Clinical trial · Interventional
Resistance Training and Creatine Supplementation for Head and Neck Cancer
Pilot Randomized Trial Evaluating Resistance Exercise Training and Creatine Supplementation in Individuals Treated for Head and Neck Cancer
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 26, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260926-000001
Summary
Brief summary (as posted)
The study will examine a 10-week resistance training program, with or without creatine monohydrate supplementation, in adult survivors of head and neck cancer. Participants will undergo screening and complete study assessments before and after the training period and at a follow-up evaluation. The study will evaluate feasibility, safety, body composition, physical function, cancer-related fatigue, quality of life, and symptom burden in this population.
Conditions
Conditions (4)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Cancer Survivorship | — | UNRESOLVED | — |
| Head and Neck Cancer | Malignant Head and Neck Neoplasm | ALIAS | 0.90 |
| Physical Function | — | UNRESOLVED | — |
| Treatment-related Muscle Loss | — | UNRESOLVED | — |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Creatine Supplementation | Dietary Supplement | — | UNRESOLVED |
| Resistance Training | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- Resistance Training and Creatine
- description
- Resistance training plus creatine monohydrate (load 0.3g/kg x 7 days, then 0.1g/kg/day)
- interventionNames
- Dietary Supplement: Creatine Supplementation
- Other: Resistance Training
- type
- PLACEBO_COMPARATOR
- label
- Resistance Training and Placebo
- description
- resistance training plus matched placebo
- interventionNames
- Other: Resistance Training
Primary outcomes (4)
- measure
- Recruitment rate
- timeFrame
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: 1. Age 18 years or older. 2. Diagnosis of head and neck cancer (AJCC stages I-IV). 3. Completed curative-intent primary treatment, including surgery, radiation, chemotherapy, or combination treatment, within the past 1 to 3 months. 4. Clearance to engage in moderate-intensity exercise based on the American College of Sports Medicine (ACSM) Preparticipation Screening Guidelines. 5. Willingness and ability to participate in both in-person and/or virtual supervised exercise sessions. 6. Willingness to adhere to the supplementation regimen throughout the study. 7. English-speaking and able to understand study instructions and complete questionnaires. 8. Access to internet for remotely supervised exercise sessions. 9. Availability for the full 10-week intervention and post-intervention assessments. Exclusion Criteria: 1. Current participation in structured resistance training 2 or more days per week within the past 6 months. 2. Cognitive, psychiatric, or neurologic conditions that would impair ability to consent or adhere to study procedures. 3. Pre-existing renal impairment. 4. Current use of creatine supplements, defined as consistently taking creatine more than 2 days per week for the past 6 months.
References
Publications (0)
Data not yet available