Clinical trial · Observational
Domestication and Implementation of the PEN-Plus Clinical Model in the Zambian Health System
PEN-Plus Initiation Grant Opportunity: Domestication and Implementation of the PEN-Plus Clinical Model in the Zambian Health System
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Cognizant of the prevalence of complicated non communicable diseases (NCD) and the attendant capacity problems faced by the health workers in primary care settings, we propose to adapt and pilot the Package of Essential Non-communicable Diseases (PEN) Plus intervention using the Interactive Systems Framework (ISF) and then implement and monitor the impact. The ISF framework proposes and organizes several implementation strategies to achieve Evidence Based Implementation (EBI) adaptation. We will apply these strategies at 2 first level hospitals (Peri-Urban and Rural) to ensure local adaptation and work towards scaling up of the WHO-PEN Plus in the rest of Zambia. This process will be inclusive, involving a Stakeholder Consultation Group that shall include the Zambian Non-Communicable diseases and injuries (NCDI) Poverty Commission and shall report bi-annually to a Project Advisory Board (PAB) chaired by the Permanent Secretary of the Ministry of Health.
Conditions
Conditions (11)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Cancer | Malignant Neoplasm | ALIAS | 0.90 |
| Cardiac Diseases | — | UNRESOLVED | — |
| Congenital Heart Disease | — | UNRESOLVED | — |
| Diabetes Mellitus | — | UNRESOLVED | — |
| Epilepsy | — | UNRESOLVED | — |
| Heart Failure | — | UNRESOLVED | — |
| Hypertension | — | UNRESOLVED | — |
| Kidney Disease | — | UNRESOLVED | — |
| Mental Health Disorders | — | UNRESOLVED | — |
| Rheumatic Heart Disease |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Supportive treatment | Combination Product | — | UNRESOLVED |
Design
Arms and outcomes
Arms (5)
- label
- Lusaka - Matero FLH
- description
- Community accessing care from first level hospitals in different parts of Zambia
- interventionNames
- Combination Product: Supportive treatment
- label
- Central - Mwachisompola FLH
- description
- Community accessing care from first level hospitals in different parts of Zambia
- interventionNames
- Combination Product: Supportive treatment
- label
- Central - Kapiri Mposhi DH
- description
- Community accessing care from first level hospitals in different parts of Zambia
- interventionNames
- Combination Product: Supportive treatment
Eligibility
Eligibility (as posted)
- Sex
- All
Show eligibility criteria text
Inclusion Criteria: * Presenting with chronic NCDs Exclusion Criteria: * Refusing to be followed up prospectively for routine visits
References
Publications (2)
- RESULThttps://journals.plos.org/globalpublichealth/article?id=10.1371/journal.pgph.0004398
- RESULThttps://static1.squarespace.com/static/64dbb4573bca0b2b659240f5/t/68a89cc8f373370f961131ad/1755880648256/Zambia+PEN-Plus+National+Operational+Plan_11Jul2025_FINAL.pdf