Clinical trial · Interventional
Hair Regrowth Following Partial Thickness Removal of SSCIS
Hair Regrowth Following Partial Thickness Stages in Mohs Micrographic Surgery of Squamous Cell Carcinoma in Situ: A Prospective Pilot Study
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 10, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260910-000001
Summary
Brief summary (as posted)
Participants are being approached to participate in this study because they are undergoing surgery for a skin cancer known as squamous cell carcinoma in situ (SCCIS) on the scalp. Standard surgical techniques may remove deeper structures that contain hair follicles, which can result in permanent hair loss. This study evaluates whether a modified surgical technique, known as partial thickness excision, can preserve hair growth and improve cosmetic outcomes. Participation involves minimal risk beyond the standard risks of Mohs surgery. If patients choose to participate, their surgery will be performed using this technique, and photographs will be taken over time to evaluate hair regrowth and healing.
Conditions
Conditions (3)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Alopecia | — | UNRESOLVED | — |
| Squamous Cell Carcinoma in Situ | Squamous Cell Carcinoma In Situ | ONTOLOGY_EXACT | 0.98 |
| Squamous Cell Carcinoma (Skin) | Skin Squamous Cell Carcinoma | ALIAS | 0.90 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Partial Thickness Excision | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- type
- EXPERIMENTAL
- label
- Partial Thickness Excision
- description
- Participants will receive excision of their squamous cell carcinoma in situ of the scalp via partial thickness excision (removal of epidermal and superficial dermal tissue) in an effort to preserve hair follicles and hair growth potential.
- interventionNames
- Procedure: Partial Thickness Excision
Primary outcomes (1)
- measure
- Hair Growth measured clinically by hair density percentage compared to baseline photo
- timeFrame
- 3 and 6 months post-procedure.
- description
- To evaluate hair growth following partial thickness excision of SCCIS at 3 and 6 months post-procedure.
Secondary outcomes (3)
- measure
- Clearance of SCCIS measured by Mohs surgeons' interpretation of margins on surgical slides.
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Adults ≥ 18 years old * Histologically confirmed SCCIS * Lesions located in the hair-bearing scalp * Ability to provide informed consent Exclusion Criteria: * Invasive, poorly differentiated, or high-risk SCC features (e.g., perineural invasion) * Recurrent SCC at the same site * Prior radiation therapy to the scalp * Scarring alopecia or active inflammatory scalp disease at the treatment site * Immunosuppression that, in the investigator's judgement, increases oncologic risk * Use of topical minoxidil, oral minoxidil, finasteride, spironolactone, or other hair-growth promoting agents
References
Publications (0)
Data not yet available