Clinical trial · Observational
Validation of Serum Metabolite Differences in Patients With Gallstones and Gallbladder Cancer
Validation of Differential Serum Levels of Ten Candidate Metabolites in Gallstone Patients With and Without Gallbladder Cancer
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
We have observed that the serum levels of certain metabolites differ between Chilean patients with gallbladder cancer and those with gallstone disease. Based on these discovery results, we selected ten candidate metabolites based on the smallest p-values among metabolites exhibiting a fold-change greater than 1.5. The aim of the present study is to validate these ten differential metabolite levels in an independent cohort of Chilean patients with gallbladder cancer and gallstone disease, and to assess the transferability of these findings to other patient populations.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Gallbladder Malignant Neoplasm | Malignant Gallbladder Neoplasm | ALIAS | 0.90 |
| Gallstone Disease | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| serum samples | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- label
- Patients diagnosed with gallbladder cancer.
- interventionNames
- Other: serum samples
- label
- Patients with gallstone disease and no evidence of gallbladder cancer upon pathological examination
- interventionNames
- Other: serum samples
Primary outcomes (1)
- measure
- Serum concentrations of five minerals among South American gallstone patients with and without gallbladder cancer
- timeFrame
- At iclusion
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Patients with gallstones and cancer-free OR - Patients with gallbladder cancer * Patients aged 18 years or older Exclusion Criteria: • Patients younger than 18 years
References
Publications (0)
Data not yet available