Clinical trial · Observational
Carotid Doppler Changes After Passive Leg Raising for Prediction of Post-Induction Hypotension in Gastrointestinal Tumor Surgery
Dynamic Changes in Carotid Artery Doppler Parameters Following Passive Leg Raising for Prediction of Post-Induction Hypotension in Patients Undergoing Elective Gastrointestinal Tumor Surgery
NCT07777159CI-TRIAL-00123054PLRnot yet recruitingClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This prospective study aims to investigate the role of the passive leg raise maneuver prior to anesthesia induction in predicting post-induction hypotension among elective gastrointestinal tumor surgery patients using carotid artery Doppler parameters.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Gastrointestinal Tumor Surgery | — | UNRESOLVED | — |
| Post-induction Hypotension (PIH) | — | UNRESOLVED | — |
Interventions
Interventions (0)
Data not yet available
No intervention recorded.
Design
Arms and outcomes
Arms (1)
- label
- Elective Gastrointestinal tumor surgery group
- description
- Patients scheduled for elective gastrointestinal tumor surgery under general anesthesia who undergo preoperative carotid Doppler assessment and a passive leg raising (PLR) maneuver
Primary outcomes (1)
- measure
- Predictive performance of dynamic changes in carotid Doppler parameters (ΔVTI, ΔPSV, ΔFTc) for post-induction hypotension
- timeFrame
- From pre-induction passive leg raising assessment to 20 minutes after general anesthesia induction
- description
- Evaluation of the predictive performance of percentage changes in carotid artery velocity time integral (ΔVTI), peak systolic velocity (ΔPSV), and corrected flow time (ΔFTc) after passive leg raising maneuver for post-induction hypotension
Secondary outcomes (4)
- measure
- Association of baseline carotid Doppler parameters with post-induction hypotension
- timeFrame
- From pre-induction assessment to 20 minutes after general anesthesia induction
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Adults aged 18 years or older * Patients scheduled for elective gastrointestinal tumor surgery * Surgery planned under general anesthesia * Body mass index (BMI) \<40 kg/m² * Written informed consent provided Exclusion Criteria: * Refusal to participate or inability to obtain written informed consent * BMI ≥40 kg/m² * Pregnancy * Emergency surgery * Difficult intubation * ASA physical status ≥IV * Pediatric patients (\<18 years) * Inability to perform carotid Doppler measurements * Arrhythmia other than continuous sinus rhythm or uncontrolled cardiac arrhythmia * Severe cardiac dysfunction or left ventricular ejection fraction \<40% * Severe valvular heart disease * Clinically significant autonomic nervous system disorders * Inadequate noninvasive blood pressure monitoring or inability to obtain the required hemodynamic measurements * Active sepsis or systemic inflammatory syndrome * Severe peripheral vascular disease or significant carotid artery stenosis (\>50%) * Severe pulmonary disease or advanced respiratory failure * Implanted cardiac device (pacemaker/ICD) * Baseline mean arterial pressure (MAP) \<65 mmHg * Preoperative systolic blood pressure \>190 mmHg or diastolic blood pressure \>110 mmHg
References
Publications (2)
- BACKGROUNDChowdhury AR, Thakuria R, Maitra S, Nath S, Baidya DK, Subramanium R, Anand RK, Kayina CA. Carotid artery corrected flow time and respiratory variation of blood flow peak velocity for prediction of hypotension after induction of general anesthesia in adult patients undergoing emergency laparotomy for peritonitis: A prospective, observational study. J Anaesthesiol Clin Pharmacol. 2023 Jul-Sep;39(3):444-450. doi: 10.4103/joacp.joacp_372_21. Epub 2023 May 5. PMID 38025582
- BACKGROUNDWang J, Li Y, Su H, Zhao J, Tu F. Carotid artery corrected flow time and respiratory variations of peak blood flow velocity for prediction of hypotension after induction of general anesthesia in elderly patients. BMC Geriatr. 2022 Nov 19;22(1):882. doi: 10.1186/s12877-022-03619-x. PMID 36402973