Perioperative Adebrelimab for Locally Advanced Cervical Cancer

Inclusion Criteria:

* Aged 18 to 75 years.
* Histologically confirmed squamous cell carcinoma, adenosquamous carcinoma, or adenocarcinoma of the cervix; FIGO 2018 stage IB3 or IIA2, or carefully selected stage IIB or IIIC1r disease following multidisciplinary team evaluation, with a maximum primary tumor diameter ≥4 cm. For participants with stage IIB or IIIC1r disease, PET/CT or an equivalent staging examination must exclude para-aortic lymph node metastasis and distant metastasis, and definitive concurrent chemoradiotherapy must remain feasible if neoadjuvant treatment is ineffective.
* Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1.
* Able to provide adequate tumor tissue for biomarker testing, defined as at least 18 qualified tissue sections.
* No prior surgery for cervical cancer, except staging procedures, and no prior radiotherapy, chemotherapy, systemic anticancer therapy, investigational therapy, or immunotherapy for cervical cancer.
* At least one measurable lesion according to RECIST version 1.1, defined as a tumor lesion with a longest diameter ≥10 mm on CT or a lymph node with a short-axis diameter ≥15 mm on CT.
* Estimated life expectancy ≥6 months.
* No primary or metastatic central nervous system disease.
* Adequate major organ function, meeting all of the following criteria:
* No blood or blood-product transfusion within 14 days before assessment;
* Absolute neutrophil count (ANC) ≥1.5 × 10⁹/L;
* Platelet count ≥80 × 10⁹/L;
* Hemoglobin ≥9 g/dL;
* Total bilirubin \<1.5 × upper limit of normal (ULN);
* Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) ≤2.5 × ULN;
* Serum creatinine ≤1.5 × ULN, or creatinine clearance ≥40 mL/min calculated using the Cockcroft-Gault formula.
* Positive for high-risk human papillomavirus (HPV) DNA.
* Written informed consent provided and willingness to comply with protocol-required follow-up.

Exclusion Criteria:

* Considered unsuitable for participation in the study by the investigator.
* Known hypersensitivity or allergy to any study drug.
* Any active, known, or suspected autoimmune disease, including but not limited to interstitial pneumonitis, uveitis, enteritis, hepatitis, arthritis, nephritis, hypophysitis, hyperthyroidism, or hypothyroidism; vitiligo; or asthma requiring medical intervention with bronchodilators.
* Congenital or acquired immunodeficiency, including HIV infection, hepatitis B, or hepatitis C.
* Prior treatment with PD-1 and/or PD-L1 inhibitors, CTLA-4 antibodies, or other agents targeting immune-regulatory receptors.
* Current use of immunosuppressive agents. Patients in a stable condition who do not require systemic immunosuppressive therapy may be eligible.
* Long-standing unhealed wounds or fractures; major surgery, severe traumatic injury, fracture, or ulcer within 4 weeks before initiation of study treatment.
* Poorly controlled cardiac symptoms or cardiovascular disease, including New York Heart Association (NYHA) class III-IV heart failure or left ventricular ejection fraction (LVEF) \<50%; abnormal coagulation function defined as INR \>1.5 or APTT \>1.5 × ULN with a bleeding tendency; or an arterial or venous thromboembolic event within 6 months before the first dose of study treatment.
* Symptomatic ascites, pleural effusion, or pericardial effusion requiring therapeutic puncture or drainage. Patients whose pleural or pericardial effusion remains stable for at least 2 weeks after drainage before the first dose of study treatment may be eligible.
* Central nervous system metastases.
* History of another malignancy, except for cured basal cell carcinoma of the skin or cervical carcinoma in situ.
* Pregnant or breastfeeding women.
* History of psychotropic drug abuse with inability to discontinue such use, or presence of a psychiatric disorder.