Clinical trial · Observational
Hemodynamic Monitoring-Guided Goal-Directed Fluid Therapy in Robotic Radical Prostatectomy
Effectiveness of Goal-Directed Fluid Therapy Guided by Minimally Invasive Hemodynamic Monitoring in Robotic Radical Prostatectomy: A Prospective Observational Study
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 9, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260909-000002
Summary
Brief summary (as posted)
This prospective observational cohort study evaluated goal-directed fluid therapy guided by minimally invasive hemodynamic monitoring in adult male patients undergoing elective robotic radical prostatectomy. Patients were prospectively enrolled and followed according to the intraoperative fluid management strategy used in routine clinical practice. Patients managed with LiDCO®Rapid-guided goal-directed fluid therapy constituted the hemodynamic monitoring-guided group, while patients managed with conventional intraoperative fluid therapy constituted the control group. No randomization or additional research-related intervention was performed. The study compared the two fluid management strategies with respect to intraoperative crystalloid fluid administration and selected perioperative clinical and laboratory parameters.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Prostate Cancer | Malignant Prostate Neoplasm | CURATED_EXACT | 0.92 |
| Robotic Radical Prostatectomy | — | UNRESOLVED | — |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Conventional fluid therapy | Other | — | UNRESOLVED |
| LiDCO-guided goal-directed fluid therapy | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- label
- LiDCO-guided goal-directed fluid therapy
- description
- Patients managed with minimally invasive hemodynamic monitoring-guided goal-directed fluid therapy during robotic radical prostatectomy.
- interventionNames
- Other: LiDCO-guided goal-directed fluid therapy
- label
- Conventional fluid therapy
- description
- Patients managed with conventional intraoperative fluid therapy during robotic radical prostatectomy.
- interventionNames
- Other: Conventional fluid therapy
Primary outcomes (1)
- measure
- Total intraoperative crystalloid fluid volume administered
- timeFrame
- From anesthesia induction to the end of surgery, assessed over approximately 5 hours.
- description
Eligibility
Eligibility (as posted)
- Sex
- Male
- Minimum age
- 18 Years
- Maximum age
- 80 Years
Show eligibility criteria text
Inclusion Criteria: * Male patients aged 18 to 80 years * Patients scheduled for elective robotic radical prostatectomy * American Society of Anesthesiologists physical status I-III * Patients who provide written informed consent Exclusion Criteria: * Refusal to participate in the study * Cardiac rhythm disturbances * Severe left ventricular dysfunction, defined as ejection fraction \<40% * Severe valvular heart disease or active heart failure * Chronic renal failure, dialysis dependency, or preoperative creatinine \>2 mg/dL * Hemoglobin \<8 g/dL * Pre-existing hematological conditions requiring planned blood transfusion * Body mass index \>40 kg/m² * Major peripheral vascular disease * Implanted pacemaker or implantable cardioverter-defibrillator * Chronic obstructive pulmonary disease * Conditions associated with increased intra-abdominal pressure * Emergency surgery
References
Publications (4)
- BACKGROUNDCannesson M, Le Manach Y, Hofer CK, Goarin JP, Lehot JJ, Vallet B, Tavernier B. Assessing the diagnostic accuracy of pulse pressure variations for the prediction of fluid responsiveness: a "gray zone" approach. Anesthesiology. 2011 Aug;115(2):231-41. doi: 10.1097/ALN.0b013e318225b80a. PMID 21705869
- BACKGROUNDJun JH, Chung RK, Baik HJ, Chung MH, Hyeon JS, Lee YG, Park SH. The tidal volume challenge improves the reliability of dynamic preload indices during robot-assisted laparoscopic surgery in the Trendelenburg position with lung-protective ventilation. BMC Anesthesiol. 2019 Aug 7;19(1):142. doi: 10.1186/s12871-019-0807-6. PMID 31390982
- BACKGROUNDOstermann M, Auzinger G, Grocott M, Morton-Bailey V, Raphael J, Shaw AD, Zarbock A; POQI XI Investigators. Perioperative fluid management: evidence-based consensus recommendations from the international multidisciplinary PeriOperative Quality Initiative. Br J Anaesth. 2024 Dec;133(6):1263-1275. doi: 10.1016/j.bja.2024.07.038. Epub 2024 Sep 27. PMID 39341776
- BACKGROUNDMyles PS, Bellomo R, Corcoran T, Forbes A, Peyton P, Story D, Christophi C, Leslie K, McGuinness S, Parke R, Serpell J, Chan MTV, Painter T, McCluskey S, Minto G, Wallace S; Australian and New Zealand College of Anaesthetists Clinical Trials Network and the Australian and New Zealand Intensive Care Society Clinical Trials Group. Restrictive versus Liberal Fluid Therapy for Major Abdominal Surgery. N Engl J Med. 2018 Jun 14;378(24):2263-2274. doi: 10.1056/NEJMoa1801601. Epub 2018 May 9. PMID 29742967