Clinical trial · Observational
EUS-DFI in Solid Pancreatic Lesions
Role of Endoscopic Ultrasound-guided Detective Flow Imaging (EUS-DFI) for the Evaluation of Solid Pancreatic Tumours: A Prospective, International Multicenter Study
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This prospective, international, multicenter observational study aims to evaluate the role of Endoscopic Ultrasound-guided Detective Flow Imaging (EUS-DFI) in the characterization of solid pancreatic lesions. The study will assess microvascularization patterns identified by EUS-DFI and their association with the final diagnosis, using histopathology or clinical follow-up as the reference standard. Secondary objectives include evaluating interobserver agreement and the diagnostic accuracy of DFI vascular patterns for differentiating benign and malignant pancreatic lesions.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Pancreatic Neoplasms | Pancreatic Neoplasm | ONTOLOGY_EXACT | 0.98 |
| Pancreatic Solid Lesions | — | UNRESOLVED | — |
Interventions
Interventions (0)
Data not yet available
Design
Arms and outcomes
Arms (0)
[]Primary outcomes (3)
- measure
- DFI vascularization pattern
- timeFrame
- At the time of the EUS procedure
- description
- Classification of vascularization pattern as hypovascular, isovascular, hypervascular or indeterminate on DFI.
- measure
- Presence of vessels
- timeFrame
- At the time of the EUS procedure
- description
- Presence or absence of vessels identified on DFI.
- measure
- Vessel distribution
- timeFrame
- At the time of the EUS procedure
- description
- Classification of vessel distribution as intratumoral or peritumoral on DFI.
Secondary outcomes (2)
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Adults aged 18 years or older. * Presence of a solid pancreatic lesion identified during endoscopic ultrasound (EUS), regardless of the indication for the examination. * Ability and willingness to provide written informed consent. Exclusion Criteria: * Predominantly cystic pancreatic lesions. * Anatomical abnormalities preventing adequate EUS examination. * Limited ability to understand the study procedures or provide informed consent. * Refusal to sign the informed consent form.
References
Publications (3)
- BACKGROUNDMiwa H, Sugimori K, Yonei S, Yoshimura H, Endo K, Oishi R, Funaoka A, Tsuchiya H, Kaneko T, Numata K, Maeda S. Differential Diagnosis of Solid Pancreatic Lesions Using Detective Flow Imaging Endoscopic Ultrasonography. Diagnostics (Basel). 2024 Apr 24;14(9):882. doi: 10.3390/diagnostics14090882. PMID 38732296
- BACKGROUNDMulqui MV, Caillol F, Ratone JP, Hoibian S, Dahel Y, Meunier E, Archimbaud C, Giovannini M. Detective flow imaging versus contrast-enhanced EUS in solid pancreatic lesions. Endosc Ultrasound. 2024 Jul-Aug;13(4):248-252. doi: 10.1097/eus.0000000000000076. Epub 2024 Aug 23. PMID 39318752
- BACKGROUNDYamashita Y, Kitano M. Role of contrast-enhanced harmonic endoscopic ultrasonography (EUS) and EUS elastography in pancreatic lesions. Clin Endosc. 2024 Mar;57(2):164-174. doi: 10.5946/ce.2023.074. Epub 2024 Jan 17. PMID 38229442