Clinical trial · Observational
A Study for Postoperative Delirium in Older Patients With Intracranial Tumors
A Study on Prevention and Treatment Mechanisms for Postoperative Delirium in Older Patients With Intracranial Tumors
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Postoperative delirium is a common acute central nervous system syndrome, which often occurs 1-5 days after surgery. Postoperative delirium can prolong the length of hospital stay, increase the mortality rate, and is also associated with long-term postoperative cognitive dysfunction. However, the pathogenesis of postoperative delirium in elderly patients undergoing neurosurgical procedures, who are at high risk for ostoperative delirium, remains unclear. This study aims to elucidate the underlying mechanisms of postoperative delirium in this population and inform the development of effective prevention and treatment strategies.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Brain Tumor | Brain Neoplasm | ALIAS | 0.90 |
| Delirium | — | UNRESOLVED | — |
Interventions
Interventions (0)
Data not yet available
Design
Arms and outcomes
Arms (2)
- label
- Intraoperative hypotension
- label
- Without intraoperative hypotension
Primary outcomes (1)
- measure
- The association between intraoperative hypotension and postoperative delirium
- timeFrame
- The surgery day and twice a day (from 8:00 to 10:00 and from 18:00 to 20:00) during the first postoperative 5 days.
- description
- Intraoperative hypotension was defined by absolute mean arterial pressure (MAP) thresholds (sustained MAP \< 75, 70, 65, or 60 mm Hg for \> 1 min) or relative MAP reductions (10%, 20%, 30%, or 40% below preoperative baseline). The Confusion Assessment Method for the Intensive Care Unit scale (CAM-ICU) or 3 min diagnostic interview for CAM (3D-CAM) will be applied to assess postoperative delirium.
Secondary outcomes (3)
- measure
- Characteristic of electroencephalogram
- timeFrame
- The surgery day
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 60 Years
Show eligibility criteria text
Inclusion Criteria: * Patients undergoing elective craniotomy for intracranial tumour resection * Patients who will provide written informed consent Exclusion Criteria: * Patients with severe preoperative cognitive impairment precluding subsequent assessments * History of psychotropic medication use * Previous history of neurosurgical operation * Severe bradycardia (heart rate \< 40 beats per minute) * Sick-sinus syndrome or atrioventricular block of grade Ⅱ or above * Severe hepatic insufficiency (Child-Pugh grade C) * Renal failure requiring renal replacement therapy
References
Publications (0)
Data not yet available