Clinical trial · Observational
CT-Determined Sarcopenia and Mortality in Critically Ill Cancer Patients
Association Between Computed Tomography-Determined Sarcopenia and 28-Day Mortality in Critically Ill Cancer Patients: An Analytical Observational Study
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The goal of this observational study is to evaluate the association between computed tomography-determined sarcopenia and muscle quality impairment with 28-day mortality in adult patients (aged 18 and older) with solid or hematologic malignancies admitted to the Intensive Care Unit (ICU). The main question it aims to answer is: Is lower psoas muscle quality, calculated using the Hounsfield Unit Average Calculation (HUAC), associated with increased 28-day mortality in critically ill cancer patients? Researchers will compare patients who survived at 28 days with those who died to evaluate whether tomographic muscle measurements (HUAC and total psoas area) and clinical nutritional scores (mNUTRIC) differ between groups and predict mortality. Participants' records will be evaluated through: * A retrospective review of electronic medical records to collect demographic, clinical, oncologic, laboratory, and disease severity scores (APACHE II, SOFA, mNUTRIC). * Quantitative tomographic assessment of the right and left psoas muscle area and radiation attenuation density (in Hounsfield Units) using existing computed tomography (CT) scans performed during routine clinical care. * Follow-up of 28-day vital status (alive or deceased) after ICU admission.
Conditions
Conditions (4)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Cancer | Malignant Neoplasm | ALIAS | 0.90 |
| Critical Illness | — | UNRESOLVED | — |
| Malnutrition | — | UNRESOLVED | — |
| Sarcopenia | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Computed Tomography Muscle Assessment (HUAC) | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- label
- Survivors
- description
- Critically ill cancer patients admitted to the ICU who survived at 28 days post-admission.
- interventionNames
- Other: Computed Tomography Muscle Assessment (HUAC)
- label
- Non survivors
- description
- Critically ill cancer patients admitted to the ICU who died within 28 days post-admission
- interventionNames
- Other: Computed Tomography Muscle Assessment (HUAC)
Primary outcomes (1)
- measure
- 28-Day All-Cause Mortality
- timeFrame
- At 28 days post-ICU admission
- description
- Vital status (alive or deceased) of critically ill cancer patients evaluated at 28 days following their admission to the Intensive Care Unit (ICU). The association with muscle quality metrics, specifically the Hounsfield Unit Average Calculation (HUAC) of the psoas muscles obtained via computed tomography (CT) scan, will be assessed.
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Adult patients aged 18 years or older. * Confirmed diagnosis of solid or hematological malignancy. * Admitted to the Intensive Care Unit (ICU) between January 1, 2022, and December 31, 2025. * Availability of an abdominal computed tomography (CT) scan performed during routine clinical care at the time of or prior to ICU admission. Exclusion Criteria: * Missing or incomplete clinical, laboratory, or outcome data in the electronic medical record. * Non-evaluable abdominal CT scans due to motion artifacts, metal artifacts, or lack of cross-sectional visibility of the bilateral psoas muscles.
References
Publications (0)
Data not yet available