Effect of Mechanical Power-based Lung-protective Ventilation During One-lung Ventilation

The goal of this clinical trial is to determine whether a mechanical power-based lung-protective ventilation strategy during one-lung ventilation reduces the incidence of postoperative pulmonary complications in adult patients undergoing lung resection surgery. Mechanical power during pressure-regulated volume control mode is calculated using the formula below. Mechanical power (J/min) = 0.098 x respiratory rate x tidal volume x (inspiratory airway pressure above positive end-expiratory pressure + positive end-expiratory pressure) The main questions it aims to answer are: * Does a mechanical power-based lung-protective ventilation strategy significantly lower the incidence of major postoperative pulmonary complications compared to conventional ventilation? * How does this strategy impact intraoperative hemodynamic and vital profiles (e.g., blood pressure, cardiac output, vasopressor requirements, and blood oxygen saturation) during one-lung ventilation? Participants will: * Be randomized to receive either a mechanical power-based lung-protective ventilation strategy or a conventional lung-protective ventilation strategy exclusively during one-lung ventilation. * Be closely monitored for the occurrence of major postoperative pulmonary complications (atelectasis, pneumonia, acute respiratory distress syndrome, and pulmonary aspiration) and adverse events for 1 month postoperatively.

Sex

All

Minimum age

19 Years

Inclusion Criteria

* American Society of Anesthesiologists (ASA) physical status I-III
* Elective thoracic surgery requiring lung lobectomy under one-lung ventilation
* Age 18 years or older
* Written informed consent obtained from the patient

Exclusion Criteria

* Prior history of thoracic surgery
* Emergency surgery
* Pregnancy or lactation
* Known contraindication to one-lung ventilation
* Inability to provide informed consent or cooperate with the study protocol