Clinical trial · Interventional
Improving HPV Vaccination Coverage Among Adolescent Girls in Mali and Côte d'Ivoire Through Community Health Worker Follow-up
Improving HPV Immunization Coverage Among Adolescent Girls in Mali and Côte d'Ivoire Through an Innovative Community-Based Follow-Up: A Randomized Controlled Trial With a Waitlist Design
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 16, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260916-000001
Summary
Brief summary (as posted)
The goal of this trial is to learn if a community health worker (CHW) follow-up program can improve HPV vaccination coverage among adolescent girls in Mali and Côte d'Ivoire. The main questions it aims to answer are: Does the CHW follow-up program increase the number of girls who get vaccinated against HPV? Does the CHW follow-up program help girls get vaccinated sooner? Researchers will compare girls who receive proactive CHW home visits and digital follow-up reminders to girls who receive standard community outreach, to see if the CHW follow-up program works to increase HPV vaccination. Participants will: Be visited at home by a community health worker, who will check their HPV vaccination status Receive an invitation to get vaccinated, and reminders and follow-up visits if not yet vaccinated (intervention group only, until crossover) Have their vaccination status recorded through routine community health records, with no additional tests, surveys, or clinic visits required After an initial assessment period, girls in the standard-outreach group will also begin receiving the CHW follow-up program.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Papillomavirus Infections | — | UNRESOLVED | — |
| Uterine Cervical Neoplasms | Cervical Neoplasm | ALIAS | 0.90 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| HPV vaccination pro-active community-based follow-up model | Behavioral | — | UNRESOLVED |
| Standard community mobilization | Behavioral | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- ACTIVE_COMPARATOR
- label
- Standard community mobilization with routine HPV vaccination follow-up
- description
- Control arm: standard community mobilization with routine HPV vaccination follow-up (CHW identification and vaccination-status verification only).
- interventionNames
- Behavioral: Standard community mobilization
- type
- EXPERIMENTAL
- label
- CHW home visits with proactive invitation of unvaccinated girls and automated digital follow-up
- description
- CHW home visits with proactive invitation of unvaccinated girls and automated digital follow-up reminders, supported by a real-time supervisor dashboard.
- interventionNames
- Behavioral: HPV vaccination pro-active community-based follow-up model
Primary outcomes (1)
- measure
Eligibility
Eligibility (as posted)
- Sex
- Female
- Minimum age
- 9 Years
- Maximum age
- 14 Years
Show eligibility criteria text
Inclusion Criteria: * Female adolescent residing within a participating Muso Health catchment area in Mali or Côte d'Ivoire * Age-eligible for HPV vaccination under national immunization guidelines during the study period: 10 years of age in Mali; 9 to 14 years of age in Côte d'Ivoire * Not yet age-eligible at study launch but expected to reach the nationally recommended vaccination age during the study period Exclusion Criteria: * Residence outside the defined study catchment areas * Not identifiable or registered in the Community Health Toolkit (CHT) programmatic data system
References
Publications (17)
- BACKGROUNDSandie AB, Keita Y, Coulibaly R, Coulibaly Y, Diall I, Koffi JAK, et al. Amélioration des couvertures vaccinales des enfants de 0 à 23 mois par une intervention innovante de suivi communautaire en Côte d'Ivoire et au Mali Protocole de recherche pour une étude de séries chronologiques interrompues contrôlées utilisant les données de routine. Muso Health; 2025.
- BACKGROUNDGavi the Vaccine Alliance. Mali: HPV vaccination takes root one year after its introduction. 2025.
- BACKGROUNDGavi the Vaccine Alliance. Mali rolls out cancer-blocking jab 2024
- BACKGROUNDMinistere de la Sante dlHPedlCMU. Rapport technique de la campagne nationale de vaccination de la cohorte multi-ages contre le HPV en Côte d'Ivoire : du 07 au 13 avril 2025
- BACKGROUNDGavi the Vaccine Alliance. Gavi supports Côte d'Ivoire's largest HPV vaccination campaign targeting over 3 million girls.
- BACKGROUNDDainguy M, Kouadio E, Kouakou K, Doubané S. Determinants of Human Papilloma Virus Vaccination Status among Adolescent Schoolgirls in Abidjan. HEALTH SCIENCES AND DISEASE. 2024.
- BACKGROUNDWorld Health Organization Regional Office for Africa. HPV Vaccination: Paving the Path toward Cervical Cancer Elimination in Africa. WHO AFRO; 2024.
- BACKGROUNDWorld Health Organization Regional Office for Africa. Advancing the cervical cancer elimination agenda in the African region. WHO AFRO; 2023.
- BACKGROUNDWorld Health Organization. Global strategy to accelerate the elimination of cervical cancer as a public health problem. 2020.
- BACKGROUNDWorld Health Organization. Cervical cancer. WHO Fact Sheet. 2024
- BACKGROUNDRivero-Mendoza D, Gjoka K, Singh L, Adkins L, Bylund CL, Staras SAS, Salloum RG, Shenkman E, Egbounye NC, Mkuu RS. Health System Strategies to Improve the Uptake of Cervical Cancer Screening in Sub-Saharan Africa: A Scoping Systematic Review. Health Promot Pract. 2026 May;27(3):576-599. doi: 10.1177/15248399251370668. Epub 2025 Oct 3.