Clinical trial · Observational

Impact of Demography, Ethnicity, Co-morbidities and Inequalities on Outcomes in DLBCL Across the UKCHART Network

DECIPHER - Impact of Demography, Ethnicity, Co-morbidities and Inequalities on Outcomes in DLBCL Across the UKCHART Network

NCT07813585CI-TRIAL-00126209DECIPHERnot yet recruitingClinicalTrials.gov clinicaltrialsPublishedExplore in graph →

Summary

Brief summary (as posted)

DECIPHER is a retrospective multicentre observational cohort study using data collected across UKCHART sites. The study will evaluate the impact of ethnicity, socioeconomic deprivation and comorbidity burden on treatment delivery and outcomes in adults diagnosed with DLBCL between 2021 and 2025.

Conditions

Conditions (1)

Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.

Condition (as posted)	Mapped entity	Match	Confidence
Lymphoma	Lymphoma	ONTOLOGY_EXACT	0.90

Interventions

Interventions (0)

Data not yet available

No intervention recorded.

Design

Arms and outcomes

Arms (0)

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Primary outcomes (2)

measure
Treatment completion
timeFrame
Time Period between 2021-2026
description
Delivered versus planned number of frontline chemoimmunotherapy cycles
measure
Dose intensity reduction
timeFrame
Time Period between 2021-2026
description
Occurrence and magnitude (%) of chemotherapy dose reductions, particularly reductions \>25% from planned treatment

Secondary outcomes (4)

measure
Overall Survival (OS)
timeFrame
Time Period between 2021-2026
description
Measured as time from diagnosis (or treatment start, as defined in the SAP) to death from any cause

Eligibility

Eligibility (as posted)

Sex: All
Minimum age: 18 Years

Show eligibility criteria text

Inclusion Criteria:

* Adults aged ≥18 years.
* Newly diagnosed DLBCL.
* Managed within participating UKCHART sites.

Exclusion Criteria:

* Transformed lymphoma.
* Insufficient linkage data.

References

Publications (0)

Data not yet available

No reference posted for this study.