Clinical trial · Observational
Postoperative Outcomes After Partial Duodenopancreatectomy Versus Total Pancreatectomy
Postoperative Outcomes After Partial Duodenopancreatectomy Versus Total Pancreatectomy - a Nationwide Propensity Score Matched and Mediation Analysis
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 26, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260926-000001
Summary
Brief summary (as posted)
The goal of this observational study is to compare short-term outcomes after partial pancreatoduodenectomy and total pancreatectomy in adults undergoing elective surgery for pancreatic or periampullary neoplasms in Switzerland. The main questions it aims to answer are: Is total pancreatectomy associated with higher in-hospital mortality than partial pancreatoduodenectomy? Do postoperative complications and failure to rescue differ between the two procedures? Researchers will compare patients undergoing total pancreatectomy with those undergoing partial pancreatoduodenectomy to assess differences in mortality, postoperative complications and failure to rescue. Propensity score matching and mediation analysis will be used to reduce potential bias and evaluate the independent association of surgical procedure with mortality and failure to rescue. This retrospective study uses anonymised data from the Swiss national inpatient database between 2013 and 2022. Participants will not receive any study-related intervention and will not be contacted.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Pancreas Neoplasm | Pancreatic Neoplasm | ALIAS | 0.90 |
Interventions
Interventions (0)
Data not yet available
Design
Arms and outcomes
Arms (2)
- label
- Patients undergoing PD for pancreatic neoplasm
- label
- Patients undergoing TP for pancreatic neoplasm
Primary outcomes (1)
- measure
- Mortality
- timeFrame
- Perioperatively
- description
- In-hospital mortality
Secondary outcomes (2)
- measure
- Complications
- timeFrame
- Perioperatively
- description
- Postoperative complications
- measure
- Failure to rescue
- timeFrame
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 20 Years
Show eligibility criteria text
Inclusion Criteria: * patients \>20 years * peripancreatic / pancreatic neoplasm * total pancreatectomy or partial duodenopancreatectomy Exclusion Criteria: * patients \<20 years * emergency admission * other pancreatic surgery * other disease than peripancreatic neoplasm * incomplete documentation
References
Publications (0)
Data not yet available