Clinical trial · Observational
China Treatment Trial for Tumor in Sellar Region With Unruptured Intracranial Aneurysm
Treatment Strategies for Tumor in Sellar Region With Unruptured Intracranial Aneurysms in the Chinese Population
NCT07809178CI-TRIAL-00126176ChTTSRUIAnot yet recruitingClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 10, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260910-000001
Summary
Brief summary (as posted)
The goal of this observational study is to learn about the treatment strategies for tumor in sellar region with unruptured intracranial aneurysms in the Chinese population. The main question it aims to answer is: For patients with tumor in sellar region combined with unruptured intracranial aneurysms, which condition should be treated first?
Conditions
Conditions (9)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Chordoma | Chordoma | ONTOLOGY_EXACT | 0.98 |
| Craniopharyngioma | Craniopharyngioma | ONTOLOGY_EXACT | 0.90 |
| Germinoma | Germinoma | ONTOLOGY_EXACT | 0.90 |
| Hypothalamic Neoplasms | Hypothalamic Neoplasm | ONTOLOGY_EXACT | 0.98 |
| Meningioma | Meningioma | ONTOLOGY_EXACT | 0.90 |
| Optic Pathway Glioma | Visual Pathway Glioma | ALIAS | 0.90 |
| Pituitary Neuroendocrine Tumor | Pituitary Neuroendocrine Tumor | CURATED_BROADER | 0.80 |
| Rathke Cleft Cysts | — | UNRESOLVED | — |
| Unruptured Intracranial Aneurysms | — | UNRESOLVED | — |
Interventions
Interventions (3)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Aneurysm treatment followed by tumor resection | Procedure | — | UNRESOLVED |
| Observation | Other | — | UNRESOLVED |
| Tumor resection followed by aneurysm treatment | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (3)
- label
- Priority to Tumor
- description
- Tumor resection followed by aneurysm treatment
- interventionNames
- Procedure: Tumor resection followed by aneurysm treatment
- label
- Priority to Aneurysm
- description
- Aneurysm treatment followed by tumor resection
- interventionNames
- Procedure: Aneurysm treatment followed by tumor resection
- label
- Only Tumor
- description
- Tumor resection without aneurysm treatment but observation
- interventionNames
- Other: Observation
Primary outcomes (2)
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 75 Years
Show eligibility criteria text
Inclusion Criteria: 1. Preoperative enhanced head MRI showing a suspected diagnosis of a sella region lesion, and preoperative head CTA/DSA confirming an unruptured intracranial aneurysm. 2. Patients with primary sella region tumor and unruptured intracranial aneurysms that have not previously accepted surgical treatment. 3. Patients with tumor in sellar region requiring craniotomy or endoscopic transnasal surgery and/or an aneurysm requiring craniotomy, endovascular treatment, or observation only. 4. The patients are in good general health, without severe underlying medical conditions, and capable of tolerating surgical treatment. 5. Patients or their legal guardians have signed an informed consent form and voluntarily agreed to participate in the clinical trial. Exclusion Criteria: 1. Patients with recurrent sella region tumors. 2. Patients with previously treated intracranial aneurysm. 3. Pregnant or breastfeeding women. 4. Any other condition that, in the investigator's judgment, makes the patient unsuitable for trial participation.
References
Publications (5)
- RESULTAlmeida Silva JM, Campos RR, Souza RR, Sette Dos Santos ME, Aguiar GB. Spontaneous subarachnoid haemorrhage from rupture of an anterior communicating artery aneurysm in a patient with pituitary macroadenoma. Neurocirugia (Astur). 2014 Mar-Apr;25(2):81-5. doi: 10.1016/j.neucir.2013.03.005. Epub 2013 Jul 9. PMID 23845268
- RESULTSchwab KE, Gailloud P, Wyse G, Tamargo RJ. Limitations of magnetic resonance imaging and magnetic resonance angiography in the diagnosis of intracranial aneurysms. Neurosurgery. 2008 Jul;63(1):29-34; discussion 34-5. doi: 10.1227/01.NEU.0000335068.53190.46. PMID 18728566
- RESULTOshino S, Nishino A, Suzuki T, Arita H, Tateishi A, Matsumoto K, Shimokawa T, Kinoshita M, Yoshimine T, Saitoh Y. Prevalence of cerebral aneurysm in patients with acromegaly. Pituitary. 2013 Jun;16(2):195-201. doi: 10.1007/s11102-012-0404-x. PMID 22752346
- RESULTde Sena Barbosa MG, Otavio da Silva V, Santos Ferreira LH, de Souza RLV, Pipek LZ, de Oliveira Almeida G, Figueiredo EG, Rabelo NN, Chaurasia B. Intracranial aneurysm coexisting with pituitary adenoma: a systematic review. Ann Med Surg (Lond). 2024 Oct 25;86(12):7232-7237. doi: 10.1097/MS9.0000000000002692. eCollection 2024 Dec. PMID 39649870
- RESULTCai K, Jia Y, Jin L, Qiao N, Xiao Y, Wu W, Ru S, Liu F, Liu C, Cao L, Gui S. Adult craniopharyngioma concomitant with unruptured intracranial aneurysms: incidence, risk factors, and treatment strategies. J Neurosurg. 2024 Jun 14;141(6):1712-1722. doi: 10.3171/2024.3.JNS232258. Print 2024 Dec 1. PMID 38875730