Clinical trial · Observational

Early Discharge After Colorectal Surgery

RECUPERA-C Study: Protocol: Personalised and Controlled Rapid Recovery After Colorectal Surgery

NCT07827378CI-TRIAL-00126449RECUPERA-Cnot yet recruitingClinicalTrials.gov clinicaltrialsPublishedExplore in graph →

Summary

Brief summary (as posted)

RECUPERA-C is a prospective observational pilot study evaluating the feasibility and safety of an early discharge strategy within 48 hours after minimally invasive colorectal surgery. The study will assess whether patients can meet predefined clinical and functional discharge criteria, and will identify factors that may prevent early discharge. C-reactive protein and neutrophil-to-lymphocyte ratio will also be evaluated as exploratory markers of postoperative complications.

Conditions

Conditions (2)

Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.

Condition (as posted)	Mapped entity	Match	Confidence
Cancer	Malignant Neoplasm	ALIAS	0.90
Colo-rectal Cancer	—	UNRESOLVED	—

Interventions

Interventions (0)

Data not yet available

No intervention recorded.

Design

Arms and outcomes

Arms (1)

label
Colorectal Surgery Patients
description
Adult patients undergoing elective major minimally invasive colorectal surgery. A structured early discharge pathway (≤48 hours) will be applied based on predefined clinical and functional criteria.

Primary outcomes (1)

measure
Proportion of patients fulfilling all predefined clinical and functional criteria for early discharge (≤48 hours after surgery)
timeFrame
Within 48 hours after surgery
description
Proportion of patients fulfilling all predefined clinical and functional criteria for early discharge (≤48 hours after surgery)

Eligibility

Eligibility (as posted)

Sex: All
Minimum age: 18 Years

Show eligibility criteria text

Inclusion Criteria:

* Age ≥18 years.
* Elective major colorectal surgery for benign or malignant disease.
* Minimally invasive approach (laparoscopic or robotic).
* ASA physical status I-III.
* Functional independence in basic activities of daily living.
* Adequate home support and the ability to access and return to the hospital if required.
* Adequate understanding of the perioperative plan.
* Written informed consent.

Exclusion Criteria:

* Emergency surgery.
* Significant intraoperative complications.
* Major multivisceral resections.
* New ostomy creation.
* Functional dependence or significant cognitive impairment.
* Decompensation of major comorbidities.
* Anticipated need for postoperative admission to an intensive care unit.
* Social circumstances that may make early discharge unsafe.

References

Publications (17)

BACKGROUNDAlsharqawi N, Alhashemi M, Kaneva P, Baldini G, Fiore JF Jr, Feldman LS, Lee L. Validity of the I-FEED score for postoperative gastrointestinal function in patients undergoing colorectal surgery. Surg Endosc. 2020 May;34(5):2219-2226. doi: 10.1007/s00464-019-07011-6. Epub 2019 Jul 30. PMID 31363895
BACKGROUNDChung F, Chan VW, Ong D. A post-anesthetic discharge scoring system for home readiness after ambulatory surgery. J Clin Anesth. 1995 Sep;7(6):500-6. doi: 10.1016/0952-8180(95)00130-a. PMID 8534468
BACKGROUNDPajaron-Guerrero M, Fernandez-Miera MF, Duenas-Puebla JC, Cagigas-Fernandez C, Allende-Mancisidor I, Cristobal-Poch L, Gomez-Fleitas M, Manzano-Peral MA, Gonzalez-Fernandez CR, Aguilera-Zubizarreta A, Sanroma-Mendizabal P; Hospital Valdecilla ERAS Study Group. Early Discharge Programme on Hospital-at-Home Evaluation for Patients with Immediate Postoperative Course after Laparoscopic Colorectal Surgery. Eur Surg Res. 2017;58(5-6):263-273. doi: 10.1159/000479004. Epub 2017 Aug 9. PMID 28793287
BACKGROUNDvan Outersterp L, Laurijs SHH, Amraoui YE, Peeters AE, Verdaasdonk EEG. Monitoring early discharge after laparoscopic colon surgery: an interventional study. Surg Endosc. 2025 Jun;39(6):3654-3661. doi: 10.1007/s00464-025-11716-2. Epub 2025 Apr 29. PMID 40301154
BACKGROUNDLeenen JPL, Ardesch V, Patijn G. Remote Home Monitoring of Continuous Vital Sign Measurements by Wearables in Patients Discharged After Colorectal Surgery: Observational Feasibility Study. JMIR Perioper Med. 2023 May 5;6:e45113. doi: 10.2196/45113. PMID 37145849
BACKGROUNDDos Santos BDN, Beruti C, Azevedo J, Herrando I, Vieira P, Domingos H, Heald R, Fernandez L, Parvaiz A. Using inflammatory parameters for safe and early discharge after minimally invasive colorectal surgery for colorectal cancer. Tech Coloproctol. 2025 Apr 7;29(1):97. doi: 10.1007/s10151-025-03134-2. PMID 40192855