSciences | Business decision | Sponsor / business decision |
| NCT02516696 | BiRd vs. Rd as Initial Therapy in Multiple Myeloma(BiRd vs Rd) | Phase 3 | terminated | Aug 6, 2015 | Weill Medical College of Cornell University | low enrollment | Enrollment / accrual |
| NCT05152459 | Tazemetostat in Combination With Umbralisib and Ublituximab for the Treatment Relapsed or… | Phase 1 / Phase 2 | withdrawn | Dec 9, 2021 | City of Hope Medical Center | Feasibility | Other (stated, no rule matched) |
| NCT02063113 | Vulnerability and Therapeutic Changes in Older Patients With Multiple Myeloma.(MYELOME-PA) | N/A | terminated | Feb 14, 2014 | Nantes University Hospital | inclusion difficulty | Other (stated, no rule matched) |
| NCT03850028 | Molecular Imaging Using Radiolabeled Atezolizumab to Assess Atezolizumab Biodistribution… | N/A | withdrawn | Feb 21, 2019 | University Medical Center Groningen | Closed prematurely because the accrual was not achieved | Enrollment / accrual |
| NCT01728259 | First-line Pomalidomide, Bortezomib, and Dexamethasone For AL Amyloidosis or LCDD | Phase 1 | terminated | Nov 19, 2012 | Barbara Ann Karmanos Cancer Institute | FDA placed the study on a clinical hold, due to the concerns by the FDA and Health Canada, Celgene… | Other (stated, no rule matched) |
| NCT02914938 | A Study of ME-401 in Subjects With CLL/SLL, FL, and B-cell Non Hodgkin's Lymphoma | Phase 1 | terminated | Sep 26, 2016 | MEI Pharma, Inc. | discontinuation of zandelisib program | Other (stated, no rule matched) |
| NCT02376699 | Safety Study of SEA-CD40 in Cancer Patients | Phase 1 | terminated | Mar 3, 2015 | Seagen Inc. | Study closed due to portfolio prioritization | Sponsor / business decision |
| NCT03999658 | A Study of STI-3031 (an Anti-PD-L1 Antibody) in Patients With Selected… | Phase 2 | withdrawn | Jun 27, 2019 | Sorrento Therapeutics, Inc. | Sorrento Therapeutics filed for chapter 11 bankruptcy. | Other (stated, no rule matched) |
| NCT04348006 | Assessment of Bortezomib (Alvocade ®) Efficacy and Safety in Newly Diagnosed Multiple…(MM) | Phase 4 | withdrawn | Apr 15, 2020 | Al-Rasheed University College | No patients were enrolled in the study | Enrollment / accrual |
| NCT05393999 | SABRE: A Single-arm Prospective Study Measuring Safety and Tolerability of SARS-CoV-2…(SABRE) | Phase 2 | withdrawn | May 27, 2022 | Imperial College Healthcare NHS Trust | The drug was found to be ineffective against Omicron, so the study was terminated and no patients… | Enrollment / accrual |
| NCT05431179 | A Study of Zilovertamab and Ibrutinib in Patients With Relapsed or Refractory Mantle Cell… | Phase 3 | withdrawn | Jun 24, 2022 | Oncternal Therapeutics, Inc | Due to a strategic reprioritization based on the rapidly changing clinical and commercial landscape… | Sponsor / business decision |
| NCT03919214 | Hypertension Management in Cancer Patients | N/A | terminated | Apr 18, 2019 | Duke University | Initially suspended due to Covid-19. After much consideration, it was determined that we do not… | COVID-19 / pandemic |
| NCT03371420 | PET Imaging of Subjects Using 124I-PU-AD | Early Phase 1 | terminated | Dec 13, 2017 | Samus Therapeutics, Inc. | Company has ceased operations | Sponsor / business decision |
| NCT03465540 | Safety, Tolerability, Pharmacokinetics and Efficacy of AMG 397 in Subjects With Selected… | Phase 1 | terminated | Mar 14, 2018 | Amgen | Strategic decisions | Sponsor / business decision |
| NCT04045028 | A Study to Evaluate the Safety, Tolerability, Pharmacokinetics (PK), Pharmacodynamics… | Phase 1 | terminated | Aug 5, 2019 | Genentech, Inc. | Slow recruitment | Enrollment / accrual |
| NCT03411031 | Elotuzumab Plus Lenalidomide (Elo/Rev) for Serologic Relapse/Progression While on… | Phase 2 | terminated | Jan 25, 2018 | H. Lee Moffitt Cancer Center and Research Institute | Sponsor no longer providing drug | Other (stated, no rule matched) |
