Clinical trial · Interventional
Nebulized Lidocaine And Ketamine Before Fiberoptic Bronchoscopy
Nebulized Lidocaine And Ketamine As Premedication Before Fiberoptic Bronchoscopy: A Case-Control Study
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The current study is looked for the comparison between nebulized lidocaine and ketamine, nebulized lidocaine, and usual lidocaine spray in the oral and nasal cavities before flexible bronchoscopy. The investigators are looking for different outcomes including mainly cough suppression during the procedure, patient tolerance and discomfort, operator and patients' satisfaction, and safety of the use of these medications especially regarding nebulized ketamine.
Conditions
Conditions (3)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Fiberoptic Bronchoscopy (FOB) | — | UNRESOLVED | — |
| Lung Cancer (Diagnosis) | Malignant Lung Neoplasm | CURATED_EXACT | 0.85 |
| Premedication | — | UNRESOLVED | — |
Interventions
Interventions (3)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Lidocaine spray (2%) | Drug | — | UNRESOLVED |
| Nebulized Lidocaine | Drug | — | UNRESOLVED |
| Nebulized lidocaine and ketamine | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (3)
- type
- ACTIVE_COMPARATOR
- label
- interventional A Group
- description
- This group of patient were given nebulized lidacaine and ketamine before FOB.
- interventionNames
- Drug: Nebulized lidocaine and ketamine
- type
- ACTIVE_COMPARATOR
- label
- Interventional B Group
- description
- This group of patient were given nebulized lidacaine only before FOB.
- interventionNames
- Drug: Nebulized Lidocaine
- type
- PLACEBO_COMPARATOR
- label
- Control group
- description
- This group of patient were given lidacaine spray to the oral and nasal cavity before FOB.
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * All patients were assigned for FOB for diagnostic causes as part of their usual care. * All patients were assigned for FOB for therapeutic causes as part of their usual care. Exclusion Criteria: * unstable angina or recent myocardial infarction, * hypoxemia that is not corrected by oxygen therapy, * increased intracranial pressure or recent cerebrovascular stroke, * uncontrolled uraemia, * uncontrolled hypertension, * current viral infections or colds, * history of allergy to lidocaine or ketamine, * altered mental status, or * non-corrected coagulopathy
References
Publications (2)
- RESULTDreher M, Cornelissen CG, Reddemann MA, Muller A, Hubel C, Muller T. Nebulized versus Standard Local Application of Lidocaine during Flexible Bronchoscopy: A Randomized Controlled Trial. Respiration. 2016;92(4):266-273. doi: 10.1159/000449135. Epub 2016 Sep 10. PMID 27614989
- RESULTDhooria S, Chaudhary S, Ram B, Sehgal IS, Muthu V, Prasad KT, Aggarwal AN, Agarwal R. A Randomized Trial of Nebulized Lignocaine, Lignocaine Spray, or Their Combination for Topical Anesthesia During Diagnostic Flexible Bronchoscopy. Chest. 2020 Jan;157(1):198-204. doi: 10.1016/j.chest.2019.06.018. Epub 2019 Jul 9. PMID 31299247