A Study of Ear Nerve Stimulation to Treat Eye Inflammation

Inclusion Criteria:

* Age ≥18 years
* Ocular inflammatory condition-specifically, at least 1 eye with intra/subretinal fluid or both eyes with an inflammatory ocular surface condition
* Able to attend all study visits at approximately the same time of day (within a 3-h window)

For participants in the intra/subretinal fluid group:

* The presence of a natural crystalline lens or intraocular lens
* Pupils that can dilate to at least 3 mm in the study eye(s)
* The absence of opaque natural crystalline lenses or the presence of any ocular disease that prevents the view of the retina for imaging

Exclusion Criteria:

* Having or exhibiting any of the following:

  * Evidence of active infection
  * Chronically implanted electronic medical device, including pacemakers, defibrillators, cochlear implants, spinal stimulators, and vagus nerve stimulators
  * Evidence of any skin condition at the stimulation site
  * Untreated or poorly controlled psychiatric illness
  * Evidence of significant neurological conditions, including multiple sclerosis, amyotrophic lateral sclerosis, Parkinson's disease, seizure, stroke, and dementia
  * Low blood pressure, bradycardia, or hypoglycemia
  * History of bleeding disorders, including sickle cell anemia, anemia syndromes, monocytosis, and thrombocytopenia
  * History of vagotomy
  * History of partial or complete splenectomy
  * History of HIV infection or AIDS
  * History of recurrent vasovagal syncope episodes
* Receipt of any of the following medications within 1 week of the first visit:

  * Anticholinergic (Benadryl)
  * Antihypertensive (α-methyldopa)
  * Epinephrine-related drugs, norepinephrine-related drugs, and drugs that stimulate release of epinephrine and/or norepinephrine (Micronefrin, Asthmanefrin)
  * Alpha and/or beta adrenoceptor blocking agents
  * Antiseizure medications
  * Other medications, supplements, etc. that may interfere with the study results
* Substance abuse (alcoholism or other) problem
* Consumption of alcohol within 1 day of a study visit
* Currently using or have used recreational drugs, tobacco, and/or nicotine products within 1 week of the first visit