Clinical trial · Interventional
Right Colon Enema to Improve Bowel Preparation Quality During Colonoscopy
RIGHT-CLEAN Trial: A Multi-centre Randomised Controlled Trial of Intra-procedural Right Colon Enema Versus no Enema to Improve Total Colonic Bowel Preparation at Colonoscopy.
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 26, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260926-000001
Summary
Brief summary (as posted)
Colonoscopy is a test that lets doctors look inside the large bowel to find and remove growths called polyps, which can develop into bowel cancer. Before the test, people take a bowel preparation to empty the bowel. Even so, the right side of the bowel is often not clean enough, and polyps there can be missed. This study is testing whether giving an enema (a small amount of fluid passed into the bowel) during the colonoscopy makes the right side of the bowel cleaner. Participants having a routine colonoscopy at Westmead Hospital or Auburn Hospital will be assigned by chance to either receive the enema during the procedure or to have their colonoscopy in the usual way. Neither group takes any extra preparation at home. The researchers will compare how clean the right side of the bowel is in each group, using a standard scoring system, and will also look at how many polyps are found. The aim is to find out whether this simple step improves the quality of colonoscopy.
Conditions
Conditions (4)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Bowel Preparation Quality | — | UNRESOLVED | — |
| Colonic Polyps | — | UNRESOLVED | — |
| Colonoscopy | — | UNRESOLVED | — |
| Colorectal Neoplasms | Colorectal Neoplasm | ONTOLOGY_EXACT | 0.98 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Sodium phosphate enema | Drug | — | UNRESOLVED |
| Water instillation | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- Intra-procedural right colon Fleet enema
- description
- Immediately after confirmed caecal intubation and randomisation, with the colonoscope tip in the right colon, a Fleet sodium phosphate enema is instilled into the right colon through the colonoscope working channel. The right colon is then refilled to the hepatic flexure using the foot-pump water jet. The fluid is not suctioned; the right lower quadrant is agitated by manual percussion. The lumen is re-insufflated with CO2 and the scope returned to the caecum before withdrawal begins, allowing the instilled solution and mobilised faecal residue to be carried distally through the transverse and left colon.
- interventionNames
- Drug: Sodium phosphate enema
- type
- PLACEBO_COMPARATOR
- label
- Water control
- description
- Colonoscopy lets doctors look inside the large bowel to find and remove growths called polyps. Before the test, people take a bowel preparation to empty the bowel, but the right side of the bowel is often still not clean enough, and polyps there can be missed. This study is testing whether a small enema given through the colonoscope into the right side of the bowel, during the procedure, makes the whole bowel cleaner. Once the camera reaches the far end of the bowel, participants are assigned by chance to receive either the enema or the same volume of water. Everything else about the procedure is the same in both groups, and no extra preparation is taken at home. The recordings of each procedure are reviewed by independent experts who do not know which group the participant was in, and who score how clean each part of the bowel was. The researchers will also compare how many polyps were found in each group.
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 85 Years
Show eligibility criteria text
Inclusion Criteria: * Age 18 to 85 years * Undergoing elective full colonoscopy for any indication * Successful caecal intubation achieved during the procedure, confirmed prior to randomisation * Able to provide written informed consent Exclusion Criteria: * Emergency colonoscopy * Known inflammatory bowel disease with active colitis in the examined segment * Familial polyposis syndromes * Prior major right hemicolectomy or altered anatomy preventing standard right colon assessment * Known obstructing colorectal malignancy precluding safe progression or adequate examination * Pregnancy * Renal failure (eGFR less than 30 mL/min) * Previous sodium phosphate enema within the preceding 24 hours * Contraindication to sodium phosphate administration as determined by the treating endoscopist
References
Publications (0)
Data not yet available