Clinical trial · Interventional
Exercise and Diet Responses in Adult Men With Obesity by MC4R Genotype and Metabolic Health
Association of MC4R rs17782313 Polymorphism and Metabolic Phenotype With Responses to a 12-Week Combined Exercise and Dietary Intervention in Adult Men With Obesity
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This study evaluated whether differences in the MC4R rs17782313 gene variant and metabolic health status were associated with different responses to a 12-week exercise and dietary intervention in adult men with obesity. A total of 40 men aged 18 to 59 years with obesity participated in the study. At baseline, participants were classified as having metabolically healthy obesity or metabolically unhealthy obesity according to metabolic risk factors. All participants received the same supervised lifestyle intervention, which included aerobic exercise, resistance training, and an individualized energy-controlled diet. Body weight, body composition, physical fitness, blood pressure, blood glucose, blood lipids, glycated hemoglobin, and fasting insulin were measured before and after the 12-week intervention. Blood samples were also collected for MC4R rs17782313 genotyping. The study examined whether changes after the intervention differed according to baseline metabolic phenotype and MC4R genotype.
Conditions
Conditions (3)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Metabolically Healthy Obesity | — | UNRESOLVED | — |
| Metabolically Unhealthy Obesity | — | UNRESOLVED | — |
| Obesity | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Supervised Aerobic and Resistance Exercise | Behavioral | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- type
- EXPERIMENTAL
- label
- Combined Exercise and Dietary Intervention
- description
- All participants received the same 12-week supervised lifestyle intervention consisting of aerobic exercise, resistance training, and an individualized energy-controlled diet. Participants were subsequently classified according to baseline metabolic phenotype and MC4R rs17782313 genotype for subgroup analyses; these classifications did not determine intervention assignment.
- interventionNames
- Behavioral: Supervised Aerobic and Resistance Exercise
Primary outcomes (1)
- measure
- Change From Baseline in Body Weight at Week 12
- timeFrame
- Baseline and Week 12
- description
- Body weight was measured in kilograms using a calibrated electronic scale, with participants wearing light clothing and no shoes. Change in body weight was calculated as the body weight measured at Week 12 minus the baseline body weight.
Eligibility
Eligibility (as posted)
- Sex
- Male
- Minimum age
- 18 Years
- Maximum age
- 59 Years
Show eligibility criteria text
Inclusion Criteria: * Male sex * Age 18 to 59 years * Body mass index of at least 28 kg/m2 * Waist circumference of at least 90 cm * Able and willing to provide written informed consent * Able and willing to participate in the 12-week supervised exercise and dietary intervention and complete the scheduled assessments Exclusion Criteria: * Severe hepatic insufficiency * Severe renal insufficiency * Cardiovascular disease * Other clinically significant vascular disease * Current use of glucose-lowering medication * Current use of antihypertensive medication * Current use of lipid-lowering medication * Unable or unwilling to comply with the intervention and assessment schedule
References
Publications (0)
Data not yet available