| NCT01899326 | Desipramine Hydrochloride and Filgrastim For Stem Cell Mobilization in Patients With… | N/A | terminated | Jul 15, 2013 | Albert Einstein College of Medicine | The study was stopped during the interim analysis due to low accrual after the widespread use of… | Efficacy / futility |
| NCT00558961 | Dose Escalation Study of Gleevec and Chlorambucil in Previously Treated Chronic…(GL-CLB-001) | Phase 1 / Phase 2 | terminated | Nov 16, 2007 | Jewish General Hospital | Unsatisfactory enrollment | Enrollment / accrual |
| NCT04075721 | First in Human Dose Escalation of M3258 as a Single Agent and Expansion Study of M3258 in… | Phase 1 | terminated | Sep 3, 2019 | EMD Serono Research & Development Institute, Inc. | The study was early discontinued due to lack of participant enrollment. | Enrollment / accrual |
| NCT05365100 | A Study of BN102 in Patients With Previously Treated CLL/SLL and B-cell NHL | Phase 1 / Phase 2 | withdrawn | May 9, 2022 | BioNova Pharmaceuticals (Shanghai) LTD. | Due to company decision | Sponsor / business decision |
| NCT04635735 | Study of Ipilimumab After Stem Cell Transplantation in People With Relapsed/Refractory… | Phase 1 / Phase 2 | terminated | Nov 19, 2020 | Memorial Sloan Kettering Cancer Center | Lack of accrual | Enrollment / accrual |
| NCT05209308 | Rituximab Plus Venetoclax in Combination With Zandelisib in Subjects With CLL(CORAL) | Phase 2 | withdrawn | Jan 26, 2022 | MEI Pharma, Inc. | Discontinuation of zandelisib development | Other (stated, no rule matched) |
| NCT04521335 | Study of Disulfiram and Copper Gluconate in Patients With Treatment-Refractory Multiple…(Repurpose-1) | Phase 1 | terminated | Aug 20, 2020 | University of Utah | Closed at PI's Request | Other (stated, no rule matched) |
| NCT03639610 | PK of Melphalan During Treatment With Melflufen and Dexamethasone in Patients With RRMM…(BRIDGE) | Phase 2 | terminated | Aug 21, 2018 | Oncopeptides AB | The sponsor decided to terminate the study following an FDA request of a partial clinical hold. | Sponsor / business decision |
| NCT04156659 | Study of Tisagenlecleucel in Chinese Pediatric and Young Adult Subjects With Relapsed or… | Phase 2 | withdrawn | Nov 7, 2019 | Novartis Pharmaceuticals | This study was cancelled before enrolling any patients for business related reasons. | Enrollment / accrual |
| NCT03445663 | Study Evaluating AMG 424 in Subjects With Multiple Myeloma | Phase 1 | terminated | Feb 26, 2018 | Xencor, Inc. | Previous sponsor business decision not to proceed with the AMG 424 asset. | Sponsor / business decision |
| NCT04895410 | Study to Assess Adverse Events and Change in Disease Activity of Intravenous (IV)… | Phase 1 | terminated | May 20, 2021 | AbbVie | Strategic considerations | Sponsor / business decision |
| NCT04236141 | A Study to Evaluate the Efficacy and Safety of Polatuzumab Vedotin in Combination With… | Phase 3 | terminated | Jan 22, 2020 | Hoffmann-La Roche | Sponsor's decision, no safety concerns | Safety / toxicity |
| NCT05513612 | Novel CAR-T Cell Therapy in the Treatment of Hematopoietic and Lymphoid Malignancies | Phase 1 | withdrawn | Aug 24, 2022 | Shanghai Pudong Hospital | The study is not initiated and we want it to be withdrawn. | Other (stated, no rule matched) |
| NCT03370185 | Phase 2 Study of Duvelisib in Previously Treated Patients With Chronic Lymphocytic…(BRIO) | Phase 2 | withdrawn | Dec 12, 2017 | SecuraBio | Reassessing corporate priorities. | Other (stated, no rule matched) |
| NCT02292225 | Duvelisib With Obinutuzumab in Patients With CLL/SLL Previously Treated With a BTKi… | Phase 1 | terminated | Nov 17, 2014 | SecuraBio | The scope of the program has been reduced to focus resources on studies which can potentially… | Other (stated, no rule matched) |
| NCT02807454 | A Study to Determine the Safety and Efficacy for the Combination of Durvalumab and…(FUSIONMM-003) | Phase 2 | terminated | Jun 21, 2016 | Celgene | Health Authority request due to class effect | Other (stated, no rule matched) |
