Clinical trial · Interventional
SHORTened Duration of TAMoxifen
SHORTened Duration of TAMoxifen for Risk Reduction in Breast Intraepithelial Neoplasms in Post-menopausal Women
NCT07806630CI-TRIAL-00126151active not recruitingPhase 2ClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 9, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260909-000002
Summary
Brief summary (as posted)
The purpose of this study is to learn whether a shorter-duration, low-dose tamoxifen regimen can reduce the risk of developing breast cancer or breast cancer recurrence in post-menopausal women who are at increased risk for breast cancer.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| High Risk for Invasive Breast Cancer | — | UNRESOLVED | — |
Interventions
Interventions (2)
Design
Arms and outcomes
Arms (1)
- type
- EXPERIMENTAL
- label
- Low dose Tamoxifen
- interventionNames
- Drug: Tamoxifen
- Drug: Tamoxifen (Nolvadex)
Primary outcomes (1)
- measure
- Low Dose Tamoxifen
- timeFrame
- 18 Months
- description
- To evaluate the efficacy of a de-escalated, 18-month regimen of low-dose tamoxifen (10 mg every other day) in reducing the risk of disease recurrence or invasive breast cancer in post-menopausal women with breast intraepithelial neoplasia or an elevated 5-year Gail model risk.
Secondary outcomes (2)
- measure
- Evaluation of Tamoxifen Tolerability
- timeFrame
- 18 months
- description
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 30 Years
Show eligibility criteria text
Inclusion Criteria: * 1\. Patient at high risk for invasive breast cancer (either A or B) A. Post-menopausal women diagnosed with ductal carcinoma in situ (DCIS), Lobular carcinoma in situ (LCIS), atypical ductal hyperplasia (ADH), and atypical lobular hyperplasia (ALH) who meet the following criteria: * DCIS/LCIS * Lesion size ≤3cm * Low or intermediate grade * Lesion completely excised by surgical excision * Margins \>2cm for DCIS * Estrogen receptor (ER) positive and/or Progesterone receptor positive (defined as ≥10%) * ADH/ALH o Lesion completely excised by surgical excision B. Patients at increased risk of breast cancer based on Gail model criteria (5- year risk ≥1.66%) without prior history of DCIS, LCIS, atypical hyperplasia, or invasive breast cancer. 2\. No history of pathogenic germline mutations that increase the lifetime risk of breast cancer. If genetic testing was not done, then patients must have no more than two first-degree relatives diagnosed with breast cancer. 3\. Should have received adjuvant radiation for DCIS, if recommended by the radiation oncologist. 4\. No prior history of invasive carcinoma, DCIS, LCIS, ADH, and/or ALH in bilateral breasts. 5\. ECOG performance status ≤ 2 6. No use of hormone replacement therapy for at least 5 years. Exclusion Criteria: 1. Evidence of invasive or microinvasive breast cancer. 2. Current use of dicumarols and CYP2D6 inhibitors, such as selective serotonin reuptake inhibitors. 3. Patients who have had a bilateral mastectomy for risk reduction. 4. Prior history of any malignancy in the last 5 years (except squamous cell carcinoma/basal cell carcinoma of skin) 5. Patients who are known to be pregnant 6. Patients who cannot voluntarily provide informed consent. Evidence of dementia, altered mental status, or any psychiatric condition that would prohibit understanding or rendering of informed consent. 7. Life expectancy of less than 1 year per treating physician. 8. Prior treatment with tamoxifen or an aromatase inhibitor. \-
References
Publications (0)
Data not yet available
No reference posted for this study.