| NCT05176691 | HMPL-760 Safety and Tolerability Study in Patients With Previously Treated CLL/SLL or NHL | Phase 1 | withdrawn | Jan 4, 2022 | Hutchmed | HUTCHMED has decided to discontinue the HMPL 760 study. | Other (stated, no rule matched) |
| NCT04877080 | CD19 and BCMA Targeted Fast Dual CAR-T for CD19+ Refractory/Relapsed B-NHL | Phase 1 | withdrawn | May 7, 2021 | 920th Hospital of Joint Logistics Support Force of People's Liberation Army of China | The PI decides to withdraw the research. | Other (stated, no rule matched) |
| NCT03123393 | TAK-659 in Participants With Relapsed or Refractory Diffuse Large B-Cell Lymphoma (DLBCL) | Phase 2 | terminated | Apr 21, 2017 | Calithera Biosciences, Inc | Lack of efficacy of the drug; no safety concern | Safety / toxicity |
| NCT04804254 | Study to Evaluate Adverse Events, Change in Disease Activity, Movement of Oral ABBV-623… | Phase 1 | terminated | Mar 18, 2021 | AbbVie | Strategic considerations | Sponsor / business decision |
| NCT03876028 | Study of Tisagenlecleucel in Combination With Ibrutinib in r/r Diffuse Large B-cell… | Phase 1 | terminated | Mar 15, 2019 | Novartis Pharmaceuticals | Business reasons | Sponsor / business decision |
| NCT02077959 | Lenalidomide and Pidilizumab in Treating Patients With Relapsed or Refractory Multiple… | Phase 1 | terminated | Mar 4, 2014 | Ohio State University Comprehensive Cancer Center | Pharmaceutical Companies decision | Other (stated, no rule matched) |
| NCT05408026 | Study of Combination POM, BTZ, Low-Dose DEX, and DARA (PVD-DARA) in Patients With RRMM | Phase 1 / Phase 2 | withdrawn | Jun 7, 2022 | Alliance Foundation Trials, LLC. | Study withdrawn, trial therapy deemed no longer novel and there was a lack of site interest. | Other (stated, no rule matched) |
| NCT05493618 | Pembrolizumab, Belantamab and Dexamethasone in Refractory Multiple Myeloma. | Phase 1 / Phase 2 | withdrawn | Aug 9, 2022 | Hackensack Meridian Health | Study Drug Unavailability | Other (stated, no rule matched) |
| NCT02389543 | Study of Selinexor (KPT- 330), Lenalidomide, & Dexamethasone in Relapsed/Refractory…(SLAM) | Phase 1 / Phase 2 | withdrawn | Mar 17, 2015 | Karyopharm Therapeutics Inc | Terminated this trial and added a Lenalidomide arm to KCP-330-017 | Other (stated, no rule matched) |
| NCT02628704 | Selinexor, Carfilzomib, and Dexamethasone Versus Placebo, Carfilzomib, and Dexamethasone…(SCORE) | Phase 2 | withdrawn | Dec 11, 2015 | Karyopharm Therapeutics Inc | not stated | Not stated |
| NCT01028716 | Donor Peripheral Blood Stem Cell Transplant in Treating Patients With Hematologic… | Phase 2 | terminated | Dec 9, 2009 | Fred Hutchinson Cancer Center | The study experienced lower accrual rates after the onset of COVID. Upon review of the collected… | COVID-19 / pandemic |
| NCT05228249 | Loncastuximab Tesirine in Combination With Chemotherapy Prior to Stem Cell Transplant for… | Phase 1 | withdrawn | Feb 8, 2022 | Fred Hutchinson Cancer Center | PI left institution and funding sponsor closed study. Study did not open to accrual, and no… | Investigator |
| NCT01838369 | A Phase II Study of BI-505 in Smoldering Multiple Myeloma | Phase 2 | terminated | Apr 24, 2013 | BioInvent International AB | Sponsor's decision | Sponsor / business decision |
| NCT02393248 | Open-Label, Dose-Escalation Study of Pemigatinib in Subjects With Advanced Malignancies -… | Phase 1 / Phase 2 | terminated | Mar 19, 2015 | Incyte Corporation | not stated | Not stated |
| NCT00096460 | Autologous or Donor Stem Cell Transplantation in Treating Patients With Recurrent… | Phase 2 / Phase 3 | terminated | Nov 10, 2004 | Medical College of Wisconsin | lower than anticipated accrual | Enrollment / accrual |
Stop reasons are registrant-reported free text and are displayed verbatim (truncated; hover for the full text). Categories come from explicit keyword rules and are never inferred from the study design, sponsor or outcome; a study that stopped for several reasons is filed under the first rule that matched. A TERMINATED status does not imply a negative result.
Data updated 24 days agoSource updated Jun 15, 2023source: clinicaltrials